MX376594B - Evaluacion de la actividad de la via de señalizacion celular utilizando combinacion(es) lineal(es) de expresiones de genes objetivo. - Google Patents

Evaluacion de la actividad de la via de señalizacion celular utilizando combinacion(es) lineal(es) de expresiones de genes objetivo.

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Publication number
MX376594B
MX376594B MX2015008177A MX2015008177A MX376594B MX 376594 B MX376594 B MX 376594B MX 2015008177 A MX2015008177 A MX 2015008177A MX 2015008177 A MX2015008177 A MX 2015008177A MX 376594 B MX376594 B MX 376594B
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Mexico
Prior art keywords
signaling pathway
evaluation
target gene
linear combination
cellular signaling
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MX2015008177A
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English (en)
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MX2015008177A (es
Inventor
Ooijen Hendrik Jan Van
De Wiel Paul Arnold Van
Wilhelmus Franciscus Johannes Verhaegh
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Innosign B V
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Publication date
Application filed by Innosign B V filed Critical Innosign B V
Publication of MX2015008177A publication Critical patent/MX2015008177A/es
Publication of MX376594B publication Critical patent/MX376594B/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G06N5/048—Fuzzy inferencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
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    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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Abstract

La presente invención se refiere a métodos específicos para inferir la actividad de una vía de señalización celular en el tejido y/o las células de un sujeto médico con base por lo menos en los niveles de expresión de uno o más genes objetivo de la vía de señalización celular medios en una muestra extraída del tejido y/o las células del sujeto médico, aparato que comprende un compresor digital configurado para realizar estos métodos y un medio de almacenamiento no transitorio que almacena instrucciones que son ejecutables por dispositivo de procesamiento digital para realizar estos métodos.
MX2015008177A 2012-12-26 2013-12-18 Evaluacion de la actividad de la via de señalizacion celular utilizando combinacion(es) lineal(es) de expresiones de genes objetivo. MX376594B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261745839P 2012-12-26 2012-12-26
PCT/IB2013/061066 WO2014102668A2 (en) 2012-12-26 2013-12-18 Assessment of cellular signaling pathway activity using linear combination(s) of target gene expressions;

Publications (2)

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MX2015008177A MX2015008177A (es) 2015-09-16
MX376594B true MX376594B (es) 2025-03-07

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US (2) US11306360B2 (es)
EP (1) EP2938745B1 (es)
JP (2) JP6449779B2 (es)
KR (1) KR102279844B1 (es)
CN (2) CN105074005A (es)
AU (2) AU2013368945B2 (es)
BR (1) BR112015015131A2 (es)
CA (1) CA2896414C (es)
DK (1) DK2938745T3 (es)
ES (1) ES2878196T3 (es)
MX (1) MX376594B (es)
RU (1) RU2721130C2 (es)
WO (1) WO2014102668A2 (es)

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EP3461916A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat3 cellular signaling pathway activity using mathematical modelling of target gene expression
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CN108187050A (zh) * 2018-01-18 2018-06-22 石河子大学 抑制食管癌细胞增殖的药物
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CN111166884B (zh) * 2020-01-15 2021-12-03 广州中医药大学第一附属医院 Foxf1基因在制备用于骨质疏松症药物中的应用
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Publication number Publication date
WO2014102668A2 (en) 2014-07-03
RU2721130C2 (ru) 2020-05-18
JP2016509472A (ja) 2016-03-31
JP2019076096A (ja) 2019-05-23
ES2878196T3 (es) 2021-11-18
US11306360B2 (en) 2022-04-19
CN105074005A (zh) 2015-11-18
DK2938745T3 (da) 2020-11-30
AU2020202706B2 (en) 2022-06-16
AU2013368945A1 (en) 2015-08-13
AU2020202706A1 (en) 2020-05-14
US20230030858A1 (en) 2023-02-02
CA2896414C (en) 2023-06-20
WO2014102668A3 (en) 2014-08-21
EP2938745B1 (en) 2020-10-07
KR102279844B1 (ko) 2021-07-21
MX2015008177A (es) 2015-09-16
EP2938745A2 (en) 2015-11-04
CN111961726A (zh) 2020-11-20
AU2013368945B2 (en) 2020-01-23
JP6721665B2 (ja) 2020-07-15
KR20150100896A (ko) 2015-09-02
US20150347672A1 (en) 2015-12-03
JP6449779B2 (ja) 2019-01-09
BR112015015131A2 (pt) 2017-07-11
CA2896414A1 (en) 2014-07-03
RU2015131009A (ru) 2017-01-30

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