MEP42608A - Technical synthesis method for producing tropenol - Google Patents

Technical synthesis method for producing tropenol

Info

Publication number: MEP42608A
Authority: ME; Montenegro
Prior art keywords: synthesis method; tropenol; technical synthesis; producing; producing tropenol
Prior art date: 2001-06-28

Application number

MEP-426/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Armin Walter Rapp

Rainer Sobotta

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-28

Filing date

2002-06-08

Publication date

2011-02-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP42608(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-06-08 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2011-02-10 Publication of MEP42608A publication Critical patent/MEP42608A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Lock And Its Accessories (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

MEP-426/08A 2001-06-28 2002-06-08 Technical synthesis method for producing tropenol MEP42608A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10131200		2001-06-28
PCT/EP2002/006290 WO2003002562A1 (de)	2001-06-28	2002-06-08	Technische syntheseverfahren zur herstellung von tropenol

Publications (1)

Publication Number	Publication Date
MEP42608A true MEP42608A (en)	2011-02-10

Family

ID=7689774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-426/08A MEP42608A (en)	2001-06-28	2002-06-08	Technical synthesis method for producing tropenol

Country Status (40)

Country	Link
US (1)	US6610849B2 (cs)
EP (3)	EP1404673B1 (cs)
JP (2)	JP4485192B2 (cs)
KR (3)	KR100866272B1 (cs)
CN (2)	CN1288154C (cs)
AR (1)	AR039056A1 (cs)
AT (3)	ATE527257T1 (cs)
AU (2)	AU2002257820B2 (cs)
BG (2)	BG66398B1 (cs)
BR (1)	BR0210664B1 (cs)
CA (1)	CA2451573C (cs)
CO (1)	CO5650166A2 (cs)
CY (1)	CY1107681T1 (cs)
CZ (1)	CZ296187B6 (cs)
DE (2)	DE50209948D1 (cs)
DK (3)	DK1475379T3 (cs)
EA (2)	EA009808B1 (cs)
EC (1)	ECSP034927A (cs)
EE (1)	EE05403B1 (cs)
EG (1)	EG23203A (cs)
ES (3)	ES2242022T3 (cs)
HR (2)	HRP20090110A2 (cs)
HU (2)	HU230036B1 (cs)
IL (2)	IL159239A0 (cs)
ME (1)	MEP42608A (cs)
MX (1)	MXPA03011516A (cs)
MY (1)	MY122932A (cs)
NO (1)	NO328154B1 (cs)
NZ (2)	NZ541395A (cs)
PE (1)	PE20030123A1 (cs)
PL (1)	PL209520B1 (cs)
PT (2)	PT1404673E (cs)
RS (1)	RS50436B (cs)
SA (1)	SA02230194B1 (cs)
SI (2)	SI1404673T1 (cs)
SK (1)	SK288022B6 (cs)
TW (1)	TW574220B (cs)
UA (2)	UA76761C2 (cs)
WO (1)	WO2003002562A1 (cs)
ZA (1)	ZA200308895B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10141377A1 (de)	2001-08-23	2003-03-13	Boehringer Ingelheim Pharma	Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) *	2002-05-31	2004-06-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Industrial process for preparing tropenol
US20090162562A1 (en) *	2007-12-24	2009-06-25	Bangalore Aswatha Nagaraj	Methods for Applying Thermal Barrier Coating Systems
HRP20141004T1 (hr) *	2008-01-10	2015-02-13	Generics	Novi postupak pripreme estera skopina
CA2931876A1 (en)	2009-08-07	2011-02-10	Generics [Uk] Limited	Anhydrate of tiotropium bromide
WO2011015884A1 (en)	2009-08-07	2011-02-10	Generics [Uk] Limited	Process to prepare scopine esters
CN102351856B (zh) *	2011-08-24	2013-05-01	商丘市韶华药业有限公司	一种α-托品醇的纯化方法
ITRM20110508A1 (it)	2011-09-27	2013-03-28	Lusochimica Spa	Processo per la preparazione degli esteri della scopina.
LT2607351T (lt) *	2011-12-22	2017-06-12	Cerbios-Pharma S.A.	Ciklinių tretinių aminų nepertraukiamo alkilinimo būdas
CN113292574B (zh) *	2020-02-21	2022-05-03	四川大学	一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) *	2020-04-13	2021-09-21	石家庄四药有限公司	异丙托溴铵的合成方法
CN113264929B (zh) *	2021-05-02	2023-10-10	润生药业有限公司	一种噻托溴铵的制备方法
CN115925534B (zh) *	2023-01-03	2025-03-07	绍兴民生医药股份有限公司	高纯度托品酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3931041C2 (de) *	1989-09-16	2000-04-06	Boehringer Ingelheim Kg	Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EE03877B1 (et) *	1994-04-19	2002-10-15	Neurosearch A/S	Tropaan-2-aldoksiimi derivaadid neurotransmitteritagasihaarde inhibiitoritena
DE19515625C2 (de) *	1995-04-28	1998-02-19	Boehringer Ingelheim Kg	Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

