MX2020003502A - Tratamiento de glomerulosclerosis segmentaria focal con antagonistas ccr2. - Google Patents

Tratamiento de glomerulosclerosis segmentaria focal con antagonistas ccr2.

Info

Publication number
MX2020003502A
MX2020003502A MX2020003502A MX2020003502A MX2020003502A MX 2020003502 A MX2020003502 A MX 2020003502A MX 2020003502 A MX2020003502 A MX 2020003502A MX 2020003502 A MX2020003502 A MX 2020003502A MX 2020003502 A MX2020003502 A MX 2020003502A
Authority
MX
Mexico
Prior art keywords
segmentary
glomerulosclerosis
focal
treatment
ccr2 antagonists
Prior art date
Application number
MX2020003502A
Other languages
English (en)
Other versions
MX386699B (es
Inventor
Rajinder Singh
Zhenhua Miao
Thomas J Schall
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of MX2020003502A publication Critical patent/MX2020003502A/es
Publication of MX386699B publication Critical patent/MX386699B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)

Abstract

En la presente descripción se proporcionan métodos para tratar la glomerulosclerosis segmentaria focal, dichos métodos incluyen administrar a un sujeto que la necesita una cantidad terapéuticamente eficaz de un antagonista de CCR2. En algunas modalidades, el antagonista de CCR2 se usa 5 en monoterapia. En algunas modalidades, el antagonista de CCR2 se usa en terapia de combinación. En algunas modalidades, el agente terapéutico adicional es un bloqueador de RAAS y/o un inhibidor de receptores de endotelina.
MX2020003502A 2017-10-11 2018-10-10 Tratamiento de glomerulosclerosis segmentaria focal con antagonistas ccr2 MX386699B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762570778P 2017-10-11 2017-10-11
PCT/US2018/055244 WO2019075086A1 (en) 2017-10-11 2018-10-10 TREATMENT OF FOCAL SEGMENTAL GLOBEROSCLEROSIS WITH CCR2 ANTAGONISTS

Publications (2)

Publication Number Publication Date
MX2020003502A true MX2020003502A (es) 2021-09-30
MX386699B MX386699B (es) 2025-03-19

Family

ID=66101688

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003502A MX386699B (es) 2017-10-11 2018-10-10 Tratamiento de glomerulosclerosis segmentaria focal con antagonistas ccr2

Country Status (17)

Country Link
US (3) US10758540B2 (es)
EP (1) EP3694504A4 (es)
JP (1) JP2020536919A (es)
KR (1) KR20200070299A (es)
CN (1) CN111417389A (es)
AR (1) AR113440A1 (es)
AU (1) AU2018347361A1 (es)
BR (1) BR112020007183A2 (es)
CA (1) CA3078809A1 (es)
CL (1) CL2020000974A1 (es)
IL (1) IL273717A (es)
MX (1) MX386699B (es)
RU (1) RU2020113612A (es)
SG (1) SG11202002975YA (es)
TW (1) TW201922246A (es)
WO (1) WO2019075086A1 (es)
ZA (1) ZA202002049B (es)

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KR20230015874A (ko) 2019-12-17 2023-01-31 치누크 세라퓨틱스, 인크. 아트라센탄에 의해 iga 신장병증을 치료하는 방법
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WO2022198264A1 (en) * 2021-03-23 2022-09-29 Dimerix Bioscience Pty Ltd Treatment of inflammatory diseases
JP7782035B2 (ja) 2021-11-09 2025-12-08 エイジャックス セラピューティクス， インコーポレイテッド Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール
TW202325289A (zh) 2021-11-09 2023-07-01 美商雅捷可斯治療公司 Ｊａｋ２抑制劑之形式及組合物
JP2025183466A (ja) * 2022-11-11 2025-12-17 株式会社アークメディスン 化合物、エンドセリンａ受容体拮抗剤、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物

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Also Published As

Publication number Publication date
JP2020536919A (ja) 2020-12-17
CA3078809A1 (en) 2019-04-18
US20210000834A1 (en) 2021-01-07
ZA202002049B (en) 2021-10-27
KR20200070299A (ko) 2020-06-17
RU2020113612A3 (es) 2022-04-29
EP3694504A4 (en) 2021-07-14
US10758540B2 (en) 2020-09-01
US20190134042A1 (en) 2019-05-09
AR113440A1 (es) 2020-05-06
US20220296601A1 (en) 2022-09-22
US11382915B2 (en) 2022-07-12
EP3694504A1 (en) 2020-08-19
RU2020113612A (ru) 2021-11-12
CN111417389A (zh) 2020-07-14
TW201922246A (zh) 2019-06-16
AU2018347361A1 (en) 2020-04-30
SG11202002975YA (en) 2020-04-29
WO2019075086A1 (en) 2019-04-18
BR112020007183A2 (pt) 2020-09-24
IL273717A (en) 2020-05-31
CL2020000974A1 (es) 2020-08-14
MX386699B (es) 2025-03-19

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