MX2020009617A - Determinación espectrométrica de masa de testosterona en muestra multplexada de un paciente. - Google Patents
Determinación espectrométrica de masa de testosterona en muestra multplexada de un paciente.Info
- Publication number
- MX2020009617A MX2020009617A MX2020009617A MX2020009617A MX2020009617A MX 2020009617 A MX2020009617 A MX 2020009617A MX 2020009617 A MX2020009617 A MX 2020009617A MX 2020009617 A MX2020009617 A MX 2020009617A MX 2020009617 A MX2020009617 A MX 2020009617A
- Authority
- MX
- Mexico
- Prior art keywords
- testosterone
- mass spectrometric
- samples
- multiplexed
- patient samples
- Prior art date
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 title abstract 10
- 229960003604 testosterone Drugs 0.000 title abstract 5
- 239000013610 patient sample Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
Abstract
En la presente se proporcionan métodos para la alta cuantificación de producción de testosterona, utilizando al menos dos diferentes agentes de derivación de diferentes masas. En otro aspecto, en la presente se proporcionan métodos para determinar la cantidad de testosterona en cada pluralidad de muestras humanas con un solo ensayo espectrométrico de masa al someter a cada pluralidad de muestras humanas a diferentes agentes de derivación para generar una testosterona derivada de manera diferente en cada pluralidad de las muestras; al combinar la pluralidad de las muestras para formar una muestras multiplexada; y cuantificar la cantidad de testosterona en cada muestra por medio de espectrometría de masa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862644351P | 2018-03-16 | 2018-03-16 | |
| PCT/US2019/022618 WO2019178565A1 (en) | 2018-03-16 | 2019-03-15 | Mass spectrometric determination of testosterone in multiplexed patient samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020009617A true MX2020009617A (es) | 2020-12-07 |
Family
ID=67905411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009617A MX2020009617A (es) | 2018-03-16 | 2019-03-15 | Determinación espectrométrica de masa de testosterona en muestra multplexada de un paciente. |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11674969B2 (es) |
| EP (1) | EP3765841A4 (es) |
| JP (3) | JP7326356B2 (es) |
| CN (1) | CN112189137A (es) |
| CA (1) | CA3094088A1 (es) |
| MX (1) | MX2020009617A (es) |
| WO (1) | WO2019178565A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112379009A (zh) * | 2020-10-15 | 2021-02-19 | 生物岛实验室 | 生物样本中类固醇激素的检测方法及该方法所用试剂盒 |
| CN121100280A (zh) * | 2023-03-17 | 2025-12-09 | 奎斯特诊断投资有限公司 | 质谱法对多重化样本中睾酮的改进定量 |
| CN118688366B (zh) * | 2024-08-26 | 2024-12-20 | 杭州佰辰医疗器械有限公司 | 一种提取血清中游离睾酮的试剂盒及提取方法和检测方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE342061T1 (de) | 1994-02-18 | 2006-11-15 | Applied Research Systems | Verwendung eines nicht-neutralisierenden antikörpers spezifisch für die beta-untereinheit von luteinisierendem hormon zur erhöhung der fertilität |
| US7045296B2 (en) * | 2001-05-08 | 2006-05-16 | Applera Corporation | Process for analyzing protein samples |
| US7807472B2 (en) * | 2002-04-15 | 2010-10-05 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for separation and detection of ketosteroids and other carbonyl-containing compounds |
| US6977143B1 (en) | 2003-09-08 | 2005-12-20 | Quest Diagnostics Investments Incorporated | Determination of testosterone by mass spectrometry |
| JP2005300430A (ja) * | 2004-04-14 | 2005-10-27 | Shimadzu Corp | ラベル化ペプチドの特異的検出法、および片在ピークの特異的検出法 |
