MX2020002231A - Composiciones anestesicas de liberacion sostenida, y metodos de preparacion de las mismas. - Google Patents

Composiciones anestesicas de liberacion sostenida, y metodos de preparacion de las mismas.

Info

Publication number
MX2020002231A
MX2020002231A MX2020002231A MX2020002231A MX2020002231A MX 2020002231 A MX2020002231 A MX 2020002231A MX 2020002231 A MX2020002231 A MX 2020002231A MX 2020002231 A MX2020002231 A MX 2020002231A MX 2020002231 A MX2020002231 A MX 2020002231A
Authority
MX
Mexico
Prior art keywords
anesthetic
amide
type
preparing
methods
Prior art date
Application number
MX2020002231A
Other languages
English (en)
Other versions
MX393126B (es
Inventor
Keelung Hong
Hao - Wen KAO
Yi - Yu Lin
Luke S S Guo
Original Assignee
Tlc Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tlc Biopharmaceuticals Inc filed Critical Tlc Biopharmaceuticals Inc
Publication of MX2020002231A publication Critical patent/MX2020002231A/es
Publication of MX393126B publication Critical patent/MX393126B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se provee una composición anestésica para administrar localmente un anestésico tipo amida en un sujeto en necesidad de la misma; la composición anestésica tiene vesículas multilaminares con anestésico tipo amida atrapado preparado hidratando una estructura de lípidos altamente atrapada que comprende un anestésico tipo amida y una mezcla de lípidos con una solución de regulador de pH acuoso a un pH mayor de 5.5; se provee también un método para preparar una composición anestésica usando un procedimiento más simple y más factible para la fabricación a gran escala y para proveer una alta relación molar de contenido de anestésico tipo amida a fosfolípido en comparación con la técnica anterior; esta composición anestésica tiene una duración de eficacia prolongada adaptada al suministro de fármacos.
MX2020002231A 2017-08-28 2018-08-28 Composiciones anestesicas de liberacion sostenida, y metodos de preparacion de las mismas MX393126B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762550983P 2017-08-28 2017-08-28
US201862621730P 2018-01-25 2018-01-25
PCT/US2018/048329 WO2019046293A1 (en) 2017-08-28 2018-08-28 EXTENDED RELEASE ANESTHETIC COMPOSITIONS AND METHODS OF PREPARATION THEREOF

Publications (2)

Publication Number Publication Date
MX2020002231A true MX2020002231A (es) 2022-06-14
MX393126B MX393126B (es) 2025-03-24

Family

ID=63668016

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002231A MX393126B (es) 2017-08-28 2018-08-28 Composiciones anestesicas de liberacion sostenida, y metodos de preparacion de las mismas

Country Status (22)

