NL8002577A - Bis(4-demethoxydaunorubicine)dihydrazonderivaten en hun zouten. - Google Patents

Bis(4-demethoxydaunorubicine)dihydrazonderivaten en hun zouten. Download PDF

Info

Publication number: NL8002577A
Authority: NL; Netherlands
Prior art keywords: parts; formula; amino; diyl; bis
Prior art date: 1979-05-03

Application number

NL8002577A

Other languages

English (en)

Dutch (nl)

Original Assignee

Apple Martin Allen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-03

Filing date

1980-05-02

Publication date

1980-11-05

1980-05-02 Application filed by Apple Martin Allen filed Critical Apple Martin Allen

1980-11-05 Publication of NL8002577A publication Critical patent/NL8002577A/nl

Links

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239000012259 ether extract Substances 0.000 description 1
MDKXBBPLEGPIRI-UHFFFAOYSA-N ethoxyethane;methanol Chemical compound OC.CCOCC MDKXBBPLEGPIRI-UHFFFAOYSA-N 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000008273 gelatin Chemical class 0.000 description 1
229920000159 gelatin Chemical class 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
239000008187 granular material Substances 0.000 description 1
QCNWZROVPSVEJA-UHFFFAOYSA-N heptadecanedioic acid Natural products OC(=O)CCCCCCCCCCCCCCCC(O)=O QCNWZROVPSVEJA-UHFFFAOYSA-N 0.000 description 1
229940042795 hydrazides for tuberculosis treatment Drugs 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
FUKUFMFMCZIRNT-UHFFFAOYSA-N hydron;methanol;chloride Chemical compound Cl.OC FUKUFMFMCZIRNT-UHFFFAOYSA-N 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000012280 lithium aluminium hydride Substances 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
YDCHPLOFQATIDS-UHFFFAOYSA-N methyl 2-bromoacetate Chemical compound COC(=O)CBr YDCHPLOFQATIDS-UHFFFAOYSA-N 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
KGCNHWXDPDPSBV-UHFFFAOYSA-N p-nitrobenzyl chloride Chemical compound [O-][N+](=O)C1=CC=C(CCl)C=C1 KGCNHWXDPDPSBV-UHFFFAOYSA-N 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
229910003446 platinum oxide Inorganic materials 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Chemical class 0.000 description 1
239000001267 polyvinylpyrrolidone Chemical class 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
235000015497 potassium bicarbonate Nutrition 0.000 description 1
229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
239000011736 potassium bicarbonate Substances 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
239000000843 powder Substances 0.000 description 1
WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
238000010839 reverse transcription Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000000661 sodium alginate Chemical class 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
JBJWASZNUJCEKT-UHFFFAOYSA-M sodium;hydroxide;hydrate Chemical compound O.[OH-].[Na+] JBJWASZNUJCEKT-UHFFFAOYSA-M 0.000 description 1
239000012453 solvate Substances 0.000 description 1
229940063673 spermidine Drugs 0.000 description 1
229940063675 spermine Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

NL8002577A 1979-05-03 1980-05-02 Bis(4-demethoxydaunorubicine)dihydrazonderivaten en hun zouten. NL8002577A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/035,657 US4275192A (en)	1979-05-03	1979-05-03	Bis(4-demethoxydaunorubicin)dihydrazone derivatives and pharmacologically acceptable salts thereof
US3565779		1979-05-03

Publications (1)

Publication Number	Publication Date
NL8002577A true NL8002577A (nl)	1980-11-05

Family

ID=21884000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8002577A NL8002577A (nl)	1979-05-03	1980-05-02	Bis(4-demethoxydaunorubicine)dihydrazonderivaten en hun zouten.

