MX2022012148A - Metodos para cultivar celulas y kits y aparatos para ello. - Google Patents

Metodos para cultivar celulas y kits y aparatos para ello.

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Publication number
MX2022012148A
MX2022012148A MX2022012148A MX2022012148A MX2022012148A MX 2022012148 A MX2022012148 A MX 2022012148A MX 2022012148 A MX2022012148 A MX 2022012148A MX 2022012148 A MX2022012148 A MX 2022012148A MX 2022012148 A MX2022012148 A MX 2022012148A
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MX
Mexico
Prior art keywords
methods
agents
cells
reagents
multimerized
Prior art date
Application number
MX2022012148A
Other languages
English (en)
Inventor
Lothar Germeroth
Christian Stemberger
Keenan Bashour
Patricia Gräf
Original Assignee
Juno Therapeutics Gmbh
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Filing date
Publication date
Application filed by Juno Therapeutics Gmbh filed Critical Juno Therapeutics Gmbh
Publication of MX2022012148A publication Critical patent/MX2022012148A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C07K2319/00—Fusion polypeptide
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/50—Cell markers; Cell surface determinants
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract

Se proporcionan en la presente métodos que se relacionan, en algunos aspectos, a la incubación o cultivo, tal como para inducir estimulación de expansión (proliferación), activación, coestimulación y/o supervivencia, de una composición de células, tal como una población de linfocitos. En algunos aspectos, se proporcionan métodos y reactivos para la estimulación, por ejemplo, de expansión (proliferación), supervivencia o persistencia, activación, coestimulación u otro efecto, de poblaciones celulares que involucran el enlace de agentes a una molécula sobre la superficie de las células, para de esta manera proporcionar una o más señales a las células. En algunos casos, los reactivos son reactivos que contienen una pluralidad de sitios de enlace para agentes, tales como reactivos de multimerización, y de esta manera el uno o más agentes se multimerizan mediante el enlace reversiblemente al reactivo, por ejemplo, para de esta manera crear un reactivo estimulador (agente multimerizado) que tienen agentes estimuladores multimerizados sobre el mismo. En algunos aspectos, el agente multimerizado puede proporcionar expansión o proliferación u otra estimulación de una población de células, y luego tales agentes estimuladores se pueden remover mediante la interrupción del enlace reversible. También se proporcionan composiciones, aparato y métodos de uso de los mismos.
MX2022012148A 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello. MX2022012148A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562245261P 2015-10-22 2015-10-22
US201562245252P 2015-10-22 2015-10-22

Publications (1)

Publication Number Publication Date
MX2022012148A true MX2022012148A (es) 2023-03-01

Family

ID=57394616

Family Applications (3)

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MX2018004874A MX2018004874A (es) 2015-10-22 2016-10-20 Metodos para cultivar celulas y kits y aparatos para ello.
MX2022012147A MX2022012147A (es) 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello.
MX2022012148A MX2022012148A (es) 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello.

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MX2018004874A MX2018004874A (es) 2015-10-22 2016-10-20 Metodos para cultivar celulas y kits y aparatos para ello.
MX2022012147A MX2022012147A (es) 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello.

Country Status (15)

Country Link
US (2) US11466253B2 (es)
EP (1) EP3365434A1 (es)
JP (3) JP6895959B2 (es)
KR (1) KR102908806B1 (es)
CN (2) CN117106716A (es)
AU (1) AU2016341529B2 (es)
CA (1) CA3002745A1 (es)
HK (1) HK1258931A1 (es)
IL (2) IL307934A (es)
MA (1) MA45488A (es)
MX (3) MX2018004874A (es)
PH (1) PH12018500860A1 (es)
RU (1) RU2761557C2 (es)
SG (1) SG11201803330WA (es)
WO (1) WO2017068421A1 (es)

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