PL2807172T3 - Pochodne pirymidooksazocyny jako inhibitory mTOR - Google Patents
Pochodne pirymidooksazocyny jako inhibitory mTORInfo
- Publication number
- PL2807172T3 PL2807172T3 PL13712331T PL13712331T PL2807172T3 PL 2807172 T3 PL2807172 T3 PL 2807172T3 PL 13712331 T PL13712331 T PL 13712331T PL 13712331 T PL13712331 T PL 13712331T PL 2807172 T3 PL2807172 T3 PL 2807172T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrimidooxazocine
- mtor
- inhibitors
- derivatives
- pyrimidooxazocine derivatives
- Prior art date
Links
- ZHKMLTCNJQHQMU-UHFFFAOYSA-N 2H-pyrimido[4,5-g]oxazocine Chemical class O1NC=CC=CC2=C1C=NC=N2 ZHKMLTCNJQHQMU-UHFFFAOYSA-N 0.000 title 1
- 229940124302 mTOR inhibitor Drugs 0.000 title 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1250768A FR2986232B1 (fr) | 2012-01-26 | 2012-01-26 | Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique |
| EP13712331.1A EP2807172B1 (en) | 2012-01-26 | 2013-01-25 | Pyrimidooxazocine derivatives as mtor-inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2807172T3 true PL2807172T3 (pl) | 2017-05-31 |
Family
ID=47997597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13712331T PL2807172T3 (pl) | 2012-01-26 | 2013-01-25 | Pochodne pirymidooksazocyny jako inhibitory mTOR |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9120812B2 (pl) |
| EP (1) | EP2807172B1 (pl) |
| JP (1) | JP6068508B2 (pl) |
| KR (1) | KR20140125389A (pl) |
| CN (1) | CN104203958B (pl) |
| AR (1) | AR089782A1 (pl) |
| AU (1) | AU2013213261B2 (pl) |
| BR (1) | BR112014018226A8 (pl) |
| CA (1) | CA2862747A1 (pl) |
| CY (1) | CY1118852T1 (pl) |
| DK (1) | DK2807172T3 (pl) |
| ES (1) | ES2617880T3 (pl) |
| FR (1) | FR2986232B1 (pl) |
| HR (1) | HRP20170288T1 (pl) |
| HU (1) | HUE031917T2 (pl) |
| IL (1) | IL233774A (pl) |
| LT (1) | LT2807172T (pl) |
| MX (1) | MX348841B (pl) |
| PL (1) | PL2807172T3 (pl) |
| PT (1) | PT2807172T (pl) |
| RU (1) | RU2627269C2 (pl) |
| SG (1) | SG11201404325VA (pl) |
| SI (1) | SI2807172T1 (pl) |
| TW (1) | TWI572608B (pl) |
| UY (1) | UY34594A (pl) |
| WO (1) | WO2013111106A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106831721B (zh) | 2013-10-16 | 2019-10-22 | 上海璎黎药业有限公司 | 稠合杂环化合物、其制备方法、药物组合物和用途 |
| WO2016050201A1 (zh) * | 2014-09-29 | 2016-04-07 | 山东轩竹医药科技有限公司 | 高选择性取代嘧啶类pi3k抑制剂 |
| US10307707B2 (en) * | 2017-05-17 | 2019-06-04 | Thomas P. Daly | 1-amino-2-methyl-2-propanol derivatives |
| JP2022500384A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス, インコーポレイテッド | 組み合わせ療法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4417720B2 (ja) * | 2002-01-18 | 2010-02-17 | 杏林製薬株式会社 | 縮合二環式ピリミジン誘導体 |
| MXPA05005425A (es) * | 2002-11-22 | 2005-11-23 | Japan Tobacco Inc | Heterociclos que contienen nitrogeno, biciclicos, fusionados. |
| JP5877064B2 (ja) * | 2008-11-11 | 2016-03-02 | エックスカバリー ホールディング カンパニー エルエルシー | PI3K/mTORキナーゼ阻害剤 |
| KR20120087808A (ko) * | 2009-05-26 | 2012-08-07 | 엑셀리시스, 인코포레이티드 | PI3K/m TOR의 억제제로서의 벤즈옥사제핀 및 이의 사용 및 제조 방법 |
| CA2799764A1 (en) * | 2010-05-19 | 2011-11-24 | Xcovery Holding Company, Llc. | Mtor selective kinase inhibitors |
-
2012
- 2012-01-26 FR FR1250768A patent/FR2986232B1/fr not_active Expired - Fee Related
-
2013
- 2013-01-23 AR ARP130100196A patent/AR089782A1/es unknown
- 2013-01-25 EP EP13712331.1A patent/EP2807172B1/en active Active
- 2013-01-25 KR KR1020147023238A patent/KR20140125389A/ko not_active Abandoned
- 2013-01-25 ES ES13712331.1T patent/ES2617880T3/es active Active
- 2013-01-25 UY UY0001034594A patent/UY34594A/es not_active Application Discontinuation
- 2013-01-25 TW TW102102986A patent/TWI572608B/zh not_active IP Right Cessation
- 2013-01-25 RU RU2014134640A patent/RU2627269C2/ru not_active IP Right Cessation
- 2013-01-25 CN CN201380016539.XA patent/CN104203958B/zh active Active
- 2013-01-25 BR BR112014018226A patent/BR112014018226A8/pt not_active Application Discontinuation
- 2013-01-25 LT LTEP13712331.1T patent/LT2807172T/lt unknown
- 2013-01-25 AU AU2013213261A patent/AU2013213261B2/en not_active Ceased
- 2013-01-25 US US14/374,838 patent/US9120812B2/en active Active
- 2013-01-25 PL PL13712331T patent/PL2807172T3/pl unknown
- 2013-01-25 HR HRP20170288TT patent/HRP20170288T1/hr unknown
- 2013-01-25 PT PT137123311T patent/PT2807172T/pt unknown
- 2013-01-25 DK DK13712331.1T patent/DK2807172T3/en active
- 2013-01-25 HU HUE13712331A patent/HUE031917T2/en unknown
- 2013-01-25 WO PCT/IB2013/050656 patent/WO2013111106A1/en not_active Ceased
- 2013-01-25 SI SI201330547A patent/SI2807172T1/sl unknown
- 2013-01-25 MX MX2014009084A patent/MX348841B/es active IP Right Grant
- 2013-01-25 CA CA2862747A patent/CA2862747A1/en not_active Abandoned
- 2013-01-25 JP JP2014553846A patent/JP6068508B2/ja active Active
- 2013-01-25 SG SG11201404325VA patent/SG11201404325VA/en unknown
-
2014
- 2014-07-23 IL IL233774A patent/IL233774A/en active IP Right Grant
-
2017
- 2017-02-28 CY CY20171100270T patent/CY1118852T1/el unknown
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