Country Link
US (2) US11793799B2 (es)
EP (1) EP3675816B1 (es)
JP (1) JP7173615B2 (es)
KR (2) KR102800917B1 (es)
CN (2) CN111182889A (es)
AU (2) AU2018323436B2 (es)
CA (1) CA3073734A1 (es)
CY (1) CY1126137T1 (es)
DK (1) DK3675816T3 (es)
ES (1) ES2946919T3 (es)
FI (1) FI3675816T3 (es)
HR (1) HRP20230535T1 (es)
HU (1) HUE062202T2 (es)
LT (1) LT3675816T (es)
MX (1) MX393126B (es)
PL (1) PL3675816T3 (es)
PT (1) PT3675816T (es)
RS (1) RS64297B1 (es)
SI (1) SI3675816T1 (es)
SM (1) SMT202300163T1 (es)
TW (1) TWI806894B (es)
WO (1) WO2019046293A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111182889A (zh) * 2017-08-28 2020-05-19 美商Tlc生物医药公司 缓释麻醉剂组成物及其制备方法
CN115350154A (zh) 2018-03-30 2022-11-18 美商Tlc生物医药公司 用以制备麻醉剂组成物的脂质饼块及其用途
JP2022523208A (ja) 2019-02-26 2022-04-21 ティーエルシー バイオファーマシューティカルズ、インク． 疼痛の治療に使用するための医薬組成物
WO2020259670A1 (zh) 2019-06-28 2020-12-30 江苏恒瑞医药股份有限公司 一种缓释脂质组合物及其制备方法
CN113116823B (zh) * 2019-12-30 2024-02-20 江苏恒瑞医药股份有限公司 一种脂质体及其制备方法
WO2021143745A1 (zh) 2020-01-14 2021-07-22 中国科学院上海药物研究所 一种长效罗哌卡因药物组合物及其制备方法和用途
CN114668723A (zh) * 2020-12-25 2022-06-28 江苏恒瑞医药股份有限公司 一种含有局部麻醉药的脂质体及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2592791A1 (fr) * 1986-01-14 1987-07-17 Ire Celltarg Sa Composition pharmaceutique, contenant un anesthesique local et/ou un analgesique central encapsule dans des liposomes
US5244678A (en) 1986-01-14 1993-09-14 Ire-Celltarg S.A. Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes
US5227165A (en) * 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
GB9605915D0 (en) 1996-03-21 1996-05-22 Univ Bruxelles Liposome encapsulated amphiphilic drug compositions
GB9609779D0 (en) 1996-05-10 1996-07-17 Univ Bruxelles Freeze dried liposome encapsulated amphiphilic drug compositions and a process for the preparation thereof
CA2304096C (en) 1997-09-18 2003-09-09 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
CA2326348C (en) 1998-03-31 2009-10-06 Yissum Research Development Company Of The Hebrew University In Jerusalem Liposomal bupivacaine compositions and methods of preparation
IL140892A0 (en) 1998-08-12 2002-02-10 Yissum Res Dev Co Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
JP5484059B2 (ja) 2006-10-06 2014-05-07 エスシーアイエル テクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 脊髄核インプラント
WO2013146386A1 (ja) * 2012-03-27 2013-10-03 学校法人関西医科大学 局所麻酔薬持続性徐放製剤
WO2014043665A2 (en) 2012-09-17 2014-03-20 Interdigital Patent Holdings, Inc. Self-optimization of backhaul radio reseources and small cell backhaul delay estimation
JPWO2014046191A1 (ja) * 2012-09-21 2016-08-18 テルモ株式会社 局所麻酔薬持続徐放性リポソーム製剤
CN103142458B (zh) * 2013-01-22 2015-09-09 莱普德制药有限公司 无成瘾性镇痛缓释递药系统的组方与制备方法
WO2018048460A1 (en) * 2014-04-21 2018-03-15 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
CN111182889A (zh) * 2017-08-28 2020-05-19 美商Tlc生物医药公司 缓释麻醉剂组成物及其制备方法

Also Published As

Publication number Publication date
EP3675816B1 (en) 2023-05-17
US11793799B2 (en) 2023-10-24
KR20200044902A (ko) 2020-04-29
KR20250029892A (ko) 2025-03-05
SMT202300163T1 (it) 2023-09-06
PL3675816T3 (pl) 2023-09-25
JP2020531540A (ja) 2020-11-05
RS64297B1 (sr) 2023-07-31
EP3675816A1 (en) 2020-07-08
US20200188374A1 (en) 2020-06-18
WO2019046293A1 (en) 2019-03-07
RU2020112204A (ru) 2021-10-04
AU2023266253A1 (en) 2023-12-07
AU2018323436B2 (en) 2023-12-21
DK3675816T3 (da) 2023-05-30
HRP20230535T1 (hr) 2023-09-15
CN111182889A (zh) 2020-05-19
AU2018323436A1 (en) 2020-03-12
FI3675816T3 (fi) 2023-06-02
ES2946919T3 (es) 2023-07-27
CN118105349A (zh) 2024-05-31
SI3675816T1 (sl) 2023-10-30
JP7173615B2 (ja) 2022-11-16
CA3073734A1 (en) 2019-03-07
BR112020003743A2 (pt) 2020-09-01
US12280043B2 (en) 2025-04-22
MX393126B (es) 2025-03-24
TW201919598A (zh) 2019-06-01
KR102800917B1 (ko) 2025-04-24
PT3675816T (pt) 2023-05-31
RU2020112204A3 (es) 2022-02-28
TWI806894B (zh) 2023-07-01
CY1126137T1 (el) 2023-11-15
AU2023266253B2 (en) 2025-01-30
HUE062202T2 (hu) 2023-10-28
LT3675816T (lt) 2023-06-26
US20240000764A1 (en) 2024-01-04

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