MX2014011103A - Moduladores del receptor x del higado. - Google Patents

Moduladores del receptor x del higado.

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Publication number
MX2014011103A
MX2014011103A MX2014011103A MX2014011103A MX2014011103A MX 2014011103 A MX2014011103 A MX 2014011103A MX 2014011103 A MX2014011103 A MX 2014011103A MX 2014011103 A MX2014011103 A MX 2014011103A MX 2014011103 A MX2014011103 A MX 2014011103A
Authority
MX
Mexico
Prior art keywords
liver
receptor modulators
compounds
receptor
disease
Prior art date
Application number
MX2014011103A
Other languages
English (en)
Other versions
MX354818B (es
Inventor
Katerina Leftheris
Colin Tice
Wei Zhao
Suresh B Singh
Linghang Zhuang
Yajun Zheng
Chengguo Dong
Yi Fan
Stephen Lotesta
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of MX2014011103A publication Critical patent/MX2014011103A/es
Publication of MX354818B publication Critical patent/MX354818B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

Se proveen aquí compuestos novedosos y sales farmacéuticamente aceptables de los mismos que son moduladores del receptor X del hígado; también se proveen composiciones que comprenden los compuestos de la invención y un portador; adicionalmente se describen el uso de los compuestos en la presente y métodos de tratamiento de una enfermedad o trastorno asociado con el receptor X del hígado.
MX2014011103A 2012-03-16 2013-03-14 Moduladores del receptor x del higado. MX354818B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261612051P 2012-03-16 2012-03-16
PCT/US2013/031242 WO2013138565A1 (en) 2012-03-16 2013-03-14 Liver x receptor modulators

Publications (2)

Publication Number Publication Date
MX2014011103A true MX2014011103A (es) 2014-12-05
MX354818B MX354818B (es) 2018-03-21

Family

ID=47997957

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014011103A MX354818B (es) 2012-03-16 2013-03-14 Moduladores del receptor x del higado.

Country Status (27)

Country Link
US (4) US9006244B2 (es)
EP (1) EP2825541B1 (es)
JP (3) JP6114814B2 (es)
KR (1) KR102069912B1 (es)
CN (1) CN104203951B (es)
AU (1) AU2013232066B2 (es)
CA (1) CA2866218C (es)
CY (1) CY1118318T1 (es)
DK (1) DK2825541T3 (es)
EA (1) EA026907B1 (es)
ES (1) ES2598653T3 (es)
HR (1) HRP20161196T1 (es)
HU (1) HUE029402T2 (es)
IL (1) IL234265B (es)
IN (1) IN2014DN07636A (es)
LT (1) LT2825541T (es)
ME (1) ME02534B (es)
MX (1) MX354818B (es)
NZ (1) NZ629122A (es)
PL (1) PL2825541T3 (es)
PT (1) PT2825541T (es)
RS (1) RS55166B1 (es)
SG (1) SG11201405328SA (es)
SI (1) SI2825541T1 (es)
SM (1) SMT201600374B (es)
WO (1) WO2013138565A1 (es)
ZA (1) ZA201406326B (es)

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BR112017002260A2 (pt) * 2014-08-07 2017-11-21 Vitae Pharmaceuticals Inc derivados de piperazina como moduladores do receptor x do fígado
US20190125745A1 (en) * 2014-12-17 2019-05-02 Rgenix, Inc. Treatment and diagnosis of cancer
CN105017262B (zh) * 2015-07-07 2017-05-03 广东也乐新材料制造有限公司 一种醛基取代多环杂芳烃化合物的合成方法
CN105288658B (zh) * 2015-10-30 2018-08-28 中国人民解放军第三军医大学 miR-18a-5p抑制剂在制备防治骨质疏松药物中的应用
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