| US7834313B2 (en) * | 2008-08-08 | 2010-11-16 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for plasma-renin |
| US20110301063A1 (en) * | 2009-02-24 | 2011-12-08 | Netzel Brian C | Multiplexing derivatized anayltes using mass spectroscopy |
| DE102009028237A1 (de) | 2009-08-05 | 2011-02-17 | Robert Bosch Gmbh | Verfahren und Vorrichtung zur Regeneration eines Partikelfilters mit einer im Abgaskanal nachgeordneten Abgassonde |
| CA2783708C (en) * | 2009-12-11 | 2018-09-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry of steroidal compounds in multiplex samples |
| US9834578B2 (en) | 2010-05-27 | 2017-12-05 | University Of Utah Research Foundation | Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry |
| WO2011156505A1 (en) | 2010-06-09 | 2011-12-15 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of derivatized methylmalonic acid |
| CN107064330B (zh) | 2010-12-28 | 2022-02-25 | 探索诊断投资公司 | 通过质谱法定量胰岛素 |
| CN103443621B (zh) | 2011-02-07 | 2016-06-29 | 美国控股实验室公司 | 用于测定睾酮在样品中的存在或量的方法和系统 |
| WO2013102786A1 (en) | 2012-01-05 | 2013-07-11 | Dh Technologies Development Pte. Ltd. | Enhancement of sensitivity and specificity of ketosteroids and keto or aldehyde containing analytes |
| JP6041125B2 (ja) | 2012-07-06 | 2016-12-07 | 株式会社あすか製薬メディカル | エストロゲンの超高感度測定法 |
| JP2015121406A (ja) | 2013-12-20 | 2015-07-02 | 株式会社島津製作所 | 液体クロマトグラフ質量分析装置用イオン化プローブ及び液体クロマトグラフ質量分析装置 |
| US10559456B2 (en) | 2014-02-21 | 2020-02-11 | Purdue Research Foundation | Systems and methods for analyzing an extracted sample using an immiscible extraction solvent |
| EP3148662B1 (en) | 2014-05-30 | 2025-10-15 | Tecan SP, Inc. | Extraction, derivatization, and quantification of analytes |
| BR112017025097B1 (pt) | 2015-05-27 | 2021-05-11 | Quest Diagnostics Investments Llc | método para quantificação espectrométrica de massa de analitos extraídos de um dispositivo de microamostragem |
| CN106645373B (zh) * | 2016-09-29 | 2019-03-08 | 中国农业科学院油料作物研究所 | 一种磷脂的精确定量分析方法 |
-
2019
- 2019-03-15 CN CN201980032010.4A patent/CN112189137A/zh active Pending
- 2019-03-15 MX MX2020009617A patent/MX2020009617A/es unknown
- 2019-03-15 EP EP19768146.3A patent/EP3765841A4/en active Pending
- 2019-03-15 CA CA3094088A patent/CA3094088A1/en active Pending
- 2019-03-15 WO PCT/US2019/022618 patent/WO2019178565A1/en not_active Ceased
- 2019-03-15 JP JP2020573092A patent/JP7326356B2/ja active Active
- 2019-03-15 US US16/355,552 patent/US11674969B2/en active Active
-
2023
- 2023-05-04 US US18/143,226 patent/US12140599B2/en active Active
- 2023-08-02 JP JP2023125964A patent/JP7515672B2/ja active Active
-
2024
- 2024-07-02 JP JP2024106593A patent/JP7690653B2/ja active Active
- 2024-10-14 US US18/914,420 patent/US20250035651A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7690653B2 (ja) | 2025-06-10 |
| JP7326356B2 (ja) | 2023-08-15 |
| US20250035651A1 (en) | 2025-01-30 |
| US20230273226A1 (en) | 2023-08-31 |
| JP2021518567A (ja) | 2021-08-02 |
| CA3094088A1 (en) | 2019-09-19 |
| US12140599B2 (en) | 2024-11-12 |
| JP7515672B2 (ja) | 2024-07-12 |
| JP2024147597A (ja) | 2024-10-16 |
| BR112020018817A2 (pt) | 2021-02-09 |
| EP3765841A4 (en) | 2022-06-08 |
| CN112189137A (zh) | 2021-01-05 |
| WO2019178565A1 (en) | 2019-09-19 |
| JP2023164797A (ja) | 2023-11-14 |
| US11674969B2 (en) | 2023-06-13 |
| US20190285654A1 (en) | 2019-09-19 |
| EP3765841A1 (en) | 2021-01-20 |
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