MX365948B - Sintesis asimetrica de una pirrolidin-2-carboxamida sustituida. - Google Patents
Sintesis asimetrica de una pirrolidin-2-carboxamida sustituida.Info
- Publication number
- MX365948B MX365948B MX2015010561A MX2015010561A MX365948B MX 365948 B MX365948 B MX 365948B MX 2015010561 A MX2015010561 A MX 2015010561A MX 2015010561 A MX2015010561 A MX 2015010561A MX 365948 B MX365948 B MX 365948B
- Authority
- MX
- Mexico
- Prior art keywords
- carboxamide
- asymmetric synthesis
- substituted pyrrolidine
- chloro
- phenyl
- Prior art date
Links
- 238000011914 asymmetric synthesis Methods 0.000 title 1
- VLJNHYLEOZPXFW-UHFFFAOYSA-N pyrrolidine-2-carboxamide Chemical class NC(=O)C1CCCN1 VLJNHYLEOZPXFW-UHFFFAOYSA-N 0.000 title 1
- TVTXCJFHQKSQQM-LJQIRTBHSA-N 4-[[(2r,3s,4r,5s)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid Chemical compound COC1=CC(C(O)=O)=CC=C1NC(=O)[C@H]1[C@H](C=2C(=C(Cl)C=CC=2)F)[C@@](C#N)(C=2C(=CC(Cl)=CC=2)F)[C@H](CC(C)(C)C)N1 TVTXCJFHQKSQQM-LJQIRTBHSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epidemiology (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Abstract
La presente invención proporciona un método mejorado para la producción a gran escala del compuesto ácido 4- {[(2R,3S,4R,5S)-3 -(3-cloro-2-fluoro-fenil)-4-(4-cloro-2-fluoro-fenil)-4-ciano-5-(2 ,2-dimetil-propil)-pirrolidín-2-carbonil]-amino}-3-metoxi-benzoic o.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767395P | 2013-02-21 | 2013-02-21 | |
| US201361909520P | 2013-11-27 | 2013-11-27 | |
| PCT/EP2014/053057 WO2014128094A1 (en) | 2013-02-21 | 2014-02-18 | Asymmetric synthesis of a substituted pyrrolidine-2-carboxamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015010561A MX2015010561A (es) | 2015-11-16 |
| MX365948B true MX365948B (es) | 2019-06-19 |
Family
ID=50179579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015010561A MX365948B (es) | 2013-02-21 | 2014-02-18 | Sintesis asimetrica de una pirrolidin-2-carboxamida sustituida. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9828340B2 (es) |
| EP (1) | EP2958893B1 (es) |
| JP (1) | JP6148351B2 (es) |
| KR (1) | KR101726116B1 (es) |
| CN (2) | CN107686459A (es) |
| AU (1) | AU2014220865B2 (es) |
| BR (1) | BR112015015880B1 (es) |
| CA (1) | CA2894826C (es) |
| DK (1) | DK2958893T3 (es) |
| ES (1) | ES2630392T3 (es) |
| HU (1) | HUE033534T2 (es) |
| IL (1) | IL239888B (es) |
| MX (1) | MX365948B (es) |
| PL (1) | PL2958893T3 (es) |
| RU (1) | RU2015133939A (es) |
| SG (1) | SG11201505150TA (es) |
| SI (1) | SI2958893T1 (es) |
| WO (1) | WO2014128094A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3131878A1 (en) | 2014-04-15 | 2017-02-22 | F. Hoffmann-La Roche AG | Solid forms of a pharmaceutically active compound |
| GB201919219D0 (en) | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| EP4204812A2 (en) | 2020-08-27 | 2023-07-05 | Otsuka Pharmaceutical Co., Ltd. | Biomarkers for cancer therapy using mdm2 antagonists |
| GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8354444B2 (en) * | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
| US20120010235A1 (en) * | 2010-07-12 | 2012-01-12 | Xin-Jie Chu | N-substituted pyrrolidines |
| US20120046306A1 (en) | 2010-08-18 | 2012-02-23 | David Joseph Bartkovitz | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists |
| US20120065210A1 (en) * | 2010-09-15 | 2012-03-15 | Xin-Jie Chu | Substituted hexahydropyrrolo[1,2-c]imidazolones |
-
2014
- 2014-02-18 EP EP14706519.7A patent/EP2958893B1/en active Active
- 2014-02-18 PL PL14706519T patent/PL2958893T3/pl unknown
- 2014-02-18 JP JP2015558415A patent/JP6148351B2/ja active Active
- 2014-02-18 BR BR112015015880-3A patent/BR112015015880B1/pt active IP Right Grant
- 2014-02-18 SI SI201430263T patent/SI2958893T1/sl unknown
- 2014-02-18 WO PCT/EP2014/053057 patent/WO2014128094A1/en not_active Ceased
- 2014-02-18 HU HUE14706519A patent/HUE033534T2/en unknown
- 2014-02-18 CA CA2894826A patent/CA2894826C/en active Active
- 2014-02-18 DK DK14706519.7T patent/DK2958893T3/en active
- 2014-02-18 SG SG11201505150TA patent/SG11201505150TA/en unknown
- 2014-02-18 CN CN201710951225.9A patent/CN107686459A/zh active Pending
- 2014-02-18 KR KR1020157022501A patent/KR101726116B1/ko active Active
- 2014-02-18 US US14/766,049 patent/US9828340B2/en active Active
- 2014-02-18 CN CN201480009671.2A patent/CN105026370B/zh active Active
- 2014-02-18 RU RU2015133939A patent/RU2015133939A/ru not_active Application Discontinuation
- 2014-02-18 ES ES14706519.7T patent/ES2630392T3/es active Active
- 2014-02-18 MX MX2015010561A patent/MX365948B/es active IP Right Grant
- 2014-02-18 AU AU2014220865A patent/AU2014220865B2/en active Active
-
2015
- 2015-07-09 IL IL239888A patent/IL239888B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2894826C (en) | 2021-03-23 |
| US9828340B2 (en) | 2017-11-28 |
| EP2958893B1 (en) | 2017-05-03 |
| CA2894826A1 (en) | 2014-08-28 |
| IL239888A0 (en) | 2015-08-31 |
| HK1211294A1 (en) | 2016-05-20 |
| ES2630392T3 (es) | 2017-08-21 |
| BR112015015880B1 (pt) | 2022-07-19 |
| RU2015133939A (ru) | 2017-03-27 |
| SI2958893T1 (sl) | 2017-08-31 |
| DK2958893T3 (en) | 2017-07-10 |
| AU2014220865B2 (en) | 2017-03-30 |
| BR112015015880A2 (pt) | 2017-07-11 |
| CN105026370A (zh) | 2015-11-04 |
| CN107686459A (zh) | 2018-02-13 |
| AU2014220865A1 (en) | 2015-07-02 |
| US20160002158A1 (en) | 2016-01-07 |
| JP6148351B2 (ja) | 2017-06-14 |
| CN105026370B (zh) | 2017-11-10 |
| WO2014128094A1 (en) | 2014-08-28 |
| AU2014220865A8 (en) | 2015-08-20 |
| MX2015010561A (es) | 2015-11-16 |
| IL239888B (en) | 2018-11-29 |
| JP2016509037A (ja) | 2016-03-24 |
| KR20150109439A (ko) | 2015-10-01 |
| SG11201505150TA (en) | 2015-09-29 |
| HUE033534T2 (en) | 2017-12-28 |
| PL2958893T3 (pl) | 2017-09-29 |
| KR101726116B1 (ko) | 2017-04-11 |
| EP2958893A1 (en) | 2015-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |