NO990653L - Produksjon og bruk av sammensetninger som omfatter h°ye konsentrasjoner av vitamin B12-aktivitet - Google Patents

Produksjon og bruk av sammensetninger som omfatter h°ye konsentrasjoner av vitamin B12-aktivitet

Info

Publication number: NO990653L
Authority: NO; Norway
Prior art keywords: vitamin; cells; compositions; activity; production
Prior art date: 1996-08-12

Application number

NO990653A

Other languages

English (en)

Norwegian (no)

Other versions

NO990653D0 (no

Inventor

Hendrik Louis Bijl

Original Assignee

Gist Brocades Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-12

Filing date

1999-02-11

Publication date

1999-04-09

1999-02-11 Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv

1999-02-11 Publication of NO990653D0 publication Critical patent/NO990653D0/no

1999-04-09 Publication of NO990653L publication Critical patent/NO990653L/no

Links

229930003779 Vitamin B12 Natural products 0.000 title abstract 7
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 title abstract 7
239000011715 vitamin B12 Substances 0.000 title abstract 7
235000019163 vitamin B12 Nutrition 0.000 title abstract 7
239000000203 mixture Substances 0.000 title abstract 4
239000007788 liquid Substances 0.000 abstract 2
230000000813 microbial effect Effects 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Polymers & Plastics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Epidemiology (AREA)
Birds (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nutrition Science (AREA)
Mycology (AREA)
Animal Husbandry (AREA)
Tropical Medicine & Parasitology (AREA)
Dermatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)

NO990653A 1996-08-12 1999-02-11 Produksjon og bruk av sammensetninger som omfatter h°ye konsentrasjoner av vitamin B12-aktivitet NO990653L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP96202254		1996-08-12
EP97200054		1997-01-14
PCT/EP1997/004568 WO1998006868A2 (en)	1996-08-12	1997-08-12	Production and use of compositions comprising high concentrations of vitamin b12 activity

Publications (2)

Publication Number	Publication Date
NO990653D0 NO990653D0 (no)	1999-02-11
NO990653L true NO990653L (no)	1999-04-09

Family

ID=26143080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO990653A NO990653L (no)	1996-08-12	1999-02-11	Produksjon og bruk av sammensetninger som omfatter h°ye konsentrasjoner av vitamin B12-aktivitet

Country Status (22)

