NL8400933A - Meclofenaminezuur bevattende topicale farmaceutische preparaten. - Google Patents

Meclofenaminezuur bevattende topicale farmaceutische preparaten. Download PDF

Info

Publication number: NL8400933A
Authority: NL; Netherlands
Prior art keywords: polyethylene glycol; acid; triglyceride; group; oil
Prior art date: 1983-04-18

Application number

NL8400933A

Other languages

English (en)

Dutch (nl)

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-18

Filing date

1984-03-23

Publication date

1984-11-16

1984-03-23 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1984-11-16 Publication of NL8400933A publication Critical patent/NL8400933A/nl

Links

SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 title claims description 30
229960003803 meclofenamic acid Drugs 0.000 title claims description 30
230000000699 topical effect Effects 0.000 title claims description 8
239000000825 pharmaceutical preparation Substances 0.000 title description 2
229920001223 polyethylene glycol Polymers 0.000 claims description 50
239000002202 Polyethylene glycol Substances 0.000 claims description 49
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 19
150000002148 esters Chemical class 0.000 claims description 18
239000000203 mixture Substances 0.000 claims description 16
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 14
239000006071 cream Substances 0.000 claims description 13
239000003921 oil Substances 0.000 claims description 13
235000019198 oils Nutrition 0.000 claims description 13
239000003755 preservative agent Substances 0.000 claims description 12
230000002335 preservative effect Effects 0.000 claims description 12
239000004166 Lanolin Substances 0.000 claims description 11
229940039717 lanolin Drugs 0.000 claims description 11
235000019388 lanolin Nutrition 0.000 claims description 11
239000002480 mineral oil Substances 0.000 claims description 11
235000010446 mineral oil Nutrition 0.000 claims description 11
-1 polyethylene Polymers 0.000 claims description 10
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 9
238000002360 preparation method Methods 0.000 claims description 9
239000000243 solution Substances 0.000 claims description 9
238000003756 stirring Methods 0.000 claims description 8
239000002562 thickening agent Substances 0.000 claims description 8
239000004698 Polyethylene Substances 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 7
238000009472 formulation Methods 0.000 claims description 7
229920000573 polyethylene Polymers 0.000 claims description 7
239000000839 emulsion Substances 0.000 claims description 6
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 6
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 6
238000000034 method Methods 0.000 claims description 6
235000010199 sorbic acid Nutrition 0.000 claims description 6
239000004334 sorbic acid Substances 0.000 claims description 6
229940075582 sorbic acid Drugs 0.000 claims description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
YDCVUQVGJSAAKA-UHFFFAOYSA-N octadecanoic acid;prop-1-ene Chemical compound CC=C.CCCCCCCCCCCCCCCCCC(O)=O YDCVUQVGJSAAKA-UHFFFAOYSA-N 0.000 claims description 5
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
239000007864 aqueous solution Substances 0.000 claims description 4
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
229940075614 colloidal silicon dioxide Drugs 0.000 claims description 4
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 4
206010061218 Inflammation Diseases 0.000 claims description 3
DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 3
BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims description 3
230000004054 inflammatory process Effects 0.000 claims description 3
238000002156 mixing Methods 0.000 claims description 3
RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 2
239000005711 Benzoic acid Substances 0.000 claims description 2
DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 2
235000019482 Palm oil Nutrition 0.000 claims description 2
235000010233 benzoic acid Nutrition 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
229960002216 methylparaben Drugs 0.000 claims description 2
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 2
239000002540 palm oil Substances 0.000 claims description 2
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
229960003415 propylparaben Drugs 0.000 claims description 2
239000013589 supplement Substances 0.000 claims description 2
229940075529 glyceryl stearate Drugs 0.000 claims 1
BJHIKXHVCXFQLS-OTWZMJIISA-N keto-L-sorbose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-OTWZMJIISA-N 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
229960004592 isopropanol Drugs 0.000 description 5
PYSICVOJSJMFKP-UHFFFAOYSA-N 3,5-dibromo-2-chloropyridine Chemical compound ClC1=NC=C(Br)C=C1Br PYSICVOJSJMFKP-UHFFFAOYSA-N 0.000 description 4
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
229940075507 glyceryl monostearate Drugs 0.000 description 3
150000002334 glycols Chemical class 0.000 description 3
238000010438 heat treatment Methods 0.000 description 3
229940068918 polyethylene glycol 400 Drugs 0.000 description 3
159000000000 sodium salts Chemical class 0.000 description 3
KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
MWEOKSUOWKDVIK-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCCOCCOCCOCCOCCOCCOCCO MWEOKSUOWKDVIK-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
239000008103 glucose Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
229940070765 laurate Drugs 0.000 description 2
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
229940032041 peg-8 laurate Drugs 0.000 description 2
239000002904 solvent Substances 0.000 description 2
FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
CTXGTHVAWRBISV-UHFFFAOYSA-N 2-hydroxyethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCO CTXGTHVAWRBISV-UHFFFAOYSA-N 0.000 description 1
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
102000003820 Lipoxygenases Human genes 0.000 description 1
108090000128 Lipoxygenases Proteins 0.000 description 1
102000004020 Oxygenases Human genes 0.000 description 1
108090000417 Oxygenases Proteins 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000003470 adrenal cortex hormone Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
229940124599 anti-inflammatory drug Drugs 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
229940114079 arachidonic acid Drugs 0.000 description 1
235000021342 arachidonic acid Nutrition 0.000 description 1
206010003246 arthritis Diseases 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036765 blood level Effects 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
239000006184 cosolvent Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
235000020778 linoleic acid Nutrition 0.000 description 1
230000007257 malfunction Effects 0.000 description 1
239000000155 melt Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229940093625 propylene glycol monostearate Drugs 0.000 description 1
150000003180 prostaglandins Chemical class 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical group CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NL8400933A 1983-04-18 1984-03-23 Meclofenaminezuur bevattende topicale farmaceutische preparaten. NL8400933A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48597383A	1983-04-18	1983-04-18
US48597383		1983-04-18

