MEP34708A - Macrolide-conjugates with anti-inflammatory activity - Google Patents

Macrolide-conjugates with anti-inflammatory activity

Info

Publication number: MEP34708A
Authority: ME; Montenegro
Prior art keywords: steroidal; macrolide; formula; conjugates; inflammatory activity
Prior art date: 2003-04-24

Application number

MEP-347/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Mladen Mercep

Milan Mesic

Linda Tomaskovic

Stribor Markovic

Boska Hrvacic

Oresta Makaruha

Visnja Poljak

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-24

Filing date

2004-04-23

Publication date

2011-05-10

2004-04-23 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2011-05-10 Publication of MEP34708A publication Critical patent/MEP34708A/xx

Links

230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
230000003637 steroidlike Effects 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Genetics & Genomics (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

MEP-347/08A 2003-04-24 2004-04-23 Macrolide-conjugates with anti-inflammatory activity MEP34708A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HR20030324A HRP20030324A2 (en)	2003-04-24	2003-04-24	Compounds of antiinflammatory effect
PCT/IB2004/001235 WO2004094449A1 (en)	2003-04-24	2004-04-23	Macrolide-conjugates with anti-inflammatory activity

Publications (1)

Publication Number	Publication Date
MEP34708A true MEP34708A (en)	2011-05-10

Family

ID=33307078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-347/08A MEP34708A (en)	2003-04-24	2004-04-23	Macrolide-conjugates with anti-inflammatory activity

Country Status (27)

Country	Link
US (1)	US7579334B2 (de)
EP (2)	EP2070940B1 (de)
JP (1)	JP4613366B2 (de)
KR (1)	KR101107336B1 (de)
CN (1)	CN100393741C (de)
AR (1)	AR044083A1 (de)
AT (1)	ATE518876T1 (de)
AU (1)	AU2004232546B2 (de)
BR (1)	BRPI0410490A (de)
CA (1)	CA2523081C (de)
CL (1)	CL2004000872A1 (de)
CY (2)	CY1109491T1 (de)
DE (1)	DE602004022047D1 (de)
DK (2)	DK2070940T3 (de)
ES (2)	ES2330109T3 (de)
HR (3)	HRP20030324A2 (de)
IS (2)	IS2736B (de)
ME (1)	MEP34708A (de)
MX (1)	MXPA05011359A (de)
NO (2)	NO333909B1 (de)
PL (2)	PL2070940T3 (de)
PT (2)	PT1633771E (de)
RS (1)	RS52621B (de)
RU (1)	RU2355699C2 (de)
SI (2)	SI1633771T1 (de)
WO (1)	WO2004094449A1 (de)
ZA (1)	ZA200508388B (de)

Families Citing this family (16)

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TW200420573A (en)	2002-09-26	2004-10-16	Rib X Pharmaceuticals Inc	Bifunctional heterocyclic compounds and methods of making and using same
HRP20030324A2 (en)	2003-04-24	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	Compounds of antiinflammatory effect
EP1723159B1 (de)	2004-02-27	2019-06-12	Melinta Therapeutics, Inc.	Makrozyklische verbindungen, deren herstellung und verwendung
US20060183696A1 (en) *	2004-08-12	2006-08-17	Pliva-Istrazivacki Institut D.O.O.	Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
KR20070046917A (ko) *	2004-08-12	2007-05-03	글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오.	위장관의 염증성 질환의 치료를 위한 세포-특이적컨쥬게이트의 용도
ES2337915T3 (es) *	2004-10-27	2010-04-30	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Conjugados con adtividad antiinflamatoria.
AU2006327181A1 (en) *	2005-12-22	2007-06-28	Hydra Biosciences, Inc.	TRPA1 inhibitors for treating pain
WO2007093840A2 (en) *	2006-02-15	2007-08-23	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
JP2011513391A (ja) *	2008-03-05	2011-04-28	パナセアバイオテックリミテッド	ミコフェノラートを含有する徐放性医薬組成物およびその方法
CN102838660B (zh) *	2011-06-23	2016-11-02	上海市第一人民医院	一种抑制炎症免疫反应的小肽及其应用
EP2948152A4 (de) *	2013-01-23	2016-12-14	Sphaera Pharma Private Ltd	Neuartige verbindungen von 11-beta-hydroxy-steroiden zur verwendung bei einer mitochondrien-biogenese und krankheiten im zusammenhang mit mitochondrien-dysfunktion oder -abreicherung
BR112015021388A2 (pt)	2013-03-08	2017-07-18	Allergan Inc	conjugados esteroides de ciclosporina a
US20140256666A1 (en) *	2013-03-08	2014-09-11	Allergan, Inc.	Antibiotic conjugates with nonsteroidal anti-inflammatory drugs
RU2015138893A (ru) *	2013-03-08	2017-04-13	Аллерган, Инк.	Конъюгаты антибиотиков, связанные со стероидными препаратами
RU2015138891A (ru)	2013-03-08	2017-04-11	Аллерган, Инк.	Конъюгаты антибиотиков, напрямую связанные со стероидными препаратами
WO2016013030A2 (en)	2014-07-23	2016-01-28	Sphaera Pharma Pvt. Ltd.	Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof

