MX2020005166A - Uso de un antagonista de vegf para tratar trastornos oculares angiogenicos. - Google Patents

Uso de un antagonista de vegf para tratar trastornos oculares angiogenicos.

Info

Publication number
MX2020005166A
MX2020005166A MX2020005166A MX2020005166A MX2020005166A MX 2020005166 A MX2020005166 A MX 2020005166A MX 2020005166 A MX2020005166 A MX 2020005166A MX 2020005166 A MX2020005166 A MX 2020005166A MX 2020005166 A MX2020005166 A MX 2020005166A
Authority
MX
Mexico
Prior art keywords
weeks
vegf antagonist
present
administration
eye disorders
Prior art date
Application number
MX2020005166A
Other languages
English (en)
Inventor
Robert L Vitti
Alyson J Berliner
Karen Chu
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=64755724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020005166(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2020005166A publication Critical patent/MX2020005166A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención proporciona métodos para tratar o prevenir la retinopatía diabética, por ejemplo, retinopatía diabética no proliferativa, mediante la administración secuencial de múltiples dosis de un antagonista de VEGF a un paciente. Los métodos de la presente invención incluyen la administración de un aflibercept de 2 mg por inyección intravítrea q8 semanas después de tres o cinco dosis mensuales iniciales (2q8) o 2 mg cada 16 semanas después de tres dosis mensuales iniciales y un intervalo de 8 semanas (2q16). Además, la presente invención proporciona métodos para revertir o detener la progresión de NPDR a PDR (por ejemplo, tal que el DRSS se reduce en 2 o 3 niveles) o prevenir la aparición o recurrencia de una complicación que amenaza la visión mediante la administración de aflibercept de acuerdo con los regímenes de dosificación establecidos en este documento.
MX2020005166A 2017-11-30 2018-11-29 Uso de un antagonista de vegf para tratar trastornos oculares angiogenicos. MX2020005166A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762593033P 2017-11-30 2017-11-30
US201862644425P 2018-03-17 2018-03-17
US201862748782P 2018-10-22 2018-10-22
PCT/US2018/063025 WO2019108770A1 (en) 2017-11-30 2018-11-29 Use of a vegf antagonist to treat angiogenic eye disorders

Publications (1)

Publication Number Publication Date
MX2020005166A true MX2020005166A (es) 2020-09-03

Family

ID=64755724

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005166A MX2020005166A (es) 2017-11-30 2018-11-29 Uso de un antagonista de vegf para tratar trastornos oculares angiogenicos.

Country Status (25)

Country Link
US (3) US10973879B2 (es)
EP (4) EP4122486A1 (es)
JP (3) JP7339248B2 (es)
KR (2) KR20200093621A (es)
CN (1) CN111465407A (es)
AU (2) AU2018375398C1 (es)
BR (1) BR112020010659A2 (es)
CA (1) CA3083611A1 (es)
DK (1) DK3716992T3 (es)
ES (1) ES2927049T3 (es)
HR (1) HRP20221335T1 (es)
HU (1) HUE059827T2 (es)
IL (3) IL312323B1 (es)
LT (1) LT3716992T (es)
MX (1) MX2020005166A (es)
MY (1) MY201127A (es)
NZ (1) NZ764953A (es)
PL (1) PL3716992T3 (es)
PT (1) PT3716992T (es)
RS (1) RS63703B1 (es)
SG (1) SG11202004268PA (es)
SI (1) SI3716992T1 (es)
SM (1) SMT202200374T1 (es)
WO (1) WO2019108770A1 (es)
ZA (1) ZA202002821B (es)

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Also Published As

Publication number Publication date
RS63703B1 (sr) 2022-11-30
US12280093B2 (en) 2025-04-22
EP4279135A3 (en) 2024-02-21
LT3716992T (lt) 2022-09-12
US20210205410A1 (en) 2021-07-08
US20190290725A1 (en) 2019-09-26
US10973879B2 (en) 2021-04-13
MY201127A (en) 2024-02-07
IL312323B1 (en) 2026-04-01
JP7339248B2 (ja) 2023-09-05
SI3716992T1 (sl) 2022-10-28
PL3716992T3 (pl) 2022-12-19
HUE059827T2 (hu) 2023-01-28
SG11202004268PA (en) 2020-06-29
HRP20221335T1 (hr) 2022-12-23
AU2018375398C1 (en) 2026-01-15
ZA202002821B (en) 2021-08-25
EP4122486A1 (en) 2023-01-25
DK3716992T3 (da) 2022-09-12
IL274711B2 (en) 2024-10-01
JP2023159323A (ja) 2023-10-31
IL312323A (en) 2024-06-01
IL326641A (en) 2026-04-01
PT3716992T (pt) 2022-08-31
AU2025201179A1 (en) 2025-03-13
BR112020010659A2 (pt) 2020-11-10
ES2927049T3 (es) 2022-11-02
CN111465407A (zh) 2020-07-28
CA3083611A1 (en) 2019-06-06
JP2025069279A (ja) 2025-04-30
KR20240074890A (ko) 2024-05-28
JP2021505535A (ja) 2021-02-18
IL274711A (en) 2020-07-30
WO2019108770A1 (en) 2019-06-06
US20250268983A1 (en) 2025-08-28
EP3716992B1 (en) 2022-08-10
AU2018375398B2 (en) 2024-11-21
IL274711B1 (en) 2024-06-01
AU2018375398A1 (en) 2020-06-18
EP4609914A2 (en) 2025-09-03
EP4279135A2 (en) 2023-11-22
NZ764953A (en) 2026-03-27
EP3716992A1 (en) 2020-10-07
KR20200093621A (ko) 2020-08-05
EP4609914A3 (en) 2025-10-15
SMT202200374T1 (it) 2022-11-18

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