|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
DE69632062T2
(de)
|
1995-11-02 |
2004-11-18 |
Schering Corp. |
Kontinuierliche, niedrigdosierte zytokine-infusionstherapie
|
|
US5908621A
(en)
*
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5981709A
(en)
*
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
US5985263A
(en)
*
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
WO1999048535A1
(en)
*
|
1998-03-26 |
1999-09-30 |
Schering Corporation |
Formulations for protection of peg-interferon alpha conjugates
|
|
US6180096B1
(en)
|
1998-03-26 |
2001-01-30 |
Schering Corporation |
Formulations for protection of peg-interferon alpha conjugates
|
|
EE05214B1
(et)
*
|
1998-04-28 |
2009-10-15 |
Applied Research Systems ARS Holding N.V. |
Polool-IFN- β konjugaat, selle valmistamismeetod ja farmatseutiline kompositsioon
|
|
AU766597B2
(en)
|
1998-05-15 |
2003-10-16 |
Schering Corporation |
Combination therapy comprising ribavirin and interferon alpha in antiviral treatment naive patients having chronic hepatitis C infection
|
|
DK1087778T3
(da)
*
|
1998-06-08 |
2005-12-19 |
Hoffmann La Roche |
Anvendelse af PEG-IFN-alfa og Ribavirin til behandling af kronisk hepatitis C
|
|
US6277830B1
(en)
*
|
1998-10-16 |
2001-08-21 |
Schering Corporation |
5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
|
|
IL129299A0
(en)
*
|
1999-03-31 |
2000-02-17 |
Mor Research Applic Ltd |
Monoclonal antibodies antigens and diagnosis of malignant diseases
|
|
NZ514417A
(en)
*
|
1999-04-08 |
2003-10-31 |
Schering Corp |
Use of pegylated interferon alpha in chronic myeloid leukemia (CML) therapy
|
|
US6362162B1
(en)
|
1999-04-08 |
2002-03-26 |
Schering Corporation |
CML Therapy
|
|
US6923966B2
(en)
|
1999-04-08 |
2005-08-02 |
Schering Corporation |
Melanoma therapy
|
|
US6605273B2
(en)
|
1999-04-08 |
2003-08-12 |
Schering Corporation |
Renal cell carcinoma treatment
|
|
EP1535622B1
(en)
|
1999-04-08 |
2008-12-31 |
Schering Corporation |
Melanoma therapy
|
|
CZ299516B6
(cs)
*
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
|
US6313143B1
(en)
*
|
1999-12-16 |
2001-11-06 |
Hoffmann-La Roche Inc. |
Substituted pyrroles
|
|
KR100773323B1
(ko)
|
2000-01-10 |
2007-11-05 |
맥시겐 홀딩스 리미티드 |
지-씨에스에프 접합체
|
|
EP1908477A3
(en)
*
|
2000-01-24 |
2008-06-11 |
Schering Corporation |
Combination of temozolomide and pegylated interferon-alpha for treating cancer
|
|
EP1251866A1
(en)
*
|
2000-01-24 |
2002-10-30 |
Schering Corporation |
Combination of temozolomide and pegylated interferon-alpha for treating cancer
|
|
CA2739933A1
(en)
|
2000-02-11 |
2001-08-16 |
Bayer Healthcare Llc |
Factor vii or viia-like molecules
|
|
US6476062B2
(en)
|
2000-03-30 |
2002-11-05 |
Schering Corporation |
Chemokine receptor antagonists
|
|
US6756037B2
(en)
|
2000-03-31 |
2004-06-29 |
Enzon, Inc. |
Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