2002
- 2002-06-03 US US10/160,702 patent/US6610849B2/en not_active Expired - Lifetime
- 2002-06-08 DK DK04018550T patent/DK1475379T3/da active
- 2002-06-08 KR KR1020037017010A patent/KR100866272B1/ko not_active Expired - Lifetime
- 2002-06-08 EA EA200501081A patent/EA009808B1/ru not_active IP Right Cessation
- 2002-06-08 JP JP2003508943A patent/JP4485192B2/ja not_active Expired - Lifetime
- 2002-06-08 DK DK02727610T patent/DK1404673T3/da active
- 2002-06-08 DK DK07101821.2T patent/DK1808435T3/da active
- 2002-06-08 HU HU0400332A patent/HU230036B1/hu unknown
- 2002-06-08 NZ NZ541395A patent/NZ541395A/en not_active IP Right Cessation
- 2002-06-08 EE EEP200400045A patent/EE05403B1/xx not_active IP Right Cessation
- 2002-06-08 SI SI200230153T patent/SI1404673T1/xx unknown
- 2002-06-08 HR HR20090110A patent/HRP20090110A2/xx not_active Application Discontinuation
- 2002-06-08 KR KR1020087014692A patent/KR100886342B1/ko not_active Expired - Lifetime
- 2002-06-08 PT PT02727610T patent/PT1404673E/pt unknown
- 2002-06-08 AT AT07101821T patent/ATE527257T1/de active
- 2002-06-08 DE DE50209948T patent/DE50209948D1/de not_active Expired - Lifetime
- 2002-06-08 DE DE50203015T patent/DE50203015D1/de not_active Expired - Lifetime
- 2002-06-08 PL PL366942A patent/PL209520B1/pl unknown
- 2002-06-08 EA EA200301292A patent/EA006393B1/ru not_active IP Right Cessation
- 2002-06-08 AT AT02727610T patent/ATE294801T1/de active
- 2002-06-08 AU AU2002257820A patent/AU2002257820B2/en not_active Expired
- 2002-06-08 RS YUP-1011/03A patent/RS50436B/sr unknown
- 2002-06-08 EP EP02727610A patent/EP1404673B1/de not_active Expired - Lifetime
- 2002-06-08 ES ES02727610T patent/ES2242022T3/es not_active Expired - Lifetime
- 2002-06-08 WO PCT/EP2002/006290 patent/WO2003002562A1/de not_active Ceased
- 2002-06-08 BR BRPI0210664-7B1A patent/BR0210664B1/pt active IP Right Grant
- 2002-06-08 CZ CZ20040149A patent/CZ296187B6/cs not_active IP Right Cessation
- 2002-06-08 ME MEP-426/08A patent/MEP42608A/xx unknown
- 2002-06-08 EP EP07101821A patent/EP1808435B1/de not_active Expired - Lifetime
- 2002-06-08 HR HR20031085A patent/HRP20031085B1/xx not_active IP Right Cessation
- 2002-06-08 AT AT04018550T patent/ATE359285T1/de active
