MEP0408A - Derivati hinociklicnog hinazolina kao inhibitori pde7 - Google Patents

Derivati hinociklicnog hinazolina kao inhibitori pde7

Info

Publication number: MEP0408A
Authority: ME; Montenegro
Prior art keywords: spirocyclic; pde7 inhibitors; quinazoline derivatives; pain; compounds
Prior art date: 2005-12-02

Application number

MEP-04/08A

Other languages

Bosnian (bs)

English (en)

Inventor

David James Rawson

Nigel Alan Swain

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-02

Filing date

2006-11-23

Publication date

2010-02-10

2006-11-23 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

2010-02-10 Publication of MEP0408A publication Critical patent/MEP0408A/xx

Links

229940123304 Phosphodiesterase 7 inhibitor Drugs 0.000 title abstract 2
239000002606 phosphodiesterase VII inhibitor Substances 0.000 title abstract 2
125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000002993 cycloalkylene group Chemical group 0.000 abstract 1
208000004296 neuralgia Diseases 0.000 abstract 1
208000021722 neuropathic pain Diseases 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

MEP-04/08A 2005-12-02 2006-11-23 Derivati hinociklicnog hinazolina kao inhibitori pde7 MEP0408A (xx)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US74185405P	2005-12-02	2005-12-02
US79118606P	2006-04-10	2006-04-10
PCT/IB2006/003388 WO2007063391A2 (en)	2005-12-02	2006-11-23	Spirocyclic quinazoline derivatives as pde7 inhibitors

Publications (1)

Publication Number	Publication Date
MEP0408A true MEP0408A (xx)	2010-02-10

Family

ID=37882213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-04/08A MEP0408A (xx)	2005-12-02	2006-11-23	Derivati hinociklicnog hinazolina kao inhibitori pde7

Country Status (22)

Country	Link
US (1)	US7507742B2 (es)
EP (1)	EP1957467A2 (es)
JP (1)	JP2009517453A (es)
KR (1)	KR101009554B1 (es)
AP (1)	AP2008004470A0 (es)
AR (1)	AR058266A1 (es)
AU (1)	AU2006321349A1 (es)
BR (1)	BRPI0619126A2 (es)
CA (1)	CA2631535C (es)
CR (1)	CR10039A (es)
EA (1)	EA200801145A1 (es)
EC (1)	ECSP088484A (es)
GT (1)	GT200600494A (es)
MA (1)	MA30014B1 (es)
ME (1)	MEP0408A (es)
NL (1)	NL2000336C2 (es)
NO (1)	NO20082077L (es)
PE (1)	PE20071087A1 (es)
RS (1)	RS20080233A (es)
TW (1)	TW200732307A (es)
UY (1)	UY29979A1 (es)
WO (1)	WO2007063391A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL126999A (en)	1996-07-24	2002-03-10	Warner Lambert Co	Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain
JP4173909B1 (ja) *	2005-04-28	2008-10-29	ファイザー・リミテッド	アミノ酸誘導体
WO2008119057A2 (en) *	2007-03-27	2008-10-02	Omeros Corporation	The use of pde7 inhibitors for the treatment of movement disorders
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
CA2687944A1 (en) *	2007-05-24	2008-11-27	Pfizer Limited	Spirocyclic quinazoline derivatives and their use as pde7 inhibitors
JP2010043063A (ja) *	2008-05-09	2010-02-25	Agency For Science Technology & Research	川崎病の診断及び治療
SG176571A1 (en) *	2009-05-19	2012-01-30	Vivia Biotech Sl	Methods for providing personalized medicine tests ex vivo for hematological neoplasms
NZ628054A (en)	2010-11-08	2016-03-31	Omeros Corp	Treatment of addiction and impulse-control disorders using pde7 inhibitors
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
CU24152B1 (es)	2010-12-20	2016-02-29	Irm Llc	1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
US11685745B2 (en)	2017-07-12	2023-06-27	Dart Neuroscience, Llc	Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors
IL318817A (en)	2022-08-18	2025-04-01	Mitodicure Gmbh	Use of a therapeutic agent with PHOSPHODIESTERASE-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exercise intolerance

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001083772A1 (en)	2000-04-28	2001-11-08	Merck Patent Gmbh	Splice variant of camp phosphodiesterase type 7 (pde7a3)
WO2002076953A1 (en)	2001-03-21	2002-10-03	Warner-Lambert Company Llc	New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
EP1400244A1 (en)	2002-09-17	2004-03-24	Warner-Lambert Company LLC	New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
EP1855686A1 (en) *	2005-03-01	2007-11-21	Pfizer Limited	Use of pde7 inhibitors for the treatment of neuropathic pain