|
|
US6777387B2
(en)
|
2000-03-31 |
2004-08-17 |
Enzon Pharmaceuticals, Inc. |
Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
|
|
US6924270B2
(en)
|
2000-04-20 |
2005-08-02 |
Schering Corporation |
Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
|
|
DE60135393D1
(de)
|
2000-06-30 |
2008-09-25 |
Zymogenetics Inc |
Allelische Variante des Interferon-ähnlichen Proteins Zcyto21
|
|
ATE471956T1
(de)
*
|
2001-01-30 |
2010-07-15 |
Kyowa Hakko Kirin Co Ltd |
Verzweigte polyalkylenglykole
|
|
WO2002074806A2
(en)
|
2001-02-27 |
2002-09-26 |
Maxygen Aps |
New interferon beta-like molecules
|
|
DE10112825A1
(de)
|
2001-03-16 |
2002-10-02 |
Fresenius Kabi De Gmbh |
HESylierung von Wirkstoffen in wässriger Lösung
|
|
WO2003062290A1
(en)
|
2002-01-16 |
2003-07-31 |
Biocompatibles Uk Limited |
Polymer conjugates
|
|
KR100888371B1
(ko)
*
|
2002-01-17 |
2009-03-13 |
동아제약주식회사 |
가지 달린 고분자 유도체와 인터페론 결합체를 포함하는 항바이러스제
|
|
DE10209821A1
(de)
|
2002-03-06 |
2003-09-25 |
Biotechnologie Ges Mittelhesse |
Kopplung von Proteinen an ein modifiziertes Polysaccharid
|
|
DE10209822A1
(de)
|
2002-03-06 |
2003-09-25 |
Biotechnologie Ges Mittelhesse |
Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
|
|
UA86744C2
(en)
|
2002-06-21 |
2009-05-25 |
Ново Нордиск Хэлс Кеа Аг |
Pegylated factor vii glycoforms
|
|
MXPA05000796A
(es)
|
2002-07-24 |
2005-04-19 |
Hoffmann La Roche |
Aditivos de acidos polialquilenglicolicos.
|
|
US7087229B2
(en)
*
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
EP1400533A1
(en)
*
|
2002-09-11 |
2004-03-24 |
Fresenius Kabi Deutschland GmbH |
HASylated polypeptides, especially HASylated erythropoietin
|
|
BR0314227A
(pt)
|
2002-09-11 |
2005-10-25 |
Fresenius Kabi De Gmbh |
Derivados de amido de hidroxialquila
|
|
TWI318629B
(en)
*
|
2002-09-20 |
2009-12-21 |
Pharmacia Corp |
Process for decreasing aggregate levels of pegylated protein
|
|
US7538092B2
(en)
|
2002-10-08 |
2009-05-26 |
Fresenius Kabi Deutschland Gmbh |
Pharmaceutically active oligosaccharide conjugates
|
|
EP1565205A4
(en)
*
|
2002-11-18 |
2006-07-05 |
Maxygen Inc |
Interferon-alpha polypeptides and conjugates
|
|
US7314613B2
(en)
*
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
|
GB0301014D0
(en)
*
|
2003-01-16 |
2003-02-19 |
Biocompatibles Ltd |
Conjugation reactions
|
|
US20050176108A1
(en)
*
|
2003-03-13 |
2005-08-11 |
Young-Min Kim |
Physiologically active polypeptide conjugate having prolonged in vivo half-life
|
|
CA2458085A1
(en)
|
2003-03-21 |
2004-09-21 |
F. Hoffmann-La Roche Ag |
Transcriptional activity assay
|
|
WO2005014655A2
(en)
|
2003-08-08 |
2005-02-17 |
Fresenius Kabi Deutschland Gmbh |
Conjugates of hydroxyalkyl starch and a protein
|
|
CN1867581B
(zh)
|
2003-10-10 |
2012-02-01 |
诺沃挪第克公司 |
Il-21衍生物
|
|
EP2641611A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
|
BRPI0507169A
