MX2017007191A - Procedimiento de produccion de cristales de derivado de diazabiciclooctano y preparacion liofilizada estable. - Google Patents
Procedimiento de produccion de cristales de derivado de diazabiciclooctano y preparacion liofilizada estable.Info
- Publication number
- MX2017007191A MX2017007191A MX2017007191A MX2017007191A MX2017007191A MX 2017007191 A MX2017007191 A MX 2017007191A MX 2017007191 A MX2017007191 A MX 2017007191A MX 2017007191 A MX2017007191 A MX 2017007191A MX 2017007191 A MX2017007191 A MX 2017007191A
- Authority
- MX
- Mexico
- Prior art keywords
- crystals
- compound
- stable
- diazabiciclooctan
- liophilized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
Los objetos de la presente invención consisten en proporcionar un procedimiento para producir cristales del compuesto (I) con facilidad en una escala industrial y una composición liofilizada estable de compuesto (I); se halló que sometiendo una solución acuosa que contiene el compuesto (I) y una sal inorgánica tal como cloruro de sodio a liofilización da como resultado una composición liofilizada con buena estabilidad de almacenamiento, en donde el compuesto (I) es cristalino y también que los cristales del compuesto (I) se pueden obtener de dicha solución acuosa sin liofilización. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014246425 | 2014-12-05 | ||
| PCT/JP2015/084094 WO2016088863A1 (ja) | 2014-12-05 | 2015-12-04 | ジアザビシクロオクタン誘導体の結晶及び安定な凍結乾燥製剤の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017007191A true MX2017007191A (es) | 2017-08-28 |
Family
ID=56091802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017007191A MX2017007191A (es) | 2014-12-05 | 2015-12-04 | Procedimiento de produccion de cristales de derivado de diazabiciclooctano y preparacion liofilizada estable. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10294224B2 (es) |
| EP (1) | EP3228620B1 (es) |
| JP (1) | JP6779787B2 (es) |
| KR (1) | KR102555657B1 (es) |
| CN (1) | CN107001366B (es) |
| AR (2) | AR102915A1 (es) |
| AU (1) | AU2015355970B2 (es) |
| BR (1) | BR112017010445B8 (es) |
| CA (1) | CA2969192C (es) |
| ES (1) | ES2821826T3 (es) |
| IL (1) | IL252691B (es) |
| MX (1) | MX2017007191A (es) |
| MY (1) | MY190283A (es) |
| RU (1) | RU2732129C2 (es) |
| SG (1) | SG11201704576SA (es) |
| TW (1) | TWI691499B (es) |
| WO (1) | WO2016088863A1 (es) |
| ZA (1) | ZA201704063B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE046893T2 (hu) | 2012-05-30 | 2020-04-28 | Meiji Seika Pharma Co Ltd | Új ß-laktamáz inhibitor és eljárás elõállítására |
| CN105612159A (zh) | 2013-10-08 | 2016-05-25 | 明治制果药业株式会社 | 二氮杂二环辛烷衍生物的结晶及其制备方法 |
| SG11201704576SA (en) * | 2014-12-05 | 2017-07-28 | Meiji Seika Pharma Co Ltd | Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation |
| KR20200091395A (ko) | 2017-09-27 | 2020-07-30 | 페도라 파마슈티칼스 인코포레이티드 | 디아자비시클로옥탄 유도체의 결정형 및 그의 제조 방법 |
| EP3687504B1 (en) | 2017-09-27 | 2024-11-27 | Meiji Seika Pharma Co., Ltd. | Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same |
| TW201920174A (zh) | 2017-09-27 | 2019-06-01 | 瑞士商羅氏大藥廠股份有限公司 | 二氮雜雙環辛烷衍生物之醫藥形式及其製法 |
| JP6375463B1 (ja) * | 2018-02-28 | 2018-08-15 | 日本曹達株式会社 | ビス（フルオロスルホニル）アミドアルカリ金属塩粉末の製造方法 |
| CN110314163A (zh) * | 2018-03-30 | 2019-10-11 | 杭州森泽医药科技有限公司 | 一种拉氧头孢钠药物组合物及应用 |
| JP7638693B2 (ja) * | 2020-12-15 | 2025-03-04 | 大阪瓦斯株式会社 | ヒドロキシアルカン酸結晶の製造方法及びヒドロキシアルカン酸の結晶多形体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB1589317A (en) * | 1977-11-24 | 1981-05-13 | Lilly Co Eli | Freeze drying cephalothin sodium |
| JPS6019759B2 (ja) | 1977-11-24 | 1985-05-17 | イ−ライ・リリ−・アンド・カンパニ− | 非経口投予用１１１１５１５２１３９１９９東京都中央区京橋２丁目３番１３号 |
| JPS6019759A (ja) | 1983-07-15 | 1985-01-31 | Nippon Soda Co Ltd | ホルムアミドオキシム誘導体その製造方法及び農園芸用殺菌剤 |
| JPS60255723A (ja) | 1984-05-31 | 1985-12-17 | Ono Pharmaceut Co Ltd | メシル酸ガベキサートの結晶性凍結乾燥製剤及びその製造方法 |
| JPH07117533B2 (ja) | 1985-08-28 | 1995-12-18 | 株式会社生体科学研究所 | トランスフエリンおよびその用途 |
| PL157979B1 (pl) | 1989-02-14 | 1992-07-31 | Sprezyna z dwoma stanami równowagi trwalej PL PL | |
