MX2020009714A - Ratones de una desintegrina y metaloproteasa 6 (adam6). - Google Patents

Ratones de una desintegrina y metaloproteasa 6 (adam6).

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Publication number
MX2020009714A
MX2020009714A MX2020009714A MX2020009714A MX2020009714A MX 2020009714 A MX2020009714 A MX 2020009714A MX 2020009714 A MX2020009714 A MX 2020009714A MX 2020009714 A MX2020009714 A MX 2020009714A MX 2020009714 A MX2020009714 A MX 2020009714A
Authority
MX
Mexico
Prior art keywords
adam6
mice
sequence
mouse
ortholog
Prior art date
Application number
MX2020009714A
Other languages
English (en)
Inventor
Andrew J Murphy
Lynn Macdonald
Sean Stevens
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45998616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020009714(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2020009714A publication Critical patent/MX2020009714A/es

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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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    • C12N9/14—Hydrolases (3)
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    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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Abstract

Se proporcionan ratones que comprenden una reducción o eliminación de actividad ADAM6 a partir de un locus de ADAM6 endógeno, o que carecen de un locus endógeno que codifica una proteína ADAM6 de ratón, en donde los ratones comprenden una secuencia que codifica un ADAM6 u ortólogo u homólogo o fragmento del mismo, que es funcional en un ratón macho. En una modalidad, la secuencia es una secuencia ectópica de ADAM6 o una secuencia que le confiere a un ratón macho la capacidad de generar descendencia por apareamiento. También se proporcionan ratones y células con loci de cadena pesada de inmunoglobulina genéticamente modificados, que comprenden una secuencia ectópica de nucléotidos que codifica un ADAM6 de ratón o fragmento funcional u homólogo u ortólogo del mismo.
MX2020009714A 2011-02-25 2013-08-21 Ratones de una desintegrina y metaloproteasa 6 (adam6). MX2020009714A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161446895P 2011-02-25 2011-02-25
US201161497650P 2011-06-16 2011-06-16
US201261595200P 2012-02-06 2012-02-06

Publications (1)

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MX2020009714A true MX2020009714A (es) 2020-10-07

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MX2016013717A MX375115B (es) 2011-02-25 2012-02-24 Ratones de una desintegrina y metaloproteasa 6 (adam6).
MX2013009649A MX343009B (es) 2011-02-25 2012-02-24 Ratones de una desintegrina y metaloproteasa 6 (adam6).
MX2020009714A MX2020009714A (es) 2011-02-25 2013-08-21 Ratones de una desintegrina y metaloproteasa 6 (adam6).

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MX2016013717A MX375115B (es) 2011-02-25 2012-02-24 Ratones de una desintegrina y metaloproteasa 6 (adam6).
MX2013009649A MX343009B (es) 2011-02-25 2012-02-24 Ratones de una desintegrina y metaloproteasa 6 (adam6).

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US (12) US8642835B2 (es)
EP (7) EP2813573B1 (es)
JP (8) JP2014507137A (es)
KR (1) KR101387377B1 (es)
CN (2) CN103429746B (es)
AU (6) AU2012243291B2 (es)
BR (1) BR112013021771B1 (es)
CA (1) CA2820824A1 (es)
CY (5) CY1116301T1 (es)
DE (5) DE14154967T1 (es)
DK (6) DK2550363T3 (es)
ES (6) ES2532487T3 (es)
FI (3) FI2578688T4 (es)
HR (5) HRP20230526T1 (es)
HU (5) HUE062552T2 (es)
IL (4) IL226727A (es)
IN (1) IN2013CN07629A (es)
LT (4) LT2738259T (es)
ME (3) ME03732B (es)
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MY (1) MY172713A (es)
NZ (3) NZ813867A (es)
PL (5) PL4067496T3 (es)
PT (5) PT2738259T (es)
RS (5) RS53880B1 (es)
RU (2) RU2722373C2 (es)
SG (4) SG10201405135RA (es)
SI (5) SI2578688T2 (es)
SM (5) SMT201900581T1 (es)
WO (1) WO2012141798A1 (es)
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DK2813573T1 (da) 2015-01-12
HRP20200294T1 (hr) 2020-05-29
SI2738258T2 (sl) 2023-05-31
IL273986A (en) 2020-05-31
US20150210776A1 (en) 2015-07-30
US10072095B2 (en) 2018-09-11
EP2738259B1 (en) 2019-11-27
DE12192727T1 (de) 2013-07-11
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US8642835B2 (en) 2014-02-04
SG10201913155QA (en) 2020-02-27
HUE046746T2 (hu) 2020-03-30
ES2532487T3 (es) 2015-03-27
EP2550363B1 (en) 2014-12-10
NZ776770A (en) 2023-03-31
EP2578688A1 (en) 2013-04-10
EP4067496A1 (en) 2022-10-05
ES2748832T5 (es) 2023-06-08
RU2013125717A (ru) 2014-12-10
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US20240306617A1 (en) 2024-09-19
IL268671A (en) 2019-10-31
JP2014507137A (ja) 2014-03-27
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EP2738259A3 (en) 2014-07-30
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FI2578688T4 (fi) 2023-05-05
CY1116301T1 (el) 2017-02-08
US12207628B2 (en) 2025-01-28
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US10694725B2 (en) 2020-06-30
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SMT201900581T1 (it) 2019-11-13
DK2738258T1 (da) 2014-11-24
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RU2582261C2 (ru) 2016-04-20
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