MY8700708A - 2-(fluoroalkylthio) substituted penems, processes for preparing them, and pharmaceutical compositions containing them - Google Patents

2-(fluoroalkylthio) substituted penems, processes for preparing them, and pharmaceutical compositions containing them

Info

Publication number: MY8700708A
Authority: MY; Malaysia
Prior art keywords: fluoroalkylthio; preparing; processes; pharmaceutical compositions; compositions containing
Prior art date: 1981-11-25

Application number

MY708/87A

Other languages

English (en)

Inventor

Girijavallabhan Vivyoo Moophil

Mccombie Stuart Walter

Ganguly Ashit Kumat

Pinto Patrick Anthony

Versace Richard William

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-11-25

Filing date

1987-12-30

Publication date

1987-12-31

1987-12-30 Application filed by Schering Corp filed Critical Schering Corp

1987-12-31 Publication of MY8700708A publication Critical patent/MY8700708A/xx

Links

150000002961 penems Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salts Chemical class 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

MY708/87A 1981-11-25 1987-12-30 2-(fluoroalkylthio) substituted penems, processes for preparing them, and pharmaceutical compositions containing them MY8700708A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/324,931 US4411906A (en)	1981-11-25	1981-11-25	(5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates

Publications (1)

Publication Number	Publication Date
MY8700708A true MY8700708A (en)	1987-12-31

Family

ID=23265741

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MY708/87A MY8700708A (en)	1981-11-25	1987-12-30	2-(fluoroalkylthio) substituted penems, processes for preparing them, and pharmaceutical compositions containing them

Country Status (22)

Country	Link
US (2)	US4411906A (de)
EP (1)	EP0080162B1 (de)
JP (1)	JPS5892683A (de)
KR (1)	KR890005148B1 (de)
AT (1)	ATE20666T1 (de)
AU (1)	AU560838B2 (de)
CA (1)	CA1207753A (de)
DE (1)	DE3271955D1 (de)
DK (1)	DK153553C (de)
FI (1)	FI76091C (de)
HK (1)	HK56889A (de)
HU (1)	HU190044B (de)
IE (1)	IE54219B1 (de)
IL (1)	IL67327A0 (de)
MY (1)	MY8700708A (de)
NO (1)	NO159796C (de)
NZ (1)	NZ202574A (de)
OA (1)	OA07255A (de)
PH (1)	PH19647A (de)
PT (1)	PT75878B (de)
SG (1)	SG88388G (de)
ZA (1)	ZA828602B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5835190A (ja) *	1981-08-25	1983-03-01	Sankyo Co Ltd	ペネム−３−カルボン酸誘導体
ATE28648T1 (de) *	1982-03-26	1987-08-15	Hoechst Uk Ltd	7-oxo-4-thia-1-azabicyclo(3,2,0)heptan-derivate
EP0110280B1 (de) *	1982-11-29	1994-10-12	Schering Corporation	Verfahren zur Herstellung von Penem-Verbindungen
GB8321677D0 (en) *	1983-08-11	1983-09-14	Erba Farmitalia	Preparation of penems
US5053502A (en) *	1986-07-21	1991-10-01	Schering Corporation	Anhydro penicillin derivatives
US4767853A (en) *	1986-07-21	1988-08-30	Schering Corporation	Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
US5075438A (en) *	1986-07-21	1991-12-24	Schering Corporation	Synthesis of azetidinones
US4948885A (en) *	1986-07-21	1990-08-14	Schering-Plough Corp.	Synthesis of azetidinones
US4876338A (en) *	1986-07-21	1989-10-24	Schering Corporation	Synthesis of azetidinones using CuCl
WO1999036098A1 (en) *	1998-01-13	1999-07-22	Suntory Limited	Antibacterial composition for topical administration containing antibiotics

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4168314A (en) *	1977-11-17	1979-09-18	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4301074A (en) *	1977-11-17	1981-11-17	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
EP0003960B1 (de) *	1978-02-02	1983-06-29	Ciba-Geigy Ag	6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
US4386030A (en) *	1979-12-31	1983-05-31	Merck & Co., Inc.	Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
DE3169939D1 (en) *	1980-02-28	1985-05-23	Schering Corp	2-penem compounds, pharmaceutical compositions containing them and methods for their preparation
US4650794A (en) *	1982-04-29	1987-03-17	Merck & Co., Inc.	6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
US4614738A (en) *	1983-03-25	1986-09-30	Schering Corporation	2-(N-heterocycloaliphaticthio)penems
US4587241A (en) *	1983-11-28	1986-05-06	Schering Corporation	Heterocyclic substituted penems

1981
- 1981-11-25 US US06/324,931 patent/US4411906A/en not_active Expired - Lifetime
1982
- 1982-11-18 AT AT82110612T patent/ATE20666T1/de not_active IP Right Cessation
- 1982-11-18 DE DE8282110612T patent/DE3271955D1/de not_active Expired
- 1982-11-18 EP EP82110612A patent/EP0080162B1/de not_active Expired
- 1982-11-22 PH PH28169A patent/PH19647A/en unknown
- 1982-11-22 NO NO823903A patent/NO159796C/no unknown
- 1982-11-22 JP JP57205336A patent/JPS5892683A/ja active Pending
- 1982-11-22 DK DK519382A patent/DK153553C/da not_active IP Right Cessation
- 1982-11-22 ZA ZA828602A patent/ZA828602B/xx unknown
- 1982-11-22 AU AU90787/82A patent/AU560838B2/en not_active Ceased
- 1982-11-22 FI FI823997A patent/FI76091C/fi not_active IP Right Cessation
- 1982-11-22 PT PT75878A patent/PT75878B/pt not_active IP Right Cessation
- 1982-11-22 NZ NZ202574A patent/NZ202574A/en unknown
- 1982-11-22 IE IE2765/82A patent/IE54219B1/en not_active IP Right Cessation
- 1982-11-23 OA OA57848A patent/OA07255A/xx unknown
- 1982-11-23 CA CA000416189A patent/CA1207753A/en not_active Expired
- 1982-11-23 KR KR8205286A patent/KR890005148B1/ko not_active Expired
- 1982-11-23 IL IL67327A patent/IL67327A0/xx not_active IP Right Cessation
- 1982-11-24 HU HU823777A patent/HU190044B/hu not_active IP Right Cessation
1985
- 1985-07-19 US US06/757,047 patent/US4814442A/en not_active Expired - Fee Related
1987
- 1987-12-30 MY MY708/87A patent/MY8700708A/xx unknown
1988
- 1988-12-24 SG SG883/88A patent/SG88388G/en unknown
1989
- 1989-07-13 HK HK568/89A patent/HK56889A/xx unknown

Also Published As

Publication number	Publication date
HK56889A (en)	1989-07-21
NO159796C (no)	1989-02-08
DK153553C (da)	1988-12-19
EP0080162A1 (de)	1983-06-01
NO159796B (no)	1988-10-31
IE822765L (en)	1983-05-25
JPS5892683A (ja)	1983-06-02
CA1207753A (en)	1986-07-15
AU9078782A (en)	1983-06-02
ATE20666T1 (de)	1986-07-15
FI823997A0 (fi)	1982-11-22
FI823997L (fi)	1983-05-26
NO823903L (no)	1983-05-26
US4814442A (en)	1989-03-21
AU560838B2 (en)	1987-04-16
DK519382A (da)	1983-05-26
KR840002403A (ko)	1984-07-02
EP0080162B1 (de)	1986-07-09
DK153553B (da)	1988-07-25
NZ202574A (en)	1986-06-11
KR890005148B1 (ko)	1989-12-14
ZA828602B (en)	1983-09-28
US4411906A (en)	1983-10-25
PH19647A (en)	1986-06-04
FI76091C (fi)	1988-09-09
PT75878B (en)	1986-01-15
IL67327A0 (en)	1983-03-31
SG88388G (en)	1989-06-16
HU190044B (en)	1986-08-28
DE3271955D1 (en)	1986-08-14
OA07255A (fr)	1984-04-30
FI76091B (fi)	1988-05-31
IE54219B1 (en)	1989-07-19
PT75878A (en)	1982-12-01

