MX2020006594A - Inhibidores de exo-azaespiro de la interaccion menina-mll. - Google Patents

Inhibidores de exo-azaespiro de la interaccion menina-mll.

Info

Publication number
MX2020006594A
MX2020006594A MX2020006594A MX2020006594A MX2020006594A MX 2020006594 A MX2020006594 A MX 2020006594A MX 2020006594 A MX2020006594 A MX 2020006594A MX 2020006594 A MX2020006594 A MX 2020006594A MX 2020006594 A MX2020006594 A MX 2020006594A
Authority
MX
Mexico
Prior art keywords
menin
inhibitors
exo
aza spiro
mll interaction
Prior art date
Application number
MX2020006594A
Other languages
English (en)
Inventor
Patrick René Angibaud
Virginie Sophie Poncelet
Olivier Alexis Georges Querolle
Wei Cai
Vineet Pande
Daniel Jason Krosky
Aaron Nathaniel Patrick
James Patrick Edwards
Xuedong Dai
Liqiang Fu
Linglong Kong
Yingtao Liu
Zhao - Kui WAN
Geb Herkert Barbara Morschhäuser
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2020006594A publication Critical patent/MX2020006594A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a agentes farmacéuticos útiles para terapia y/o profilaxis en un mamífero, composición farmacéutica que comprende dichos compuestos, y su uso como inhibidores de la interacción proteína/proteína menina/MLL, útiles para tratar enfermedades tales como cáncer, síndrome mielodisplásico (MDS) y diabetes.
MX2020006594A 2017-12-20 2018-12-19 Inhibidores de exo-azaespiro de la interaccion menina-mll. MX2020006594A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017117536 2017-12-20
CN2018091521 2018-06-15
PCT/CN2018/121960 WO2019120209A1 (en) 2017-12-20 2018-12-19 Exo-aza spiro inhibitors of menin-mll interaction

Publications (1)

Publication Number Publication Date
MX2020006594A true MX2020006594A (es) 2020-09-09

Family

ID=66993097

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006594A MX2020006594A (es) 2017-12-20 2018-12-19 Inhibidores de exo-azaespiro de la interaccion menina-mll.

Country Status (12)

Country Link
US (1) US20230039917A1 (es)
EP (1) EP3728260A4 (es)
JP (1) JP7307729B2 (es)
KR (1) KR20200101389A (es)
CN (1) CN111601807B (es)
AU (1) AU2018389145B2 (es)
BR (1) BR112020012461A2 (es)
CA (1) CA3083624A1 (es)
IL (1) IL275457A (es)
MA (1) MA51337A (es)
MX (1) MX2020006594A (es)
WO (1) WO2019120209A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102916887B1 (ko) 2016-06-10 2026-01-22 비타이 파마슈티컬즈, 엘엘씨 메닌-mll 상호 작용의 억제제
CN110950818B (zh) * 2019-12-18 2021-12-28 浙江海翔药业股份有限公司 顺式-2,6-二甲基吗啉的纯化方法
TWI878414B (zh) 2019-12-19 2025-04-01 比利時商健生藥品公司 經取代之直鏈螺環接衍生物
WO2021207335A1 (en) 2020-04-07 2021-10-14 Syndax Pharmaceuticals, Inc. Combinations of menin inhibitors and cyp3a4 inhibitors and methods of use thereof
CN114478568A (zh) * 2020-10-27 2022-05-13 苏州优理生物医药科技有限公司 一种噻吩并嘧啶类化合物、包含其药物组合物及其应用
EP4294798A1 (en) * 2021-02-19 2023-12-27 Kalvista Pharmaceuticals Limited Factor xiia inhibitors
AU2022275192A1 (en) 2021-05-08 2024-01-04 Janssen Pharmaceutica Nv Substituted spiro derivatives
WO2022237626A1 (en) 2021-05-08 2022-11-17 Janssen Pharmaceutica Nv Substituted spiro derivatives
CA3213074A1 (en) * 2021-05-14 2022-11-17 Salvacion Cacatian Inhibitors of the menin-mll interaction
WO2024110649A1 (en) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors and menin inhibitors for treating cancer
AR132185A1 (es) 2023-03-24 2025-06-04 Acerta Pharma Bv COMPUESTOS DE 1-H-PIRROLO[2,3-c]PIRIDINA

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993552B2 (en) 2009-09-04 2015-03-31 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
EP2736901A1 (en) 2011-07-28 2014-06-04 Cellzome Limited Heterocyclyl pyrimidine analogues as jak inhibitors
US9216993B2 (en) 2013-03-13 2015-12-22 The Regents Of The University Of Michigan Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
MA40957A (fr) 2014-10-09 2017-09-19 Biomarin Pharm Inc Inhibiteurs de biosynthèse d'héparane sulfate pour traiter des maladies
HK1246593A1 (zh) 2015-06-04 2018-09-14 Kura Oncology, Inc. 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物
AR104020A1 (es) * 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
CN108779116A (zh) * 2015-12-22 2018-11-09 生命医药公司 多发性内分泌瘤蛋白-mll相互作用的抑制剂
MX387806B (es) 2016-03-16 2025-03-19 Kura Oncology Inc Inhibidores biciclicos con puente sustituidos de menina-mll y metodos de uso
EP3429591B1 (en) 2016-03-16 2023-03-15 Kura Oncology, Inc. Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use
KR20190015275A (ko) 2016-05-02 2019-02-13 더 리젠츠 오브 더 유니버시티 오브 미시간 메닌 억제제로서의 피페리딘
WO2017207387A1 (en) * 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction
KR102916887B1 (ko) * 2016-06-10 2026-01-22 비타이 파마슈티컬즈, 엘엘씨 메닌-mll 상호 작용의 억제제
WO2018024602A1 (en) 2016-08-04 2018-02-08 Bayer Aktiengesellschaft 2,7-diazaspiro[4.4]nonanes
EP3512858B1 (en) 2016-09-14 2023-11-08 Janssen Pharmaceutica NV Fused bicyclic inhibitors of menin-mll interaction
TWI738864B (zh) * 2016-09-14 2021-09-11 比利時商健生藥品公司 Ｍｅｎｉｎ-ｍｌｌ相互作用之螺二環抑制劑
JP2019529421A (ja) 2016-09-16 2019-10-17 ヴァイティー ファーマシューティカルズ，エルエルシー ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤
EA201991448A1 (ru) 2017-01-06 2019-12-30 Янссен Фармацевтика Нв Азепановые ингибиторы взаимодействия менин-mll
US11396517B1 (en) * 2017-12-20 2022-07-26 Janssen Pharmaceutica Nv Exo-aza spiro inhibitors of menin-MLL interaction

Also Published As

Publication number Publication date
US20230039917A1 (en) 2023-02-09
AU2018389145B2 (en) 2023-02-02
WO2019120209A1 (en) 2019-06-27
AU2018389145A1 (en) 2020-05-21
CN111601807B (zh) 2023-03-31
MA51337A (fr) 2020-10-28
JP2021506882A (ja) 2021-02-22
IL275457A (en) 2020-08-31
CN111601807A (zh) 2020-08-28
BR112020012461A2 (pt) 2020-11-24
CA3083624A1 (en) 2019-06-27
JP7307729B2 (ja) 2023-07-12
EP3728260A4 (en) 2021-08-11
EP3728260A1 (en) 2020-10-28
KR20200101389A (ko) 2020-08-27
RU2020123548A (ru) 2022-01-20
RU2020123548A3 (es) 2022-02-17

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