NL1005677C2 - Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan. - Google Patents

Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan. Download PDF

Info

Publication number: NL1005677C2
Authority: NL; Netherlands
Prior art keywords: growth factors; milk; fraction; derivative; cation exchanger
Prior art date: 1997-03-27

Application number

NL1005677A

Other languages

English (en)

Dutch (nl)

Inventor

Klaas Daniel Kussendrager

Marinus Gerardus Cornel Kivits

Hubert Karel Lemmen

Theodorus Johannes Anto Kessel

Original Assignee

Campina Melkunie Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-27

Filing date

1997-03-27

Publication date

1998-09-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19764687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL1005677(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-03-27 Application filed by Campina Melkunie Bv filed Critical Campina Melkunie Bv

1997-03-27 Priority to NL1005677A priority Critical patent/NL1005677C2/nl

1998-03-24 Priority to US09/046,821 priority patent/US6010698A/en

1998-03-25 Priority to EP98200945A priority patent/EP0869134B1/de

1998-03-25 Priority to DK98200945T priority patent/DK0869134T3/da

1998-03-25 Priority to AT98200945T priority patent/ATE214074T1/de

1998-03-25 Priority to DE69804031T priority patent/DE69804031T2/de

1998-03-26 Priority to JP12264598A priority patent/JP3403066B2/ja

1998-03-26 Priority to AU59659/98A priority patent/AU705166B2/en

1998-03-27 Priority to NZ330061A priority patent/NZ330061A/xx

1998-09-29 Publication of NL1005677C2 publication Critical patent/NL1005677C2/nl

1998-09-29 Application granted granted Critical

1999-08-20 Priority to AU44646/99A priority patent/AU4464699A/en

Links

239000003102 growth factor Substances 0.000 title claims abstract description 67
238000000034 method Methods 0.000 title claims abstract description 45
235000013336 milk Nutrition 0.000 title claims abstract description 38
239000008267 milk Substances 0.000 title claims abstract description 38
210000004080 milk Anatomy 0.000 title claims abstract description 38
239000000203 mixture Substances 0.000 title claims description 10
150000001768 cations Chemical class 0.000 claims abstract description 33
230000008569 process Effects 0.000 claims abstract description 4
102000010445 Lactoferrin Human genes 0.000 claims description 28
108010063045 Lactoferrin Proteins 0.000 claims description 28
CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 28
235000021242 lactoferrin Nutrition 0.000 claims description 28
229940078795 lactoferrin Drugs 0.000 claims description 28
108010023244 Lactoperoxidase Proteins 0.000 claims description 27
102000045576 Lactoperoxidases Human genes 0.000 claims description 27
229940057428 lactoperoxidase Drugs 0.000 claims description 27
238000010626 work up procedure Methods 0.000 claims description 12
238000001179 sorption measurement Methods 0.000 claims description 10
241000894006 Bacteria Species 0.000 claims description 8
239000007788 liquid Substances 0.000 claims description 8
239000000047 product Substances 0.000 claims description 7
238000010438 heat treatment Methods 0.000 claims description 6
238000001471 micro-filtration Methods 0.000 claims description 6
238000011033 desalting Methods 0.000 claims description 5
238000000108 ultra-filtration Methods 0.000 claims description 5
150000002500 ions Chemical class 0.000 claims description 3
235000018102 proteins Nutrition 0.000 claims description 3
102000004169 proteins and genes Human genes 0.000 claims description 3
108090000623 proteins and genes Proteins 0.000 claims description 3
238000000909 electrodialysis Methods 0.000 claims description 2
238000004108 freeze drying Methods 0.000 claims description 2
238000001694 spray drying Methods 0.000 claims description 2
238000004811 liquid chromatography Methods 0.000 claims 1
239000013589 supplement Substances 0.000 claims 1
238000010828 elution Methods 0.000 abstract description 12
238000011282 treatment Methods 0.000 abstract description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 36
239000011780 sodium chloride Substances 0.000 description 20
239000000243 solution Substances 0.000 description 17
239000007858 starting material Substances 0.000 description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
150000003839 salts Chemical class 0.000 description 5
229920002684 Sepharose Polymers 0.000 description 4
238000011210 chromatographic step Methods 0.000 description 4
238000001035 drying Methods 0.000 description 4
239000005862 Whey Substances 0.000 description 3
102000007544 Whey Proteins Human genes 0.000 description 3
108010046377 Whey Proteins Proteins 0.000 description 3
230000009471 action Effects 0.000 description 3
230000001143 conditioned effect Effects 0.000 description 3
239000012528 membrane Substances 0.000 description 3
235000020183 skimmed milk Nutrition 0.000 description 3
102400001107 Secretory component Human genes 0.000 description 2
239000011324 bead Substances 0.000 description 2
230000008901 benefit Effects 0.000 description 2
235000013351 cheese Nutrition 0.000 description 2
238000005238 degreasing Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
230000002124 endocrine Effects 0.000 description 2
239000003925 fat Substances 0.000 description 2
238000001914 filtration Methods 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
238000000746 purification Methods 0.000 description 2
238000000926 separation method Methods 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
102100037852 Insulin-like growth factor I Human genes 0.000 description 1
206010067482 No adverse event Diseases 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
210000003022 colostrum Anatomy 0.000 description 1
235000021277 colostrum Nutrition 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000011068 loading method Methods 0.000 description 1
235000021073 macronutrients Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
231100000989 no adverse effect Toxicity 0.000 description 1
230000011164 ossification Effects 0.000 description 1
239000002245 particle Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000005086 pumping Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000008439 repair process Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Vascular Medicine (AREA)
Microbiology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Peptides Or Proteins (AREA)
Dairy Products (AREA)
Saccharide Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Seasonings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NL1005677A 1997-03-27 1997-03-27 Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan. NL1005677C2 (nl)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
NL1005677A NL1005677C2 (nl)	1997-03-27	1997-03-27	Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.
US09/046,821 US6010698A (en)	1997-03-27	1998-03-24	Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative
AT98200945T ATE214074T1 (de)	1997-03-27	1998-03-25	Verfahren zur gewinnung von wachstumfaktoren aus milch oder milchderivaten
DK98200945T DK0869134T3 (da)	1997-03-27	1998-03-25	Fremgangsmåde til udvinding af vækstfaktorer fra mælk eller et mælkederivat
EP98200945A EP0869134B1 (de)	1997-03-27	1998-03-25	Verfahren zur Gewinnung von Wachstumfaktoren aus Milch oder Milchderivaten
DE69804031T DE69804031T2 (de)	1997-03-27	1998-03-25	Verfahren zur Gewinnung von Wachstumfaktoren aus Milch oder Milchderivaten
JP12264598A JP3403066B2 (ja)	1997-03-27	1998-03-26	牛乳あるいは牛乳誘導物から細胞増殖因子あるいは１種または２種以上の細胞増殖因子を含む組成物を回収する方法
AU59659/98A AU705166B2 (en)	1997-03-27	1998-03-26	Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative
NZ330061A NZ330061A (en)	1997-03-27	1998-03-27	Process for recovering growth factors from milk or a milk derivative by separating out an growth factor enriched fraction and then further treating this fraction
AU44646/99A AU4464699A (en)	1997-03-27	1999-08-20	Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL1005677A NL1005677C2 (nl)	1997-03-27	1997-03-27	Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.
NL1005677		1997-03-27

