MY146646A - 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds for the treatment of tuberculosis - Google Patents

2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds for the treatment of tuberculosis

Info

Publication number: MY146646A
Authority: MY; Malaysia
Prior art keywords: group; nitroimidazo; dihydro; formula; tuberculosis
Prior art date: 2003-10-31

Application number

MYPI20044505A

Other languages

English (en)

Inventor

Hidetsugu Tsubouchi

Kinue Ohguro

Takumi Sumida

Takeshi Hasegawa

Kazuho Tanaka

Isao Takemura

Hirofumi Sasaki

Motohiro Itotani

Yoshikazu Haraguchi

Shin Miyamura

Makoto Matsumoto

Hiroyuki Hashizume

Tatsuo Tomishige

Masanori Kawasaki

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-31

Filing date

2004-10-30

Publication date

2012-09-14

2004-10-30 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

2012-09-14 Publication of MY146646A publication Critical patent/MY146646A/en

Links

QISRGAUYEHQMJV-UHFFFAOYSA-N 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole Chemical class C1COC2=NC([N+](=O)[O-])=CN21 QISRGAUYEHQMJV-UHFFFAOYSA-N 0.000 title 1
201000008827 tuberculosis Diseases 0.000 title 1
-1 2, 3-DIHYDRO-6-NITROIMIDAZO [2,1-B]OXAZOLE COMPOUND Chemical class 0.000 abstract 3
241000187479 Mycobacterium tuberculosis Species 0.000 abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
241000894006 Bacteria Species 0.000 abstract 1
YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

MYPI20044505A 2003-10-31 2004-10-30 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds for the treatment of tuberculosis MY146646A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003373206		2003-10-31
JP2004111720		2004-04-06

Publications (1)

Publication Number	Publication Date
MY146646A true MY146646A (en)	2012-09-14

Family

ID=34554779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MYPI20044505A MY146646A (en)	2003-10-31	2004-10-30	2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds for the treatment of tuberculosis

Country Status (19)

Country	Link
US (1)	US8163753B2 (de)
EP (1)	EP1678185B1 (de)
KR (1)	KR100851802B1 (de)
AR (1)	AR046777A1 (de)
AT (1)	ATE410430T1 (de)
AU (1)	AU2004285811B2 (de)
BR (1)	BRPI0414909A (de)
CA (1)	CA2539335A1 (de)
CY (1)	CY1108481T1 (de)
DE (1)	DE602004017037D1 (de)
DK (1)	DK1678185T3 (de)
ES (1)	ES2314460T3 (de)
MY (1)	MY146646A (de)
PL (1)	PL1678185T3 (de)
PT (1)	PT1678185E (de)
RU (1)	RU2365593C2 (de)
SI (1)	SI1678185T1 (de)
TW (1)	TWI335331B (de)
WO (1)	WO2005042542A1 (de)

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PL1906926T3 (pl) *	2005-07-28	2011-04-29	Otsuka Pharma Co Ltd	Kompozycja farmaceutyczna zawierająca pochodne 2,3-dihydro-6-nitroimidazo[2,1-B]oksazolu
JP2007106746A (ja) *	2005-09-13	2007-04-26	Tosoh Corp	新規アリールホモピペラジン類、またはその塩と製造方法
TW201233389A (en)	2005-10-05	2012-08-16	Otsuka Pharma Co Ltd	Antituberculous therapeutic drugs and kit containing the same
JP5105818B2 (ja) *	2005-10-05	2012-12-26	大塚製薬株式会社	医薬組成物
US8399666B2 (en)	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
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GB2431927B (en) *	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
JP2009521464A (ja) *	2005-12-23	2009-06-04	ノバルティスアクチエンゲゼルシャフト	ニトロイミダゾール化合物
EP2027121A1 (de) *	2006-05-22	2009-02-25	Merck Frosst Canada Ltd.	Cyclische aminderivate als inhibitoren von stearoyl-coenzym-a-delta-9-desaturase
US7678791B2 (en)	2006-07-12	2010-03-16	Cumbre Ip Ventures, L.P.	Nitroheteroaryl-containing rifamycin derivatives
AR070301A1 (es) *	2007-05-08	2010-03-31	Otsuka Pharma Co Ltd	Compuesto epoxi y metodo para producir el mismo
CN101965353B (zh) *	2008-03-26	2014-12-17	丹诺医药(苏州）有限公司	共价连接到取代苯基噁唑烷酮的双环硝基咪唑类
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
WO2010081851A1 (en)	2009-01-14	2010-07-22	Genoscience Pharma	Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
NZ598165A (en) *	2009-07-31	2013-05-31	Global Alliance For Tb Drug Dev	Nitroimidazooxazine and nitroimidazooxazole analogues and their uses
US9051333B2 (en)	2011-04-15	2015-06-09	Otsuka Pharmaceutical Co., Ltd.	6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
KR20130083592A (ko) *	2012-01-13	2013-07-23	현대약품 주식회사	치환된 피페리딘 유도체 및 이의 제조방법
KR101650716B1 (ko) *	2012-11-22	2016-08-24	한국화학연구원	바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
IN2013DE02954A (de) *	2013-10-04	2015-04-10	Council Scient Ind Res
US11279714B2 (en) *	2014-06-20	2022-03-22	Institut Pasteur Korea	Anti-infective compounds
EP2974729A1 (de)	2014-07-17	2016-01-20	Abivax	Chinolinderivate zur Verwendung bei der Behandlung von Entzündungskrankheiten
TWI687409B (zh)	2014-08-28	2020-03-11	日商大塚製藥股份有限公司	稠合雜環化合物
MX383020B (es) *	2014-10-01	2025-03-13	Henkel Ag & Co Kgaa	Aceleradores de curado para composiciones curables anaerobicas.
JP6467042B2 (ja) *	2014-10-21	2019-02-06	カウンシルオブサイエンティフィックアンドインダストリアルリサーチ	抗マイコバクテリア剤としての置換１，２，３−トリアゾール−１−イル−メチル−２，３−ジヒドロ−２−メチル−６−ニトロイミダゾ［２，１−ｂ］オキサゾールとその調製方法
EP3252059A4 (de) *	2015-01-29	2018-07-11	Medshine Discovery Inc.	Nitroimidazolderivat gegen lungentuberkulose
US10851079B2 (en)	2016-02-26	2020-12-01	Otsuka Pharmaceutical Co., Ltd.	Piperidine derivative
WO2018112842A1 (en) *	2016-12-22	2018-06-28	Merck Sharp & Dohme Corp.	6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
CN112236141A (zh)	2018-06-11	2021-01-15	大塚制药株式会社	包含德拉马尼的组合物
EP3669873A1 (de)	2018-12-20	2020-06-24	Abivax	Chinolinderivate zur verwendung bei der behandlung von entzündlichen krankheiten
CN112300192B (zh) *	2019-08-02	2023-08-11	南京长澳医药科技有限公司	硝基咪唑类化合物及其制备方法和用途

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AR041198A1 (es)	2002-10-11	2005-05-04	Otsuka Pharma Co Ltd	Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
TW200838855A (en) *	2002-10-15	2008-10-01	Otsuka Pharma Co Ltd	Method for preparing 1-substituted-4-nitroimidazole compound
SI1678185T1 (sl) *	2003-10-31	2009-02-28	Otsuka Pharma Co Ltd	Spojine 2,3-dihidro-6-nitroimidazo (2,1-b) oksazol za zdravljenje tuberkuloze
PL1906926T3 (pl) *	2005-07-28	2011-04-29	Otsuka Pharma Co Ltd	Kompozycja farmaceutyczna zawierająca pochodne 2,3-dihydro-6-nitroimidazo[2,1-B]oksazolu

2004
- 2004-10-29 SI SI200430914T patent/SI1678185T1/sl unknown
- 2004-10-29 TW TW093132982A patent/TWI335331B/zh not_active IP Right Cessation
- 2004-10-29 AT AT04793412T patent/ATE410430T1/de active
- 2004-10-29 EP EP04793412A patent/EP1678185B1/de not_active Expired - Lifetime
- 2004-10-29 RU RU2006118794/04A patent/RU2365593C2/ru not_active IP Right Cessation
- 2004-10-29 PL PL04793412T patent/PL1678185T3/pl unknown
- 2004-10-29 PT PT04793412T patent/PT1678185E/pt unknown
- 2004-10-29 AR ARP040103961A patent/AR046777A1/es not_active Application Discontinuation
- 2004-10-29 BR BRPI0414909-2A patent/BRPI0414909A/pt not_active IP Right Cessation
- 2004-10-29 US US10/574,597 patent/US8163753B2/en not_active Expired - Fee Related
- 2004-10-29 DE DE602004017037T patent/DE602004017037D1/de not_active Expired - Lifetime
- 2004-10-29 KR KR1020067006629A patent/KR100851802B1/ko not_active Expired - Fee Related
- 2004-10-29 DK DK04793412T patent/DK1678185T3/da active
- 2004-10-29 CA CA002539335A patent/CA2539335A1/en not_active Abandoned
- 2004-10-29 ES ES04793412T patent/ES2314460T3/es not_active Expired - Lifetime
- 2004-10-29 WO PCT/JP2004/016492 patent/WO2005042542A1/en not_active Ceased
- 2004-10-29 AU AU2004285811A patent/AU2004285811B2/en not_active Ceased
- 2004-10-30 MY MYPI20044505A patent/MY146646A/en unknown
2008
- 2008-11-03 CY CY20081101251T patent/CY1108481T1/el unknown

