MX2017002365A - Compuestos diaza- y triaza-triciclicos sustituidos con ciclohexil-etilo como antagonistas de indol-amina-2,3-dioxigenasa (ido) para el tratamiento de cancer. - Google Patents

Compuestos diaza- y triaza-triciclicos sustituidos con ciclohexil-etilo como antagonistas de indol-amina-2,3-dioxigenasa (ido) para el tratamiento de cancer.

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Publication number
MX2017002365A
MX2017002365A MX2017002365A MX2017002365A MX2017002365A MX 2017002365 A MX2017002365 A MX 2017002365A MX 2017002365 A MX2017002365 A MX 2017002365A MX 2017002365 A MX2017002365 A MX 2017002365A MX 2017002365 A MX2017002365 A MX 2017002365A
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MX
Mexico
Prior art keywords
cyclohexyl
triaza
ido
dioxygenase
indole
Prior art date
Application number
MX2017002365A
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English (en)
Inventor
A Sherer Brian
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Merck Patent Gmbh
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Publication date
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Publication of MX2017002365A publication Critical patent/MX2017002365A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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  • Health & Medical Sciences (AREA)
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  • Dermatology (AREA)
  • Virology (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con compuestos diaza-y triaza-tricíclicos sustituidos con ciclohexiletilo, tales como, por ejemplo, derivados de 5-(2-ciclohexil)etil)-5H-imidazo[5,1-a]i soindol, 1-ciclohexil-2-[4,6,10-triazatriciclo[6.4.0.0ˆ[2,6]]dodec a-1(8),2,4,9,11-pentaen-7-il]etan-1-ol y derivados de 1-ciclohexil-2-[4,6,9,11-tetraazatriciclo[6.4.0.0ˆ[2,6]]dodeca-1( 8),2,4,9,11-pentaen-7-il]etan-1-ol como antagonistas de indol-amina-2,3-dioxigenasa (IDO) para el tratamiento de, por ejemplo, cáncer, trastorno proliferativo, enfermedad viral, sepsis, neumonía, bacteriemia, trauma, tuberculosis, enfermedad parasitaria, neuroinflamación, esquizofrenia, depresión, enfermedad neurodegenerativa y dolor.
MX2017002365A 2014-09-05 2015-09-04 Compuestos diaza- y triaza-triciclicos sustituidos con ciclohexil-etilo como antagonistas de indol-amina-2,3-dioxigenasa (ido) para el tratamiento de cancer. MX2017002365A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462046242P 2014-09-05 2014-09-05
US201562151011P 2015-04-22 2015-04-22
PCT/US2015/048474 WO2016037026A1 (en) 2014-09-05 2015-09-04 Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer

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MX2017002365A true MX2017002365A (es) 2017-05-17

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MX2017002365A MX2017002365A (es) 2014-09-05 2015-09-04 Compuestos diaza- y triaza-triciclicos sustituidos con ciclohexil-etilo como antagonistas de indol-amina-2,3-dioxigenasa (ido) para el tratamiento de cancer.

Country Status (17)

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US (2) US9771370B2 (es)
EP (1) EP3189054B1 (es)
JP (1) JP6680766B2 (es)
KR (1) KR20170044144A (es)
CN (1) CN107074859B (es)
AU (1) AU2015311826B2 (es)
BR (1) BR112017003764A2 (es)
CA (1) CA2956465A1 (es)
CL (1) CL2017000420A1 (es)
ES (1) ES2751602T3 (es)
IL (1) IL250890B (es)
MX (1) MX2017002365A (es)
PH (1) PH12017500196A1 (es)
RU (1) RU2017111200A (es)
SG (2) SG10201804868PA (es)
WO (1) WO2016037026A1 (es)
ZA (1) ZA201700737B (es)

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CA2956465A1 (en) * 2014-09-05 2016-03-10 Merck Patent Gmbh Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer
GB201418300D0 (en) * 2014-10-15 2014-11-26 Redx Pharma Ltd Compounds

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