MX2020005944A - Analogos espirobiciclicos novedosos. - Google Patents

Analogos espirobiciclicos novedosos.

Info

Publication number
MX2020005944A
MX2020005944A MX2020005944A MX2020005944A MX2020005944A MX 2020005944 A MX2020005944 A MX 2020005944A MX 2020005944 A MX2020005944 A MX 2020005944A MX 2020005944 A MX2020005944 A MX 2020005944A MX 2020005944 A MX2020005944 A MX 2020005944A
Authority
MX
Mexico
Prior art keywords
spirobicyclic
analogues
novel
compounds
present
Prior art date
Application number
MX2020005944A
Other languages
English (en)
Inventor
Lieven Meerpoel
Dirk Brehmer
Vineet Pande
Weimei Sun
Tongfei Wu
Jonas Verhoeven
Guido Alfons F Verniest
Johannes Wilhelmus John F Thuring
Scott E Denmark
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2020005944A publication Critical patent/MX2020005944A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a análogos espirobicíclicos novedosos de fórmula (ver fórmula I) en donde las variables tienen el significado definido en las reivindicaciones. Los compuestos de acuerdo con la presente invención son útiles como inhibidores PRMT5; la invención se refiere además a composiciones farmacéuticas que comprenden dichos compuestos como principio activo, así como también al uso de dichos compuestos como un medicamento.
MX2020005944A 2017-12-08 2018-12-06 Analogos espirobiciclicos novedosos. MX2020005944A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762596441P 2017-12-08 2017-12-08
EP18163867 2018-03-26
PCT/EP2018/083808 WO2019110734A1 (en) 2017-12-08 2018-12-06 Novel spirobicyclic analogues

Publications (1)

Publication Number Publication Date
MX2020005944A true MX2020005944A (es) 2020-08-24

Family

ID=64664279

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005944A MX2020005944A (es) 2017-12-08 2018-12-06 Analogos espirobiciclicos novedosos.

Country Status (13)

Country Link
US (3) US11059850B2 (es)
EP (2) EP3720865B1 (es)
JP (1) JP7352544B2 (es)
KR (1) KR20200097280A (es)
CN (1) CN111479817B (es)
AU (1) AU2018379456B2 (es)
BR (1) BR112020010815A2 (es)
CA (1) CA3084449A1 (es)
ES (1) ES2978117T3 (es)
IL (1) IL275129B2 (es)
MA (1) MA51004A (es)
MX (1) MX2020005944A (es)
WO (1) WO2019110734A1 (es)

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TN2019000212A1 (en) 2017-02-27 2021-01-07 Janssen Pharmaceutica Nv Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor
US11059850B2 (en) * 2017-12-08 2021-07-13 Janssen Pharmaceutica Nv Spirobicyclic analogues
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IL318073A (en) * 2019-03-25 2025-02-01 California Inst Of Techn PRMT5 inhibitors and their uses
TW202112375A (zh) 2019-06-06 2021-04-01 比利時商健生藥品公司 使用ｐｒｍｔ５抑制劑治療癌症之方法
KR20220019766A (ko) * 2019-06-12 2022-02-17 얀센 파마슈티카 엔.브이. 신규 스피로바이사이클릭 중간체
US12403137B2 (en) 2019-10-28 2025-09-02 Tango Therapeutics, Inc. Compounds and methods of use
CN114929234A (zh) * 2020-01-07 2022-08-19 辉瑞公司 用于治疗银屑病及其他自体免疫性病况的方法中的prmt5抑制剂
WO2022026892A1 (en) 2020-07-31 2022-02-03 Tango Therapeutics, Inc. Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers
US12492178B2 (en) 2021-09-01 2025-12-09 Empathbio, Inc. Stable polymorph of R-MDMA HCl
US11912680B2 (en) 2021-12-28 2024-02-27 Empathbio, Inc. Nitric oxide releasing prodrugs of MDA and MDMA
WO2026008533A1 (en) 2024-07-01 2026-01-08 Janssen Pharmaceutica Nv Prmt5 inhibitors for treating adenomas

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Also Published As

Publication number Publication date
AU2018379456B2 (en) 2022-11-24
US12145961B2 (en) 2024-11-19
US20230303612A1 (en) 2023-09-28
US20200369707A1 (en) 2020-11-26
WO2019110734A1 (en) 2019-06-13
RU2020122212A (ru) 2022-01-10
ES2978117T3 (es) 2024-09-05
CN111479817A (zh) 2020-07-31
MA51004A (fr) 2020-10-14
BR112020010815A2 (pt) 2020-11-10
EP4385996A3 (en) 2024-07-31
RU2020122212A3 (es) 2022-01-10
CA3084449A1 (en) 2019-06-13
EP3720865A1 (en) 2020-10-14
IL275129A (en) 2020-07-30
US11059850B2 (en) 2021-07-13
AU2018379456A1 (en) 2020-06-25
IL275129B2 (en) 2023-10-01
US11702441B2 (en) 2023-07-18
IL275129B1 (en) 2023-06-01
EP3720865C0 (en) 2024-03-13
KR20200097280A (ko) 2020-08-18
EP3720865B1 (en) 2024-03-13
JP7352544B2 (ja) 2023-09-28
US20210380627A1 (en) 2021-12-09
EP4385996A2 (en) 2024-06-19
JP2021505582A (ja) 2021-02-18
CN111479817B (zh) 2023-03-21

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