MX2015014351A - Compuestos de union a nhe3 (intercambiador de sodio-hidrogeno 3) y metodos para inhibir transporte de fosfato. - Google Patents

Compuestos de union a nhe3 (intercambiador de sodio-hidrogeno 3) y metodos para inhibir transporte de fosfato.

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Publication number
MX2015014351A
MX2015014351A MX2015014351A MX2015014351A MX2015014351A MX 2015014351 A MX2015014351 A MX 2015014351A MX 2015014351 A MX2015014351 A MX 2015014351A MX 2015014351 A MX2015014351 A MX 2015014351A MX 2015014351 A MX2015014351 A MX 2015014351A
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MX
Mexico
Prior art keywords
nhe3
methods
phosphate
kidneys
patient
Prior art date
Application number
MX2015014351A
Other languages
English (en)
Other versions
MX382203B (es
Inventor
Jason G Lewis
Jeffrey W Jacobs
Dominique Charmot
Christopher Carreras
Eric Labonte
Original Assignee
Ardelyx Inc
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Publication date
Application filed by Ardelyx Inc filed Critical Ardelyx Inc
Publication of MX2015014351A publication Critical patent/MX2015014351A/es
Publication of MX382203B publication Critical patent/MX382203B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a agentes que modula a NHE3 y/o que se unen a NHE3 que tienen actividad como inhibidores del transporte de fosfato, que incluyen inhibidores del transporte de fosfato en el tracto gastrointestinal y los riñones, y métodos para su uso como agente terapéutico o profiláctico. Modalidades de la presente invención incluyen métodos para inhibir las absorción de fosfato en el tracto gastrointestinal o riñones de un paciente en necesidad de disminución de fosfato, que comprenden administrar al paciente un compuesto que se une a NHE3 y es sustancialmente activo en el tracto gastrointestinal o riñones para inhibir el transporte de iones de fosfato (Pi) en este después de la administración al paciente en necesidad del mismo.
MX2015014351A 2013-04-12 2014-04-10 Compuestos de union a nhe3 (intercambiador de sodio-hidrogeno 3) y metodos para inhibir transporte de fosfato. MX382203B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361811613P 2013-04-12 2013-04-12
US201361888879P 2013-10-09 2013-10-09
PCT/US2014/033603 WO2014169094A2 (en) 2013-04-12 2014-04-10 Nhe3-binding compounds and methods for inhibiting phosphate transport

Publications (2)

Publication Number Publication Date
MX2015014351A true MX2015014351A (es) 2016-04-20
MX382203B MX382203B (es) 2025-03-11

Family

ID=51690123

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015014351A MX382203B (es) 2013-04-12 2014-04-10 Compuestos de union a nhe3 (intercambiador de sodio-hidrogeno 3) y metodos para inhibir transporte de fosfato.
MX2021005172A MX2021005172A (es) 2013-04-12 2015-10-12 Compuestos de union a nhe3 (intercambiador de sodio-hidrogeno 3) y metodos para inhibir el transporte de fosfato.

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Application Number Title Priority Date Filing Date
MX2021005172A MX2021005172A (es) 2013-04-12 2015-10-12 Compuestos de union a nhe3 (intercambiador de sodio-hidrogeno 3) y metodos para inhibir el transporte de fosfato.

Country Status (27)

Country Link
US (4) US10272079B2 (es)
EP (3) EP3988120A1 (es)
JP (6) JP6377132B2 (es)
KR (4) KR20250026881A (es)
CN (2) CN105392483B (es)
AU (2) AU2014250956B2 (es)
BR (1) BR112015025805A2 (es)
CA (1) CA2909169A1 (es)
CY (1) CY1121929T1 (es)
DK (1) DK2983667T3 (es)
ES (1) ES2735992T3 (es)
HR (1) HRP20191000T1 (es)
HU (1) HUE044550T2 (es)
IL (3) IL302151A (es)
LT (1) LT2983667T (es)
MX (2) MX382203B (es)
NZ (1) NZ752535A (es)
PL (1) PL2983667T3 (es)
PT (1) PT2983667T (es)
RS (1) RS58969B1 (es)
RU (1) RU2675364C2 (es)
SI (1) SI2983667T1 (es)
SM (1) SMT201900386T1 (es)
TW (3) TWI724332B (es)
UY (1) UY35532A (es)
WO (1) WO2014169094A2 (es)
ZA (1) ZA201508006B (es)

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US10543207B2 (en) 2008-12-31 2020-01-28 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
HRP20191000T1 (hr) * 2013-04-12 2019-09-20 Ardelyx, Inc. Spojevi za vezanje nhe3 i metode inhibiranja transporta fosfata
AU2014305843B2 (en) * 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
RU2703456C2 (ru) 2014-07-25 2019-10-17 Тайсо Фармасьютикал Ко., Лтд. Фенилтетрагидроизохинолиновое соединение, замещенное гетероарилом
JP6903923B2 (ja) * 2016-01-22 2021-07-14 大正製薬株式会社 ヘテロアリールで置換されたフェニルテトラヒドロイソキノリン化合物を有効成分として含有する医薬
MX395405B (es) * 2017-01-09 2025-03-25 Ardelyx Inc Compuestos útiles para tratar trastornos del tracto gastrointestinal.
MX2019008171A (es) * 2017-01-09 2020-02-05 Ardelyx Inc Inhibidores del antiporte mediado por nhe.
WO2020051014A1 (en) 2018-09-04 2020-03-12 Teva Pharmaceuticals International Gmbh Processes for the preparation of tenapanor and intermediates thereof
WO2020084349A1 (en) * 2018-10-25 2020-04-30 Opko Ireland Global Holdings, Ltd Methods of treatment with mixed metal compounds
WO2020181555A1 (zh) * 2019-03-14 2020-09-17 深圳仁泰医药科技有限公司 Nhe3抑制剂的晶型a及其制备方法和应用
EA202192414A1 (ru) * 2019-05-16 2022-03-02 Эли Лилли Энд Компани Соединения-ингибиторы натрий-водородного обменника 3
EP4706758A3 (en) 2019-05-21 2026-05-06 Ardelyx, Inc. Methods for inhibiting phosphate transport
CN112679427B (zh) * 2019-10-17 2023-05-12 江苏恒瑞医药股份有限公司 四氢异喹啉类衍生物、其制备方法及其在医药上的应用
CN116963725A (zh) 2020-12-04 2023-10-27 阿德利克斯股份有限公司 特纳帕诺的口服制剂
CN114805202A (zh) * 2021-01-28 2022-07-29 江西济民可信集团有限公司 苯磺酰胺类化合物及其制备方法和应用

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