(pt)
|
2004-02-02 |
2007-06-26 |
Ambrx Inc |
polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
|
|
CN100355784C
(zh)
*
|
2004-02-12 |
2007-12-19 |
江苏恒瑞医药股份有限公司 |
聚乙二醇修饰α-干扰素1b的制备方法
|
|
JP5191729B2
(ja)
|
2004-03-11 |
2013-05-08 |
フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
還元的アミノ化によって製造される、ヒドロキシアルキルデンプンとタンパク質とのコンジュゲート
|
|
CN101115769A
(zh)
|
2004-05-19 |
2008-01-30 |
马克西根公司 |
干扰素-α多肽和偶联物
|
|
US7632924B2
(en)
|
2004-06-18 |
2009-12-15 |
Ambrx, Inc. |
Antigen-binding polypeptides and their uses
|
|
WO2006004959A2
(en)
*
|
2004-06-30 |
2006-01-12 |
Egen Corporation |
Pegylated interferon alpha-1b
|
|
WO2006091231A2
(en)
|
2004-07-21 |
2006-08-31 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
CA2576549C
(en)
|
2004-08-12 |
2011-01-18 |
Schering Corporation |
Stable pegylated interferon formulation
|
|
BRPI0519430A2
(pt)
|
2004-12-22 |
2009-02-10 |
Ambrx Inc |
hormânio do crescimento humano modificado
|
|
US20060233740A1
(en)
*
|
2005-03-23 |
2006-10-19 |
Bossard Mary J |
Conjugates of an hGH moiety and a polymer
|
|
EP1888633A4
(en)
|
2005-05-18 |
2010-01-27 |
Maxygen Inc |
UNFOLDED INTERFERON ALPHA POLYPEPTIDE
|
|
ES2553160T3
(es)
|
2005-06-17 |
2015-12-04 |
Novo Nordisk Health Care Ag |
Reducción y derivatización selectivas de proteínas Factor VII transformadas por ingeniería que comprenden al menos una cisteína no nativa
|
|
CA2612901A1
(en)
*
|
2005-06-20 |
2007-01-04 |
Pepgen Corporation |
Low-toxicity, long-circulating chimeras of human interferon- alpha analogs and interferon tau
|
|
AU2005335491B2
(en)
|
2005-08-18 |
2010-11-25 |
Ambrx, Inc. |
Compositions of tRNA and uses thereof
|
|
JP4261531B2
(ja)
|
2005-09-06 |
2009-04-30 |
株式会社Nrlファーマ |
ラクトフェリン複合体及びその製造方法
|
|
DK2339014T3
(en)
|
2005-11-16 |
2015-07-20 |
Ambrx Inc |
Methods and compositions comprising non-natural amino acids
|
|
CN101002944B
(zh)
*
|
2006-01-17 |
2012-07-25 |
中国科学院过程工程研究所 |
支链聚乙二醇-干扰素结合物及其制备方法
|
|
CN101002945B
(zh)
|
2006-01-20 |
2012-09-05 |
清华大学 |
一种用于肿瘤治疗的新型复合物
|
|
CN100475270C
(zh)
|
2006-01-20 |
2009-04-08 |
清华大学 |
一种治疗肿瘤的药物及其应用
|
|
JPWO2007132882A1
(ja)
|
2006-05-16 |
2009-09-24 |
財団法人 東京都医学研究機構 |
Hcv感染症を治療または予防するための医薬組成物
|
|
KR20090013816A
(ko)
|
2006-05-24 |
2009-02-05 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
연장된 생체내 반감기를 갖는 인자 ⅸ 유사체
|
|
JP5399906B2
(ja)
|
2006-09-08 |
2014-01-29 |
アンブルックス,インコーポレイテッド |
脊椎動物細胞用のハイブリッドサプレッサーtrna
|
|
CN106008699A
(zh)
|
2006-09-08 |
2016-10-12 |
Ambrx公司 |
经修饰的人类血浆多肽或Fc骨架和其用途
|
|
CN1966547B
(zh)
*
|
2006-11-06 |
2011-11-09 |
中国药科大学 |
双链结构的聚乙二醇衍生物的制备及其与药物分子的结合
|
|
CA2668478C
(en)
*
|
2006-11-07 |
2015-05-26 |
Dsm Ip Assets B.V. |
Carbamate, thiocarbamate or carbamide comprising a biomolecular moiety
|
|
KR101079993B1
(ko)
|
2006-11-17 |
2011-11-04 |
동아제약주식회사 |
폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체
|
|
CN101219219B
(zh)
|
2007-01-10 |
2013-02-13 |
北京普罗吉生物科技发展有限公司 |
包含血管抑素或其片段的复合物、其制备方法及应用
|
|
JP5515224B2
(ja)
|
2007-02-28 |
2014-06-11 |
日油株式会社 |
多分岐鎖ポリオキシアルキレン誘導体
|
|
CN107501407B
(zh)
|
2007-03-30 |
2022-03-18 |
Ambrx公司 |
经修饰fgf-21多肽和其用途
|
|
CL2008002399A1
(es)
*
|
2007-08-16 |
2009-01-02 |
Pharmaessentia Corp |
Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
|
|
AU2007358605B8
(en)
|
2007-09-04 |
2012-02-02 |
Biosteed Gene Expression Tech. Co., Ltd. |
Polyethylene glycol modified interferon alpha 2b and preparation method and applications thereof
|
|
KR101483814B1
(ko)
|
2007-09-04 |
2015-01-16 |
바이오스티드 진 익스프레션 테크. 컴파니 리미티드 |
폴리에틸렌 글리콜에 의해 변형된 인터페론 알파 2a, 이의 합성 방법 및 용도
|
|
MX2010005317A
(es)
|
2007-11-20 |
2010-06-02 |
Ambrx Inc |
Polipeptidos de insulina modificados y sus usos.
|
|
EP2070950A1
(en)
|
2007-12-14 |
2009-06-17 |
Fresenius Kabi Deutschland GmbH |
Hydroxyalkyl starch derivatives and process for their preparation
|
|
KR20100103595A
(ko)
*
|
2008-01-18 |
2010-09-27 |
에프. 호프만-라 로슈 아게 |
비-글라이코실화된 단백질의 정제
|
|
AU2009209565B2
(en)
*
|
2008-02-01 |
2013-09-19 |
Ascendis Pharma As |
Prodrug comprising a self-cleavable linker
|
|
MX344166B
(es)
|
2008-02-08 |
2016-12-07 |
Ambrx Inc |
Leptina-polipeptidos modificados y sus usos.
|
|
US9840546B2
(en)
|
2008-04-03 |
2017-12-12 |
Biosteed Gene Expression Tech. Co., Ltd. |
Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof
|
|
MX344559B
(es)
|
2008-04-29 |
2016-12-20 |
Ascendis Pharma As |
Compuestos de hormona de crecimiento humana recombinante unidos al peg.
|
|
TW201010692A
(en)
|
2008-06-19 |
2010-03-16 |
Public Univ Corp Nagoya City Univ |
Pharmaceutical composition for treatment or prevention of hbv infection
|
|
AU2009268841B2
(en)
|
2008-07-08 |
2014-02-06 |
Board Of Regents, The University Of Texas System |
Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (STATS)
|
|
CN102159230A
(zh)
|
2008-07-23 |
2011-08-17 |
Ambrx公司 |
经修饰的牛g-csf多肽和其用途
|
|
BR122012024318A2
(pt)
|
2008-09-26 |
2019-07-30 |
Ambrx, Inc. |
Polipeptídeos modificados de eritropoetina animal e seus usos
|
|
AU2009296267B2
(en)
|
2008-09-26 |
2013-10-31 |
Ambrx, Inc. |
Non-natural amino acid replication-dependent microorganisms and vaccines
|
|
IT1399351B1
(it)
|
2009-06-16 |
2013-04-16 |
Fidia Farmaceutici |
Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
|
|
EP2459211A1
(en)
|
2009-07-31 |
2012-06-06 |
Medtronic, Inc. |
Continuous subcutaneous administration of interferon- to hepatitis c infected patients
|
|
EA201200650A1
(ru)
|
2009-10-30 |
2012-12-28 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Курсы комбинированного лечения вируса гепатита с, включающие bi201335, интерферон-альфа и рибавирин
|
|
MX337432B
(es)
|
2009-12-15 |
2016-03-04 |
Ascendis Pharma As |
Composicion de la hormona del crecimiento seca enlazada transitoriamente a un portador del polimero.
