ATE342061T1 - Verwendung eines nicht-neutralisierenden antikörpers spezifisch für die beta-untereinheit von luteinisierendem hormon zur erhöhung der fertilität - Google Patents

Verwendung eines nicht-neutralisierenden antikörpers spezifisch für die beta-untereinheit von luteinisierendem hormon zur erhöhung der fertilität

Info

Publication number
ATE342061T1
ATE342061T1 AT95911043T AT95911043T ATE342061T1 AT E342061 T1 ATE342061 T1 AT E342061T1 AT 95911043 T AT95911043 T AT 95911043T AT 95911043 T AT95911043 T AT 95911043T AT E342061 T1 ATE342061 T1 AT E342061T1
Authority
AT
Austria
Prior art keywords
present
stimulating
luteinizing hormone
fertility
activity
Prior art date
Application number
AT95911043T
Other languages
English (en)
Inventor
William R Moyle
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of ATE342061T1 publication Critical patent/ATE342061T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Control Of Eletrric Generators (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
AT95911043T 1994-02-18 1995-02-17 Verwendung eines nicht-neutralisierenden antikörpers spezifisch für die beta-untereinheit von luteinisierendem hormon zur erhöhung der fertilität ATE342061T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19938294A 1994-02-18 1994-02-18

Publications (1)

Publication Number Publication Date
ATE342061T1 true ATE342061T1 (de) 2006-11-15

Family

ID=22737277

Family Applications (2)

Application Number Title Priority Date Filing Date
AT97122148T ATE314392T1 (de) 1994-02-18 1995-02-17 Einzelketten-gonadotropin
AT95911043T ATE342061T1 (de) 1994-02-18 1995-02-17 Verwendung eines nicht-neutralisierenden antikörpers spezifisch für die beta-untereinheit von luteinisierendem hormon zur erhöhung der fertilität

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT97122148T ATE314392T1 (de) 1994-02-18 1995-02-17 Einzelketten-gonadotropin

Country Status (11)

Country Link
US (2) US7001597B1 (de)
EP (3) EP0751782B1 (de)
JP (3) JPH09509418A (de)
AT (2) ATE314392T1 (de)
AU (1) AU695111B2 (de)
CA (1) CA2183564C (de)
DE (2) DE69535260T2 (de)
DK (1) DK0751782T3 (de)
ES (2) ES2251731T3 (de)
PT (1) PT751782E (de)
WO (1) WO1995022340A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2250975A1 (en) * 1996-04-15 1997-10-23 The Board Of Trustees Of The Leland Stanford Junior University Soluble 7-transmembrane domain g-protein-coupled receptor compositions and methods
WO1998021238A1 (fr) * 1996-11-12 1998-05-22 Teikoku Hormone Mfg. Co., Ltd. Gonadotrophine chorionique equine, monocatenaire et recombinee
ZA987497B (en) * 1997-09-08 1999-02-23 Akzo Nobel Nv Expression of gonadotropins in dictyostelium
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
US5981249A (en) * 1998-02-05 1999-11-09 Spectral Diagnostics, Inc. Single-chain polypeptides comprising creatine kinase M and creatine kinase B
CA2344277A1 (en) * 1998-09-22 2000-03-30 University Of Maryland, Baltimore Cystine knot growth factor mutants
DE19910394A1 (de) * 1999-03-03 2000-09-07 Schering Ag Substanzen für die Fertilitätskontrolle
US6342411B1 (en) * 1999-09-03 2002-01-29 Motorola Inc. Electronic component and method for manufacture
KR20010077538A (ko) * 2000-02-03 2001-08-20 김강권 단일체인 융모성성선자극호르몬 및 그 제조방법
JP2001333772A (ja) 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
AU2001255624A1 (en) * 2000-04-25 2001-11-07 Washington University Single-chain fertility hormones with variable lh activity
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
DE602004030524D1 (de) * 2003-09-26 2011-01-27 Centre Nat Rech Scient Antikörper modulierende die biologische Aktivität von Pferd-Choriongonadotropin
JP7326356B2 (ja) * 2018-03-16 2023-08-15 クエスト ダイアグノスティックス インヴェストメンツ エルエルシー 多重化した患者サンプル中のテストステロンのマススペクトロメトリーによる決定
BR102019004147A2 (pt) 2019-02-28 2020-10-06 Ouro Fino Saude Animal Participacoes S.A. Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso
DE102023213284A1 (de) 2023-12-22 2025-06-26 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung und Verfahren zur Analyse einer Hormon-Konzentration

