MY8700708A - 2-(fluoroalkylthio) substituted penems, processes for preparing them, and pharmaceutical compositions containing them - Google Patents

2-(fluoroalkylthio) substituted penems, processes for preparing them, and pharmaceutical compositions containing them

Info

Publication number
MY8700708A
MY8700708A MY708/87A MY8700708A MY8700708A MY 8700708 A MY8700708 A MY 8700708A MY 708/87 A MY708/87 A MY 708/87A MY 8700708 A MY8700708 A MY 8700708A MY 8700708 A MY8700708 A MY 8700708A
Authority
MY
Malaysia
Prior art keywords
fluoroalkylthio
preparing
processes
pharmaceutical compositions
compositions containing
Prior art date
Application number
MY708/87A
Other languages
English (en)
Inventor
Girijavallabhan Vivyoo Moophil
Mccombie Stuart Walter
Ganguly Ashit Kumat
Pinto Patrick Anthony
Versace Richard William
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MY8700708A publication Critical patent/MY8700708A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MY708/87A 1981-11-25 1987-12-30 2-(fluoroalkylthio) substituted penems, processes for preparing them, and pharmaceutical compositions containing them MY8700708A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/324,931 US4411906A (en) 1981-11-25 1981-11-25 (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates

Publications (1)

Publication Number Publication Date
MY8700708A true MY8700708A (en) 1987-12-31

Family

ID=23265741

Family Applications (1)

Application Number Title Priority Date Filing Date
MY708/87A MY8700708A (en) 1981-11-25 1987-12-30 2-(fluoroalkylthio) substituted penems, processes for preparing them, and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (2) US4411906A (fr)
EP (1) EP0080162B1 (fr)
JP (1) JPS5892683A (fr)
KR (1) KR890005148B1 (fr)
AT (1) ATE20666T1 (fr)
AU (1) AU560838B2 (fr)
CA (1) CA1207753A (fr)
DE (1) DE3271955D1 (fr)
DK (1) DK153553C (fr)
FI (1) FI76091C (fr)
HK (1) HK56889A (fr)
HU (1) HU190044B (fr)
IE (1) IE54219B1 (fr)
IL (1) IL67327A0 (fr)
MY (1) MY8700708A (fr)
NO (1) NO159796C (fr)
NZ (1) NZ202574A (fr)
OA (1) OA07255A (fr)
PH (1) PH19647A (fr)
PT (1) PT75878B (fr)
SG (1) SG88388G (fr)
ZA (1) ZA828602B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
EP0091576B1 (fr) * 1982-03-26 1987-07-29 Hoechst Uk Limited Dérivés du 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane
ATE112778T1 (de) * 1982-11-29 1994-10-15 Schering Corp Verfahren zur herstellung von penem-verbindungen.
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4767853A (en) * 1986-07-21 1988-08-30 Schering Corporation Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
US4876338A (en) * 1986-07-21 1989-10-24 Schering Corporation Synthesis of azetidinones using CuCl
US5075438A (en) * 1986-07-21 1991-12-24 Schering Corporation Synthesis of azetidinones
US4948885A (en) * 1986-07-21 1990-08-14 Schering-Plough Corp. Synthesis of azetidinones
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
DE69922296T2 (de) * 1998-01-13 2005-10-27 Daiichi Suntory Pharma Co., Ltd. Antibakterille zusammensetzung zur topischen anwendung, enthaltend faropenem

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
EP0042026B1 (fr) * 1978-02-02 1986-01-08 Ciba-Geigy Ag Dérivés d'azétidin-2-one 3,4-disubstitués et procédé de préparation
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
ATE12773T1 (de) * 1980-02-28 1985-05-15 Schering Corp 2-penem-verbindungen, sie enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung.
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
US4614738A (en) * 1983-03-25 1986-09-30 Schering Corporation 2-(N-heterocycloaliphaticthio)penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems

Also Published As

Publication number Publication date
IE822765L (en) 1983-05-25
CA1207753A (fr) 1986-07-15
PH19647A (en) 1986-06-04
SG88388G (en) 1989-06-16
FI76091B (fi) 1988-05-31
KR840002403A (ko) 1984-07-02
ATE20666T1 (de) 1986-07-15
PT75878B (en) 1986-01-15
NO159796B (no) 1988-10-31
DE3271955D1 (en) 1986-08-14
HU190044B (en) 1986-08-28
DK519382A (da) 1983-05-26
HK56889A (en) 1989-07-21
IE54219B1 (en) 1989-07-19
NO823903L (no) 1983-05-26
IL67327A0 (en) 1983-03-31
NO159796C (no) 1989-02-08
US4814442A (en) 1989-03-21
PT75878A (en) 1982-12-01
DK153553B (da) 1988-07-25
FI823997L (fi) 1983-05-26
AU560838B2 (en) 1987-04-16
EP0080162B1 (fr) 1986-07-09
JPS5892683A (ja) 1983-06-02
FI823997A0 (fi) 1982-11-22
NZ202574A (en) 1986-06-11
EP0080162A1 (fr) 1983-06-01
FI76091C (fi) 1988-09-09
DK153553C (da) 1988-12-19
AU9078782A (en) 1983-06-02
KR890005148B1 (ko) 1989-12-14
ZA828602B (en) 1983-09-28
OA07255A (fr) 1984-04-30
US4411906A (en) 1983-10-25

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