NL8006659A - Nieuwe, in de darm uiteenvallende tabletten en werkwijze voor hun bereiding. - Google Patents

Nieuwe, in de darm uiteenvallende tabletten en werkwijze voor hun bereiding. Download PDF

Info

Publication number: NL8006659A
Authority: NL; Netherlands
Prior art keywords: tablets; coating; tablets according; plasticizers; cellulose
Prior art date: 1979-12-10

Application number

NL8006659A

Other languages

English (en)

Dutch (nl)

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-12-10

Filing date

1980-12-08

Publication date

1981-07-01

1980-12-08 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1981-07-01 Publication of NL8006659A publication Critical patent/NL8006659A/nl

Links

238000002360 preparation method Methods 0.000 title claims description 8
238000000034 method Methods 0.000 title claims description 7
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
239000011248 coating agent Substances 0.000 claims description 15
210000001072 colon Anatomy 0.000 claims description 14
239000004480 active ingredient Substances 0.000 claims description 13
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 10
DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims description 10
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 10
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 10
239000008108 microcrystalline cellulose Substances 0.000 claims description 10
229940016286 microcrystalline cellulose Drugs 0.000 claims description 10
239000004014 plasticizer Substances 0.000 claims description 10
229920002678 cellulose Polymers 0.000 claims description 9
239000001913 cellulose Substances 0.000 claims description 9
235000010980 cellulose Nutrition 0.000 claims description 9
238000000576 coating method Methods 0.000 claims description 9
239000002904 solvent Substances 0.000 claims description 9
239000000203 mixture Substances 0.000 claims description 8
239000011247 coating layer Substances 0.000 claims description 7
239000001856 Ethyl cellulose Substances 0.000 claims description 6
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical group CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
235000019325 ethyl cellulose Nutrition 0.000 claims description 6
229920001249 ethyl cellulose Polymers 0.000 claims description 6
GVIRAXRGZUXHCI-UHFFFAOYSA-N 2-acetyloxycarbonylbenzoic acid Chemical compound CC(=O)OC(=O)C1=CC=CC=C1C(O)=O GVIRAXRGZUXHCI-UHFFFAOYSA-N 0.000 claims description 5
230000007935 neutral effect Effects 0.000 claims description 5
230000009278 visceral effect Effects 0.000 claims description 4
239000007921 spray Substances 0.000 claims description 3
238000005507 spraying Methods 0.000 claims description 3
210000001835 viscera Anatomy 0.000 claims 1
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 20
210000000813 small intestine Anatomy 0.000 description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
230000004807 localization Effects 0.000 description 10
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
210000002784 stomach Anatomy 0.000 description 5
210000000936 intestine Anatomy 0.000 description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
210000000845 cartilage Anatomy 0.000 description 3
230000003111 delayed effect Effects 0.000 description 3
241000894006 Bacteria Species 0.000 description 2
229920000297 Rayon Polymers 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
239000000975 dye Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
230000000968 intestinal effect Effects 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 2
229960005205 prednisolone Drugs 0.000 description 2
239000011347 resin Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
239000000126 substance Substances 0.000 description 2
WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
208000004881 Amebiasis Diseases 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
241000252983 Caecum Species 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
241000282412 Homo Species 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
206010061217 Infestation Diseases 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
210000001015 abdomen Anatomy 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940125717 barbiturate Drugs 0.000 description 1
235000021152 breakfast Nutrition 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
210000004534 cecum Anatomy 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
239000011162 core material Substances 0.000 description 1
230000029087 digestion Effects 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
210000002429 large intestine Anatomy 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
235000012054 meals Nutrition 0.000 description 1
CVRCFLFEGNKMEC-UHFFFAOYSA-N naphthalen-1-yl 2-hydroxybenzoate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC2=CC=CC=C12 CVRCFLFEGNKMEC-UHFFFAOYSA-N 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
229940053050 neomycin sulfate Drugs 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NL8006659A 1979-12-10 1980-12-08 Nieuwe, in de darm uiteenvallende tabletten en werkwijze voor hun bereiding. NL8006659A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR7930202A FR2471186A1 (fr)	1979-12-10	1979-12-10	Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation
FR7930202		1980-12-08

Publications (1)

Publication Number	Publication Date
NL8006659A true NL8006659A (nl)	1981-07-01

Family

ID=9232570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8006659A NL8006659A (nl)	1979-12-10	1980-12-08	Nieuwe, in de darm uiteenvallende tabletten en werkwijze voor hun bereiding.

Country Status (12)

Country	Link
US (1)	US4432966A (th)
JP (1)	JPS5692817A (th)
AT (1)	AT373146B (th)
BE (1)	BE886558A (th)
CA (1)	CA1157378A (th)
CH (1)	CH645021A5 (th)
DE (1)	DE3046559A1 (th)
FR (1)	FR2471186A1 (th)
GB (1)	GB2066070B (th)
IT (1)	IT1146245B (th)
NL (1)	NL8006659A (th)
SE (1)	SE445886B (th)

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* Cited by examiner, † Cited by third party
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1979
- 1979-12-10 FR FR7930202A patent/FR2471186A1/fr active Granted
1980
- 1980-10-30 SE SE8007639A patent/SE445886B/sv not_active IP Right Cessation
- 1980-12-08 NL NL8006659A patent/NL8006659A/nl not_active Application Discontinuation
- 1980-12-09 CA CA000366449A patent/CA1157378A/fr not_active Expired
- 1980-12-09 CH CH907580A patent/CH645021A5/fr not_active IP Right Cessation
- 1980-12-09 IT IT50333/80A patent/IT1146245B/it active
- 1980-12-09 BE BE0/203093A patent/BE886558A/fr not_active IP Right Cessation
- 1980-12-09 JP JP17270680A patent/JPS5692817A/ja active Granted
- 1980-12-09 GB GB8039377A patent/GB2066070B/en not_active Expired
- 1980-12-10 DE DE19803046559 patent/DE3046559A1/de active Granted
- 1980-12-10 AT AT0599780A patent/AT373146B/de not_active IP Right Cessation
1982
- 1982-08-31 US US06/413,483 patent/US4432966A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GB2066070B (en)	1983-07-06
FR2471186B1 (th)	1984-06-29
DE3046559A1 (de)	1981-09-17
IT8050333A0 (it)	1980-12-09
IT1146245B (it)	1986-11-12
CA1157378A (fr)	1983-11-22
FR2471186A1 (fr)	1981-06-19
SE445886B (sv)	1986-07-28
JPS5692817A (en)	1981-07-27
AT373146B (de)	1983-12-27
DE3046559C2 (th)	1988-12-22
SE8007639L (sv)	1981-06-11
CH645021A5 (fr)	1984-09-14
ATA599780A (de)	1983-05-15
GB2066070A (en)	1981-07-08
BE886558A (fr)	1981-06-09
US4432966A (en)	1984-02-21
JPH0258246B2 (th)	1990-12-07

Legal Events

Date	Code	Title
1985-01-01	A85	Still pending on 85-01-01
1988-02-01	BA	A request for search or an international-type search has been filed
1988-02-01	BB	A search report has been drawn up
1988-05-02	BC	A request for examination has been filed
1993-08-02	BV	The patent application has lapsed

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