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514505A (en) * 1982-05-21 1985-04-30 The Trustees Of Columbia University In The City Of New York Monoclonal antibody mixtures and use thereof for enhanced sensitivity immunoassays
US5284778A (en) * 1985-08-12 1994-02-08 The Trustees Of Columbia University In The City Of New York Sensitive bioassay using monoclonal antibodies which bind to hormone-receptor complexes
US4973577A (en) * 1986-04-04 1990-11-27 The Salk Institute For Biological Studies FSH-releasing peptides
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
AU612370B2 (en) * 1987-05-21 1991-07-11 Micromet Ag Targeted multifunctional proteins
CA2082424C (en) * 1990-05-08 2003-09-23 Robert K. Campbell Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
EP0673383B1 (de) * 1991-06-18 2000-05-31 University Of Medicine & Dentistry Of New Jersey Analoga von glykoproteinhormonen mit geänderter rezeptorbindungsspezifität und aktivität und verfahren zur darstellung und verwendung derselben
AU5670194A (en) * 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
CA2173750C (en) * 1994-08-12 2011-03-22 Irving Boime Single-chain forms of the glycoprotein hormone quartet

Also Published As

Publication number Publication date
CA2183564A1 (en) 1995-08-24
DE69534723D1 (de) 2006-02-02
DE69534723T2 (de) 2006-08-31
ATE314392T1 (de) 2006-01-15
ES2251731T3 (es) 2006-05-01
JPH11263799A (ja) 1999-09-28
CA2183564C (en) 2010-07-13
US20070253955A1 (en) 2007-11-01
EP0751782B1 (de) 2006-10-11
EP0839831B1 (de) 2005-12-28
AU1878795A (en) 1995-09-04
WO1995022340A1 (en) 1995-08-24
DE69535260T2 (de) 2007-08-09
ES2273335T3 (es) 2007-05-01
EP0751782A1 (de) 1997-01-08
PT751782E (pt) 2007-01-31
EP0839831A2 (de) 1998-05-06
JP2002060347A (ja) 2002-02-26
JPH09509418A (ja) 1997-09-22
EP0751782A4 (de) 2000-09-27
DK0751782T3 (da) 2007-01-29
US7001597B1 (en) 2006-02-21
EP0839831A3 (de) 1999-09-29
EP1849802A2 (de) 2007-10-31
DE69535260D1 (de) 2006-11-23
AU695111B2 (en) 1998-08-06

Similar Documents

Publication Publication Date Title
ATE342061T1 (de) Verwendung eines nicht-neutralisierenden antikörpers spezifisch für die beta-untereinheit von luteinisierendem hormon zur erhöhung der fertilität
Flack et al. Increased biological activity due to basic isoforms in recombinant human follicle-stimulating hormone produced in a human cell line
CA2053864A1 (en) Modified forms of reproductive hormones
NZ223154A (en) Composition and method for producing superovulation in cattle comprising fsh and lh
BELLVÉ et al. Cell proliferation in the mammalian testis: biology of the seminiferous growth factor (SGF)
Zhang et al. Macrophages in human reproductive tissues contain luteinizing hormone/chorionic gonadotropin receptors
DE3884776D1 (de) Durch "site-directed" Mutagenese modifzierte Glukoprotein-Hormone und Verfahren zu deren Verwendung.
Feig et al. Mitogenic polypeptide of the mammalian seminiferous epithelium: biochemical characterization and partial purification.
Iqbal Khan et al. Studies on the mechanism of action of the inhibitory effect of prostaglandin F2α on cyclic AMP accumulation in rat corpora lutea of various ages
Kardami et al. Selected muscle and nerve extracts contain an activity which stimulates myoblast proliferation and which is distinct from transferrin
Jablonka-Shariff et al. Expression and bioactivity of a single chain recombinant equine luteinizing hormone (reLH)
ATE115409T1 (de) Glykoprotein-hormonrezeptor-moleküle.
Ulloa-Aguirre et al. Effects of gonadotrophin-releasing hormone, recombinant human activin-A and sex steroid hormones upon the follicle-stimulating isohormones secreted by rat anterior pituitary cells in culture
Hakola et al. Recombinant forms of rat and human luteinizing hormone and follicle-stimulating hormone; comparison of functions in vitro and in vivo
Xing et al. Efficient preparation of glycoprotein hormones lacking an α-subunit oligosaccharide
KR900702048A (ko) 고나도트로핀 및 그에 의한 과할성 작용제의 제조 방법
ATE491726T1 (de) Antikörper modulierende die biologische aktivität von pferd-choriongonadotropin
Rembold et al. Inhibition of allatotropic activity and ovary development in Locusta migratoria by anti-brain-antibodies
DE KONING RecoITibinant Reproduction
Carter et al. Comparative aspects of placental evolution: a workshop report
DE4000327A1 (de) Arzneimittel zur verbesserung der ovarreaktion und der eizell- und embryonen- produktion bei haussaeugetieren
Matteri et al. Biochemical and biological properties of urinary follicle‐stimulating hormone (FSH) from the rhesus monkey (Macaca mulatta)
Quesnel et al. Solubilization and purification of the gonadotropin (GTH II) receptor from rainbow trout (Oncorhynchus mykiss) ovaries
Rennels et al. The Anterior Pituitary Gland—Its Cells and Hormones
Chand et al. A reference preparation of buffalo pituitary follicle stimulating hormone using lectin affinity chromatography

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0751782

Country of ref document: EP

EEFA Change of the company name