MX9201317A - Nuevos derivados de imidazo pirina, procedimiento para su preparacion y composicion farmaceutica que los contiene. - Google Patents

Nuevos derivados de imidazo pirina, procedimiento para su preparacion y composicion farmaceutica que los contiene.

Info

Publication number
MX9201317A
MX9201317A MX9201317A MX9201317A MX9201317A MX 9201317 A MX9201317 A MX 9201317A MX 9201317 A MX9201317 A MX 9201317A MX 9201317 A MX9201317 A MX 9201317A MX 9201317 A MX9201317 A MX 9201317A
Authority
MX
Mexico
Prior art keywords
pirina
imidazo
procedure
preparation
pharmaceutical composition
Prior art date
Application number
MX9201317A
Other languages
English (en)
Inventor
Werner Mederski
Johannes Sombroek
Pierre Schelling
Norbert Beier
Ingeborg Lues
Klaus-Otto Minck
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX9201317A publication Critical patent/MX9201317A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
MX9201317A 1991-03-27 1992-03-25 Nuevos derivados de imidazo pirina, procedimiento para su preparacion y composicion farmaceutica que los contiene. MX9201317A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4110019A DE4110019C2 (de) 1991-03-27 1991-03-27 Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number Publication Date
MX9201317A true MX9201317A (es) 1992-10-01

Family

ID=6428299

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9201317A MX9201317A (es) 1991-03-27 1992-03-25 Nuevos derivados de imidazo pirina, procedimiento para su preparacion y composicion farmaceutica que los contiene.

Country Status (16)

Country Link
EP (1) EP0505893B1 (es)
JP (1) JP3382963B2 (es)
KR (1) KR100253772B1 (es)
AT (1) ATE194005T1 (es)
AU (1) AU655458B2 (es)
CA (1) CA2063926C (es)
CZ (1) CZ280591B6 (es)
DE (2) DE4110019C2 (es)
DK (1) DK0505893T3 (es)
ES (1) ES2148156T3 (es)
GR (1) GR3034230T3 (es)
HU (1) HU221010B1 (es)
IE (1) IE920968A1 (es)
MX (1) MX9201317A (es)
PT (1) PT505893E (es)
TW (1) TW213913B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4141788A1 (de) * 1991-12-18 1993-06-24 Merck Patent Gmbh Imidazopyridine
DE4211474A1 (de) * 1992-04-06 1993-10-07 Merck Patent Gmbh Imidazopyridine
DE4305602A1 (de) * 1992-06-17 1993-12-23 Merck Patent Gmbh Imidazopyridine
DE4225835A1 (de) * 1992-08-05 1994-02-10 Merck Patent Gmbh Verfahren zur Herstellung von Imidazopyridinen
DE4236026A1 (de) * 1992-10-24 1994-04-28 Merck Patent Gmbh Imidazopyridine
DE4242459A1 (de) * 1992-12-16 1994-06-23 Merck Patent Gmbh Imidazopyridine
DE4318813A1 (de) * 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine
DE4333697A1 (de) * 1993-10-02 1995-04-06 Merck Patent Gmbh Verfahren zur Herstellung von 3-Aminopyridinen aus 3-Nitropyridinen
DE4339868A1 (de) * 1993-11-23 1995-05-24 Merck Patent Gmbh Imidazopyridazine
DE4341453A1 (de) * 1993-12-06 1995-06-08 Merck Patent Gmbh Imidazopyridine
DE4432860A1 (de) * 1994-09-15 1996-03-21 Merck Patent Gmbh Imidazopyridine
DE19845153A1 (de) * 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
US20040242568A1 (en) 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
JP2007511467A (ja) 2003-05-14 2007-05-10 タケダ サン ディエゴ インコーポレイテッド ジペプチジルペプチダーゼインヒビター
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
MXPA06001601A (es) 2003-08-13 2006-08-25 Takeda Pharmaceutical Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa.
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2005026148A1 (en) 2003-09-08 2005-03-24 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN102079743B (zh) 2004-03-15 2020-08-25 武田药品工业株式会社 二肽基肽酶抑制剂
US7687638B2 (en) 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
JP2008524331A (ja) 2004-12-21 2008-07-10 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
NZ566799A (en) 2005-09-14 2011-04-29 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors for treating diabetes
WO2007035629A2 (en) 2005-09-16 2007-03-29 Takeda Pharmaceutical Company Limited Process for the preparation of pyrimidinedione derivatives
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011520986A (ja) * 2008-05-22 2011-07-21 アムジエン・インコーポレーテツド タンパク質キナーゼ阻害薬としての複素環類
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
BR112018077075A2 (pt) 2016-06-29 2019-04-30 Universite De Montreal heterociclos de biarilmetila

