NL222157A - - Google Patents
Info
- Publication number
- NL222157A NL222157A NL222157DA NL222157A NL 222157 A NL222157 A NL 222157A NL 222157D A NL222157D A NL 222157DA NL 222157 A NL222157 A NL 222157A
- Authority
- NL
- Netherlands
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657154—Cyclic esteramides of oxyacids of phosphorus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEA26234A DE1054997B (de) | 1956-12-20 | 1956-12-20 | Verfahren zur Herstellung von cyclischen Thiophosphorsaeure-esteramiden |
| DEA28444A DE1116672B (de) | 1956-12-20 | 1957-12-04 | Verfahren zur Herstellung von cyclischen Phosphorsaeure- und Thiophosphorsaeureesteramiden |
| DEA24298A DE1057119B (de) | 1956-12-20 | 1957-12-04 | Verfahren zur Herstellung von cyclischen Phosphorsaeure-esteramiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL222157A true NL222157A (fr) |
Family
ID=27208860
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL222157D NL222157A (fr) | 1956-12-20 | ||
| NL99649D NL99649C (fr) | 1956-12-20 | ||
| NL99688D NL99688C (fr) | 1956-12-20 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL99649D NL99649C (fr) | 1956-12-20 | ||
| NL99688D NL99688C (fr) | 1956-12-20 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US3018302A (fr) |
| BE (2) | BE554888A (fr) |
| CH (3) | CH361279A (fr) |
| DE (3) | DE1054997B (fr) |
| FR (2) | FR1246708A (fr) |
| GB (2) | GB812651A (fr) |
| NL (3) | NL99688C (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3270093A (en) * | 1963-04-19 | 1966-08-30 | Tenneco Chem | Omicron, omicron-neopentylene-nu-diethylphosphoroamidothioate |
| US3286001A (en) * | 1963-06-07 | 1966-11-15 | Continental Oil Co | Reaction products of organophosphorus monohalides with mercaptoalkylamines |
| US3335129A (en) * | 1963-11-21 | 1967-08-08 | Wyandotte Chemicals Corp | Phosphoramidates |
| DE2110333A1 (de) * | 1971-03-04 | 1972-09-14 | Audi Nsu Auto Union Ag | Kreiskolben-Brennkraftmaschine |
| PL100390B1 (pl) | 1975-10-06 | 1978-09-30 | Sposob wytwarzania 2-tlenku-2-/bis/2-chloroetylo/-amino/-1-/okso-3-aza-2-fosfacykloheksanu/cyklofosfamidu/o czynnosci optycznej | |
| DE3132221A1 (de) * | 1981-08-14 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung |
| DE3133077A1 (de) * | 1981-08-21 | 1983-03-10 | Henkel KGaA, 4000 Düsseldorf | Neue cytostatisch wirksame epoxidgruppen tragende 1,3,2-oxazaphosphorin-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung in pharmazeutischen zubereitungen |
| US5227374A (en) * | 1982-11-12 | 1993-07-13 | Mead Johnson & Company | Lyophilized cyclophosphamide |
| US4537883A (en) * | 1982-11-12 | 1985-08-27 | Mead Johnson & Company | Lyophilized cyclophosphamide |
| US4659699A (en) * | 1983-08-22 | 1987-04-21 | Cetus-Ben Venue Therapeutics | Process for freeze drying cyclophosphamide |
| US4879286A (en) * | 1987-01-28 | 1989-11-07 | Lyphomed, Inc. | Cyclophosphamide |
| IT1251472B (it) * | 1991-09-12 | 1995-05-15 | Boehringer Mannheim Italia | Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono |
| DE19739159C1 (de) * | 1997-09-06 | 1999-01-28 | Asta Medica Ag | Verfahren zur Herstellung von Oxazaphosphorin-2-aminen |
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| EP1060182B1 (fr) | 1998-03-06 | 2012-12-19 | Metabasis Therapeutics, Inc. | Nouveaux promedicaments pour composes contenant du phosphore |
| IL145052A0 (en) * | 1999-03-05 | 2002-06-30 | Metabasis Therapeutics Inc | Novel phosphorus-containing prodrugs |
| US7205404B1 (en) * | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| EP1210354A1 (fr) | 1999-09-08 | 2002-06-05 | Metabasis Therapeutics, Inc. | Promedicaments destines a l'administration specifique de medicaments au foie |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| AU2003235501A1 (en) * | 2002-05-13 | 2003-11-11 | Metabasis Therapeutics, Inc. | PMEA and PMPA cyclic producing synthesis |
| NZ536328A (en) * | 2002-05-13 | 2007-11-30 | Metabasis Therapeutics Inc | Novel phosphonic acid based prodrugs of PMEA and its analogues |
| EP1556398B1 (fr) | 2002-10-31 | 2009-09-09 | Metabasis Therapeutics, Inc. | Nouveaux promedicaments de cytarabine monophosphate |
| US20050182252A1 (en) * | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| MXPA06014013A (es) * | 2004-06-08 | 2007-03-15 | Metabasis Therapeutics Inc | Sintesis mediada por acidos de lewis de esteres ciclicos. |
| US10449210B2 (en) * | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
| CN106456654A (zh) | 2014-05-09 | 2017-02-22 | 奥罗医学制药有限公司 | 环磷酰胺液体浓缩制剂 |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| US10849916B2 (en) | 2014-07-11 | 2020-12-01 | Dr. Reddys Laboratories Limited | Stable liquid formulations of cyclophosphamide and its impurities |
| WO2016005962A2 (fr) | 2014-07-11 | 2016-01-14 | Dr. Reddy’S Laboratories Limited | Formulations liquides stables de cyclophosphamide et procédés associés |
| US10016447B2 (en) | 2014-09-26 | 2018-07-10 | Intas Pharmaceuticals Ltd. | Pharmaceutical composition having improved content uniformity |
| JP6891118B2 (ja) | 2014-12-23 | 2021-06-18 | インテレクチュアル プロパティ アソシエイツ エルエルシーＩｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ａｓｓｏｃｉａｔｅｓ， ＬＬＣ | 経皮投与のための方法及び製剤 |
| WO2016156927A1 (fr) | 2015-04-02 | 2016-10-06 | PRZEDSIĘBIORSTWO PRODUKCYJNO-WDROŻENIOWE IFOTAM Sp. z o.o. | Procédé de production de n,n-bis (2-chloroéthyl)tétrahydro-2 h-1,3,2-oxazaphosphorine-2-amine 2-oxyde |
| WO2017207719A1 (fr) | 2016-06-02 | 2017-12-07 | Amneal Pharmaceuticals Company Gmbh | Composition de cyclophosphamide et son procédé de préparation |
| US20190083386A1 (en) | 2017-09-15 | 2019-03-21 | Ampersand Biopharmaceuticals, Inc. | Methods and formulations for transdermal administration of buffering agents |
| CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
| CN116178440B (zh) * | 2022-12-23 | 2025-12-30 | 杏林中医药科技(广州)有限公司 | 一种肝脏靶向烷化剂及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1065418B (de) * | 1953-03-21 | 1959-09-17 | Montecatini Soc. Gen. per 1'Industria Mineraria e Chimica, Mailand (Italien) | Verfahren zur Herstellung von heterocyclischen Phosphorverbindungen |
| NL236264A (fr) * | 1958-02-20 | 1900-01-01 |
-
0
- FR FR75178D patent/FR75178E/fr not_active Expired
- BE BE563332D patent/BE563332A/xx unknown
- BE BE554888D patent/BE554888A/xx unknown
- NL NL222157D patent/NL222157A/xx unknown
- NL NL99649D patent/NL99649C/xx active
- NL NL99688D patent/NL99688C/xx active
-
1956
- 1956-12-20 DE DEA26234A patent/DE1054997B/de active Pending
-
1957
- 1957-01-30 GB GB3283/57A patent/GB812651A/en not_active Expired
- 1957-02-04 FR FR731011A patent/FR1246708A/fr not_active Expired
- 1957-02-09 CH CH361279D patent/CH361279A/de unknown
- 1957-11-28 CH CH5317357A patent/CH369451A/de unknown
- 1957-12-04 DE DEA24298A patent/DE1057119B/de active Pending
- 1957-12-04 DE DEA28444A patent/DE1116672B/de active Pending
-
1958
- 1958-04-15 US US728568A patent/US3018302A/en not_active Expired - Lifetime
- 1958-12-03 CH CH6689458A patent/CH370406A/de unknown
- 1958-12-03 GB GB39031/58A patent/GB853044A/en not_active Expired
-
1959
- 1959-07-27 US US829528A patent/US3074992A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CH370406A (de) | 1963-07-15 |
| US3074992A (en) | 1963-01-22 |
| BE563332A (fr) | |
| BE554888A (fr) | |
| NL99649C (fr) | |
| FR75178E (fr) | 1961-09-08 |
| GB812651A (en) | 1959-04-29 |
| US3018302A (en) | 1962-01-23 |
| DE1057119B (de) | 1959-05-14 |
| CH361279A (de) | 1962-04-15 |
| DE1054997B (de) | 1959-04-16 |
| DE1116672B (de) | 1961-11-09 |
| CH369451A (de) | 1963-05-31 |
| NL99688C (fr) | |
| GB853044A (en) | 1960-11-02 |
| FR1246708A (fr) | 1960-11-25 |