NL7601132A - Cytotoxic medicaments bonded to polymeric carrier - e.g. dextran, which is itself bonded to immunoglobulin specific for cells to be killed - Google Patents
Cytotoxic medicaments bonded to polymeric carrier - e.g. dextran, which is itself bonded to immunoglobulin specific for cells to be killedInfo
- Publication number
- NL7601132A NL7601132A NL7601132A NL7601132A NL7601132A NL 7601132 A NL7601132 A NL 7601132A NL 7601132 A NL7601132 A NL 7601132A NL 7601132 A NL7601132 A NL 7601132A NL 7601132 A NL7601132 A NL 7601132A
- Authority
- NL
- Netherlands
- Prior art keywords
- bonded
- cells
- polymeric carrier
- killed
- dextran
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 2
- 231100000433 cytotoxic Toxicity 0.000 title abstract 2
- 230000001472 cytotoxic effect Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 102000018358 immunoglobulin Human genes 0.000 title abstract 2
- 229920002307 Dextran Polymers 0.000 title 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4695/75A GB1496011A (en) | 1974-11-22 | 1975-02-04 | Defoaming composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7601132A true NL7601132A (en) | 1976-08-06 |
Family
ID=9782062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7601132A NL7601132A (en) | 1975-02-04 | 1976-02-04 | Cytotoxic medicaments bonded to polymeric carrier - e.g. dextran, which is itself bonded to immunoglobulin specific for cells to be killed |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS51126281A (da) |
| BE (1) | BE838273A (da) |
| DK (1) | DK43676A (da) |
| NL (1) | NL7601132A (da) |
| SE (1) | SE7601125L (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57143326A (en) * | 1981-03-03 | 1982-09-04 | Teijin Ltd | Polymer linked to cellular toxic substance and its preparation |
| DE3205847A1 (de) * | 1981-05-08 | 1982-12-16 | Farmitalia Carlo Erba S.p.A., 20159 Milano | Daunorubicinprotein-konjugate |
| JPS60172935A (ja) * | 1984-02-16 | 1985-09-06 | Green Cross Corp:The | 制癌作用物質複合体の製造方法 |
| JPS611622A (ja) * | 1984-06-14 | 1986-01-07 | Teijin Ltd | 細胞毒性複合体及びその製造法 |
| FR2586564B1 (fr) * | 1985-09-04 | 1989-04-07 | Pierre Tran Ba Loc | Composes immuno-suppresseurs et leur procede de preparation |
| JPS62228025A (ja) * | 1985-12-27 | 1987-10-06 | Teijin Ltd | 抗体複合体の製造方法 |
| US5030719A (en) * | 1986-08-28 | 1991-07-09 | Teijin Limited | Cytotoxic antibody conjugates and a process for preparation thereof |
| JPH0662438B2 (ja) * | 1986-08-28 | 1994-08-17 | 帝人株式会社 | 殺細胞性抗体複合体及びその製造方法 |
| US5149782A (en) * | 1988-08-19 | 1992-09-22 | Tanox Biosystems, Inc. | Molecular conjugates containing cell membrane-blending agents |
| JP2626654B2 (ja) * | 1990-03-31 | 1997-07-02 | 科学技術振興事業団 | 標的指向性高分子医薬化合物及びその中間体 |
-
1976
- 1976-02-03 JP JP51010786A patent/JPS51126281A/ja active Pending
- 1976-02-03 DK DK43676*#A patent/DK43676A/da not_active Application Discontinuation
- 1976-02-03 SE SE7601125A patent/SE7601125L/ not_active Application Discontinuation
- 1976-02-04 NL NL7601132A patent/NL7601132A/xx not_active Application Discontinuation
- 1976-02-04 BE BE164096A patent/BE838273A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE7601125L (sv) | 1976-08-05 |
| JPS51126281A (en) | 1976-11-04 |
| DK43676A (da) | 1976-08-05 |
| BE838273A (fr) | 1976-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |