PL2807172T3 - Pochodne pirymidooksazocyny jako inhibitory mTOR - Google Patents

Pochodne pirymidooksazocyny jako inhibitory mTOR

Info

Publication number
PL2807172T3
PL2807172T3 PL13712331T PL13712331T PL2807172T3 PL 2807172 T3 PL2807172 T3 PL 2807172T3 PL 13712331 T PL13712331 T PL 13712331T PL 13712331 T PL13712331 T PL 13712331T PL 2807172 T3 PL2807172 T3 PL 2807172T3
Authority
PL
Poland
Prior art keywords
pyrimidooxazocine
mtor
inhibitors
derivatives
pyrimidooxazocine derivatives
Prior art date
Application number
PL13712331T
Other languages
English (en)
Inventor
Alain Braun
Olivier Crespin
Yann Foricher
Gilbert Marciniak
Nicolas Muzet
Eric Nicolai
Cécile Pascal
Bertrand Vivet
Fabrice Viviani
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of PL2807172T3 publication Critical patent/PL2807172T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL13712331T 2012-01-26 2013-01-25 Pochodne pirymidooksazocyny jako inhibitory mTOR PL2807172T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1250768A FR2986232B1 (fr) 2012-01-26 2012-01-26 Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique
EP13712331.1A EP2807172B1 (en) 2012-01-26 2013-01-25 Pyrimidooxazocine derivatives as mtor-inhibitors

Publications (1)

Publication Number Publication Date
PL2807172T3 true PL2807172T3 (pl) 2017-05-31

Family

ID=47997597

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13712331T PL2807172T3 (pl) 2012-01-26 2013-01-25 Pochodne pirymidooksazocyny jako inhibitory mTOR

Country Status (26)

Country Link
US (1) US9120812B2 (pl)
EP (1) EP2807172B1 (pl)
JP (1) JP6068508B2 (pl)
KR (1) KR20140125389A (pl)
CN (1) CN104203958B (pl)
AR (1) AR089782A1 (pl)
AU (1) AU2013213261B2 (pl)
BR (1) BR112014018226A8 (pl)
CA (1) CA2862747A1 (pl)
CY (1) CY1118852T1 (pl)
DK (1) DK2807172T3 (pl)
ES (1) ES2617880T3 (pl)
FR (1) FR2986232B1 (pl)
HR (1) HRP20170288T1 (pl)
HU (1) HUE031917T2 (pl)
IL (1) IL233774A (pl)
LT (1) LT2807172T (pl)
MX (1) MX348841B (pl)
PL (1) PL2807172T3 (pl)
PT (1) PT2807172T (pl)
RU (1) RU2627269C2 (pl)
SG (1) SG11201404325VA (pl)
SI (1) SI2807172T1 (pl)
TW (1) TWI572608B (pl)
UY (1) UY34594A (pl)
WO (1) WO2013111106A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106831721B (zh) 2013-10-16 2019-10-22 上海璎黎药业有限公司 稠合杂环化合物、其制备方法、药物组合物和用途
WO2016050201A1 (zh) * 2014-09-29 2016-04-07 山东轩竹医药科技有限公司 高选择性取代嘧啶类pi3k抑制剂
US10307707B2 (en) * 2017-05-17 2019-06-04 Thomas P. Daly 1-amino-2-methyl-2-propanol derivatives
JP2022500384A (ja) 2018-09-10 2022-01-04 ミラティ セラピューティクス, インコーポレイテッド 組み合わせ療法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4417720B2 (ja) * 2002-01-18 2010-02-17 杏林製薬株式会社 縮合二環式ピリミジン誘導体
MXPA05005425A (es) * 2002-11-22 2005-11-23 Japan Tobacco Inc Heterociclos que contienen nitrogeno, biciclicos, fusionados.
JP5877064B2 (ja) * 2008-11-11 2016-03-02 エックスカバリー ホールディング カンパニー エルエルシー PI3K/mTORキナーゼ阻害剤
KR20120087808A (ko) * 2009-05-26 2012-08-07 엑셀리시스, 인코포레이티드 PI3K/m TOR의 억제제로서의 벤즈옥사제핀 및 이의 사용 및 제조 방법
CA2799764A1 (en) * 2010-05-19 2011-11-24 Xcovery Holding Company, Llc. Mtor selective kinase inhibitors

Also Published As

Publication number Publication date
BR112014018226A2 (pl) 2017-06-20
WO2013111106A1 (en) 2013-08-01
FR2986232B1 (fr) 2014-02-14
RU2014134640A (ru) 2016-03-27
LT2807172T (lt) 2017-03-27
HUE031917T2 (en) 2017-08-28
UY34594A (es) 2013-09-02
RU2627269C2 (ru) 2017-08-04
CN104203958A (zh) 2014-12-10
DK2807172T3 (en) 2017-03-06
AU2013213261A1 (en) 2014-08-21
IL233774A (en) 2016-06-30
CN104203958B (zh) 2017-05-31
AR089782A1 (es) 2014-09-17
US20140378433A1 (en) 2014-12-25
ES2617880T3 (es) 2017-06-20
EP2807172A1 (en) 2014-12-03
CA2862747A1 (en) 2013-08-01
JP2015504914A (ja) 2015-02-16
KR20140125389A (ko) 2014-10-28
CY1118852T1 (el) 2018-01-10
SI2807172T1 (sl) 2017-03-31
HRP20170288T1 (hr) 2017-04-21
EP2807172B1 (en) 2016-11-30
TWI572608B (zh) 2017-03-01
SG11201404325VA (en) 2014-08-28
US9120812B2 (en) 2015-09-01
PT2807172T (pt) 2017-03-06
BR112014018226A8 (pt) 2017-07-11
FR2986232A1 (fr) 2013-08-02
JP6068508B2 (ja) 2017-01-25
AU2013213261B2 (en) 2017-07-20
TW201333016A (zh) 2013-08-16
MX348841B (es) 2017-06-30
MX2014009084A (es) 2015-02-05

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