Country	Link
US (2)	US5955321A (de)
EP (1)	EP0824152B1 (de)
KR (1)	KR20000029904A (de)
CN (1)	CN1229440A (de)
AR (1)	AR022986A1 (de)
AT (1)	ATE228171T1 (de)
AU (1)	AU730618B2 (de)
BE (1)	BE1010976A5 (de)
BR (1)	BR9710884A (de)
CA (1)	CA2261286A1 (de)
DE (1)	DE69717207T2 (de)
DK (1)	DK0824152T3 (de)
ES (1)	ES2187720T3 (de)
HU (1)	HUP9903580A3 (de)
IL (1)	IL128032A0 (de)
IT (1)	IT1293968B1 (de)
NL (1)	NL1006764C2 (de)
NO (1)	NO990653L (de)
NZ (1)	NZ333821A (de)
PL (1)	PL331514A1 (de)
PT (1)	PT824152E (de)
WO (1)	WO1998006868A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5739313A (en) *	1995-11-13	1998-04-14	Regents Of The University Of Minnesota	Radionuclide labeling of vitamin B12 and coenzymes thereof
GB9806444D0 (en) *	1998-03-25	1998-05-27	Mars Uk Ltd	Food
AU3042500A (en) *	1998-12-18	2000-07-12	Dsm N.V.	Improved process for the production of vitamin b12
US6806363B1 (en) *	1999-04-16	2004-10-19	Mayo Foundation For Medical Education & Research	Cobalamin conjugates useful as antitumor agents
US7314732B2 (en) *	2000-02-17	2008-01-01	Tfk Inc.	Drug and manufacturing method of same
US20020151525A1 (en) *	2000-10-25	2002-10-17	Collins Douglas A.	Transcobalamin receptor binding conjugates useful for treating abnormal cellular proliferation
US20030018009A1 (en) *	2001-06-20	2003-01-23	Collins Douglas A.	Adenosyl-cobalamin fortified compositions
TWI328612B (en)	2002-07-25	2010-08-11	Dsm Ip Assets Bv	Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12
WO2004044215A2 (en) *	2002-11-14	2004-05-27	Dsm Ip Assets B.V.	Formulations comprising vitamin b12, method of production and use thereof
ATE509624T1 (de)	2005-12-23	2011-06-15	Nutricia Nv	Zusammensetzung enthaltend mehrfach ungesättigte fettsäuren, proteine, mangan und/oder molybden und nukleotide/nukleoside, zur behandlung von demenz
DE102010023324A1 (de) *	2010-06-10	2011-12-15	Thomas Schütz	Verwendung von Corrinoiden zur kosmetischen Anwendung bei gesundem Fell bzw. gesunder Haut, sowie zur kosmetischen Pflege bei Fell- und Hauterkrankungen bei Klein- und Groß-Tieren (warm- und kaltblütig), (z.B. bei Fischen, Vögeln, Pferden, Rindern, Kamelen, Hunden Katzen, Reptilien)
FR2973700B1 (fr) *	2011-04-05	2013-04-26	Oreal	Nouvel actif derivant d'une bacterie appartenant au genre vitreoscilla sp. utile pour prevenir et/ou traiter les etats pelliculaires du cuir chevelu
US12268718B2 (en) *	2012-01-16	2025-04-08	Labyrinth Holdings Llc	Control of cellular redox levels
WO2013109635A1 (en)	2012-01-16	2013-07-25	Elizabeth Mckenna	Compositions and methods for the treatment of hepatic diseases and disorders
EP2898073A4 (de)	2012-09-21	2016-03-23	Elizabeth Mckenna	Natürlich vorkommende cpg-oligonukleotidzusammensetzungen und therapeutische anwendungen davon
DE102013100891A1 (de)	2013-01-29	2014-07-31	Erdinger Weissbräu Franz Brombach e.K.	Verfahren zur Herstellung eines Sauergutes, einer Maische oder Würze, eines Getränks, eines Konzentrats sowie die damit hergestellten Erzeugnisse und Verwendung von Milchsäurebakterien, eines Sauerguts, einer Maische, einer Würze oder eines Konzentrats
DE102013008335A1 (de)	2013-01-29	2014-07-31	Erdinger Weissbräu Franz Brombach e.K.	Verfahren zur Herstellung eines Nahrungsmittels sowie das damit hergestellte Nahrungsmittel und Verwendung von Milchsäurebakterien, eines Sauerguts, einer Maische, einer Würze, eines Getränks oder eines Konzentrats
DE102013008336A1 (de)	2013-01-29	2014-07-31	Erdinger Weissbräu Franz Brombach e.K.	Verfahren zur Herstellung eines Malzes sowie damit hergestelltes Malz, Verfahren zur Herstellung eines Weichwassers sowie damit hergestelltes Weichwasser; Verwendung von Milchsäurebakterien
DE102014110182A1 (de)	2014-07-18	2016-01-21	Erdinger Weißbräu Werner Brombach GmbH & Co. KG	Verfahren zur Herstellung eines Nahrungsmittels oder einer Vorstufe desselben, Nahrungsmittel oder eine Vorstufe desselben und entsprechende Verwendung
DE102017120283A1 (de)	2017-09-04	2019-03-07	Erdinger Weißbräu Werner Brombach GmbH & Co. KG	Verfahren zur Herstellung eines Nahrungsmittels oder einer Vorstufe desselben, Nahrungsmittel oder eine Vorstufe desselben und eine entsprechende Verwendung
CN110759959B (zh) *	2018-07-28	2023-04-07	广济药业（孟州）有限公司	一种从发酵液中分离提取维生素b12的方法
CN112074195A (zh) *	2019-04-11	2020-12-11	高丽营养有限公司	苹果醋营养补充剂
WO2021171294A1 (en) *	2020-02-27	2021-09-02	Hinoman Ltd.	Bacterial cultures for increasing vitamin b12 in plants
WO2026057677A1 (en)	2024-09-11	2026-03-19	Unikline B.V.	A novel composition comprising adenosyl cobalamin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3146165A (en) *	1960-08-26	1964-08-25	Distillers Co Yeast Ltd	Composition containing cobalamin and glutathione and process of employing same
US4383110A (en) *	1980-11-29	1983-05-10	Nippon Oil Company, Ltd.	Process for purifying and separating vitamin B12
JPH03244376A (ja) *	1982-02-26	1991-10-31	Nippon Oil Co Ltd	ビタミンｂ↓１↓２生産菌
EP0087920B1 (de) *	1982-02-26	1987-06-24	Nippon Oil Co. Ltd.	Verfahren zur Herstellung von Vitamin B12 mittels Fermentationstechnik und Vitamin B12 herstellender Mikroorganismus
EP0131456A3 (de) *	1983-07-08	1986-07-23	Kureha Kagaku Kogyo Kabushiki Kaisha	Herstellung von Vitamin B12 durch Verwendung eines fusionierten Zellhybrids
HU188955B (en) *	1983-09-16	1986-05-28	Richter Gedeon Vegyeszeti Gyar Rt,Hu	Process for preparing a fermentation broth for the production of coenzyme b down 12
RU2001953C1 (ru) *	1990-10-30	1993-10-30	Всесоюзный научно-исследовательский технологический институт антибиотиков и ферментов медицинского назначени	Способ получени препарата витамина @
US5098691A (en) *	1991-05-06	1992-03-24	Colgate-Palmolive Company	Composition for disclosing dental plaque
JP3085320B2 (ja) *	1991-09-17	2000-09-04	日石三菱株式会社	ヒドロキソコバラミンの製造方法
CN1087522A (zh) *	1992-09-14	1994-06-08	韦斯塔药品有限公司	用于治疗和预防婴儿代谢紊乱的组合物
EP0647717A1 (de) *	1993-10-06	1995-04-12	Takeda Chemical Industries, Ltd.	Verfahren zur Herstellung von Vitamin B12
DE4344141C1 (de) *	1993-12-20	1995-07-13	Coiffeur Consulting Team Elect	Kosmetisches Produkt zur spezifischen Haarpflege
US5925625A (en) *	1994-05-13	1999-07-20	Merkus; Franciscus W. H. M.	Pharmaceutical composition for the intranasal administration of hydroxocobalamin
FR2740973B1 (fr) *	1995-11-15	1998-02-06	Lipha	Nouvelle forme d'administration de l'hydroxocobalamine et son utilisation dans les intoxications par les cyanures

1997
- 1997-08-11 AR ARP970103634A patent/AR022986A1/es not_active Application Discontinuation
- 1997-08-12 AU AU42065/97A patent/AU730618B2/en not_active Ceased
- 1997-08-12 KR KR1019997001087A patent/KR20000029904A/ko not_active Withdrawn
- 1997-08-12 WO PCT/EP1997/004568 patent/WO1998006868A2/en not_active Ceased
- 1997-08-12 PT PT97202466T patent/PT824152E/pt unknown
- 1997-08-12 BR BR9710884A patent/BR9710884A/pt not_active Application Discontinuation
- 1997-08-12 DK DK97202466T patent/DK0824152T3/da active
- 1997-08-12 EP EP97202466A patent/EP0824152B1/de not_active Expired - Lifetime
- 1997-08-12 CN CN97197234A patent/CN1229440A/zh active Pending
- 1997-08-12 AT AT97202466T patent/ATE228171T1/de not_active IP Right Cessation
- 1997-08-12 NL NL1006764A patent/NL1006764C2/nl not_active IP Right Cessation
- 1997-08-12 DE DE69717207T patent/DE69717207T2/de not_active Expired - Fee Related
- 1997-08-12 ES ES97202466T patent/ES2187720T3/es not_active Expired - Lifetime
- 1997-08-12 IL IL12803297A patent/IL128032A0/xx unknown
- 1997-08-12 HU HU9903580A patent/HUP9903580A3/hu unknown
- 1997-08-12 BE BE9700673A patent/BE1010976A5/nl not_active IP Right Cessation
- 1997-08-12 NZ NZ333821A patent/NZ333821A/xx unknown
- 1997-08-12 IT IT97TO000738A patent/IT1293968B1/it active IP Right Grant
- 1997-08-12 US US08/909,715 patent/US5955321A/en not_active Expired - Lifetime
- 1997-08-12 CA CA002261286A patent/CA2261286A1/en not_active Abandoned
- 1997-08-12 PL PL97331514A patent/PL331514A1/xx unknown
1999
- 1999-01-19 US US09/232,920 patent/US6187761B1/en not_active Expired - Lifetime
- 1999-02-11 NO NO990653A patent/NO990653L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DK0824152T3 (da)	2003-03-10
ES2187720T3 (es)	2003-06-16
EP0824152B1 (de)	2002-11-20
EP0824152A2 (de)	1998-02-18
DE69717207D1 (de)	2003-01-02
DE69717207T2 (de)	2003-07-24
PL331514A1 (en)	1999-07-19
ATE228171T1 (de)	2002-12-15
BR9710884A (pt)	1999-08-17
AU730618B2 (en)	2001-03-08
NZ333821A (en)	2000-08-25
US5955321A (en)	1999-09-21
WO1998006868A3 (en)	1998-03-26
HUP9903580A2 (hu)	2000-03-28
NO990653D0 (no)	1999-02-11
IT1293968B1 (it)	1999-03-15
NL1006764A1 (nl)	1997-09-10
WO1998006868A2 (en)	1998-02-19
HUP9903580A3 (en)	2001-09-28
KR20000029904A (ko)	2000-05-25
AU4206597A (en)	1998-03-06
NL1006764C2 (nl)	1997-11-18
EP0824152A3 (de)	1998-02-25
BE1010976A5 (nl)	1999-03-02
CN1229440A (zh)	1999-09-22
US6187761B1 (en)	2001-02-13
PT824152E (pt)	2003-04-30
IL128032A0 (en)	1999-11-30
ITTO970738A1 (it)	1999-02-12
AR022986A1 (es)	2002-09-04
CA2261286A1 (en)	1998-02-19

Legal Events

Date	Code	Title	Description
2003-05-05	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO990653L (no)	1999-04-09	Produksjon og bruk av sammensetninger som omfatter h°ye konsentrasjoner av vitamin B12-aktivitet
NO170126C (no)	1992-09-16	Fremgangsmaate for fremstilling av farmasoeytiske preparater i form av suspensjoner som inneholder sucralfat
IL81616A0 (en)	1987-09-16	Controlled hue test composition and test devices
ATE305296T1 (de)	2005-10-15	Zusammensetzungen und verfahren zur behandlung von abnormaler zellvermehrung
EE9900133A (et)	1999-12-15	Produkt, selle valmistamismeetod ja kasutamine
ATE448698T1 (de)	2009-12-15	Verfahren zur extraktion von carotinoiden
ATE197159T1 (de)	2000-11-15	Nährungszusammensetzung aus dem maisquellwasser und verfahren zu deren herstellung
ES2009223A6 (es)	1989-09-16	Material antioxidante, procedimiento para prepararlo y composiciones cosmeticas y alimenticias que contienen dicho material.
NO963462L (no)	1996-08-20	Paramunitetinducer basert på kombinasjoner av poxvirus komponenter, fremgangsmåte for fremstilling derav og anvendelse som medikament
BRPI0412063A (pt)	2006-09-05	um método para produzir ácido orgánico
Shridi et al.	1988	The influence of calcium channel blockers on superoxide anions
ES2039195T3 (es)	1993-09-16	Derivado de la pirazolsulfonamida, procedimiento para su fabricacion y herbicida que lo contiene.
ES8305684A1 (es)	1983-05-01	Procedimiento para la obtencion de derivados aminopropanolicos de 2-hidroxi b-fenil-propiofenonas.
AU2668800A (en)	2000-09-04	Mixture of plant-treatment agents and waxes, method for producing same and the use thereof
DE3067566D1 (en)	1984-05-24	N-aryl-n'-imidazol-2-ylureas, process for their preparation and pharmaceutical compositions containing them
AU5428586A (en)	1986-09-11	Pharmaceutical and dietary compositions
AU590644B2 (en)	1989-11-09	Production of cholecalciferol derivatives and novel intermediates used therefor
NO983184L (no)	1998-07-10	Blanding inneholdende diosgenin
ES2130094A1 (es)	1999-06-16	Procedimiento de obtencion de un colorante alimentario, asi como este colorante y sucedaneos alimentarios con el obtenidos.
GB2322132B (en)	1999-09-22	Keratinocyte growth factor-2 products
AU1214688A (en)	1988-09-08	New fibrinolytic enzymes, methods for their production and pharmaceutical compositions containing them
ES479413A1 (es)	1980-08-16	Un procedimiento para la preparacion de una goma de xantano.
ATE258783T1 (de)	2004-02-15	Therapeutische und kosmetische mittel, ihre verwendung und herstellungsverfahren
BR9812152A (pt)	2000-07-18	Comprimidos de cloramina t prensados e processos para a sua preparação
Deitmer et al.	1986	Changes in voltage-dependent calcium currents during the cell cycle of the ciliate Stylonychia