MY8500468A - Morpholine derivatives - Google Patents

Morpholine derivatives

Info

Publication number
MY8500468A
MY8500468A MY468/85A MY8500468A MY8500468A MY 8500468 A MY8500468 A MY 8500468A MY 468/85 A MY468/85 A MY 468/85A MY 8500468 A MY8500468 A MY 8500468A MY 8500468 A MY8500468 A MY 8500468A
Authority
MY
Malaysia
Prior art keywords
lower alkyl
alkyl
hydrogen
morpholine derivatives
represents hydrogen
Prior art date
Application number
MY468/85A
Other languages
English (en)
Inventor
Alan Chapman White
Edwin Trevor Edington
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of MY8500468A publication Critical patent/MY8500468A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Lubricants (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Hydrogenated Pyridines (AREA)
MY468/85A 1979-10-20 1985-12-30 Morpholine derivatives MY8500468A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7936502 1979-10-20

Publications (1)

Publication Number Publication Date
MY8500468A true MY8500468A (en) 1985-12-31

Family

ID=10508675

Family Applications (1)

Application Number Title Priority Date Filing Date
MY468/85A MY8500468A (en) 1979-10-20 1985-12-30 Morpholine derivatives

Country Status (17)

Country Link
US (1) US4360519A (fr)
EP (1) EP0027695B1 (fr)
JP (1) JPS5665880A (fr)
KR (2) KR840002427B1 (fr)
AT (1) ATE4980T1 (fr)
AU (1) AU531586B2 (fr)
CA (1) CA1126731A (fr)
DE (1) DE3065304D1 (fr)
DK (1) DK151800C (fr)
ES (1) ES496074A0 (fr)
FI (1) FI803277A7 (fr)
GB (1) GB2061272B (fr)
GR (1) GR70235B (fr)
IE (1) IE50355B1 (fr)
MY (1) MY8500468A (fr)
PT (1) PT71940B (fr)
ZA (1) ZA806017B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2125793B (en) * 1982-08-19 1985-10-02 Wyeth John & Brother Ltd Morpholine derivatives
GB8305638D0 (en) * 1983-03-01 1983-03-30 Wyeth John & Brother Ltd Morpholine derivatives
FR2553412B1 (fr) * 1983-10-17 1986-03-21 Lafon Labor Derives de 4-alkyl-2-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
GB8418657D0 (en) * 1984-07-21 1984-08-22 Beecham Group Plc Compounds
FR2581383A1 (fr) * 1985-05-03 1986-11-07 Cerm Cent Europ Rech Mauvernay 2-alkyl-2-aryl morpholines substituees, leur preparation et les compositions pharmaceutiques les contenant
DE3621775A1 (de) * 1986-03-13 1988-01-07 Thomae Gmbh Dr K Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
JP3053222B2 (ja) * 1995-04-20 2000-06-19 ファイザー・インコーポレーテッド Ｍｍｐおよびｔｎｆ抑制剤としてのアリールスルホニルヒドロキサム酸誘導体
US7348456B2 (en) * 2002-12-19 2008-03-25 Merck & Co., Inc. Substituted amides
ES2571220T3 (es) * 2003-06-17 2016-05-24 Arena Pharm Inc Clorhidrato de 8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepina
CA2646044A1 (fr) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Procedes de preparation de 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et produits intermediaires associes
US8299241B2 (en) 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
AU2011255276B2 (en) 2010-05-21 2016-09-22 Research Triangle Institute Phenylmorpholines and analogues thereof
AU2011255456B2 (en) 2010-05-21 2017-01-19 Dignity Health Doing Business As St. Joseph's Hospital And Medical Center And Barrow Neurological Institute 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
JP2013536859A (ja) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストの非吸湿性塩
WO2012030927A2 (fr) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Formes galéniques à libération modifiée d'agonistes de 5-ht2c, utiles pour la gestion du poids
EP2939677A1 (fr) 2010-09-01 2015-11-04 Arena Pharmaceuticals, Inc. Administration de lorcasérine à des individus avec une insuffisance rénale
EP2611782A1 (fr) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Sels de lorcasérine dotés d'acides optiquement actifs
UY34436A (es) 2012-10-09 2014-07-31 Arena Pharm Inc Metodo de control del peso
EP4712966A2 (fr) * 2023-05-16 2026-03-25 SpringWorks Therapeutics, Inc. Benzopipérazine et analogues associés pour inhiber yap/taz-tead

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2835669A (en) * 1958-05-20 Process for the production of substi-
US2997469A (en) * 1961-08-22 Preparation of substituted
GB773780A (en) 1953-07-01 1957-05-01 Albert Boehringer Improvements in or relating to the preparation of substituted morpholines
GB791416A (en) 1956-04-09 1958-03-05 Albert Boehringer Improvements in or relating to the production of substituted tetrahydrooxazines
US3112311A (en) * 1957-04-05 1963-11-26 Geigy Chem Corp 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines
ES247829A1 (es) 1958-03-13 1960-03-16 Boehringer Sohn Ingelheim Procedimeinto para la obtencion de tetrahidro-oxazinas sustituidas
US3296076A (en) * 1962-06-11 1967-01-03 Boehringer Sohn Ingelheim Pilomotor shaving compositions and method of using same
GB1336732A (en) * 1970-10-28 1973-11-07 Istituto Gentili Spa Pisa Diethanolamine derivatives
GB1452701A (en) * 1974-05-07 1976-10-13 Ici Ltd Morpholine derivatives

Also Published As

Publication number Publication date
FI803277L (fi) 1981-04-21
EP0027695B1 (fr) 1983-10-12
ES8107201A1 (es) 1981-10-01
ZA806017B (en) 1982-04-28
DE3065304D1 (en) 1983-11-17
GB2061272A (en) 1981-05-13
ATE4980T1 (de) 1983-10-15
AU6292280A (en) 1981-04-30
KR840002427B1 (ko) 1984-12-27
IE50355B1 (en) 1986-04-02
US4360519A (en) 1982-11-23
DK151800C (da) 1988-06-06
DK151800B (da) 1988-01-04
DK441080A (da) 1981-04-21
AU531586B2 (en) 1983-09-01
FI803277A7 (fi) 1981-04-21
IE801995L (en) 1981-04-20
JPS5665880A (en) 1981-06-03
PT71940B (pt) 1981-08-31
GR70235B (fr) 1982-09-01
EP0027695A1 (fr) 1981-04-29
KR840002428B1 (ko) 1984-12-27
ES496074A0 (es) 1981-10-01
PT71940A (en) 1980-11-01
KR830004277A (ko) 1983-07-09
CA1126731A (fr) 1982-06-29
GB2061272B (en) 1983-08-10

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SU1179926A3 (ru) "cпocoб пoлучehия пpoизboдhыx cemиkapбaзидa или иx kиcлotho-aддиtиbhыx coлeй"