NL7601132A - Cytotoxic medicaments bonded to polymeric carrier - e.g. dextran, which is itself bonded to immunoglobulin specific for cells to be killed - Google Patents

Cytotoxic medicaments bonded to polymeric carrier - e.g. dextran, which is itself bonded to immunoglobulin specific for cells to be killed

Info

Publication number
NL7601132A
NL7601132A NL7601132A NL7601132A NL7601132A NL 7601132 A NL7601132 A NL 7601132A NL 7601132 A NL7601132 A NL 7601132A NL 7601132 A NL7601132 A NL 7601132A NL 7601132 A NL7601132 A NL 7601132A
Authority
NL
Netherlands
Prior art keywords
bonded
cells
polymeric carrier
killed
dextran
Prior art date
Application number
NL7601132A
Other languages
English (en)
Dutch (nl)
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB4695/75A external-priority patent/GB1496011A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of NL7601132A publication Critical patent/NL7601132A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44Antibodies bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
NL7601132A 1975-02-04 1976-02-04 Cytotoxic medicaments bonded to polymeric carrier - e.g. dextran, which is itself bonded to immunoglobulin specific for cells to be killed NL7601132A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4695/75A GB1496011A (en) 1974-11-22 1975-02-04 Defoaming composition

Publications (1)

Publication Number Publication Date
NL7601132A true NL7601132A (en) 1976-08-06

Family

ID=9782062

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7601132A NL7601132A (en) 1975-02-04 1976-02-04 Cytotoxic medicaments bonded to polymeric carrier - e.g. dextran, which is itself bonded to immunoglobulin specific for cells to be killed

Country Status (5)

Country Link
JP (1) JPS51126281A (da)
BE (1) BE838273A (da)
DK (1) DK43676A (da)
NL (1) NL7601132A (da)
SE (1) SE7601125L (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57143326A (en) * 1981-03-03 1982-09-04 Teijin Ltd Polymer linked to cellular toxic substance and its preparation
DE3205847A1 (de) * 1981-05-08 1982-12-16 Farmitalia Carlo Erba S.p.A., 20159 Milano Daunorubicinprotein-konjugate
JPS60172935A (ja) * 1984-02-16 1985-09-06 Green Cross Corp:The 制癌作用物質複合体の製造方法
JPS611622A (ja) * 1984-06-14 1986-01-07 Teijin Ltd 細胞毒性複合体及びその製造法
FR2586564B1 (fr) * 1985-09-04 1989-04-07 Pierre Tran Ba Loc Composes immuno-suppresseurs et leur procede de preparation
JPS62228025A (ja) * 1985-12-27 1987-10-06 Teijin Ltd 抗体複合体の製造方法
US5030719A (en) * 1986-08-28 1991-07-09 Teijin Limited Cytotoxic antibody conjugates and a process for preparation thereof
JPH0662438B2 (ja) * 1986-08-28 1994-08-17 帝人株式会社 殺細胞性抗体複合体及びその製造方法
US5149782A (en) * 1988-08-19 1992-09-22 Tanox Biosystems, Inc. Molecular conjugates containing cell membrane-blending agents
JP2626654B2 (ja) * 1990-03-31 1997-07-02 科学技術振興事業団 標的指向性高分子医薬化合物及びその中間体

Also Published As

Publication number Publication date
SE7601125L (sv) 1976-08-05
JPS51126281A (en) 1976-11-04
DK43676A (da) 1976-08-05
BE838273A (fr) 1976-08-04

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Legal Events

Date Code Title Description
BV The patent application has lapsed