MX2017013520A - Nuevas proteinas hibridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular. - Google Patents

Nuevas proteinas hibridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular.

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Publication number
MX2017013520A
MX2017013520A MX2017013520A MX2017013520A MX2017013520A MX 2017013520 A MX2017013520 A MX 2017013520A MX 2017013520 A MX2017013520 A MX 2017013520A MX 2017013520 A MX2017013520 A MX 2017013520A MX 2017013520 A MX2017013520 A MX 2017013520A
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Mexico
Prior art keywords
myostatin
novel hybrid
novel
muscle wasting
ligand trap
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MX2017013520A
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English (en)
Inventor
Han Hq
Zhou Xiaolan
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Alivegen Usa Inc
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Publication of MX2017013520A publication Critical patent/MX2017013520A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente exposición describe nuevos polipéptidos híbridos solubles de ActRIIB-ECD que retienen totalmente la afinidad de enlace para miostatina y activina A, pero demuestran un enlace significativamente reducido a BMPs, específicamente BMP-9. Las nuevas composiciones descritas en la presente pueden utilizarse para preparar nuevas proteínas híbridas de bloqueo de ligando de ActRIIB, que pueden utilizarse para modular el crecimiento de tejido muscular, óseo, cartilaginoso, graso, fibroblástico, sanguíneo y neuronal para contrarrestar la atrofia muscular, la pérdida ósea, la anemia, la inflamación y la fibrosis de manera terapéuticamente significativa. Debido a que estos nuevos inhibidores de miostatina/activina de próxima generación son moléculas más seguras y más efectivas que los inhibidores de miostatina disponibles actualmente, éstos son útiles en una amplia variedad de indicaciones clínicas.
MX2017013520A 2015-04-22 2016-04-12 Nuevas proteinas hibridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular. MX2017013520A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562150994P 2015-04-22 2015-04-22
US201562262356P 2015-12-02 2015-12-02
PCT/US2016/027046 WO2016171948A1 (en) 2015-04-22 2016-04-12 Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases

Publications (1)

Publication Number Publication Date
MX2017013520A true MX2017013520A (es) 2018-05-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013520A MX2017013520A (es) 2015-04-22 2016-04-12 Nuevas proteinas hibridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular.

Country Status (24)

Country Link
US (4) US10913782B2 (es)
EP (2) EP3286206B1 (es)
JP (2) JP6959487B2 (es)
KR (1) KR102777477B1 (es)
CN (1) CN107683287B (es)
AU (2) AU2016251640B2 (es)
CA (1) CA2983440C (es)
CY (1) CY1124124T1 (es)
DK (1) DK3286206T3 (es)
ES (1) ES2856001T3 (es)
HR (1) HRP20210725T1 (es)
HU (1) HUE054232T2 (es)
IL (1) IL255070B (es)
LT (1) LT3286206T (es)
MX (1) MX2017013520A (es)
PL (1) PL3286206T3 (es)
PT (1) PT3286206T (es)
RS (1) RS61881B1 (es)
RU (1) RU2733492C2 (es)
SG (2) SG11201708351XA (es)
SI (1) SI3286206T1 (es)
SM (1) SMT202100294T1 (es)
WO (1) WO2016171948A1 (es)
ZA (2) ZA201707821B (es)

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