MXPA02003312A - Composiciones que tienen estabilidad mejorada. - Google Patents

Composiciones que tienen estabilidad mejorada.

Info

Publication number: MXPA02003312A
Authority: MX; Mexico
Prior art keywords: composition; active; further characterized; solvent; composition according
Prior art date: 1999-09-29

Application number

MXPA02003312A

Other languages

English (en)

Spanish (es)

Inventor

Ek Nath Khanolkar Jayant

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-29

Filing date

2000-09-26

Publication date

2002-10-04

1999-12-20 Priority claimed from US09/467,333 external-priority patent/US20020082307A1/en

2000-09-26 Application filed by Procter & Gamble filed Critical Procter & Gamble

2002-10-04 Publication of MXPA02003312A publication Critical patent/MXPA02003312A/es

Links

239000000203 mixture Substances 0.000 title claims abstract description 189
239000007788 liquid Substances 0.000 claims abstract description 74
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 86
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 73
239000002904 solvent Substances 0.000 claims description 34
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
239000002738 chelating agent Substances 0.000 claims description 31
239000003638 chemical reducing agent Substances 0.000 claims description 25
239000003795 chemical substances by application Substances 0.000 claims description 21
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 19
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 13
238000000034 method Methods 0.000 claims description 13
229920001983 poloxamer Polymers 0.000 claims description 13
229960000502 poloxamer Drugs 0.000 claims description 13
229920001223 polyethylene glycol Polymers 0.000 claims description 11
239000003172 expectorant agent Substances 0.000 claims description 10
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
239000003434 antitussive agent Substances 0.000 claims description 8
229940124584 antitussives Drugs 0.000 claims description 8
210000004400 mucous membrane Anatomy 0.000 claims description 8
208000023504 respiratory system disease Diseases 0.000 claims description 8
230000000954 anitussive effect Effects 0.000 claims description 7
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 7
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
150000008064 anhydrides Chemical class 0.000 claims description 5
239000002260 anti-inflammatory agent Substances 0.000 claims description 5
229940121363 anti-inflammatory agent Drugs 0.000 claims description 5
230000001754 anti-pyretic effect Effects 0.000 claims description 5
239000000739 antihistaminic agent Substances 0.000 claims description 5
229940125715 antihistaminic agent Drugs 0.000 claims description 5
239000002221 antipyretic Substances 0.000 claims description 5
229940125716 antipyretic agent Drugs 0.000 claims description 5
239000006185 dispersion Substances 0.000 claims description 5
230000003419 expectorant effect Effects 0.000 claims description 5
229940066493 expectorants Drugs 0.000 claims description 5
229940066491 mucolytics Drugs 0.000 claims description 5
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
230000008569 process Effects 0.000 claims description 5
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
239000000850 decongestant Substances 0.000 claims description 4
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239000000938 histamine H1 antagonist Substances 0.000 claims description 4
239000003589 local anesthetic agent Substances 0.000 claims description 4
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239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
239000011734 sodium Substances 0.000 claims description 4
229910052708 sodium Inorganic materials 0.000 claims description 4
235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 4
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 4
235000019345 sodium thiosulphate Nutrition 0.000 claims description 4
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical class [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 4
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 4
GHHURQMJLARIDK-UHFFFAOYSA-N 2-hydroxypropyl octanoate Chemical compound CCCCCCCC(=O)OCC(C)O GHHURQMJLARIDK-UHFFFAOYSA-N 0.000 claims description 3
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 3
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 3
239000002202 Polyethylene glycol Substances 0.000 claims description 3
229960004308 acetylcysteine Drugs 0.000 claims description 3
239000003125 aqueous solvent Substances 0.000 claims description 3
235000014113 dietary fatty acids Nutrition 0.000 claims description 3
WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 claims description 3
150000002148 esters Chemical class 0.000 claims description 3
239000000194 fatty acid Substances 0.000 claims description 3
229930195729 fatty acid Natural products 0.000 claims description 3
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 3
