MEP13108A - Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b - Google Patents

Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b

Info

Publication number
MEP13108A
MEP13108A MEP-131/08A MEP13108A MEP13108A ME P13108 A MEP13108 A ME P13108A ME P13108 A MEP13108 A ME P13108A ME P13108 A MEP13108 A ME P13108A
Authority
ME
Montenegro
Prior art keywords
domain
antibody
cdr1
cdr2
seq
Prior art date
Application number
MEP-131/08A
Other languages
Bosnian (bs)
English (en)
Croatian (hr)
Inventor
Laura Borsi
Barbara Carnemolla
Enrica Balza
Patrizia Castellani
Luciano Zardi
Matthias Friebe
Christoph-Stephan Hilger
Original Assignee
Bayer Schering Pharma Ag
Philogen Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag, Philogen Spa filed Critical Bayer Schering Pharma Ag
Publication of MEP13108A publication Critical patent/MEP13108A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MEP-131/08A 2003-09-10 2004-09-01 Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b MEP13108A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50188103P 2003-09-10 2003-09-10
EP03255633A EP1514561A1 (de) 2003-09-10 2003-09-10 Tumorvaskulatur Zielrichtung mittels Verwendung eines gegen Fibronectin ED-B radiomarkierten Antikörpers L19
PCT/EP2004/009733 WO2005023318A1 (en) 2003-09-10 2004-09-01 Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b

Publications (1)

Publication Number Publication Date
MEP13108A true MEP13108A (en) 2011-05-10

Family

ID=34130349

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-131/08A MEP13108A (en) 2003-09-10 2004-09-01 Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b

Country Status (27)

Country Link
US (2) US20050074401A1 (de)
EP (3) EP1514561A1 (de)
JP (1) JP2007505065A (de)
KR (1) KR101129161B1 (de)
CN (1) CN100482285C (de)
AT (1) ATE499949T1 (de)
AU (2) AU2004269897B2 (de)
BR (1) BRPI0414272A (de)
CA (1) CA2536256C (de)
CR (2) CR8331A (de)
DE (1) DE602004031635D1 (de)
DK (1) DK1663320T3 (de)
EA (1) EA010653B1 (de)
EC (1) ECSP066499A (de)
ES (1) ES2361743T3 (de)
IL (1) IL173560A0 (de)
ME (1) MEP13108A (de)
NO (1) NO20061619L (de)
NZ (1) NZ545640A (de)
PL (1) PL1663320T3 (de)
PT (1) PT1663320E (de)
RS (1) RS20060176A (de)
SG (1) SG162760A1 (de)
SI (1) SI1663320T1 (de)
UA (1) UA89759C2 (de)
WO (1) WO2005023318A1 (de)
ZA (1) ZA200602014B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1259548A1 (de) * 2000-02-24 2002-11-27 Eidgenössische Technische Hochschule Zürich Antikörper gegen die ed-b domäne von fibronektin, konjugate die diesen antikörper enthalten, und deren verwendung zum nachweis und zur behandlung von angiogenese
ES2337566T3 (es) * 2002-03-11 2010-04-27 Philogen S.P.A. Anticuerpos derivados de anti ed-b l19 y vasculatura tumoral objetivo.
US7785591B2 (en) 2004-10-14 2010-08-31 Morphosys Ag Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
EP2085095B1 (de) * 2008-01-17 2012-03-07 Philogen S.p.A. Kombination aus einem Anti-EDb-Fibronectin-Antikörper-IL-2-Fusionsprotein und einem B-Zellen bindenden Molekül, B-Zellen-Vorläufern und/oder deren krebserregendem Gegenspieler
AU2015202204A1 (en) * 2008-04-30 2015-05-14 Immunogen, Inc. Cross-linkers and their uses
NZ588884A (en) * 2008-04-30 2013-05-31 Immunogen Inc Cross-linkers and their uses
WO2011147762A2 (en) * 2010-05-25 2011-12-01 Bayer Pharma Aktiengesellschaft Stabilized radiopharmaceutical composition
EP3029065B1 (de) * 2013-06-06 2020-05-27 Hefei Lifeon Pharmaceutical Co. Ltd. Humane antikörper gegen die ed-b-domäne von fibronektin und verwendungen davon
GB201621806D0 (en) 2016-12-21 2017-02-01 Philogen Spa Immunocytokines with progressive activation mechanism
US10517238B2 (en) 2017-09-18 2019-12-31 Deere & Company Implement optimization by automated adjustments
WO2020249757A1 (en) 2019-06-14 2020-12-17 Philogen S.P.A Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha
ES2987329T3 (es) 2020-05-22 2024-11-14 Philogen Spa Terapia con el inmunoconjugado de TNF-a para el tratamiento de tumores cerebrales
CN111808161A (zh) * 2020-06-01 2020-10-23 北京大学 一种对生物化合物进行放射性标记的方法
US20250073239A1 (en) 2022-01-04 2025-03-06 Philogen S.P.A. Combination of an immunocytokine comprising il-12 and a kinase inhibitor
EP4780495A1 (de) 2023-09-19 2026-07-29 Philochem AG Therapeutische kombination eines anti-edb-fibronektindomänenantikörpers il2 oder il12 fusionsproteins und eines lutetium-177-radiokonjugats
WO2026003203A1 (en) 2024-06-27 2026-01-02 Philogen S.P.A. Combination of an immunocytokine comprising targeted il2 and a jak inhibitor
CN119775344B (zh) * 2024-12-31 2025-08-26 英科新创（苏州）生物科技有限公司 水溶性吖啶磺酰胺衍生物、制备方法、其应用及试剂盒

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US20030045681A1 (en) * 1998-05-11 2003-03-06 Anthony J. Zelano Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
US8623373B2 (en) 2000-02-24 2014-01-07 Philogen S.P.A. Compositions and methods for treatment of angiogenesis in pathological lesions
EP1259548A1 (de) * 2000-02-24 2002-11-27 Eidgenössische Technische Hochschule Zürich Antikörper gegen die ed-b domäne von fibronektin, konjugate die diesen antikörper enthalten, und deren verwendung zum nachweis und zur behandlung von angiogenese
WO2001096599A2 (en) * 2000-06-15 2001-12-20 Philogen S.R.L. Methods for quantitative determination of b-fibronectin in biological fluids and tissues
PL369371A1 (en) * 2002-01-03 2005-04-18 Schering Aktiengesellschaft New methods for diagnosis and treatment of tumours
ES2337566T3 (es) * 2002-03-11 2010-04-27 Philogen S.P.A. Anticuerpos derivados de anti ed-b l19 y vasculatura tumoral objetivo.

Also Published As

Publication number Publication date
SI1663320T1 (sl) 2011-06-30
ECSP066499A (es) 2006-10-10
KR20060118430A (ko) 2006-11-23
CA2536256A1 (en) 2005-03-17
US20090214423A1 (en) 2009-08-27
NO20061619L (no) 2006-04-10
ES2361743T3 (es) 2011-06-21
EA010653B1 (ru) 2008-10-30
EA200600494A1 (ru) 2006-08-25
CR8331A (es) 2006-10-04
AU2010200271A1 (en) 2010-02-18
CN100482285C (zh) 2009-04-29
PL1663320T3 (pl) 2011-07-29
AU2004269897A1 (en) 2005-03-17
ZA200602014B (en) 2007-05-30
DE602004031635D1 (de) 2011-04-14
US20050074401A1 (en) 2005-04-07
AU2004269897B2 (en) 2009-11-05
JP2007505065A (ja) 2007-03-08
DK1663320T3 (da) 2011-06-06
RS20060176A (sr) 2008-08-07
CR20110168A (es) 2011-06-03
ATE499949T1 (de) 2011-03-15
CA2536256C (en) 2013-02-26
HK1092375A1 (zh) 2007-02-09
EP1663320A1 (de) 2006-06-07
BRPI0414272A (pt) 2006-11-07
UA89759C2 (ru) 2010-03-10
CN1849144A (zh) 2006-10-18
SG162760A1 (en) 2010-07-29
PT1663320E (pt) 2011-06-07
IL173560A0 (en) 2006-07-05
EP1663320B1 (de) 2011-03-02
EP2246070A2 (de) 2010-11-03
EP1514561A1 (de) 2005-03-16
WO2005023318A1 (en) 2005-03-17
KR101129161B1 (ko) 2012-03-28
NZ545640A (en) 2009-05-31

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