Also Published As

Publication number	Publication date
US20080119478A1 (en)	2008-05-22
EP1678185B1 (de)	2008-10-08
EP1678185A1 (de)	2006-07-12
AU2004285811A1 (en)	2005-05-12
BRPI0414909A (pt)	2006-11-07
HK1097258A1 (zh)	2007-06-22
CA2539335A1 (en)	2005-05-12
DK1678185T3 (da)	2008-12-08
ES2314460T3 (es)	2009-03-16
AU2004285811B2 (en)	2008-06-12
PL1678185T3 (pl)	2009-04-30
DE602004017037D1 (de)	2008-11-20
AR046777A1 (es)	2005-12-21
RU2365593C2 (ru)	2009-08-27
PT1678185E (pt)	2009-01-13
KR20060085644A (ko)	2006-07-27
SI1678185T1 (sl)	2009-02-28
KR100851802B1 (ko)	2008-08-13
RU2006118794A (ru)	2007-12-10
TWI335331B (en)	2011-01-01
CY1108481T1 (el)	2014-04-09
ATE410430T1 (de)	2008-10-15
US8163753B2 (en)	2012-04-24
WO2005042542A1 (en)	2005-05-12
TW200528460A (en)	2005-09-01

Publication	Publication Date	Title
TW200420568A (en)	2004-10-16	2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
BRPI0414909A (pt)	2006-11-07	composto, agente antituberculoso, e, método para produzir um composto
PH12015501098A1 (en)	2015-12-07	Antituberculous composition comprising oxazole compounds
MX2009011769A (es)	2009-11-13	Derivados de piridona como inhibidores de mapk p38a.
IL186815A (en)	2013-09-30	A 3-amino-3-alkyl-4-quinolone compound mono or 3-amino-3-alkyl-4, 4-substituted by pyrrolidinyl
MX2009010814A (es)	2009-10-29	Compuestos de hidrazida y agente controlador de artropodos dañinos que contiene el mismo.
TW200503621A (en)	2005-02-01	Pyrimidine compound and pests controlling composition containing the same
FI865037A7 (fi)	1988-06-11	Mikrobicida kompositioner.
BG108174A (en)	2004-09-30	5-phenylpyrimidines, methods and intermediate products for the production thereof and use of the same for controlling pathogenic fungi
BG104287A (en)	2000-11-30	Halogensubstituted tetracyclic derivatives of tetrahydrofuran
TNSN07357A1 (en)	2008-12-31	Indanyl-piperazine derivatives, method for preparing same and pharmaceutical compositions containing same
MXPA05013631A (es)	2006-02-24	Derivado heterociclico de metilsulfona.
UA91822C2 (ru)	2010-09-10	СОЕДИНЕНИЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА ДЛЯ ЛЕЧЕНИЯ ТУБЕРКУЛЕЗА
MX2023009666A (es)	2023-08-25	Composicion herbicida.
TW200609218A (en)	2006-03-16	Bicyclic compounds
TW200600085A (en)	2006-01-01	External preparation
TW200609220A (en)	2006-03-16	Tetrahydroisoquinolylsulphonamide derivatives, their preparation and their use in therapeutics
MY149301A (en)	2013-08-30	Epoxy compound and method for manufacturing the same
DK0841327T3 (da)	2002-01-21	Triazolantisvampemiddel
EP0995744A4 (de)	2001-02-07	Cis-substituierte fluoromethylpyrrolidin-derivate
MX2009004928A (es)	2009-09-07	Metodo para la produccion del derivado de 2-alquilo-3-aminotiofeno .
MXPA05009338A (es)	2005-11-04	7-alquenilamino-triazolopirimidinas, procedimientos para su obtencion y el uso de las mismas para controlar hongos nocivos, asi como productos que los contienen.
BR9812928A (pt)	2000-08-08	Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica
TW200716604A (en)	2007-05-01	Carboxamide compound and use thereof
TW200517446A (en)	2005-06-01	Poly-azo compound, and polarization film having said compound