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SE9100342D0 (sv)	1991-02-04	1991-02-04	Astra Ab	Novel steroid esters
SE9100341D0 (sv)	1991-02-04	1991-02-04	Astra Ab	Novel steroids
GB9225923D0 (en)	1992-12-11	1993-02-03	Rhone Poulenc Rorer Ltd	New compositions of matter
DE69311742T2 (de)	1992-12-24	1998-01-08	Rhone Poulenc Rorer Ltd	Neue steroide
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HRP20000310A2 (en)	2000-05-17	2002-02-28	Pliva Farmaceutska Ind Dioniko	New dibenzoazulene compounds as tumor necrosis factor inhibitors
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AU2003219770B2 (en)	2002-02-15	2008-10-09	Merckle Gmbh	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1483579A4 (de)	2002-02-15	2006-07-12	Merckle Gmbh	Konjugate biologisch aktiver verbindungen, verfahren zu ihrer herstellung und verwendung, formulierung und pharmazeutische anwendungen davon
US20040186063A1 (en)	2002-02-15	2004-09-23	Hans-Jurgen Gutke	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1521763A2 (de)	2002-07-08	2005-04-13	Pliva - Istrazivacki Institut d.o.o.	Nicht-steroidische entzündungshemmende wirkstoffe, zusammensetzungen und verfahren zu deren verwendung
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AU2003264917A1 (en)	2002-07-08	2004-01-23	Pliva - Istrazivacki Institut D.O.O.	Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
HRP20030324A2 (en)	2003-04-24	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	Compounds of antiinflammatory effect

