MX2014010076A - Precipitacion de la fraccion i-iv-1 de inmunoglobulinas plasmaticas. - Google Patents
Precipitacion de la fraccion i-iv-1 de inmunoglobulinas plasmaticas.Info
- Publication number
- MX2014010076A MX2014010076A MX2014010076A MX2014010076A MX2014010076A MX 2014010076 A MX2014010076 A MX 2014010076A MX 2014010076 A MX2014010076 A MX 2014010076A MX 2014010076 A MX2014010076 A MX 2014010076A MX 2014010076 A MX2014010076 A MX 2014010076A
- Authority
- MX
- Mexico
- Prior art keywords
- plasma
- provides
- immunoglobins
- precipitation
- fraction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Métodos para elaborar composiciones de proteínas sanguíneas a partir de plasma agrupado. En una modalidad, se provee un esquema de fraccionamiento con alcohol que permite aumentar significativamente el rendimiento de proteínas sanguíneas purificadas a partir de una muestra de plasma de partida. En una modalidad específica se provee un método de fraccionamiento de plasma agrupado que comprende un paso inicial de precipitación con una concentración elevada de alcohol, a pH bajo. También se proveen composiciones farmacéuticas con proteínas sanguíneas terapéuticas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261602488P | 2012-02-23 | 2012-02-23 | |
| PCT/US2013/027681 WO2013126904A1 (en) | 2012-02-23 | 2013-02-25 | Fraction i-iv-1 precipitation of immunoglobins from plasma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014010076A true MX2014010076A (es) | 2014-09-22 |
| MX365236B MX365236B (es) | 2019-05-28 |
Family
ID=47833446
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014010076A MX365236B (es) | 2012-02-23 | 2013-02-25 | Precipitacion de la fraccion i-iv-1 de inmunoglobulinas plasmaticas. |
| MX2019005999A MX2019005999A (es) | 2012-02-23 | 2014-08-21 | Precipitacion de la fraccion i-iv-1 de inmunoglobulinas plasmaticas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019005999A MX2019005999A (es) | 2012-02-23 | 2014-08-21 | Precipitacion de la fraccion i-iv-1 de inmunoglobulinas plasmaticas. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9782477B2 (es) |
| EP (2) | EP4119574A1 (es) |
| JP (1) | JP6291423B2 (es) |
| KR (1) | KR101930582B1 (es) |
| CN (1) | CN104245730B (es) |
| AR (1) | AR090425A1 (es) |
| AU (1) | AU2013203112B2 (es) |
| BR (1) | BR112014020602B1 (es) |
| CA (1) | CA2864715A1 (es) |
| CL (1) | CL2014002225A1 (es) |
| CO (1) | CO7081143A2 (es) |
| DK (1) | DK2817334T3 (es) |
| EA (1) | EA032478B1 (es) |
| ES (1) | ES2928954T3 (es) |
| HU (1) | HUE060195T2 (es) |
| IL (1) | IL234103B (es) |
| MX (2) | MX365236B (es) |
| MY (1) | MY167235A (es) |
| NZ (1) | NZ628529A (es) |
| PL (1) | PL2817334T3 (es) |
| PT (1) | PT2817334T (es) |
| SG (1) | SG11201405149UA (es) |
| SI (1) | SI2817334T1 (es) |
| TW (1) | TWI629283B (es) |
| WO (1) | WO2013126904A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013203043B2 (en) | 2013-03-15 | 2016-10-06 | Takeda Pharmaceutical Company Limited | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
| CN104004090A (zh) * | 2014-06-12 | 2014-08-27 | 新疆德源生物工程有限公司 | 一种人免疫球蛋白的制备方法 |
| CN104004091B (zh) * | 2014-06-12 | 2016-08-17 | 新疆德源生物工程有限公司 | 一种人免疫球蛋白的制备工艺 |
| GB201413227D0 (en) | 2014-07-25 | 2014-09-10 | Bioproducts Lab Ltd | Process |
