MX2020008534A - Sistemas y metodos para deteccion de modo de fallo en cromatografia del proceso. - Google Patents

Sistemas y metodos para deteccion de modo de fallo en cromatografia del proceso.

Info

Publication number
MX2020008534A
MX2020008534A MX2020008534A MX2020008534A MX2020008534A MX 2020008534 A MX2020008534 A MX 2020008534A MX 2020008534 A MX2020008534 A MX 2020008534A MX 2020008534 A MX2020008534 A MX 2020008534A MX 2020008534 A MX2020008534 A MX 2020008534A
Authority
MX
Mexico
Prior art keywords
methods
systems
detection
failure mode
process chromatography
Prior art date
Application number
MX2020008534A
Other languages
English (en)
Inventor
Eric Shierly
Bernhard Schilling
Scott Carver
Nathan L Mao
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2020008534A publication Critical patent/MX2020008534A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8651—Recording, data aquisition, archiving and storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/206—Packing or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • G01N2030/562—Packing methods or coating methods packing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/889—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 monitoring the quality of the stationary phase; column performance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Library & Information Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La descripción proporciona sistemas y métodos útiles para predecir o detectar un fallo en un proceso de cromatografía en tiempo real. En algunas modalidades, la descripción proporciona sistemas y métodos para detectar un perfil atípico en un cromatograma del proceso en cromatografía de intercambio de iones de un producto biológico.
MX2020008534A 2018-02-15 2019-02-14 Sistemas y metodos para deteccion de modo de fallo en cromatografia del proceso. MX2020008534A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862631167P 2018-02-15 2018-02-15
PCT/US2019/017942 WO2019161012A1 (en) 2018-02-15 2019-02-14 Systems and methods for failure mode detection in process chromatography

Publications (1)

Publication Number Publication Date
MX2020008534A true MX2020008534A (es) 2020-09-18

Family

ID=65635819

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020008534A MX2020008534A (es) 2018-02-15 2019-02-14 Sistemas y metodos para deteccion de modo de fallo en cromatografia del proceso.
MX2024006827A MX2024006827A (es) 2018-02-15 2020-08-14 Sistemas y metodos para deteccion de modo de fallo en cromatografia del proceso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2024006827A MX2024006827A (es) 2018-02-15 2020-08-14 Sistemas y metodos para deteccion de modo de fallo en cromatografia del proceso.

Country Status (14)

Country Link
US (3) US11499951B2 (es)
EP (1) EP3752826A1 (es)
JP (3) JP7410862B2 (es)
KR (2) KR20250091326A (es)
CN (2) CN117761227A (es)
AR (1) AR114326A1 (es)
AU (3) AU2019221563B2 (es)
CA (1) CA3088994A1 (es)
EA (1) EA202091717A1 (es)
IL (2) IL276177B2 (es)
MX (2) MX2020008534A (es)
SG (1) SG11202007078WA (es)
TW (3) TWI795527B (es)
WO (1) WO2019161012A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3752826A1 (en) 2018-02-15 2020-12-23 Regeneron Pharmaceuticals, Inc. Systems and methods for failure mode detection in process chromatography
CN117907511B (zh) * 2024-03-20 2024-06-14 浙江灵析精仪科技发展有限公司 一种多组分重叠峰的自动化解析方法、装置及电子设备
CN118443858B (zh) * 2024-07-08 2024-10-29 江苏权正检验检测有限公司 基于人工智能的高效液相色谱仪故障分析方法

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JP2009518650A (ja) * 2005-12-06 2009-05-07 ポール・コーポレーション クロマトグラフィメディア及びデバイスを検査するためのシステム及び方法
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JP4850165B2 (ja) * 2007-11-02 2012-01-11 パナソニック株式会社 クロマトグラフィー検査装置およびクロマトグラフィー試験片の劣化判定方法
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Also Published As

Publication number Publication date
TWI867847B (zh) 2024-12-21
CN111819439A (zh) 2020-10-23
TW202409561A (zh) 2024-03-01
JP2024023764A (ja) 2024-02-21
TW201945966A (zh) 2019-12-01
KR102823730B1 (ko) 2025-06-23
WO2019161012A1 (en) 2019-08-22
TW202324439A (zh) 2023-06-16
BR112020015240A2 (pt) 2021-01-26
IL276177B1 (en) 2025-12-01
AU2022259817B2 (en) 2024-11-07
JP7752673B2 (ja) 2025-10-10
SG11202007078WA (en) 2020-08-28
CN117761227A (zh) 2024-03-26
EA202091717A1 (ru) 2021-01-14
KR20200121796A (ko) 2020-10-26
CA3088994A1 (en) 2019-08-22
JP2021514058A (ja) 2021-06-03
AU2022259817A1 (en) 2022-12-01
AU2024227672A1 (en) 2024-11-14
EP3752826A1 (en) 2020-12-23
IL324756A (en) 2026-01-01
TWI795527B (zh) 2023-03-11
US11499951B2 (en) 2022-11-15
IL276177B2 (en) 2026-04-01
KR20250091326A (ko) 2025-06-20
CN111819439B (zh) 2023-11-28
US20240345048A1 (en) 2024-10-17
AR114326A1 (es) 2020-08-19
US20190248850A1 (en) 2019-08-15
JP2025178410A (ja) 2025-12-05
MX2024006827A (es) 2024-06-19
US20230020627A1 (en) 2023-01-19
TWI823782B (zh) 2023-11-21
AU2019221563A1 (en) 2020-08-13
JP7410862B2 (ja) 2024-01-10
AU2019221563B2 (en) 2022-08-04
IL276177A (en) 2020-09-30
US12025599B2 (en) 2024-07-02

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