2006
- 2006-11-23 BR BRPI0619126-6A patent/BRPI0619126A2/pt not_active Application Discontinuation
- 2006-11-23 AU AU2006321349A patent/AU2006321349A1/en not_active Abandoned
- 2006-11-23 EP EP06820991A patent/EP1957467A2/en not_active Withdrawn
- 2006-11-23 AP AP2008004470A patent/AP2008004470A0/xx unknown
- 2006-11-23 ME MEP-04/08A patent/MEP0408A/xx unknown
- 2006-11-23 JP JP2008542855A patent/JP2009517453A/ja not_active Withdrawn
- 2006-11-23 RS RSP-2008/0233A patent/RS20080233A/sr unknown
- 2006-11-23 CA CA2631535A patent/CA2631535C/en not_active Expired - Fee Related
- 2006-11-23 WO PCT/IB2006/003388 patent/WO2007063391A2/en not_active Ceased
- 2006-11-23 KR KR1020087013205A patent/KR101009554B1/ko not_active Expired - Fee Related
- 2006-11-23 EA EA200801145A patent/EA200801145A1/xx unknown
- 2006-11-27 NL NL2000336A patent/NL2000336C2/nl not_active IP Right Cessation
- 2006-11-29 PE PE2006001519A patent/PE20071087A1/es not_active Application Discontinuation
- 2006-11-29 GT GT200600494A patent/GT200600494A/es unknown
- 2006-11-30 UY UY29979A patent/UY29979A1/es not_active Application Discontinuation
- 2006-12-01 TW TW095144665A patent/TW200732307A/zh unknown
- 2006-12-01 US US11/565,953 patent/US7507742B2/en not_active Expired - Fee Related
- 2006-12-01 AR ARP060105332A patent/AR058266A1/es unknown
2008
- 2008-05-02 NO NO20082077A patent/NO20082077L/no not_active Application Discontinuation
- 2008-05-29 EC EC2008008484A patent/ECSP088484A/es unknown
- 2008-05-30 CR CR10039A patent/CR10039A/es not_active Application Discontinuation
- 2008-06-02 MA MA30981A patent/MA30014B1/fr unknown

Also Published As

Publication number	Publication date
CR10039A (es)	2008-07-10
GT200600494A (es)	2007-07-06
NL2000336C2 (nl)	2007-08-07
NL2000336A1 (nl)	2007-06-05
KR20080059338A (ko)	2008-06-26
PE20071087A1 (es)	2007-12-29
NO20082077L (no)	2008-06-04
AR058266A1 (es)	2008-01-30
CA2631535C (en)	2010-07-27
EP1957467A2 (en)	2008-08-20
TW200732307A (en)	2007-09-01
RS20080233A (sr)	2009-07-15
UY29979A1 (es)	2007-06-29
WO2007063391A2 (en)	2007-06-07
US20070129388A1 (en)	2007-06-07
AU2006321349A1 (en)	2007-06-07
EA200801145A1 (ru)	2008-10-30
AP2008004470A0 (en)	2008-06-30
MA30014B1 (fr)	2008-12-01
JP2009517453A (ja)	2009-04-30
US7507742B2 (en)	2009-03-24
CA2631535A1 (en)	2007-06-07
ECSP088484A (es)	2008-06-30
BRPI0619126A2 (pt)	2011-09-13
KR101009554B1 (ko)	2011-01-18
WO2007063391A3 (en)	2007-09-13

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NO20082077L (no)	2008-06-04	Spirosykliske quinazolinderivater som PDE7-inhibitorer
DE602004024375D1 (de)	2010-01-14	Carboxamidderivate
TW200615266A (en)	2006-05-16	Organic compounds
WO2009155121A3 (en)	2010-02-18	Inhibitors of pi3 kinase
MX2009006742A (es)	2009-08-24	Inhibidores acilaminopirazoles como fgfr.
NO20085217L (no)	2009-01-12	Effektive pyrimidinderivater i behandlingen av kreft
SE0202539D0 (sv)	2002-08-27	Compounds
MY148480A (en)	2013-04-30	Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
TW200740815A (en)	2007-11-01	P38 MAP kinase inhibitors and methods for using the same
SE0302192D0 (sv)	2003-08-08	Novel compounds
WO2010021934A3 (en)	2010-06-10	Azaindole inhibitors of iap
SE0402925D0 (sv)	2004-11-30	Novel Compounds
EP2145878A3 (en)	2010-02-24	Aurora Kinase inhibitors
SE0301320D0 (sv)	2003-05-06	Positive modulators of nicotinic acetylcholine receptors
UA96969C2 (en)	2011-12-26	Acylaminopyrazoles as fgfr inhibitors
SE0302756D0 (sv)	2003-10-17	Novel Compounds
TW200639156A (en)	2006-11-16	New compounds
EP1453506A4 (en)	2005-06-08	Topoisomerase GIFT FUNDS
SE0401763D0 (sv)	2004-07-05	Compounds
AU2002359150A8 (en)	2003-06-30	Therapeutic heterocycles
MY139228A (en)	2009-08-28	Imidazolinylmethyl aralkylsulfonamides
EA200870223A1 (ru)	2009-02-27	Производные бензоизоиндола для лечения боли
WO2004044174A3 (en)	2004-08-12	Topoisomerase-targeting agents
NO20063619L (no)	2006-10-09	Diarylmetylpiperazinderivater, fremstilling og anvendelse derav
MX2009005125A (es)	2009-11-02	Pirrolo[1,2-a]imidazoldiona efectiva en el tratamiento de neurotoxicidad periferica inducida por agentes quimioterapeuticos.