|
|
BR112012015597A2
(pt)
|
2009-12-21 |
2017-01-31 |
Ambrx Inc |
peptídeos de somatotropina suínos modificados e seus usos
|
|
MX349301B
(es)
|
2009-12-21 |
2017-07-21 |
Ambrx Inc |
Polipéptidos de somatotropina bovina modificados y sus usos.
|
|
US9815876B2
(en)
|
2010-03-05 |
2017-11-14 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
|
WO2011143274A1
(en)
|
2010-05-10 |
2011-11-17 |
Perseid Therapeutics |
Polypeptide inhibitors of vla4
|
|
JP2013529627A
(ja)
|
2010-06-24 |
2013-07-22 |
パンメド リミテッド |
ヒドロキシクロロキンまたはヒドロキシクロロキンおよび抗ウイルス剤の組合せを使用するc型肝炎ウイルス関連疾患の処置
|
|
RU2447083C1
(ru)
*
|
2010-07-20 |
2012-04-10 |
Закрытое Акционерное Общество "Биокад" |
НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ ВЫСОКООЧИЩЕННЫЙ СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА α С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ ДЕЙСТВИЕМ, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ
|
|
JP2013541937A
(ja)
|
2010-08-05 |
2013-11-21 |
エフ.ホフマン−ラ ロシュ アーゲー |
抗mhc抗体−抗ウイルス性サイトカイン融合タンパク質
|
|
EA030886B1
(ru)
|
2010-08-17 |
2018-10-31 |
Амбркс, Инк. |
Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
WO2012146630A1
(en)
|
2011-04-29 |
2012-11-01 |
F. Hoffmann-La Roche Ag |
N-terminal acylated polypeptides, methods for their production and uses thereof
|
|
CN102229667A
(zh)
*
|
2011-06-03 |
2011-11-02 |
北京伟嘉人生物技术有限公司 |
一种聚乙二醇修饰的猪α-干扰素及其制备方法和应用
|
|
RU2014103288A
(ru)
|
2011-07-01 |
2015-08-10 |
Байер Интеллектчуал Проперти Гмбх |
Слитые полипептиды релаксина и их применение
|
|
WO2013017653A1
(en)
|
2011-08-03 |
2013-02-07 |
Cytheris |
Hcv immunotherapy
|
|
WO2013137869A1
(en)
|
2012-03-14 |
2013-09-19 |
Boehringer Ingelheim International Gmbh |
Combination therapy for treating hcv infection in an hcv-hiv coinfected patient population
|
|
JP2015512900A
(ja)
|
2012-03-28 |
2015-04-30 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
特別な患者の遺伝子亜型分集団のhcv感染症を治療するための併用療法
|
|
EP2859017B1
(en)
|
2012-06-08 |
2019-02-20 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
WO2014004639A1
(en)
|
2012-06-26 |
2014-01-03 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
EP2890402B1
(en)
|
2012-08-31 |
2019-04-17 |
Sutro Biopharma, Inc. |
Modified amino acids comprising an azido group
|
|
EA023323B1
(ru)
*
|
2013-03-28 |
2016-05-31 |
Илья Александрович МАРКОВ |
Разветвленный ацилазидный пегилирующий агент, способ его получения и способ получения пегилированного интерферона
|
|
EA021610B1
(ru)
*
|
2013-03-28 |
2015-07-30 |
Илья Александрович МАРКОВ |
Жидкое противовирусное лекарственное средство
|
|
EA022617B1
(ru)
*
|
2013-03-28 |
2016-02-29 |
Илья Александрович МАРКОВ |
Монопегилированный интерферон-альфа разветвленной структуры и фармацевтическая композиция для приготовления лекарственного средства, обладающего активностью интерферона-альфа