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
EP0424317A3 (en) * 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
EP0461040A1 (fr) * 1990-06-08 1991-12-11 Roussel Uclaf Dérivés de l'imidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
DE4110019C2 (de) 2000-04-13
DE4110019A1 (de) 1992-10-01
ES2148156T3 (es) 2000-10-16
GR3034230T3 (en) 2000-12-29
EP0505893B1 (de) 2000-06-21
HUT63165A (en) 1993-07-28
EP0505893A1 (de) 1992-09-30
IE920968A1 (en) 1992-11-18
JP3382963B2 (ja) 2003-03-04
HU221010B1 (hu) 2002-07-29
AU655458B2 (en) 1994-12-22
CA2063926C (en) 2002-10-01
AU1314192A (en) 1992-10-01
KR920018049A (ko) 1992-10-21
KR100253772B1 (ko) 2000-09-01
CA2063926A1 (en) 1992-09-28
JPH05125077A (ja) 1993-05-21
DK0505893T3 (da) 2000-10-02
DE59209843D1 (de) 2000-07-27
PT505893E (pt) 2000-12-29
HU9200932D0 (en) 1992-05-28
CZ78292A3 (en) 1993-04-14
CZ280591B6 (cs) 1996-02-14
TW213913B (es) 1993-10-01
ATE194005T1 (de) 2000-07-15

Similar Documents

Publication Publication Date Title
DK0505893T3 (da) Imidazopyridiner
ES2084944T3 (es) Amidas terapeuticas.
NZ225344A (en) 3-demethylmevalonic acid derivatives and lactones and pharmaceutical compositions; intermediates for the preparation thereof
LV10441A (lv) Pirimidin-4,6-dikarbonskabes diamidi to iegusanas panemiens to pielietojums un arstniecibas lidzekli kas satur minetos savienojumus
TR199901188T1 (xx) Aromatik veya heteroaromatik radikal ile de�i�tirilmi� bifenil t�revleri, ve bunlar� i�eren farmas�tik ve kozmetik bile�imler.
DK0598770T3 (da) Pyrazinderivater samt fremstilling og anvendelse deraf
ES2063570T3 (es) Nuevos derivados de triazolopirimidina antagonistas de los receptores de la angiotensina ii; sus procedimientos de preparacion, composiciones farmaceuticas que los contienen.
ATE157088T1 (de) Neue chinolon- und naphthyridoncarbonsäurederivate
DE3688721D1 (de) Verwendung von porphyrinderivaten bei der entdeckung und behandlung von tumoren.
AU1835988A (en) New derivatives of substituted pyridine-3-carboxylic acid and use thereof
NO883074L (no) Fremgangsmaate til fremstilling av 3-desmetyl-4-fluor-mevalonsyrederivater.
FI831070L (fi) Salicylsyraderivat, foerfarande foer deras framstaellning, pao dessa foereningar baserade farmaceutprodukter och deras anvaendning
FI833200A0 (fi) Isokinolinderivat, foerfaranden foer deras framstaellning, pao dessa foereningar baserade farmaceutpreparat och deras anvaendning
EP0331092A3 (en) Alpha-amino-carboxylic-acid derivatives, their preparation and use
IE880628L (en) Substituted pyridine-2,4-dicarboxylic acid derivatives,¹processes for their preparation, the use thereof and¹medicaments based on these compounds
DE59108997D1 (de) Chromanderivate
DE3882381D1 (es)
ES2149247T3 (es) Nuevos compuestos de n-bencil-piperazina, su procedimiento de preparacion y las composiciones farmaceuticas que los incluyen.
DK0401093T3 (da) Hidtil ukendte pyrrolidonderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende disse
DK242089D0 (da) Anvendelse af pyrimido oe6,1-aaa-isoquinolin-4-on-derivater til hindring af haaraffald og foroegelse af haarvaekst
MX10256A (es) Procedimiento para preparar nuevas 3-fenil-7h-tiazolo(3, 2-b) (1, 2, 4) triazin-7-onas.
ES2106866T3 (es) Nuevos derivados de 2h-benzo(b)pirano sustituidos en la posicion 4 por arilo o n-heteroarilo, procedimiento para su preparacion y su uso, asi como preparados que contienen los compuestos.
ES2065192T3 (es) Nuevos nicotinatos de diacil-glicerol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ECSP951520A (es) Heterociclil- benzoilguanidinas, procedimiento para su preparacion y preparaciones farmaceuticas que las contienen
DK190887A (da) Nye benzodiazepinderivater samt deres fremstilling og anvendelse

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees