NL1006764C2 - Bereiding van preparaten die hoge concentraties vitamine B12 bevatten. - Google Patents

Bereiding van preparaten die hoge concentraties vitamine B12 bevatten. Download PDF

Info

Publication number: NL1006764C2
Authority: NL; Netherlands
Prior art keywords: vitamin; preparation; natural vitamin; lysate; microbial cells
Prior art date: 1996-08-12

Application number

NL1006764A

Other languages

English (en)

Dutch (nl)

Other versions

NL1006764A1 (nl

Inventor

Hendrik Louis Bijl

Original Assignee

Gist Brocades Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-12

Filing date

1997-08-12

Publication date

1997-11-18

1997-08-12 Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv

1997-09-10 Publication of NL1006764A1 publication Critical patent/NL1006764A1/xx

1997-11-18 Application granted granted Critical

1997-11-18 Publication of NL1006764C2 publication Critical patent/NL1006764C2/nl

Links

229930003779 Vitamin B12 Natural products 0.000 title claims description 134
235000019163 vitamin B12 Nutrition 0.000 title claims description 134
239000011715 vitamin B12 Substances 0.000 title claims description 134
238000002360 preparation method Methods 0.000 title claims description 44
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 title claims 13
238000000034 method Methods 0.000 claims description 38
230000000813 microbial effect Effects 0.000 claims description 19
239000007788 liquid Substances 0.000 claims description 12
238000000108 ultra-filtration Methods 0.000 claims description 12
239000002028 Biomass Substances 0.000 claims description 11
238000000926 separation method Methods 0.000 claims description 11
241000894006 Bacteria Species 0.000 claims description 10
241000186429 Propionibacterium Species 0.000 claims description 10
239000007791 liquid phase Substances 0.000 claims description 10
OAJLVMGLJZXSGX-NDSREFPTSA-L (2r,3s,4s,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12 Chemical compound [Co+3].O[C@H]1[C@H](O)[C@@H]([CH2-])O[C@H]1N1C2=NC=NC(N)=C2N=C1.C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-NDSREFPTSA-L 0.000 claims description 9
230000009089 cytolysis Effects 0.000 claims description 9
239000006166 lysate Substances 0.000 claims description 9
235000007672 methylcobalamin Nutrition 0.000 claims description 9
239000011585 methylcobalamin Substances 0.000 claims description 9
JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 claims description 9
238000011282 treatment Methods 0.000 claims description 9
239000007790 solid phase Substances 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 8
238000005406 washing Methods 0.000 claims description 8
238000011026 diafiltration Methods 0.000 claims description 6
235000015872 dietary supplement Nutrition 0.000 claims description 4
238000001035 drying Methods 0.000 claims description 4
238000009928 pasteurization Methods 0.000 claims description 4
241001468161 Acetobacterium Species 0.000 claims description 3
241000589158 Agrobacterium Species 0.000 claims description 3
241000588986 Alcaligenes Species 0.000 claims description 3
241000186063 Arthrobacter Species 0.000 claims description 3
241000589151 Azotobacter Species 0.000 claims description 3
241000193830 Bacillus <bacterium> Species 0.000 claims description 3
241000193403 Clostridium Species 0.000 claims description 3
241000186216 Corynebacterium Species 0.000 claims description 3
108090000790 Enzymes Proteins 0.000 claims description 3
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241000588722 Escherichia Species 0.000 claims description 3
241000186394 Eubacterium Species 0.000 claims description 3
241000589565 Flavobacterium Species 0.000 claims description 3
241000588769 Proteus <enterobacteria> Species 0.000 claims description 3
241000589516 Pseudomonas Species 0.000 claims description 3
241000589180 Rhizobium Species 0.000 claims description 3
241000190932 Rhodopseudomonas Species 0.000 claims description 3
241000607142 Salmonella Species 0.000 claims description 3
241000607720 Serratia Species 0.000 claims description 3
241000194017 Streptococcus Species 0.000 claims description 3
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241000589634 Xanthomonas Species 0.000 claims description 3
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241000205276 Methanosarcina Species 0.000 claims description 2
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230000001420 bacteriolytic effect Effects 0.000 claims description 2
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238000001471 micro-filtration Methods 0.000 claims 1
AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 122
239000000203 mixture Substances 0.000 description 49
RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 38
210000004027 cell Anatomy 0.000 description 27
235000000639 cyanocobalamin Nutrition 0.000 description 19
239000011666 cyanocobalamin Substances 0.000 description 19
229960002104 cyanocobalamin Drugs 0.000 description 19
239000012141 concentrate Substances 0.000 description 18
241001465754 Metazoa Species 0.000 description 16
230000000694 effects Effects 0.000 description 15
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229930003231 vitamin Natural products 0.000 description 14
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
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YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 description 4
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238000007873 sieving Methods 0.000 description 3
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XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 2
241000192125 Firmicutes Species 0.000 description 2
241000282412 Homo Species 0.000 description 2
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125000003346 cobalamin group Chemical group 0.000 description 2
239000010941 cobalt Substances 0.000 description 2
229910017052 cobalt Inorganic materials 0.000 description 2
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
239000000306 component Substances 0.000 description 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
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230000003834 intracellular effect Effects 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
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FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
239000005515 coenzyme Substances 0.000 description 1
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-1 cyano, hydroxyl Chemical group 0.000 description 1
125000002235 cyanocobalamin group Chemical group 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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NL1006764A 1996-08-12 1997-08-12 Bereiding van preparaten die hoge concentraties vitamine B12 bevatten. NL1006764C2 (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP96202254		1996-08-12
EP96202254		1996-08-12
EP97200054		1997-01-14
EP97200054		1997-01-14

Publications (2)

Publication Number	Publication Date
NL1006764A1 NL1006764A1 (nl)	1997-09-10
NL1006764C2 true NL1006764C2 (nl)	1997-11-18

Family

ID=26143080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL1006764A NL1006764C2 (nl)	1996-08-12	1997-08-12	Bereiding van preparaten die hoge concentraties vitamine B12 bevatten.

Country Status (22)

Country	Link
US (2)	US5955321A (de)
EP (1)	EP0824152B1 (de)
KR (1)	KR20000029904A (de)
CN (1)	CN1229440A (de)
AR (1)	AR022986A1 (de)
AT (1)	ATE228171T1 (de)
AU (1)	AU730618B2 (de)
BE (1)	BE1010976A5 (de)
BR (1)	BR9710884A (de)
CA (1)	CA2261286A1 (de)
DE (1)	DE69717207T2 (de)
DK (1)	DK0824152T3 (de)
ES (1)	ES2187720T3 (de)
HU (1)	HUP9903580A3 (de)
IL (1)	IL128032A0 (de)
IT (1)	IT1293968B1 (de)
NL (1)	NL1006764C2 (de)
NO (1)	NO990653L (de)
NZ (1)	NZ333821A (de)
PL (1)	PL331514A1 (de)
PT (1)	PT824152E (de)
WO (1)	WO1998006868A2 (de)