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
EP3055298B1
(en)
|
2013-10-11 |
2020-04-29 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
EP2907512A1
(en)
|
2014-02-14 |
2015-08-19 |
Commissariat A L'energie Atomique Et Aux Energies Alternatives |
Inhibitors of MMP-12 as antiviral Agents
|
|
RU2554761C1
(ru)
*
|
2014-05-13 |
2015-06-27 |
Закрытое акционерное общество "Сибирский центр фармакологии и биотехнологии" |
Противоэнтеровирусное и иммуностимулирующее средство
|
|
CN114805532A
(zh)
|
2014-10-24 |
2022-07-29 |
百时美施贵宝公司 |
修饰的fgf-21多肽及其用途
|
|
JP6820841B2
(ja)
|
2014-11-06 |
2021-01-27 |
ファーマエッセンティア コーポレイション |
ペグ化インターフェロンのための投薬計画
|
|
SG11201703870UA
(en)
|
2014-11-18 |
2017-06-29 |
Ascendis Pharma Endocrinology Div As |
Novel polymeric hgh prodrugs
|
|
PT3220892T
(pt)
|
2014-11-21 |
2021-11-05 |
Ascendis Pharma Endocrinology Div A/S |
Formas de dosagem de hormona do crescimento de longa ação
|
|
JP6668468B2
(ja)
|
2015-11-03 |
2020-03-18 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
Hbvキャプシドアセンブリ阻害剤とインターフェロンの併用療法
|
|
CN106749608B
(zh)
*
|
2015-11-18 |
2021-10-15 |
石药集团中奇制药技术(石家庄)有限公司 |
干扰素α缀合物
|
|
WO2018087345A1
(en)
|
2016-11-14 |
2018-05-17 |
F. Hoffmann-La Roche Ag |
COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
|
|
PE20191716A1
(es)
|
2017-02-08 |
2019-12-05 |
Bristol Myers Squibb Co |
Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos
|
|
RU2678332C1
(ru)
|
2017-09-08 |
2019-01-28 |
Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "СФМ") |
Пегилированный интерферон лямбда, обладающий высокой биодоступностью при пероральном применении, и способ его получения
|
|
CA3111576A1
(en)
|
2018-09-11 |
2020-03-19 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and their uses
|
|
JP2022512746A
(ja)
|
2018-10-19 |
2022-02-07 |
アンブルックス,インコーポレイテッド |
インターロイキン-10ポリペプチド複合体、その二量体、およびそれらの使用
|
|
CA3128081A1
(en)
|
2019-02-12 |
2020-08-20 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-tlr agonist conjugates
|
|
AU2020233198B2
(en)
|
2019-03-04 |
2025-05-15 |
Ascendis Pharma Endocrinology Division A/S |
Long-acting growth hormone dosage forms with superior efficacy to daily somatropin
|
|
EP4117732A1
(en)
|
2020-03-11 |
2023-01-18 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
|
JP2023538071A
(ja)
|
2020-08-20 |
2023-09-06 |
アンブルックス,インコーポレイテッド |
抗体-tlrアゴニストコンジュゲート、その方法及び使用
|
|
AU2021410080A1
(en)
*
|
2020-12-23 |
2023-06-22 |
Jazz Pharmaceuticals Ireland Ltd. |
Methods of purifying charge-shielded fusion proteins
|
|
CA3213805A1
(en)
|
2021-04-03 |
2022-10-06 |
Feng Tian |
Anti-her2 antibody-drug conjugates and uses thereof
|
|
WO2024164213A1
(zh)
|
2023-02-09 |
2024-08-15 |
谢彦晖 |
聚乙二醇修饰的白介素2、糖皮质激素和透明质酸用于治疗特应性皮炎
|
|
WO2026043823A2
(en)
|
2024-08-19 |
2026-02-26 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof
|