Country Status (15)

Country	Link
US (1)	US4275192A (fr)
JP (1)	JPS568398A (fr)
AU (1)	AU532925B2 (fr)
BE (1)	BE883106A (fr)
CA (1)	CA1137471A (fr)
CH (1)	CH643862A5 (fr)
DE (1)	DE3016974A1 (fr)
DK (1)	DK194280A (fr)
ES (2)	ES8104320A1 (fr)
FR (1)	FR2455595A1 (fr)
GB (1)	GB2050364B (fr)
IE (1)	IE49782B1 (fr)
IT (1)	IT1143092B (fr)
NL (1)	NL8002577A (fr)
SE (1)	SE8003317L (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5162512A (en) *	1982-03-09	1992-11-10	Cytogen Corporation	Amine derivatives of anthracycline antibodies
US4950738A (en) *	1984-09-13	1990-08-21	Cytogen Corporation	Amine derivatives of anthracycline antibiotics
CA1248944A (fr) *	1982-09-28	1989-01-17	Gareth J. Thomas	Glycosides d'anthracycline
FR2551442B1 (fr) *	1983-09-05	1987-04-30	Centre Nat Rech Scient	Nouveaux derives furaniques, leur preparation et leur application
JPS61227590A (ja) *	1985-04-02	1986-10-09	Microbial Chem Res Found	新規４′−デメチル−４−エピポドフイロトキシン誘導体
GB2196626B (en) *	1986-10-15	1990-09-19	Erba Farmitalia	Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
IL106992A (en) *	1988-02-11	1994-06-24	Bristol Myers Squibb Co	Acylhydrazone derivatives of anthracycline and methods for their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3957755A (en) *	1967-10-18	1976-05-18	Rhone-Poulenc S.A.	Naphthacene derivatives
US4112217A (en) *	1977-09-02	1978-09-05	Sri International	Bis-hydrazones of daunomycin and adriamycin
US4125704A (en) *	1977-09-14	1978-11-14	Sri International	Phenyl-substituted rubidazone analogs

1979
- 1979-05-03 US US06/035,657 patent/US4275192A/en not_active Expired - Lifetime
1980
- 1980-04-30 FR FR8009856A patent/FR2455595A1/fr active Granted
- 1980-05-01 DK DK194280A patent/DK194280A/da not_active Application Discontinuation
- 1980-05-02 DE DE19803016974 patent/DE3016974A1/de not_active Withdrawn
- 1980-05-02 SE SE8003317A patent/SE8003317L/xx not_active Application Discontinuation
- 1980-05-02 ES ES491116A patent/ES8104320A1/es not_active Expired
- 1980-05-02 GB GB8014862A patent/GB2050364B/en not_active Expired
- 1980-05-02 AU AU58039/80A patent/AU532925B2/en not_active Ceased
- 1980-05-02 NL NL8002577A patent/NL8002577A/nl unknown
- 1980-05-02 CA CA000351196A patent/CA1137471A/fr not_active Expired
- 1980-05-05 CH CH346980A patent/CH643862A5/de not_active IP Right Cessation
- 1980-05-05 BE BE2/462A patent/BE883106A/fr not_active IP Right Cessation
- 1980-05-05 IE IE912/80A patent/IE49782B1/en unknown
- 1980-05-05 IT IT48583/80A patent/IT1143092B/it active
- 1980-05-06 JP JP5985280A patent/JPS568398A/ja active Pending
- 1980-12-16 ES ES497801A patent/ES497801A0/es active Granted

Also Published As

Publication number	Publication date
CH643862A5 (de)	1984-06-29
JPS568398A (en)	1981-01-28
IT1143092B (it)	1986-10-22
GB2050364B (en)	1983-04-27
ES491116A0 (es)	1981-04-16
ES8104320A1 (es)	1981-04-16
BE883106A (fr)	1980-11-05
SE8003317L (sv)	1980-11-04
FR2455595A1 (fr)	1980-11-28
FR2455595B1 (fr)	1983-08-12
AU532925B2 (en)	1983-10-20
ES8200899A1 (es)	1981-11-16
DK194280A (da)	1980-11-04
AU5803980A (en)	1980-11-06
IE800912L (en)	1980-11-03
IT8048583A0 (it)	1980-05-05
IE49782B1 (en)	1985-12-11
US4275192A (en)	1981-06-23
GB2050364A (en)	1981-01-07
CA1137471A (fr)	1982-12-14
DE3016974A1 (de)	1980-11-13
ES497801A0 (es)	1981-11-16

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