MX340488B - Compuestos utiles como moduladores de trpm8. - Google Patents

Compuestos utiles como moduladores de trpm8.

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Publication number
MX340488B
MX340488B MX2013005001A MX2013005001A MX340488B MX 340488 B MX340488 B MX 340488B MX 2013005001 A MX2013005001 A MX 2013005001A MX 2013005001 A MX2013005001 A MX 2013005001A MX 340488 B MX340488 B MX 340488B
Authority
MX
Mexico
Prior art keywords
trpm8
modulators
compounds useful
compounds
sensations
Prior art date
Application number
MX2013005001A
Other languages
English (en)
Other versions
MX2013005001A (es
Inventor
Patron Andrew
Priest Chad
Noncovich Alain
Ung Jane
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of MX2013005001A publication Critical patent/MX2013005001A/es
Publication of MX340488B publication Critical patent/MX340488B/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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Abstract

La presente invención incluye compuestos útiles como moduladores de TRPM8, tales como compuestos de Fórmula (I) y el subgénero y especies de estos; productos personales que contienen esos compuestos y el uso de esos compuestos y los productos personales, particularmente el uso del aumento o inducción de sensaciones de quemestesis, tales como sensaciones de enfriamiento o frío. (ver Fórmula).
MX2013005001A 2010-11-05 2011-11-04 Compuestos utiles como moduladores de trpm8. MX340488B (es)

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US41063410P 2010-11-05 2010-11-05
US201161443490P 2011-02-16 2011-02-16
PCT/US2011/059312 WO2012061698A2 (en) 2010-11-05 2011-11-04 Compounds useful as modulators of trpm8

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MX2013005001A MX2013005001A (es) 2013-08-08
MX340488B true MX340488B (es) 2016-07-08

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DE202011110963U1 (de) * 2010-11-05 2017-11-07 Senomyx, Inc. Verbindungen, die als Modulatoren von TRPM8 nützlich sind
EP2481727A1 (en) * 2011-01-28 2012-08-01 Dompe S.p.A. TRPM8 receptor antagonists
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
US8710043B2 (en) 2011-06-24 2014-04-29 Amgen Inc. TRPM8 antagonists and their use in treatments
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
WO2014090293A1 (de) 2012-12-12 2014-06-19 Symrise Ag Zubereitungen
JP6882144B6 (ja) * 2012-12-12 2021-06-23 シムライズ アーゲー 組成物および化粧品組成物
DE202012013357U1 (de) 2012-12-12 2016-07-29 Symrise Ag Zubereitungen
US9840471B2 (en) 2013-02-19 2017-12-12 Senomyx, Inc. Compounds useful as modulators of TRPM8
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US20160317532A1 (en) 2016-11-03
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