MX2016010404A - Compuestos heterociclicos triciclicos como inhibidores de fosfoinositida 3-quinasa. - Google Patents

Compuestos heterociclicos triciclicos como inhibidores de fosfoinositida 3-quinasa.

Info

Publication number
MX2016010404A
MX2016010404A MX2016010404A MX2016010404A MX2016010404A MX 2016010404 A MX2016010404 A MX 2016010404A MX 2016010404 A MX2016010404 A MX 2016010404A MX 2016010404 A MX2016010404 A MX 2016010404A MX 2016010404 A MX2016010404 A MX 2016010404A
Authority
MX
Mexico
Prior art keywords
alkyl
phosphoinositide
kinase inhibitors
heterocyclic compounds
fluoro
Prior art date
Application number
MX2016010404A
Other languages
English (en)
Other versions
MX370151B (es
Inventor
Joseph Shuttleworth Stephen
Richard Liam Cecil Alexander
Alexandre Silva Franck
Original Assignee
Karus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karus Therapeutics Ltd filed Critical Karus Therapeutics Ltd
Publication of MX2016010404A publication Critical patent/MX2016010404A/es
Publication of MX370151B publication Critical patent/MX370151B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un compuesto de la fórmula I: (I) o una sal farmacéuticamente aceptable del mismo, en donde: W es O, N-H, N-(alquilo de C1-C10) o S; cada X es independientemente CH o N; R1 s un heterociclo saturado o insaturado de 5 a 7 miembros, opcionalmente sustituido que contiene por lo menos 1 heteroátomo seleccionado de N u O; R2 es LY; cada L es un enlace directo, alquileno de C1-C10, alquenileno de C2-C10 o alquinileno de C2-C10; Y es un heterociclo de 5-12 miembros no aromático fusionado, puenteado o espirocíclico opcionalmente sustituido que contiene hasta 4 heteroátomos seleccionados de N u O; y cada R3 es independientemente H, alquilo de C1-C10, halógeno, fluoro-alquilo de C1-C10, O-alquilo de C1-C10, NH-alquilo de C1-C10, S-alquilo de C1-C10, O-fluoro-alquilo C1-C10, NH-acilo, NH-C (O) -NH-alquilo de C1-C10, C (O) -NH-alquilo C1-C10, arilo o heteroarilo, son útiles como inhibidores de la enzima de fosfoinositida 3-quinasa clase IA, PI3K-p110d, y por lo tanto tienen utilidad potencial en la terapia de cáncer, enfermedades inmunes e inflamatorias.
MX2016010404A 2014-02-12 2015-02-12 Compuestos heterocíclicos tricíclicos como inhibidores de fosfoinositida 3-quinasa. MX370151B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1402431.9A GB201402431D0 (en) 2014-02-12 2014-02-12 Compounds
PCT/GB2015/050396 WO2015121657A1 (en) 2014-02-12 2015-02-12 Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2016010404A true MX2016010404A (es) 2016-11-30
MX370151B MX370151B (es) 2019-12-03

Family

ID=50390862

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010404A MX370151B (es) 2014-02-12 2015-02-12 Compuestos heterocíclicos tricíclicos como inhibidores de fosfoinositida 3-quinasa.

Country Status (28)

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US (4) US9981987B2 (es)
EP (1) EP3105233B1 (es)
JP (1) JP6516371B2 (es)
KR (1) KR102491796B1 (es)
CN (1) CN106103450B (es)
AU (1) AU2015216702B2 (es)
BR (1) BR112016019462B8 (es)
CA (1) CA2939045C (es)
CY (1) CY1120325T1 (es)
DK (1) DK3105233T3 (es)
ES (1) ES2673278T3 (es)
GB (1) GB201402431D0 (es)
HR (1) HRP20180768T1 (es)
HU (1) HUE037210T2 (es)
IL (1) IL247103B (es)
LT (1) LT3105233T (es)
MX (1) MX370151B (es)
NO (1) NO3105233T3 (es)
NZ (1) NZ723502A (es)
PL (1) PL3105233T3 (es)
PT (1) PT3105233T (es)
RS (1) RS57296B1 (es)
SG (1) SG11201606576UA (es)
SI (1) SI3105233T1 (es)
SM (1) SMT201800280T1 (es)
TR (1) TR201807906T4 (es)
WO (1) WO2015121657A1 (es)
ZA (1) ZA201605586B (es)

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WO2015121657A1 (en) 2015-08-20
KR20160127757A (ko) 2016-11-04
PT3105233T (pt) 2018-06-15
AU2015216702B2 (en) 2018-11-08
TR201807906T4 (tr) 2018-06-21
LT3105233T (lt) 2018-06-25
BR112016019462B8 (pt) 2023-02-23
US20160347771A1 (en) 2016-12-01
US9981987B2 (en) 2018-05-29
CA2939045C (en) 2022-09-13
SI3105233T1 (sl) 2018-10-30
NO3105233T3 (es) 2018-08-25
CN106103450B (zh) 2018-12-11
HRP20180768T1 (hr) 2018-08-10
CN106103450A (zh) 2016-11-09
NZ723502A (en) 2019-05-31
ZA201605586B (en) 2019-11-27
SG11201606576UA (en) 2016-09-29
DK3105233T3 (en) 2018-06-14
US10513530B2 (en) 2019-12-24
HUE037210T2 (hu) 2018-08-28
EP3105233A1 (en) 2016-12-21
MX370151B (es) 2019-12-03
ES2673278T3 (es) 2018-06-21
IL247103A0 (en) 2016-09-29
US20220041624A1 (en) 2022-02-10
US20190092790A1 (en) 2019-03-28
CY1120325T1 (el) 2019-07-10
GB201402431D0 (en) 2014-03-26
SMT201800280T1 (it) 2018-07-17
JP2017505343A (ja) 2017-02-16
RS57296B1 (sr) 2018-08-31
EP3105233B1 (en) 2018-03-28
IL247103B (en) 2020-03-31
CA2939045A1 (en) 2015-08-20
US11708378B2 (en) 2023-07-25
AU2015216702A1 (en) 2016-09-01
BR112016019462B1 (pt) 2023-02-07
KR102491796B1 (ko) 2023-01-27
BR112016019462A2 (es) 2017-08-15
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US20200354378A1 (en) 2020-11-12
JP6516371B2 (ja) 2019-05-22

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