HGASFNYMVGEKTF-UHFFFAOYSA-N octan-1-ol;hydrate Chemical compound O.CCCCCCCCO HGASFNYMVGEKTF-UHFFFAOYSA-N 0.000 claims description 3
238000005192 partition Methods 0.000 claims description 3
159000000001 potassium salts Chemical class 0.000 claims description 3
RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims description 3
CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims description 2
LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
239000002253 acid Substances 0.000 claims description 2
229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
159000000007 calcium salts Chemical class 0.000 claims description 2
229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims description 2
150000004665 fatty acids Chemical class 0.000 claims description 2
229940032159 propylene carbonate Drugs 0.000 claims description 2
230000003381 solubilizing effect Effects 0.000 claims 3
QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 2
239000005725 8-Hydroxyquinoline Substances 0.000 claims 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
FSVCELGFZIQNCK-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)glycine Chemical compound OCCN(CCO)CC(O)=O FSVCELGFZIQNCK-UHFFFAOYSA-N 0.000 claims 1
239000013543 active substance Substances 0.000 claims 1
230000000202 analgesic effect Effects 0.000 claims 1
239000011575 calcium Substances 0.000 claims 1
229910052791 calcium Inorganic materials 0.000 claims 1
VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 claims 1
229960003540 oxyquinoline Drugs 0.000 claims 1
MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims 1
208000024891 symptom Diseases 0.000 abstract description 13
239000004480 active ingredient Substances 0.000 abstract description 9
239000002775 capsule Substances 0.000 abstract description 8
230000000241 respiratory effect Effects 0.000 abstract description 2
239000007937 lozenge Substances 0.000 abstract 1
235000019441 ethanol Nutrition 0.000 description 43
239000000243 solution Substances 0.000 description 41
MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 40
229960001985 dextromethorphan Drugs 0.000 description 40
239000003814 drug Substances 0.000 description 29
210000000214 mouth Anatomy 0.000 description 25
235000003599 food sweetener Nutrition 0.000 description 22
238000002156 mixing Methods 0.000 description 22
239000003765 sweetening agent Substances 0.000 description 22
239000000463 material Substances 0.000 description 20
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HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 15
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235000010262 sodium metabisulphite Nutrition 0.000 description 15
239000000126 substance Substances 0.000 description 15
-1 cyprohetadine Chemical compound 0.000 description 13
229940079593 drug Drugs 0.000 description 13
239000012298 atmosphere Substances 0.000 description 12
230000008901 benefit Effects 0.000 description 12
239000008280 blood Substances 0.000 description 12
210000004369 blood Anatomy 0.000 description 12
238000009472 formulation Methods 0.000 description 12
238000007254 oxidation reaction Methods 0.000 description 12
ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 description 11
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 10
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239000007787 solid Substances 0.000 description 9
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KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 7
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150000003839 salts Chemical group 0.000 description 7
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AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 2
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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
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Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
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Chemical Kinetics & Catalysis (AREA)
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Epidemiology (AREA)
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Oncology (AREA)
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Biomedical Technology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Emergency Medicine (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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MXPA02003312A 1999-09-29 2000-09-26 Composiciones que tienen estabilidad mejorada. MXPA02003312A (es)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US15654099P	1999-09-29	1999-09-29
US09/467,333 US20020082307A1 (en)	1999-01-11	1999-12-20	Compositions having improved stability
US17928900P	2000-01-31	2000-01-31
PCT/US2000/026402 WO2001022967A1 (en)	1999-09-29	2000-09-26	Compositions having improved stability

Publications (1)

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MXPA02003312A MXPA02003312A (es)	1999-09-29	2000-09-26	Composiciones que tienen estabilidad mejorada.