2003
- 2003-04-24 HR HR20030324A patent/HRP20030324A2/hr not_active Application Discontinuation
2004
- 2004-04-22 US US10/830,858 patent/US7579334B2/en not_active Expired - Fee Related
- 2004-04-23 AR ARP040101400A patent/AR044083A1/es unknown
- 2004-04-23 ES ES04729157T patent/ES2330109T3/es not_active Expired - Lifetime
- 2004-04-23 SI SI200431253T patent/SI1633771T1/sl unknown
- 2004-04-23 MX MXPA05011359A patent/MXPA05011359A/es active IP Right Grant
- 2004-04-23 DE DE602004022047T patent/DE602004022047D1/de not_active Expired - Lifetime
- 2004-04-23 CA CA2523081A patent/CA2523081C/en not_active Expired - Lifetime
- 2004-04-23 EP EP09075145A patent/EP2070940B1/de not_active Expired - Lifetime
- 2004-04-23 PT PT04729157T patent/PT1633771E/pt unknown
- 2004-04-23 CN CNB2004800110487A patent/CN100393741C/zh not_active Expired - Fee Related
- 2004-04-23 CL CL200400872A patent/CL2004000872A1/es unknown
- 2004-04-23 AT AT09075145T patent/ATE518876T1/de active
- 2004-04-23 DK DK09075145.4T patent/DK2070940T3/da active
- 2004-04-23 KR KR1020057020252A patent/KR101107336B1/ko not_active Expired - Fee Related
- 2004-04-23 PL PL09075145T patent/PL2070940T3/pl unknown
- 2004-04-23 AU AU2004232546A patent/AU2004232546B2/en not_active Ceased
- 2004-04-23 SI SI200431768T patent/SI2070940T1/sl unknown
- 2004-04-23 RS YU20050873A patent/RS52621B/sr unknown
- 2004-04-23 ES ES09075145T patent/ES2370371T3/es not_active Expired - Lifetime
- 2004-04-23 RU RU2005131937/04A patent/RU2355699C2/ru not_active IP Right Cessation
- 2004-04-23 BR BRPI0410490-0A patent/BRPI0410490A/pt not_active Application Discontinuation
- 2004-04-23 WO PCT/IB2004/001235 patent/WO2004094449A1/en not_active Ceased
- 2004-04-23 DK DK04729157T patent/DK1633771T3/da active
- 2004-04-23 JP JP2006506511A patent/JP4613366B2/ja not_active Expired - Fee Related
- 2004-04-23 HR HR20090551T patent/HRP20090551T1/hr unknown
- 2004-04-23 EP EP04729157A patent/EP1633771B1/de not_active Expired - Lifetime
- 2004-04-23 PL PL04729157T patent/PL1633771T3/pl unknown
- 2004-04-23 ME MEP-347/08A patent/MEP34708A/xx unknown
- 2004-04-23 PT PT09075145T patent/PT2070940E/pt unknown
2005
- 2005-10-17 ZA ZA200508388A patent/ZA200508388B/xx unknown
- 2005-11-22 IS IS8141A patent/IS2736B/is unknown
- 2005-11-23 NO NO20055535A patent/NO333909B1/no not_active IP Right Cessation
2009
- 2009-10-14 CY CY20091101070T patent/CY1109491T1/el unknown
2010
- 2010-12-29 IS IS8941A patent/IS8941A/is unknown
2011
- 2011-10-19 HR HR20110763T patent/HRP20110763T1/hr unknown
- 2011-10-25 CY CY20111101008T patent/CY1111978T1/el unknown
2013
- 2013-06-28 NO NO20130898A patent/NO335552B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO333909B1 (no)	2013-10-14
EP2070940A1 (de)	2009-06-17
CL2004000872A1 (es)	2005-03-18
EP1633771A1 (de)	2006-03-15
KR20060024770A (ko)	2006-03-17
ES2330109T3 (es)	2009-12-04
DK1633771T3 (da)	2009-11-16
RS20050873A (sr)	2007-08-03
MXPA05011359A (es)	2006-05-12
ATE518876T1 (de)	2011-08-15
CA2523081C (en)	2010-08-03
BRPI0410490A (pt)	2006-06-13
IS2736B (is)	2011-06-15
CY1109491T1 (el)	2014-08-13
EP2070940A3 (de)	2009-11-25
AR044083A1 (es)	2005-08-24
JP2006524221A (ja)	2006-10-26
HK1129681A1 (en)	2009-12-04
SI1633771T1 (sl)	2009-12-31
RU2005131937A (ru)	2006-06-27
CN100393741C (zh)	2008-06-11
AU2004232546B2 (en)	2011-06-09
HRP20090551T1 (hr)	2010-01-31
EP2070940B1 (de)	2011-08-03
DK2070940T3 (da)	2011-10-31
JP4613366B2 (ja)	2011-01-19
ES2370371T3 (es)	2011-12-14
AU2004232546A1 (en)	2004-11-04
CN1777619A (zh)	2006-05-24
NO20055535D0 (no)	2005-11-23
PT2070940E (pt)	2011-11-14
CY1111978T1 (el)	2015-11-04
PT1633771E (pt)	2009-10-20
IS8941A (is)	2010-12-29
WO2004094449A8 (en)	2005-03-31
IS8141A (is)	2005-11-22
EP1633771B1 (de)	2009-07-15
NO20130898L (no)	2006-01-16
PL1633771T3 (pl)	2009-12-31
HK1086842A1 (zh)	2006-09-29
US7579334B2 (en)	2009-08-25
CA2523081A1 (en)	2004-11-04
ZA200508388B (en)	2006-07-26
PL2070940T3 (pl)	2011-12-30
NO20055535L (no)	2006-01-16
HRP20110763T1 (hr)	2011-11-30
RS52621B (sr)	2013-06-28
DE602004022047D1 (de)	2009-08-27
RU2355699C2 (ru)	2009-05-20
SI2070940T1 (sl)	2011-12-30
US20050080003A1 (en)	2005-04-14
NO335552B1 (no)	2014-12-29
WO2004094449A1 (en)	2004-11-04
KR101107336B1 (ko)	2012-01-19
HRP20030324A2 (en)	2005-02-28

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SE0303480D0 (sv)	2003-12-19	Benzofuranes
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ATE284882T1 (de)	2005-01-15	Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
TW200635592A (en)	2006-10-16	Pyridyl-substituted spiro-hydantoin compounds and use thereof