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US20030018009A1 (en) *	2001-06-20	2003-01-23	Collins Douglas A.	Adenosyl-cobalamin fortified compositions
TWI328612B (en)	2002-07-25	2010-08-11	Dsm Ip Assets Bv	Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12
WO2004044215A2 (en) *	2002-11-14	2004-05-27	Dsm Ip Assets B.V.	Formulations comprising vitamin b12, method of production and use thereof
ATE509624T1 (de)	2005-12-23	2011-06-15	Nutricia Nv	Zusammensetzung enthaltend mehrfach ungesättigte fettsäuren, proteine, mangan und/oder molybden und nukleotide/nukleoside, zur behandlung von demenz
DE102010023324A1 (de) *	2010-06-10	2011-12-15	Thomas Schütz	Verwendung von Corrinoiden zur kosmetischen Anwendung bei gesundem Fell bzw. gesunder Haut, sowie zur kosmetischen Pflege bei Fell- und Hauterkrankungen bei Klein- und Groß-Tieren (warm- und kaltblütig), (z.B. bei Fischen, Vögeln, Pferden, Rindern, Kamelen, Hunden Katzen, Reptilien)
FR2973700B1 (fr) *	2011-04-05	2013-04-26	Oreal	Nouvel actif derivant d'une bacterie appartenant au genre vitreoscilla sp. utile pour prevenir et/ou traiter les etats pelliculaires du cuir chevelu
US12268718B2 (en) *	2012-01-16	2025-04-08	Labyrinth Holdings Llc	Control of cellular redox levels
WO2013109635A1 (en)	2012-01-16	2013-07-25	Elizabeth Mckenna	Compositions and methods for the treatment of hepatic diseases and disorders
EP2898073A4 (de)	2012-09-21	2016-03-23	Elizabeth Mckenna	Natürlich vorkommende cpg-oligonukleotidzusammensetzungen und therapeutische anwendungen davon
DE102013100891A1 (de)	2013-01-29	2014-07-31	Erdinger Weissbräu Franz Brombach e.K.	Verfahren zur Herstellung eines Sauergutes, einer Maische oder Würze, eines Getränks, eines Konzentrats sowie die damit hergestellten Erzeugnisse und Verwendung von Milchsäurebakterien, eines Sauerguts, einer Maische, einer Würze oder eines Konzentrats
DE102013008335A1 (de)	2013-01-29	2014-07-31	Erdinger Weissbräu Franz Brombach e.K.	Verfahren zur Herstellung eines Nahrungsmittels sowie das damit hergestellte Nahrungsmittel und Verwendung von Milchsäurebakterien, eines Sauerguts, einer Maische, einer Würze, eines Getränks oder eines Konzentrats
DE102013008336A1 (de)	2013-01-29	2014-07-31	Erdinger Weissbräu Franz Brombach e.K.	Verfahren zur Herstellung eines Malzes sowie damit hergestelltes Malz, Verfahren zur Herstellung eines Weichwassers sowie damit hergestelltes Weichwasser; Verwendung von Milchsäurebakterien
DE102014110182A1 (de)	2014-07-18	2016-01-21	Erdinger Weißbräu Werner Brombach GmbH & Co. KG	Verfahren zur Herstellung eines Nahrungsmittels oder einer Vorstufe desselben, Nahrungsmittel oder eine Vorstufe desselben und entsprechende Verwendung
DE102017120283A1 (de)	2017-09-04	2019-03-07	Erdinger Weißbräu Werner Brombach GmbH & Co. KG	Verfahren zur Herstellung eines Nahrungsmittels oder einer Vorstufe desselben, Nahrungsmittel oder eine Vorstufe desselben und eine entsprechende Verwendung
CN110759959B (zh) *	2018-07-28	2023-04-07	广济药业（孟州）有限公司	一种从发酵液中分离提取维生素b12的方法
CN112074195A (zh) *	2019-04-11	2020-12-11	高丽营养有限公司	苹果醋营养补充剂
WO2021171294A1 (en) *	2020-02-27	2021-09-02	Hinoman Ltd.	Bacterial cultures for increasing vitamin b12 in plants
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EP0087920B1 (de) *	1982-02-26	1987-06-24	Nippon Oil Co. Ltd.	Verfahren zur Herstellung von Vitamin B12 mittels Fermentationstechnik und Vitamin B12 herstellender Mikroorganismus
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US5098691A (en) *	1991-05-06	1992-03-24	Colgate-Palmolive Company	Composition for disclosing dental plaque
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1997
- 1997-08-11 AR ARP970103634A patent/AR022986A1/es not_active Application Discontinuation
- 1997-08-12 AU AU42065/97A patent/AU730618B2/en not_active Ceased
- 1997-08-12 KR KR1019997001087A patent/KR20000029904A/ko not_active Withdrawn
- 1997-08-12 WO PCT/EP1997/004568 patent/WO1998006868A2/en not_active Ceased
- 1997-08-12 PT PT97202466T patent/PT824152E/pt unknown
- 1997-08-12 BR BR9710884A patent/BR9710884A/pt not_active Application Discontinuation
- 1997-08-12 DK DK97202466T patent/DK0824152T3/da active
- 1997-08-12 EP EP97202466A patent/EP0824152B1/de not_active Expired - Lifetime
- 1997-08-12 CN CN97197234A patent/CN1229440A/zh active Pending
- 1997-08-12 AT AT97202466T patent/ATE228171T1/de not_active IP Right Cessation
- 1997-08-12 NL NL1006764A patent/NL1006764C2/nl not_active IP Right Cessation
- 1997-08-12 DE DE69717207T patent/DE69717207T2/de not_active Expired - Fee Related
- 1997-08-12 ES ES97202466T patent/ES2187720T3/es not_active Expired - Lifetime
- 1997-08-12 IL IL12803297A patent/IL128032A0/xx unknown
- 1997-08-12 HU HU9903580A patent/HUP9903580A3/hu unknown
- 1997-08-12 BE BE9700673A patent/BE1010976A5/nl not_active IP Right Cessation
- 1997-08-12 NZ NZ333821A patent/NZ333821A/xx unknown
- 1997-08-12 IT IT97TO000738A patent/IT1293968B1/it active IP Right Grant
- 1997-08-12 US US08/909,715 patent/US5955321A/en not_active Expired - Lifetime
- 1997-08-12 CA CA002261286A patent/CA2261286A1/en not_active Abandoned
- 1997-08-12 PL PL97331514A patent/PL331514A1/xx unknown
1999
- 1999-01-19 US US09/232,920 patent/US6187761B1/en not_active Expired - Lifetime
- 1999-02-11 NO NO990653A patent/NO990653L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DK0824152T3 (da)	2003-03-10
ES2187720T3 (es)	2003-06-16
EP0824152B1 (de)	2002-11-20
EP0824152A2 (de)	1998-02-18
DE69717207D1 (de)	2003-01-02
DE69717207T2 (de)	2003-07-24
PL331514A1 (en)	1999-07-19
ATE228171T1 (de)	2002-12-15
BR9710884A (pt)	1999-08-17
AU730618B2 (en)	2001-03-08
NZ333821A (en)	2000-08-25
US5955321A (en)	1999-09-21
WO1998006868A3 (en)	1998-03-26
HUP9903580A2 (hu)	2000-03-28
NO990653D0 (no)	1999-02-11
IT1293968B1 (it)	1999-03-15
NL1006764A1 (nl)	1997-09-10
WO1998006868A2 (en)	1998-02-19
HUP9903580A3 (en)	2001-09-28
KR20000029904A (ko)	2000-05-25
NO990653L (no)	1999-04-09
AU4206597A (en)	1998-03-06
EP0824152A3 (de)	1998-02-25
BE1010976A5 (nl)	1999-03-02
CN1229440A (zh)	1999-09-22
US6187761B1 (en)	2001-02-13
PT824152E (pt)	2003-04-30
IL128032A0 (en)	1999-11-30
ITTO970738A1 (it)	1999-02-12
AR022986A1 (es)	2002-09-04
CA2261286A1 (en)	1998-02-19