- 2002-06-08 CA CA2451573A patent/CA2451573C/en not_active Expired - Fee Related
- 2002-06-08 HU HU1400554A patent/HU230379B1/hu unknown
- 2002-06-08 CN CNB028128672A patent/CN1288154C/zh not_active Expired - Lifetime
- 2002-06-08 ES ES04018550T patent/ES2285318T3/es not_active Expired - Lifetime
- 2002-06-08 NZ NZ530770A patent/NZ530770A/en not_active IP Right Cessation
- 2002-06-08 ES ES07101821T patent/ES2374981T3/es not_active Expired - Lifetime
- 2002-06-08 SK SK66-2004A patent/SK288022B6/sk not_active IP Right Cessation
- 2002-06-08 SI SI200230540T patent/SI1475379T1/sl unknown
- 2002-06-08 EP EP04018550A patent/EP1475379B1/de not_active Revoked
- 2002-06-08 CN CN2006101604057A patent/CN1982309B/zh not_active Expired - Lifetime
- 2002-06-08 PT PT04018550T patent/PT1475379E/pt unknown
- 2002-06-08 IL IL15923902A patent/IL159239A0/xx unknown
- 2002-06-08 MX MXPA03011516A patent/MXPA03011516A/es active IP Right Grant
- 2002-06-25 PE PE2002000553A patent/PE20030123A1/es not_active Application Discontinuation
- 2002-06-26 EG EG2002060738A patent/EG23203A/xx active
- 2002-06-26 TW TW91114026A patent/TW574220B/zh not_active IP Right Cessation
- 2002-06-26 MY MYPI20022420A patent/MY122932A/en unknown
- 2002-06-28 AR ARP020102453A patent/AR039056A1/es not_active Application Discontinuation
- 2002-07-10 SA SA2230194A patent/SA02230194B1/ar unknown
- 2002-08-06 UA UA2004010605A patent/UA76761C2/uk unknown
2003
- 2003-03-28 KR KR10-2003-0019708A patent/KR100530661B1/ko not_active Expired - Fee Related
- 2003-11-14 ZA ZA200308895A patent/ZA200308895B/en unknown
- 2003-12-08 IL IL159239A patent/IL159239A/en active IP Right Grant
- 2003-12-17 NO NO20035633A patent/NO328154B1/no not_active IP Right Cessation
- 2003-12-17 BG BG108462A patent/BG66398B1/bg unknown
- 2003-12-23 CO CO03112174A patent/CO5650166A2/es active IP Right Grant
- 2003-12-24 EC EC2003004927A patent/ECSP034927A/es unknown
2006
- 2006-03-09 UA UAA200602562A patent/UA86031C2/ru unknown
2007
- 2007-06-21 CY CY20071100822T patent/CY1107681T1/el unknown
2008
- 2008-04-08 AU AU2008201565A patent/AU2008201565B2/en not_active Expired
2009
- 2009-10-13 JP JP2009236400A patent/JP2010043116A/ja active Pending
2013
- 2013-05-07 BG BG10111461A patent/BG111461A/en unknown

