MX2018014160A - Procesos para preparar oligomeros de morfolino fosforodiamidato. - Google Patents
Procesos para preparar oligomeros de morfolino fosforodiamidato.Info
- Publication number
- MX2018014160A MX2018014160A MX2018014160A MX2018014160A MX2018014160A MX 2018014160 A MX2018014160 A MX 2018014160A MX 2018014160 A MX2018014160 A MX 2018014160A MX 2018014160 A MX2018014160 A MX 2018014160A MX 2018014160 A MX2018014160 A MX 2018014160A
- Authority
- MX
- Mexico
- Prior art keywords
- processes
- morpholino oligomers
- phosphorodiamidate morpholino
- preparing
- oligomer
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357134P | 2016-06-30 | 2016-06-30 | |
| US201662357153P | 2016-06-30 | 2016-06-30 | |
| US201762508256P | 2017-05-18 | 2017-05-18 | |
| PCT/US2017/040311 WO2017205879A2 (fr) | 2016-05-24 | 2017-06-30 | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018014160A true MX2018014160A (es) | 2019-04-01 |
Family
ID=64425889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014160A MX2018014160A (es) | 2016-06-30 | 2017-06-30 | Procesos para preparar oligomeros de morfolino fosforodiamidato. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3463389A4 (fr) |
| JP (1) | JP7022079B2 (fr) |
| KR (1) | KR102523522B1 (fr) |
| CN (1) | CN109152792B (fr) |
| AU (1) | AU2017270598B2 (fr) |
| CA (1) | CA3024153A1 (fr) |
| CO (1) | CO2018013831A2 (fr) |
| MX (1) | MX2018014160A (fr) |
| SG (1) | SG11201809502YA (fr) |
| WO (1) | WO2017205879A2 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| MA45183A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
| CN109152775B (zh) * | 2016-06-30 | 2022-04-26 | 萨勒普塔医疗公司 | 制备磷酸二酰胺吗啉代寡聚物的方法 |
| EP4230196A1 (fr) | 2022-02-21 | 2023-08-23 | Som Innovation Biotech, S.A. | Composés à utiliser dans le traitement des dystrophinopathies |
| KR20240105985A (ko) | 2022-12-29 | 2024-07-08 | 최해용 | 스마트폰 용 프로젝터 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3022967B2 (ja) | 1985-03-15 | 2000-03-21 | アンチバイラルズ インコーポレイテッド | 立体規則性ポリヌクレオチド結合ポリマー |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| EP0433345B1 (fr) | 1988-09-01 | 1994-04-20 | Forskningscenter Riso | Procede de synthese de peptides et support solide de realisation dudit procede |
| AU694157B2 (en) * | 1993-12-29 | 1998-07-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine adenosine antagonists |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US8076476B2 (en) * | 2007-11-15 | 2011-12-13 | Avi Biopharma, Inc. | Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits |
| US8299206B2 (en) * | 2007-11-15 | 2012-10-30 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
| MX2010004955A (es) | 2007-11-15 | 2010-06-30 | Avi Biopharma Inc | Metodo de sintesis de oligomeros de morfolina. |
| US9050373B2 (en) * | 2010-05-13 | 2015-06-09 | The Charlotte-Mecklenburg Hospital Authority | Pharmaceutical compositions comprising antisense oligonucleotides and methods of using same |
| KR20200133284A (ko) * | 2010-05-28 | 2020-11-26 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
| TWI541024B (zh) * | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| RS55610B1 (sr) | 2010-09-30 | 2017-06-30 | Nippon Shinyaku Co Ltd | Derivat morfolino nukleinske kiseline |
| WO2012150960A1 (fr) * | 2011-05-05 | 2012-11-08 | Avi Biopharma, Inc. | Conjugués peptides/oligonucléotides |
| ES2727481T3 (es) * | 2011-11-30 | 2019-10-16 | Sarepta Therapeutics Inc | Inclusión inducida de exón en atrofia muscular espinal |
| RS58529B1 (sr) * | 2013-03-14 | 2019-04-30 | Sarepta Therapeutics Inc | Sastavi koji preskaču egzon za tretiranje mišićne distrofije |
| NZ731587A (en) * | 2013-03-14 | 2021-07-30 | Sarepta Therapeutics Inc | Exon skipping compositions for treating muscular dystrophy |
| WO2014189142A1 (fr) * | 2013-05-24 | 2014-11-27 | 味の素株式会社 | Procédé de fabrication de morpholino-oligonucléotide |
| TWI737736B (zh) * | 2016-05-24 | 2021-09-01 | 美商薩羅塔治療公司 | 製備磷醯二胺嗎啉代寡聚物之方法 |
| MA49775A (fr) * | 2016-05-24 | 2020-06-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
| TW201811807A (zh) * | 2016-06-30 | 2018-04-01 | 美商薩羅塔治療公司 | 用於肌肉萎縮症之外顯子跳躍寡聚物 |
| CN109152775B (zh) * | 2016-06-30 | 2022-04-26 | 萨勒普塔医疗公司 | 制备磷酸二酰胺吗啉代寡聚物的方法 |
-
2017
- 2017-06-30 KR KR1020187036636A patent/KR102523522B1/ko active Active
- 2017-06-30 AU AU2017270598A patent/AU2017270598B2/en active Active
- 2017-06-30 JP JP2018562079A patent/JP7022079B2/ja active Active
- 2017-06-30 EP EP17803760.2A patent/EP3463389A4/fr active Pending
- 2017-06-30 CA CA3024153A patent/CA3024153A1/fr active Pending
- 2017-06-30 SG SG11201809502YA patent/SG11201809502YA/en unknown
- 2017-06-30 CN CN201780030629.2A patent/CN109152792B/zh active Active
- 2017-06-30 MX MX2018014160A patent/MX2018014160A/es unknown
- 2017-06-30 WO PCT/US2017/040311 patent/WO2017205879A2/fr not_active Ceased
-
2018
- 2018-12-19 CO CONC2018/0013831A patent/CO2018013831A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3463389A2 (fr) | 2019-04-10 |
| KR102523522B1 (ko) | 2023-04-20 |
| CO2018013831A2 (es) | 2018-12-28 |
| CA3024153A1 (fr) | 2017-11-30 |
| CN109152792A (zh) | 2019-01-04 |
| WO2017205879A2 (fr) | 2017-11-30 |
| JP7022079B2 (ja) | 2022-02-17 |
| EP3463389A4 (fr) | 2020-02-19 |
| AU2017270598A1 (en) | 2019-01-17 |
| WO2017205879A3 (fr) | 2018-01-18 |
| KR20190020674A (ko) | 2019-03-04 |
| SG11201809502YA (en) | 2018-12-28 |
| AU2017270598B2 (en) | 2022-12-01 |
| CN109152792B (zh) | 2021-09-14 |
| JP2019518748A (ja) | 2019-07-04 |
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