MX2012008644A - Inhibidores de cinasa de pirazolopiridinas. - Google Patents

Inhibidores de cinasa de pirazolopiridinas.

Info

Publication number: MX2012008644A
Authority: MX; Mexico
Prior art keywords: independently; compound; alkyl; substituted; absent
Prior art date: 2010-01-27

Application number

MX2012008644A

Other languages

English (en)

Spanish (es)

Inventor

Guy Brenchley

Julian M C Golec

Heather Twin

Juan-Miguel Jimenez

Damien Fraysse

Dean Boyall

Luca Settimo

Stephen Young

Andrew W Miller

Christopher John Davis

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-01-27

Filing date

2011-01-26

Publication date

2012-11-23

2011-01-26 Application filed by Vertex Pharma filed Critical Vertex Pharma

2012-11-23 Publication of MX2012008644A publication Critical patent/MX2012008644A/es

Links

229940043355 kinase inhibitor Drugs 0.000 title description 6
AMFYRKOUWBAGHV-UHFFFAOYSA-N 1h-pyrazolo[4,3-b]pyridine Chemical compound C1=CN=C2C=NNC2=C1 AMFYRKOUWBAGHV-UHFFFAOYSA-N 0.000 title description 5
239000003757 phosphotransferase inhibitor Substances 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 229
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238000000034 method Methods 0.000 claims abstract description 61
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230000008569 process Effects 0.000 claims abstract description 18
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 67
150000003839 salts Chemical class 0.000 claims description 49
230000001404 mediated effect Effects 0.000 claims description 44
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 34
201000006417 multiple sclerosis Diseases 0.000 claims description 34
125000000217 alkyl group Chemical group 0.000 claims description 31
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 29
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 28
GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 claims description 22
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 22
206010039073 rheumatoid arthritis Diseases 0.000 claims description 21
239000002904 solvent Substances 0.000 claims description 21
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BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 14
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OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 9
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
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MX2012008644A 2010-01-27 2011-01-26 Inhibidores de cinasa de pirazolopiridinas. MX2012008644A (es)

Applications Claiming Priority (3)

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US29864910P	2010-01-27	2010-01-27
US41042610P	2010-11-05	2010-11-05
PCT/US2011/022522 WO2011094273A1 (en)	2010-01-27	2011-01-26	Pyrazolopyridine kinase inhibitors

Publications (1)

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MX2012008644A true MX2012008644A (es)	2012-11-23

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US (1)	US9067932B2 (2)
EP (1)	EP2528917B1 (2)
JP (1)	JP5769733B2 (2)
CN (1)	CN102858769A (2)
AR (1)	AR080856A1 (2)
AU (1)	AU2011209726A1 (2)
CA (1)	CA2787315A1 (2)
MX (1)	MX2012008644A (2)
WO (1)	WO2011094273A1 (2)

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CN118923682B (zh) *	2024-07-22	2025-09-05	中国农业大学	一种化合物作为病原真菌Pmk1的抑制剂的应用

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ES2402087T3 (es) *	2008-07-23	2013-04-26	Vertex Pharmaceuticals Incorporated	Inhibidores de la pirazolopiridina quinasa
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2011
- 2011-01-26 JP JP2012551251A patent/JP5769733B2/ja active Active
- 2011-01-26 CA CA2787315A patent/CA2787315A1/en not_active Abandoned
- 2011-01-26 CN CN2011800130461A patent/CN102858769A/zh active Pending
- 2011-01-26 EP EP11703958.6A patent/EP2528917B1/en active Active
- 2011-01-26 US US13/014,505 patent/US9067932B2/en active Active
- 2011-01-26 MX MX2012008644A patent/MX2012008644A/es active IP Right Grant
- 2011-01-26 AU AU2011209726A patent/AU2011209726A1/en not_active Abandoned
- 2011-01-26 WO PCT/US2011/022522 patent/WO2011094273A1/en not_active Ceased
- 2011-01-27 AR ARP110100282A patent/AR080856A1/es unknown

Also Published As

Publication number	Publication date
EP2528917A1 (en)	2012-12-05
JP5769733B2 (ja)	2015-08-26
JP2013518111A (ja)	2013-05-20
WO2011094273A1 (en)	2011-08-04
CN102858769A (zh)	2013-01-02
US9067932B2 (en)	2015-06-30
US20120071494A1 (en)	2012-03-22
AR080856A1 (es)	2012-05-16
EP2528917B1 (en)	2016-10-19
CA2787315A1 (en)	2011-08-04
AU2011209726A1 (en)	2012-08-09

Legal Events

Date	Code	Title	Description
2014-04-21	FG	Grant or registration

Publication	Publication Date	Title
EP2328896B1 (en)	2013-10-23	Tri-cyclic pyrazolopyridine kinase inhibitors
EP2318408B1 (en)	2016-02-17	Tri-cyclic pyrazolopyridine kinase inhibitors
US9193722B2 (en)	2015-11-24	Tri-cyclic pyrazolopyridine kinase inhibitors
MX2011000839A (es)	2011-04-05	Inhibidores de pirazolpiridina cinasa.
AU2009274017A1 (en)	2010-01-28	Pyrazolopyridine kinase inhibitors
WO2011139273A1 (en)	2011-11-10	4 substituted pyrazolopyrimidines useful as pkc-theta inhibitors
EP2528917B1 (en)	2016-10-19	Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
MX2012008642A (es)	2012-11-23	Inhibidores de cinasas de pirazolopiridinas.
AU2009279611A1 (en)	2010-02-11	Aminopyridine kinase inhibitors
MX2012008641A (es)	2012-11-23	Inhibidores de cinasas de pirazolopirazinas.
MX2012008643A (es)	2013-02-26	Inhibidores de cinasas de pirazolopiridinas.
MX2011011712A (es)	2012-10-03	Pirazolopirimidinas 4-sustituidas utiles como inhibidores de pkc-theta.
AU2015201376A1 (en)	2015-04-23	Pyrazolopyridine kinase inhibitors