Legal Events

Date	Code	Title	Description
1997-11-03	AD1A	A request for search or an international type search has been filed
1998-02-02	PD2A	A request for search or an international type search has been filed
2005-05-02	VD1	Lapsed due to non-payment of the annual fee	Effective date: 20050301

Publication	Publication Date	Title
NL1006764C2 (nl)	1997-11-18	Bereiding van preparaten die hoge concentraties vitamine B12 bevatten.
US11999941B2 (en)	2024-06-04	Composition suitable for protecting microorganisms
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Golowczyc et al.	2013	Use of whey permeate containing in situ synthesised galacto-oligosaccharides for the growth and preservation of Lactobacillus plantarum
Elmayergi et al.	1971	Influence of growth of Streptomyces fradiae on pepsin-HCl digestibility and methionine content of feather meal
Cole et al.	1989	Effect of Probiotic Supplements of Lactobacillus acidophilus and Bifidobacterium adolescentis 2204 on β-glueosidase and β-glueuronidase Activity in the Lower Gut of Rats Associated with a Human Faecal Flora
CN115141775A (zh)	2022-10-04	一种提升益生菌的自身功效及富硒能力的培养方法及其应用
EP0587711A1 (de)	1994-03-23	Spurenelementreiches zusatzmittel, verfahren zu dessen herstellung, diese enthaltende zusammensetzung und deren verwendung
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Wong et al.	1983	Contribution of Streptococcus thermophilus to growth-stimulating effect of yogurt on rats
AU609444B2 (en)	1991-05-02	Improvements in probiotic-type products
JP7792086B2 (ja)	2025-12-25	腸内環境改善用食品組成物
MXPA99001243A (en)	1999-09-20	Production and use of compositions comprising high concentrations of vitamin b12 activity
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Kantachote et al.	2010	Characterization of the antiyeast compound and probiotic properties of a starter Lactobacillus plantarum DW3 for possible use in fermented plant beverages
HK1022499A (en)	2000-08-11	Production and use of compositions comprising high concentrations of vitamin b12 activity
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