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EP (1)	EP1216044A1 (cs)
JP (1)	JP2003510279A (cs)
CN (1)	CN1211085C (cs)
AU (1)	AU770376B2 (cs)
BR (1)	BR0014441A (cs)
CA (1)	CA2385990A1 (cs)
CO (1)	CO5210868A1 (cs)
CZ (1)	CZ2002947A3 (cs)
HU (1)	HUP0202797A3 (cs)
MX (1)	MXPA02003312A (cs)
PE (1)	PE20010627A1 (cs)
WO (1)	WO2001022967A1 (cs)

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US9150557B1 (en)	2014-11-05	2015-10-06	Cellix Bio Private Limited	Compositions and methods for the treatment of hyperglycemia
US9290486B1 (en)	2014-11-05	2016-03-22	Cellix Bio Private Limited	Compositions and methods for the treatment of epilepsy
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JP6679616B2 (ja)	2015-01-06	2020-04-22	セリックスバイオプライヴェートリミテッドＣｅｌｌｉｘＢｉｏＰｒｉｖａｔｅＬｉｍｉｔｅｄ	炎症及び疼痛の治療のための組成物及び方法

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2000
- 2000-09-26 MX MXPA02003312A patent/MXPA02003312A/es active IP Right Grant
- 2000-09-26 WO PCT/US2000/026402 patent/WO2001022967A1/en not_active Ceased
- 2000-09-26 CA CA002385990A patent/CA2385990A1/en not_active Abandoned
- 2000-09-26 HU HU0202797A patent/HUP0202797A3/hu unknown
- 2000-09-26 CZ CZ2002947A patent/CZ2002947A3/cs unknown
- 2000-09-26 EP EP00970493A patent/EP1216044A1/en not_active Ceased
- 2000-09-26 JP JP2001526179A patent/JP2003510279A/ja active Pending
- 2000-09-26 BR BR0014441-0A patent/BR0014441A/pt not_active Application Discontinuation
- 2000-09-26 CN CNB008134960A patent/CN1211085C/zh not_active Expired - Fee Related
- 2000-09-26 AU AU79865/00A patent/AU770376B2/en not_active Ceased
- 2000-09-29 PE PE2000001034A patent/PE20010627A1/es not_active Application Discontinuation
- 2000-09-29 CO CO00074286A patent/CO5210868A1/es not_active Application Discontinuation

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Publication number	Publication date
CZ2002947A3 (cs)	2002-08-14
EP1216044A1 (en)	2002-06-26
HUP0202797A2 (hu)	2003-01-28
AU7986500A (en)	2001-04-30
PE20010627A1 (es)	2001-06-14
HUP0202797A3 (en)	2004-05-28
CA2385990A1 (en)	2001-04-05
CO5210868A1 (es)	2002-10-30
CN1211085C (zh)	2005-07-20
AU770376B2 (en)	2004-02-19
WO2001022967A1 (en)	2001-04-05
BR0014441A (pt)	2002-06-11
JP2003510279A (ja)	2003-03-18
CN1376065A (zh)	2002-10-23

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Publication	Publication Date	Title
AU770376B2 (en)	2004-02-19	Compositions having improved stability
KR100511730B1 (ko)	2005-08-31	활성성분의 개선된 전달성을 갖는 조성물
JP2006525986A (ja)	2006-11-16	喉に医薬活性剤をデリバリーするための菓子製品
US20020086878A1 (en)	2002-07-04	Compositions having improved stability
AU771478B2 (en)	2004-03-25	Compositions having improved stability
US20030118613A1 (en)	2003-06-26	Compositions having improved delivery of actives
MXPA01007020A (en)	2002-03-05	Compositions having improved stability
MXPA01007016A (en)	2002-03-05	Compositions having improved stability
ZA200201892B (en)	2002-10-03	Compositions having improved stability.
AU2004200445A1 (en)	2004-03-04	Compositions having improved stability
MXPA01007015A (en)	2002-03-05	Compositions having improved delivery of actives
BG61892B2 (bg)	1998-08-31	Състав на основата на ибупрофен за орална употреба