NL8120252A - - Google Patents

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Publication number: NL8120252A
Authority: NL; Netherlands
Prior art keywords: voltage; limit value; swing; glucose; current
Prior art date: 1980-06-02

Application number

NL8120252A

Other languages

English (en)

Dutch (nl)

Original Assignee

Joslin Diabetes Center, Inc. Te Boston, Massachusetts, Ver. St. V. Am.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-02

Filing date

1981-06-01

Publication date

1982-05-03

1981-06-01 Application filed by Joslin Diabetes Center, Inc. Te Boston, Massachusetts, Ver. St. V. Am. filed Critical Joslin Diabetes Center, Inc. Te Boston, Massachusetts, Ver. St. V. Am.

1982-05-03 Publication of NL8120252A publication Critical patent/NL8120252A/nl

Links

WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 84
239000008103 glucose Substances 0.000 claims description 84
230000008859 change Effects 0.000 claims description 27
239000007788 liquid Substances 0.000 claims description 24
230000010354 integration Effects 0.000 claims description 12
239000013060 biological fluid Substances 0.000 claims description 10
230000002452 interceptive effect Effects 0.000 claims description 10
230000035945 sensitivity Effects 0.000 claims description 10
238000003487 electrochemical reaction Methods 0.000 claims description 7
230000001419 dependent effect Effects 0.000 claims description 6
238000000034 method Methods 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 6
230000001965 increasing effect Effects 0.000 claims description 5
230000003213 activating effect Effects 0.000 claims 2
238000006056 electrooxidation reaction Methods 0.000 claims 2
230000001737 promoting effect Effects 0.000 claims 2
230000000284 resting effect Effects 0.000 claims 1
238000005259 measurement Methods 0.000 description 15
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 14
239000004202 carbamide Substances 0.000 description 14
150000001413 amino acids Chemical class 0.000 description 13
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 13
239000012528 membrane Substances 0.000 description 6
229910052697 platinum Inorganic materials 0.000 description 6
230000003647 oxidation Effects 0.000 description 5
238000007254 oxidation reaction Methods 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
239000004809 Teflon Substances 0.000 description 3
229920006362 Teflon® Polymers 0.000 description 3
239000000872 buffer Substances 0.000 description 3
238000010586 diagram Methods 0.000 description 3
230000004044 response Effects 0.000 description 3
239000000243 solution Substances 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
230000004888 barrier function Effects 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
150000001768 cations Chemical class 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical class Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000012530 fluid Substances 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
239000012891 Ringer solution Substances 0.000 description 1
229910021607 Silver chloride Inorganic materials 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000002715 bioenergetic effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000005260 corrosion Methods 0.000 description 1
230000007797 corrosion Effects 0.000 description 1
238000003869 coulometry Methods 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
239000007789 gas Substances 0.000 description 1
150000002303 glucose derivatives Chemical class 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
239000003014 ion exchange membrane Substances 0.000 description 1
150000002605 large molecules Chemical class 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
239000000203 mixture Substances 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
UPIXZLGONUBZLK-UHFFFAOYSA-N platinum Chemical compound [Pt].[Pt] UPIXZLGONUBZLK-UHFFFAOYSA-N 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
239000000047 product Substances 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000003716 rejuvenation Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
230000011664 signaling Effects 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
-1 urine Substances 0.000 description 1
210000002700 urine Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pathology (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Electrochemistry (AREA)
Optics & Photonics (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Medical Informatics (AREA)
Surgery (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

NL8120252A 1980-06-02 1981-06-01 NL8120252A (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US15519880		1980-06-02
US06/155,198 US4340458A (en)	1980-06-02	1980-06-02	Glucose sensor
PCT/US1981/000725 WO1981003546A1 (en)	1980-06-02	1981-06-01	Method and apparatus for determining glucose in biological fluids
US8100725		1981-06-01

Publications (1)

Publication Number	Publication Date
NL8120252A true NL8120252A (da)	1982-05-03

Family

ID=22554460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8120252A NL8120252A (da)	1980-06-02	1981-06-01

Country Status (16)

Country	Link
US (2)	US4340458A (da)
EP (1)	EP0052148A4 (da)
JP (1)	JPS57500899A (da)
AU (1)	AU546417B2 (da)
BR (1)	BR8108636A (da)
CA (1)	CA1152155A (da)
CH (1)	CH660922A5 (da)
DE (1)	DE3152065A1 (da)
DK (1)	DK42982A (da)
FI (1)	FI68323C (da)
GB (2)	GB2089048B (da)
MX (1)	MX151191A (da)
NL (1)	NL8120252A (da)
NO (1)	NO159421C (da)
SE (2)	SE434887B (da)
WO (1)	WO1981003546A1 (da)

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1981
- 1981-06-01 JP JP56502289A patent/JPS57500899A/ja active Pending
- 1981-06-01 EP EP19810901848 patent/EP0052148A4/en not_active Withdrawn
- 1981-06-01 AU AU74126/81A patent/AU546417B2/en not_active Ceased
- 1981-06-01 GB GB8202427A patent/GB2089048B/en not_active Expired
- 1981-06-01 GB GB08404395A patent/GB2140567B/en not_active Expired
- 1981-06-01 BR BR8108636A patent/BR8108636A/pt unknown
- 1981-06-01 NL NL8120252A patent/NL8120252A/nl unknown
- 1981-06-01 WO PCT/US1981/000725 patent/WO1981003546A1/en not_active Ceased
- 1981-06-01 CA CA000378793A patent/CA1152155A/en not_active Expired
- 1981-06-01 DE DE813152065T patent/DE3152065A1/de not_active Withdrawn
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1982
- 1982-01-29 NO NO82820274A patent/NO159421C/no unknown
- 1982-01-29 SE SE8200511A patent/SE434887B/sv not_active IP Right Cessation
- 1982-02-01 DK DK42982A patent/DK42982A/da not_active Application Discontinuation
- 1982-02-02 FI FI820328A patent/FI68323C/fi not_active IP Right Cessation
- 1982-04-22 US US06/370,735 patent/US4396464A/en not_active Expired - Lifetime
1983
- 1983-07-25 SE SE8304129A patent/SE434888B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR8108636A (pt)	1982-04-13
CH660922A5 (de)	1987-05-29
WO1981003546A1 (en)	1981-12-10
EP0052148A4 (en)	1983-06-15
NO820274L (no)	1982-01-29
AU546417B2 (en)	1985-08-29
GB2089048B (en)	1985-01-30
FI68323C (fi)	1985-08-12
GB2089048A (en)	1982-06-16
GB2140567A (en)	1984-11-28
SE434888B (sv)	1984-08-20
US4340458A (en)	1982-07-20
MX151191A (es)	1984-10-09
FI68323B (fi)	1985-04-30
NO159421B (no)	1988-09-12
DK42982A (da)	1982-02-01
DE3152065A1 (de)	1982-08-12
NO159421C (no)	1988-12-21
SE8304129D0 (sv)	1983-07-25
GB8404395D0 (en)	1984-03-28
SE434887B (sv)	1984-08-20
US4396464A (en)	1983-08-02
EP0052148A1 (en)	1982-05-26
GB2140567B (en)	1985-06-05
SE8304129L (sv)	1983-07-25
CA1152155A (en)	1983-08-16
SE8200511L (sv)	1982-01-29
FI820328L (fi)	1982-02-02
JPS57500899A (da)	1982-05-20
AU7412681A (en)	1981-12-21

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