| US20030220521A1 (en) | 1989-07-27 | 2003-11-27 | G.D. Searle & Co. | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension |
| TW264475B (es) | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
| US6111098A (en) * | 1994-05-02 | 2000-08-29 | Shionogi & Co., Ltd. | Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same |
| JP2843444B2 (ja) | 1994-05-02 | 1999-01-06 | 塩野義製薬株式会社 | ピロリジルチオカルバペネム誘導体の結晶，該結晶を含む凍結乾燥製剤，およびその製造方法 |
| DE19531874C1 (de) | 1995-08-30 | 1996-10-02 | Daimler Benz Ag | Seitenwandbaugruppe für eine Kraftfahrzeugkarosserie |
| TWI233805B (en) * | 1999-07-01 | 2005-06-11 | Fujisawa Pharmaceutical Co | Stabilized pharmaceutical composition in lyophilized form as antifungal agent |
| FR2812635B1 (fr) | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| FR2921060B1 (fr) | 2007-09-14 | 2012-06-15 | Novexel | Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires |
| JP5038509B2 (ja) | 2008-01-18 | 2012-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | β−ラクタマーゼ阻害剤 |
| FR2930553B1 (fr) | 2008-04-29 | 2010-05-21 | Novexel | Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases |
| FR2936798B1 (fr) | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| WO2010126820A2 (en) | 2009-04-30 | 2010-11-04 | Merck Sharp & Dohme Corp. | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| SI2657234T1 (sl) | 2010-12-22 | 2017-06-30 | Meiji Seika Pharma Co., Ltd. | Derivat optično-aktivnega diazabiciklooktana in metoda za njegovo izdelavo |
| US8829191B2 (en) | 2011-06-17 | 2014-09-09 | Melanie Simone Ronsheim | Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof |
| BR112013028813B1 (pt) | 2011-08-27 | 2020-10-20 | Wockhardt Limited | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e composições farmacêuticas que os compreendem |
| CN103649088B (zh) | 2011-08-30 | 2016-05-11 | 沃克哈特有限公司 | 1, 6- 二氮杂双环[3, 2, 1]辛- 7- 酮衍生物及其在治疗细菌感染中的用途 |
| BR112014003476A2 (pt) | 2011-09-13 | 2017-03-01 | Wockhardt Ltd | compostos contendo nitrogênio e seu uso |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| HUE046893T2 (hu) | 2012-05-30 | 2020-04-28 | Meiji Seika Pharma Co Ltd | Új ß-laktamáz inhibitor és eljárás elõállítására |
| DK3050883T3 (da) | 2013-09-24 | 2020-05-25 | Meiji Seika Pharma Co Ltd | Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter |
| CN105612159A (zh) * | 2013-10-08 | 2016-05-25 | 明治制果药业株式会社 | 二氮杂二环辛烷衍生物的结晶及其制备方法 |
| SG11201704576SA (en) | 2014-12-05 | 2017-07-28 | Meiji Seika Pharma Co Ltd | Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation |
-
2015
- 2015-12-04 SG SG11201704576SA patent/SG11201704576SA/en unknown
- 2015-12-04 WO PCT/JP2015/084094 patent/WO2016088863A1/ja not_active Ceased
- 2015-12-04 KR KR1020177018148A patent/KR102555657B1/ko active Active
- 2015-12-04 EP EP15866317.9A patent/EP3228620B1/en active Active
- 2015-12-04 CN CN201580065691.6A patent/CN107001366B/zh active Active
- 2015-12-04 TW TW104140714A patent/TWI691499B/zh active
- 2015-12-04 BR BR112017010445A patent/BR112017010445B8/pt active IP Right Grant
- 2015-12-04 MY MYPI2017702007A patent/MY190283A/en unknown
- 2015-12-04 JP JP2016562689A patent/JP6779787B2/ja active Active
- 2015-12-04 CA CA2969192A patent/CA2969192C/en active Active
- 2015-12-04 US US15/532,281 patent/US10294224B2/en active Active
- 2015-12-04 AU AU2015355970A patent/AU2015355970B2/en active Active
- 2015-12-04 AR ARP150103970A patent/AR102915A1/es not_active Application Discontinuation
- 2015-12-04 RU RU2017123112A patent/RU2732129C2/ru active
- 2015-12-04 MX MX2017007191A patent/MX2017007191A/es active IP Right Grant
- 2015-12-04 ES ES15866317T patent/ES2821826T3/es active Active
-
2017
- 2017-06-05 IL IL252691A patent/IL252691B/en active IP Right Grant
- 2017-06-13 ZA ZA2017/04063A patent/ZA201704063B/en unknown
-
2019
- 2019-03-08 US US16/297,550 patent/US11117895B2/en active Active
-
2024
- 2024-07-02 AR ARP240101721A patent/AR133154A2/es unknown
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