Publication	Publication Date	Title
FI104174B1 (fi)	1999-11-30	Menetelmä terapeuttisesti käyttökelpoisten, 1,4-dihydro-4-okso-3-kinoliinikarboksyylihapon 7-[S,S]-2,8-diatsabisyklo[4.3.0]nonaani-isomeeriven valmistamiseksi
FR2691326B1 (fr)	1994-08-05	Procede pour la production de composes antimicrobiens.
MA23143A1 (fr)	1994-10-01	Procede pour la preparation de compositions vaccinantes .
GB2273655B (en)	1997-01-08	Veterinary compositions for the treatment of mastitis
DE3271955D1 (en)	1986-08-14	2-(fluoroalkylthio)substituted penems, processes for preparing them, and pharmaceutical compositions containing them
DE3860977D1 (en)	1990-12-13	(1r,5s,6s)-2-(substituiertes thio)-6-((r)-1-hydroxy-aethyl)-1-methyl-carbapenem-3-carbonsaeurederivate.
HUT45538A (en)	1988-07-28	Process for producing quinoline derivatives and pharmaceutical compositions containing them
AU5729180A (en)	1980-10-16	2-((2-aminoethyl)thio)6-(1-hydroxyethyl)penem-3-caroxylic acid
DK0393424T3 (da)	1996-02-05	Fremgangsmåde til fremstilling af 2,7-diazabicyclo(3.3.0)octaner
IL65306A (en)	1986-02-28	Bis-esters of methanediol with 6beta-hydroxymethylpenicillanic acid 1,1-dioxide and ampicillin or amoxicillin and pharmaceutical compositions containing them
IL68307A (en)	1986-12-31	Process for the preparation of 2-substituted penem derivatives
PH25530A (en)	1991-07-24	Novle quinoline derivatives, processes for preparation thereof, antibacterial agent containing them
AU1746188A (en)	1988-12-15	(5R, 6S, 1R)-6-(1-hydroxyethyl)-2-(methoxymethyl)penem-3- carboxylic acid derivatives
EP0472826A3 (en)	1992-04-29	Novel quinolinecarboxylic acid derivatives, use thereof, antibacterial agent containing the same, process for preparing said compounds and intermediate compound
EP0587182A3 (de)	1995-02-15	Verfahren zur Herstellungzusammensetzungen für wiederkäufer.
FR2688505B1 (fr)	1994-05-06	Nouveau procede de preparation de 4-pyrimidinones.
DK440187D0 (da)	1987-08-24	(5r,6s,8r)-6-(1-hydroxyethyl)-2-(3r-pyrrolidin-2-on-3-yl)-thiopenem-3-carboxylsyre
PH18096A (en)	1985-03-20	Antibacterial 6-(2-amino-2-(4-acyloxyphznyl)-acetamido penicillanoyloxymethyl penicillanate,1,1-dioxide compounds
NZ217944A (en)	1989-06-28	Intermediates for preparation of 2-(1-oxo-3 thiolanylthio)-2-penem antibiotics
GR79114B (de)	1984-10-02
PT72291B (en)	1981-12-31	Process for the preparation of 6-aminopenicillanic acid-1,1-dioxide
IL63892A (en)	1986-08-31	7-(2-(aminothiazol-4yl)acetamido)cephalosporin derivatives,processes for producing the same and pharmaceutical compositions comprising them
FI921108A0 (fi)	1992-03-13	Menetelmä alkalimetallihydroksidin valmistamiseksi