| ES2887588T3 (es) * | 2015-08-13 | 2021-12-23 | Kamada Ltd | Composiciones derivadas de pasta de fracción de Cohn y uso de las mismas |
| US11040068B2 (en) * | 2017-04-26 | 2021-06-22 | Alkahest, Inc. | Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products |
| WO2019086463A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| IL278584B2 (en) * | 2018-05-17 | 2025-08-01 | Csl Behring Ag | Method and system of protein extraction |
| CA3157446A1 (en) | 2019-11-20 | 2021-05-27 | Csl Behring Ag | Method for extracting a protein from a precipitate and method for precipitating impurities |
| EP4118108A4 (en) * | 2020-04-10 | 2024-05-15 | Plasma Technologies, LLC | COMPOSITIONS AND METHODS FOR HIGHLY EFFICIENT SIMPLIFIED PROTEIN ISOLATION |
| EP4240757A2 (en) * | 2020-11-09 | 2023-09-13 | Takeda Pharmaceutical Company Limited | Purification of fviii from plasma using silicon oxide adsorption |
| CN112250757A (zh) * | 2020-11-13 | 2021-01-22 | 广东深蓝生物科技有限公司 | 一种猪血浆中蛋白质的提取纯化方法 |
| JP2024501025A (ja) * | 2020-12-28 | 2024-01-10 | プラズマ テクノロジーズ エルエルシー | 免疫グロブリンｇのプロセススケールでの単離のためのシステム及び方法 |
| CN118580342B (zh) * | 2024-05-20 | 2025-02-07 | 广东丹霞生物制药有限公司 | 一种静脉注射用人免疫球蛋白制剂的制备工艺 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE348942B (es) | 1970-06-02 | 1972-09-18 | Statens Bakteriologiska Labor | |
| US3998946A (en) | 1975-04-23 | 1976-12-21 | The Regents Of The University Of Minnesota | Fibrinogen-free plasminogen-plasmin-free plasma and method of preparing and using same |
| US4136094A (en) | 1977-08-31 | 1979-01-23 | The Regents Of The University Of Minnesota | Preparation of intravenous human and animal gamma globulins and isolation of albumin |
| US4499073A (en) | 1981-08-24 | 1985-02-12 | Cutter Laboratories, Inc. | Intravenously injectable immune serum globulin |
| JPS5855432A (ja) * | 1981-09-29 | 1983-04-01 | Fujirebio Inc | 静脈注射用免疫グロブリンの製法 |
| DK166763B1 (da) | 1983-03-16 | 1993-07-12 | Immuno Ag | Immunoglobulin-g-holdig fraktion |
| US5177194A (en) | 1990-02-01 | 1993-01-05 | Baxter International, Inc. | Process for purifying immune serum globulins |
| FR2706466B1 (fr) | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
| US6284874B1 (en) | 1994-06-17 | 2001-09-04 | Alpha Therapeutic Corporation | Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste |
| US5616693A (en) | 1996-07-01 | 1997-04-01 | Alpha Therapeutic Corporation | Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste |
| TW491855B (en) | 1996-08-07 | 2002-06-21 | Csl Ltd | Purification of immunoglobulins |
| CA2232420A1 (en) | 1997-03-19 | 1998-09-19 | The Green Cross Corporation | Immunoglobulin preparation and preparation process thereof |
| GB9705810D0 (en) * | 1997-03-20 | 1997-05-07 | Common Services Agency | Intravenous immune globulin |
| US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
| CA2251342A1 (en) | 1997-10-23 | 1999-04-23 | Yutaka Hirao | Room temperature storable immunoglobulin preparation for intravenous injection |
| SE0001128D0 (sv) | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
| FR2824568B1 (fr) | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
| EP1413860A4 (en) * | 2001-07-05 | 2009-02-25 | Hamamatsu Photonics Kk | SPECTROSCOPIC DEVICE |
| US6893639B2 (en) * | 2001-10-19 | 2005-05-17 | Hemacare Corporation | Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates |
| DK1664123T4 (da) | 2003-09-22 | 2012-03-05 | Kamada Ltd | Storskalafremstilling af alfa-1-proteinaseinhibitor og anvendelse deraf |
| US20070244305A1 (en) | 2004-01-30 | 2007-10-18 | Suomen Punainen Risti Veripalvelu | Process for The Manufacture of Virus Safe Immunoglobulin |
| CA2557229C (en) | 2004-02-27 | 2012-07-10 | Octapharma Ag | A method of providing a purified, virus safe antibody preparation |
| US7807435B2 (en) | 2005-08-11 | 2010-10-05 | Baxter International Inc. | Method for the purification of alpha-1 proteinase inhibitor (a1PI) |
| ES2595059T3 (es) | 2007-03-20 | 2016-12-27 | Csl Behring Gmbh | Métodos para la producción a escala industrial de preparados terapéuticos del Factor H del complemento a partir de plasma humano |
| US8546548B2 (en) | 2009-05-27 | 2013-10-01 | Baxter International Inc. | Method to produce a highly concentrated immunoglobulin preparation for subcutaneous use |
| WO2011011753A1 (en) | 2009-07-23 | 2011-01-27 | Baxter International Inc. | Manufacture of factor h (fh) and fh-derivatives from plasma |
| AU2010202125B1 (en) * | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| US8772462B2 (en) * | 2010-05-26 | 2014-07-08 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
| EP2596014B1 (en) | 2010-07-23 | 2018-11-28 | Baxalta GmbH | Manufacture of inter-alpha-inhibitor proteins (iaip) from plasma |
-
2013
- 2013-02-23 TW TW102106384A patent/TWI629283B/zh active
- 2013-02-25 SG SG11201405149UA patent/SG11201405149UA/en unknown
- 2013-02-25 WO PCT/US2013/027681 patent/WO2013126904A1/en not_active Ceased
- 2013-02-25 US US13/776,448 patent/US9782477B2/en active Active
- 2013-02-25 CA CA2864715A patent/CA2864715A1/en not_active Abandoned
- 2013-02-25 NZ NZ628529A patent/NZ628529A/en unknown
- 2013-02-25 MY MYPI2014002439A patent/MY167235A/en unknown
- 2013-02-25 EP EP22191464.1A patent/EP4119574A1/en active Pending
- 2013-02-25 CN CN201380020621.XA patent/CN104245730B/zh active Active
- 2013-02-25 DK DK13708051.1T patent/DK2817334T3/da active
- 2013-02-25 AU AU2013203112A patent/AU2013203112B2/en active Active
- 2013-02-25 BR BR112014020602-3A patent/BR112014020602B1/pt active IP Right Grant
- 2013-02-25 ES ES13708051T patent/ES2928954T3/es active Active
- 2013-02-25 HU HUE13708051A patent/HUE060195T2/hu unknown
- 2013-02-25 SI SI201332012T patent/SI2817334T1/sl unknown
- 2013-02-25 PL PL13708051.1T patent/PL2817334T3/pl unknown
- 2013-02-25 EP EP13708051.1A patent/EP2817334B1/en active Active
- 2013-02-25 EA EA201491564A patent/EA032478B1/ru not_active IP Right Cessation
- 2013-02-25 JP JP2014558931A patent/JP6291423B2/ja active Active
- 2013-02-25 AR ARP130100566A patent/AR090425A1/es not_active Application Discontinuation
- 2013-02-25 PT PT137080511T patent/PT2817334T/pt unknown
- 2013-02-25 KR KR1020147026210A patent/KR101930582B1/ko active Active
- 2013-02-25 MX MX2014010076A patent/MX365236B/es active IP Right Grant
-
2014
- 2014-08-13 IL IL23410314A patent/IL234103B/en active IP Right Grant
- 2014-08-21 CL CL2014002225A patent/CL2014002225A1/es unknown
- 2014-08-21 MX MX2019005999A patent/MX2019005999A/es unknown
- 2014-09-23 CO CO14210313A patent/CO7081143A2/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: BAXALTA INCORPORATED |
|
| FG | Grant or registration |