Publications (1)

Publication Number	Publication Date
NL1005677C2 true NL1005677C2 (nl)	1998-09-29

Family

ID=19764687

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL1005677A NL1005677C2 (nl)	1997-03-27	1997-03-27	Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.

Country Status (9)

Country	Link
US (1)	US6010698A (de)
EP (1)	EP0869134B1 (de)
JP (1)	JP3403066B2 (de)
AT (1)	ATE214074T1 (de)
AU (1)	AU705166B2 (de)
DE (1)	DE69804031T2 (de)
DK (1)	DK0869134T3 (de)
NL (1)	NL1005677C2 (de)
NZ (1)	NZ330061A (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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AUPM534794A0 (en)	1994-04-28	1994-05-19	Gropep Pty Ltd	Modified milk growth factor
EP0896825B1 (de)	1997-08-14	2002-07-17	Sulzer Innotec Ag	Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
AU6232899A (en) *	1999-10-06	2001-05-10	Campina Melkunie B.V.	Use of transforming growth factor beta and growth factors in the treatment and prevention of diseases of the intestinal mucosa
DE69925870T2 (de) *	1999-10-06	2005-12-08	Campina B.V.	Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten
NZ507335A (en) *	2000-10-05	2004-10-29	New Zealand Dairy Board	Bone health compositions derived from milk comprising an acidic protein fraction but that does not contain CGMP
US6492327B2 (en) *	2000-12-19	2002-12-10	Sulzer Biologics Inc.	Isolation of purified TGF- β1 and TGF -β2 from bone tissue
MC200029A1 (fr) *	2001-04-19	2001-11-28	Jose Eisenberg	Application de trois molecules
CN1555384B (zh) *	2001-07-20	2010-05-26	坎皮纳公司	从乳制品获得具有低相互交叉污染的生长因子(TGF-β和IGF-1)、乳过氧化物酶和免疫球蛋白制剂的方法
US7622562B2 (en) *	2002-06-26	2009-11-24	Zimmer Orthobiologics, Inc.	Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
FR2841747B1 (fr)	2002-07-02	2004-08-20	Cie Laitiere Europeenne	Isolat de proteines de lait et procede pour sa preparation
US7547770B2 (en) *	2003-11-03	2009-06-16	Advanced Protein Systems	Colostral fractionation process
JP3946747B2 (ja) *	2004-02-17	2007-07-18	森永乳業株式会社	ラクトパーオキシダーゼの製造方法
WO2005085287A1 (en) *	2004-03-03	2005-09-15	En-N-Tech, Inc.	Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
AU2006246299B2 (en) *	2005-05-10	2013-10-24	Saputo Dairy Australia Pty Limited	Immunoglobulin fraction and process therefor
EP1940518A4 (de) *	2005-09-09	2009-10-21	Murray Goulburn Coop Co Ltd	Aus milch gewonnene zusammensetzung und ihre verwendung zur erhöhung der muskelmasse oder muskelstärke
AU2006289665B2 (en) *	2005-09-09	2012-10-04	Murray Goulburn Co-Operative Co Limited	Milk derived composition and use to enhance muscle mass or muscle strength
KR101540412B1 (ko) *	2005-09-09	2015-07-29	머레이 걸번 코-어퍼러티브 컴퍼니 리미티드	근육 염증 감소용 유장 성장 인자 추출물의 조성물
AU2006289666B2 (en) *	2005-09-09	2012-09-20	Saputo Dairy Australia Pty Limited	Composition of whey growth factor extract for reducing muscle inflammation
US20070212367A1 (en) *	2006-03-13	2007-09-13	Keech Andrew M	Novel immunologically active peptide fragments of a proline-rich polypeptide isolated from colostral mammalian fluids for treatment of viral and non-viral diseases or diseased conditions
NZ577195A (en) *	2006-11-10	2011-12-22	Murray Goulburn Coop Co Ltd	Process for the preparation of angiogenin using a cation exchange resin
US7919589B2 (en)	2007-07-10	2011-04-05	Glanbia Nutritionals (Ireland), Ltd.	Method for removing endotoxin from proteins
CN101256168B (zh)	2008-04-22	2012-01-25	内蒙古蒙牛乳业（集团）股份有限公司	一种牛乳中乳过氧化物酶含量的检测方法
RU2519645C2 (ru)	2008-05-14	2014-06-20	Эгрикалчер Виктория Сервисиз Пти Лтд	Применение ангиогенина или агонистов ангиогенина для лечения заболеваний и нарушений
AU2009246054B2 (en) *	2008-05-14	2014-01-23	Agriculture Victoria Services Pty Ltd	Angiogenin-enriched milk fractions
US9055752B2 (en) *	2008-11-06	2015-06-16	Intercontinental Great Brands Llc	Shelf-stable concentrated dairy liquids and methods of forming thereof
JPWO2012015037A1 (ja) *	2010-07-30	2013-09-12	森永乳業株式会社	抗菌活性増強剤
UA112972C2 (uk)	2010-09-08	2016-11-25	Інтерконтінентал Грейт Брендс ЛЛС	Рідкий молочний концентрат з високим вмістом сухих речовин
AU2013204740C1 (en)	2012-05-10	2015-10-01	Agriculture Victoria Services Pty Ltd	Methods of treating cancer using angiogenin or an angiogenin agonist
AU2013204850B2 (en) *	2012-10-08	2015-06-25	Murray Goulburn Co-Operative Co. Limited	Improved process for purifying milk proteins and products thereof
AU2013204858B2 (en) *	2012-10-08	2015-06-25	Saputo Dairy Australia Pty Limited	Improved process for purifying milk proteins and products thereof
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- 1998-03-25 AT AT98200945T patent/ATE214074T1/de not_active IP Right Cessation
- 1998-03-25 EP EP98200945A patent/EP0869134B1/de not_active Expired - Lifetime
- 1998-03-25 DE DE69804031T patent/DE69804031T2/de not_active Expired - Lifetime
- 1998-03-26 JP JP12264598A patent/JP3403066B2/ja not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
US6010698A (en)	2000-01-04
JPH1121299A (ja)	1999-01-26
DE69804031D1 (de)	2002-04-11
EP0869134A1 (de)	1998-10-07
DE69804031T2 (de)	2002-10-24
DK0869134T3 (da)	2002-07-01
AU5965998A (en)	1998-10-15
NZ330061A (en)	1999-07-29
AU705166B2 (en)	1999-05-20
EP0869134B1 (de)	2002-03-06
ATE214074T1 (de)	2002-03-15
JP3403066B2 (ja)	2003-05-06

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Date	Code	Title	Description
1998-12-01	PD2B	A search report has been drawn up
2005-12-01	VD1	Lapsed due to non-payment of the annual fee	Effective date: 20051001

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AU4464699A (en)	1999-11-04	Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative
AU5068602A (en)	2002-08-08	Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative
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