Also Published As

Publication number	Publication date
UA86031C2 (ru)	2009-03-25
EE200400045A (et)	2004-04-15
HU230379B1 (hu)	2016-03-29
ATE527257T1 (de)	2011-10-15
PT1404673E (pt)	2005-07-29
EA006393B1 (ru)	2005-12-29
BG111461A (en)	2013-08-30
PL366942A1 (en)	2005-02-07
HK1103404A1 (zh)	2007-12-21
NO20035633D0 (no)	2003-12-17
PL209520B1 (pl)	2011-09-30
CA2451573C (en)	2010-09-21
PE20030123A1 (es)	2003-03-31
CN1288154C (zh)	2006-12-06
CZ296187B6 (cs)	2006-01-11
EG23203A (en)	2004-07-31
YU101103A (en)	2006-05-25
SK288022B6 (sk)	2012-12-03
MY122932A (en)	2006-05-31
DE50209948D1 (de)	2007-05-24
WO2003002562A1 (de)	2003-01-09
BR0210664B1 (pt)	2013-12-03
HRP20031085A2 (en)	2004-04-30
NZ541395A (en)	2007-03-30
NO328154B1 (no)	2009-12-21
EE05403B1 (et)	2011-04-15
AU2008201565B2 (en)	2012-03-01
HRP20090110A2 (en)	2009-04-30
HU230036B1 (hu)	2015-05-28
EP1475379A1 (de)	2004-11-10
SI1475379T1 (sl)	2007-08-31
EA009808B1 (ru)	2008-04-28
HUP0400332A2 (hu)	2004-08-30
ECSP034927A (es)	2004-02-26
MXPA03011516A (es)	2004-03-18
BG66398B1 (bg)	2013-12-31
SI1404673T1 (sl)	2005-10-31
ZA200308895B (en)	2004-06-09
EP1404673B1 (de)	2005-05-04
DE50203015D1 (de)	2005-06-09
ES2374981T3 (es)	2012-02-23
RS50436B (sr)	2009-12-31
KR100886342B1 (ko)	2009-03-03
CZ2004149A3 (cs)	2004-05-12
SA02230194B1 (ar)	2008-03-08
US20030022917A1 (en)	2003-01-30
CN1982309B (zh)	2010-06-09
CA2451573A1 (en)	2003-01-09
HK1068613A1 (en)	2005-04-29
ATE359285T1 (de)	2007-05-15
TW574220B (en)	2004-02-01
DK1808435T3 (da)	2012-01-16
EP1808435A1 (de)	2007-07-18
ES2285318T3 (es)	2007-11-16
AU2008201565A1 (en)	2008-05-01
CN1982309A (zh)	2007-06-20
EP1808435B1 (de)	2011-10-05
EA200501081A1 (ru)	2006-06-30
KR20040023631A (ko)	2004-03-18
AU2002257820B2 (en)	2008-05-08
EP1404673A1 (de)	2004-04-07
KR20080065313A (ko)	2008-07-11
DK1475379T3 (da)	2007-09-03
DK1404673T3 (da)	2005-06-13
HRP20031085B1 (en)	2011-12-31
KR100866272B1 (ko)	2008-11-03
NZ530770A (en)	2005-11-25
BG108462A (bg)	2005-01-31
IL159239A (en)	2010-05-17
PT1475379E (pt)	2007-05-31
AR039056A1 (es)	2005-02-09
KR20030078793A (ko)	2003-10-08
ES2242022T3 (es)	2005-11-01
EA200301292A1 (ru)	2004-06-24
KR100530661B1 (ko)	2005-11-22
UA76761C2 (uk)	2006-09-15
CO5650166A2 (es)	2006-06-30
JP2004536830A (ja)	2004-12-09
IL159239A0 (en)	2004-06-01
HUP0400332A3 (en)	2007-06-28
CY1107681T1 (el)	2013-04-18
SK662004A3 (en)	2004-06-08
JP2010043116A (ja)	2010-02-25
ATE294801T1 (de)	2005-05-15
EP1475379B1 (de)	2007-04-11
US6610849B2 (en)	2003-08-26
JP4485192B2 (ja)	2010-06-16
BR0210664A (pt)	2004-08-10
CN1520413A (zh)	2004-08-11

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PL392725A1 (pl)	2010-12-06	Nowe związki pośrednie do syntezy związków triazolopirymidyny oraz sposób ich wytwarzania
BG111461A (en)	2013-08-30	TECHNICAL METHOD FOR OBTAINING TROPENOL
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NO20054614L (no)	2005-10-07	Fremgangsmate til fremstilling av 68Ga
ATE501126T1 (de)	2011-03-15	Verfahren zur herstellung von rosuvastatin
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DK1255747T3 (da)	2007-02-12	Syntese af 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-on
WO2003066558A3 (de)	2003-12-31	Herstellung von alkenonen
DK1534646T3 (da)	2008-12-01	Siliciumoxid-opslæmning og fremgangsmåde til at producere sådan opslæmning
TW200607749A (en)	2006-03-01	The method of die forming
AU2001250356A1 (en)	2001-09-24	Method for the production of spirocyclic tetronic acid derivatives
ATE424390T1 (de)	2009-03-15	Verfahren zur herstellung von delmopinol und derivaten davon
DE60314904D1 (de)	2007-08-23	Verfahren zur herstellung von chinoloncarboxylat-derivaten
YU61503A (sh)	2006-05-25	Nova so benzoilgvanidina
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