MX10471A - Procedimiento para la preparacion de nuevos 19-nor-esteroides substituidos en la posicion 7 y producto obtenido. - Google Patents
Procedimiento para la preparacion de nuevos 19-nor-esteroides substituidos en la posicion 7 y producto obtenido.Info
- Publication number
- MX10471A MX10471A MX1047188A MX1047188A MX10471A MX 10471 A MX10471 A MX 10471A MX 1047188 A MX1047188 A MX 1047188A MX 1047188 A MX1047188 A MX 1047188A MX 10471 A MX10471 A MX 10471A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- carbon atoms
- hydrogen
- optionally substituted
- image
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000000328 estrogen antagonist Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8702072A FR2610933B1 (fr) | 1987-02-18 | 1987-02-18 | Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX10471A true MX10471A (es) | 1993-09-01 |
| MX174129B MX174129B (es) | 1994-04-22 |
Family
ID=9348042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX010471A MX174129B (es) | 1987-02-18 | 1988-02-18 | Procedimiento para la preparacion de nuevos 19-nor-esteroides sustituidos en la posicion 7 y producto obtenido |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4874754A (es) |
| EP (1) | EP0280618B1 (es) |
| JP (1) | JP2717792B2 (es) |
| KR (1) | KR960007868B1 (es) |
| AT (1) | ATE81133T1 (es) |
| AU (1) | AU610560B2 (es) |
| CA (1) | CA1313653C (es) |
| DE (1) | DE3874909T2 (es) |
| ES (1) | ES2043862T3 (es) |
| FI (1) | FI92589C (es) |
| FR (1) | FR2610933B1 (es) |
| GR (1) | GR3006139T3 (es) |
| MX (1) | MX174129B (es) |
| PT (1) | PT86783B (es) |
| ZA (1) | ZA881030B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1212835B (it) * | 1983-08-18 | 1989-11-30 | Lehner Ag | Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche. |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| US5686465A (en) * | 1988-10-31 | 1997-11-11 | Endorecherche Inc. | Sex steroid activity inhibitors |
| US5204337A (en) * | 1988-10-31 | 1993-04-20 | Endorecherche Inc. | Estrogen nucleus derivatives for use in inhibition of sex steroid activity |
| HU208150B (en) * | 1988-10-31 | 1993-08-30 | Endorecherche Inc | Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives |
| US5364847A (en) * | 1989-03-10 | 1994-11-15 | Endorecherche | Inhibitors of sex steroid biosynthesis and methods for their production and use |
| DE3921059A1 (de) * | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
| ZA924811B (en) * | 1991-06-28 | 1993-12-29 | Endorecherche Inc | Controlled release systems and low dose androgens |
| US6060503A (en) * | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
| JPH07101977A (ja) * | 1993-10-05 | 1995-04-18 | Kureha Chem Ind Co Ltd | ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤 |
| CA2180548A1 (en) * | 1994-01-06 | 1995-07-13 | Masato Tanabe | Novel antiandrogenic agents and related pharmaceutical compositions and methods of use |
| CA2308773A1 (en) * | 1997-10-23 | 1999-04-29 | Ivo Jirkovsky | Estra-1,3,5(10)-triene-7alpha-thioethers |
| US6355630B1 (en) | 1997-10-23 | 2002-03-12 | American Home Products Corporation | Estra-1,3,5(10)-triene-7α-thioethers |
| US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| US6262042B1 (en) * | 1998-05-29 | 2001-07-17 | Research Triangle Institute | 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| US5962444A (en) * | 1998-05-29 | 1999-10-05 | Research Triangle Institute | 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| CN1653081A (zh) * | 2002-03-22 | 2005-08-10 | 法玛西雅公司 | 甾族化合物的c－17螺甾内酯化和6,7氧化 |
| US7235655B2 (en) * | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
| PL356465A1 (en) * | 2002-10-04 | 2004-04-05 | ANPHARM Przedsiębiorstwo Farmaceutyczne S.A. | METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE |
| WO2012058463A2 (en) | 2010-10-27 | 2012-05-03 | Dignity Health | Trimegestone (tmg) for treatment of preterm birth |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2739974A (en) | 1953-04-06 | 1956-03-27 | Searle & Co | Process of preparing delta4,6-3-ketosteroids |
| US3099664A (en) | 1959-01-12 | 1963-07-30 | Syntex Corp | 7-cyano androstane compounds |
| US3673225A (en) * | 1970-01-16 | 1972-06-27 | Organon | New 7-alkyl-steroids |
| FR2528434B1 (fr) * | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
| FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
| DE3427795A1 (de) * | 1984-07-25 | 1986-02-06 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 17(alpha)-halogenvinyl-estran-derivate, ihre herstellung und verwendung in der medizin |
-
1987
- 1987-02-18 FR FR8702072A patent/FR2610933B1/fr not_active Expired
-
1988
- 1988-02-15 ZA ZA881030A patent/ZA881030B/xx unknown
- 1988-02-17 CA CA000559130A patent/CA1313653C/fr not_active Expired - Fee Related
- 1988-02-17 AU AU11785/88A patent/AU610560B2/en not_active Ceased
- 1988-02-17 KR KR1019880001724A patent/KR960007868B1/ko not_active Expired - Fee Related
- 1988-02-17 FI FI880742A patent/FI92589C/fi not_active IP Right Cessation
- 1988-02-17 US US07/157,417 patent/US4874754A/en not_active Expired - Lifetime
- 1988-02-18 ES ES88400371T patent/ES2043862T3/es not_active Expired - Lifetime
- 1988-02-18 MX MX010471A patent/MX174129B/es unknown
- 1988-02-18 PT PT86783A patent/PT86783B/pt not_active IP Right Cessation
- 1988-02-18 DE DE8888400371T patent/DE3874909T2/de not_active Expired - Fee Related
- 1988-02-18 EP EP88400371A patent/EP0280618B1/fr not_active Expired - Lifetime
- 1988-02-18 JP JP63034136A patent/JP2717792B2/ja not_active Expired - Fee Related
- 1988-02-18 AT AT88400371T patent/ATE81133T1/de not_active IP Right Cessation
-
1992
- 1992-11-04 GR GR920402132T patent/GR3006139T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI92589C (fi) | 1994-12-12 |
| JP2717792B2 (ja) | 1998-02-25 |
| FI880742A0 (fi) | 1988-02-17 |
| ZA881030B (en) | 1989-04-26 |
| DE3874909D1 (de) | 1992-11-05 |
| PT86783A (pt) | 1988-03-01 |
| AU610560B2 (en) | 1991-05-23 |
| PT86783B (pt) | 1992-05-29 |
| AU1178588A (en) | 1988-08-25 |
| CA1313653C (fr) | 1993-02-16 |
| FI880742A7 (fi) | 1988-08-19 |
| EP0280618B1 (fr) | 1992-09-30 |
| KR960007868B1 (ko) | 1996-06-13 |
| ATE81133T1 (de) | 1992-10-15 |
| ES2043862T3 (es) | 1994-01-01 |
| JPS63222198A (ja) | 1988-09-16 |
| DE3874909T2 (de) | 1993-05-13 |
| US4874754A (en) | 1989-10-17 |
| FR2610933A1 (fr) | 1988-08-19 |
| FI92589B (fi) | 1994-08-31 |
| KR880009987A (ko) | 1988-10-06 |
| MX174129B (es) | 1994-04-22 |
| FR2610933B1 (fr) | 1989-06-09 |
| EP0280618A1 (fr) | 1988-08-31 |
| GR3006139T3 (es) | 1993-06-21 |
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