MX2015014591A - Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer. - Google Patents

Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer.

Info

Publication number
MX2015014591A
MX2015014591A MX2015014591A MX2015014591A MX2015014591A MX 2015014591 A MX2015014591 A MX 2015014591A MX 2015014591 A MX2015014591 A MX 2015014591A MX 2015014591 A MX2015014591 A MX 2015014591A MX 2015014591 A MX2015014591 A MX 2015014591A
Authority
MX
Mexico
Prior art keywords
kinase inhibitor
tor kinase
combination therapy
treating cancer
quinazolinone compound
Prior art date
Application number
MX2015014591A
Other languages
English (en)
Other versions
MX368286B (es
Inventor
Rajesh Chopra
Kristen Mae Hege
Heather Raymon
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of MX2015014591A publication Critical patent/MX2015014591A/es
Publication of MX368286B publication Critical patent/MX368286B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan en la presente métodos para tratar o prevenir un cáncer, que comprende administrar una cantidad efectiva de un inhibidor de TOR cinasa y una cantidad efectiva de un Compuesto de Quinazolinona 5-Sustituida a un paciente que tiene cáncer.
MX2015014591A 2013-04-17 2014-04-16 Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer. MX368286B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361813089P 2013-04-17 2013-04-17
US201361908408P 2013-11-25 2013-11-25
PCT/US2014/034321 WO2014172436A1 (en) 2013-04-17 2014-04-16 Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer

Publications (2)

Publication Number Publication Date
MX2015014591A true MX2015014591A (es) 2016-03-03
MX368286B MX368286B (es) 2019-09-27

Family

ID=50736202

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015014591A MX368286B (es) 2013-04-17 2014-04-16 Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer.

Country Status (14)

Country Link
US (1) US9474757B2 (es)
EP (1) EP2986322A1 (es)
JP (1) JP6382949B2 (es)
KR (1) KR102240356B1 (es)
CN (1) CN105339009B (es)
AU (1) AU2014253978B2 (es)
BR (1) BR112015026297B1 (es)
CA (1) CA2909625C (es)
HK (1) HK1221174A1 (es)
IL (1) IL242100B (es)
MX (1) MX368286B (es)
TW (1) TWI654979B (es)
WO (1) WO2014172436A1 (es)
ZA (1) ZA201507730B (es)

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EP2986318A1 (en) * 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer
CA2908957C (en) 2013-04-17 2021-05-18 Signal Pharmaceuticals, Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
EA030726B1 (ru) * 2013-04-17 2018-09-28 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи ФАРМАЦЕВТИЧЕСКИЕ СОСТАВЫ, СПОСОБЫ, ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ПРИМЕНЕНИЯ, ОТНОСЯЩИЕСЯ К 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1H-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1H)-ОНУ
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MX368286B (es) 2019-09-27
CA2909625C (en) 2021-06-01
CN105339009A (zh) 2016-02-17
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ZA201507730B (en) 2017-05-31
IL242100B (en) 2019-08-29
EP2986322A1 (en) 2016-02-24
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US20140314753A1 (en) 2014-10-23
CA2909625A1 (en) 2014-10-23
US9474757B2 (en) 2016-10-25
CN105339009B (zh) 2018-08-28
KR102240356B1 (ko) 2021-04-14
BR112015026297B1 (pt) 2022-08-23
AU2014253978A1 (en) 2015-11-12
JP6382949B2 (ja) 2018-08-29
WO2014172436A1 (en) 2014-10-23
AU2014253978B2 (en) 2019-06-06
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TW201521724A (zh) 2015-06-16
BR112015026297A2 (pt) 2017-07-25

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