Publications (1)

Publication Number	Publication Date
NL8400933A true NL8400933A (nl)	1984-11-16

Family

ID=23930121

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8400933A NL8400933A (nl)	1983-04-18	1984-03-23	Meclofenaminezuur bevattende topicale farmaceutische preparaten.

Country Status (8)

Country	Link
AU (1)	AU560035B2 (fr)
BE (1)	BE899366A (fr)
CA (1)	CA1229554A (fr)
DE (1)	DE3414377A1 (fr)
FR (1)	FR2544198B1 (fr)
GB (1)	GB2138287B (fr)
NL (1)	NL8400933A (fr)
NZ (1)	NZ207874A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1216233B (it) *	1986-07-02	1990-02-22	Menarini Sas	Utilizzazione della forma farmaceutica 'gel'contenente acido n (2,6 dicloro m tolil) antranilico (acido meclofenamico) impiegabile in terapia per uso topico.
EP0318488A4 (fr) *	1986-08-18	1990-02-26	Biota Scient Management	Stimulation de l'angiogenese et promotion de l'endothelialisation.
US5332577A (en) *	1988-12-27	1994-07-26	Dermamed	Transdermal administration to humans and animals
US5241925A (en) *	1988-12-27	1993-09-07	Dermamed	Apparatus and techniques for administering veterinary medicaments
US5324521A (en) *	1989-12-18	1994-06-28	Dermamed	Systems for transdermal administration of medicaments

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5238030A (en) *	1975-07-04	1977-03-24	Gaba Ag	Mouth and tooth reparing agent
US4185100A (en) *	1976-05-13	1980-01-22	Johnson & Johnson	Topical anti-inflammatory drug therapy
NL175882C (nl) *	1977-03-28		Procter & Gamble	Farmaceutisch preparaat, dat een verbinding met ontstekingtegengaande werking bevat.
JPS5826815A (ja) *	1981-08-10	1983-02-17	Ikeda Mohandou:Kk	非ステロイド抗炎症軟膏およびその製法

1984
- 1984-02-23 CA CA000448165A patent/CA1229554A/fr not_active Expired
- 1984-02-29 AU AU25148/84A patent/AU560035B2/en not_active Ceased
- 1984-03-22 FR FR8404440A patent/FR2544198B1/fr not_active Expired
- 1984-03-23 NL NL8400933A patent/NL8400933A/nl not_active Application Discontinuation
- 1984-04-06 BE BE6/47951A patent/BE899366A/fr not_active IP Right Cessation
- 1984-04-11 GB GB08409412A patent/GB2138287B/en not_active Expired
- 1984-04-16 DE DE19843414377 patent/DE3414377A1/de not_active Withdrawn
- 1984-04-17 NZ NZ20787484A patent/NZ207874A/en unknown

Also Published As

Publication number	Publication date
NZ207874A (en)	1987-01-23
AU560035B2 (en)	1987-03-26
CA1229554A (fr)	1987-11-24
GB2138287A (en)	1984-10-24
BE899366A (fr)	1984-10-08
FR2544198A1 (fr)	1984-10-19
GB2138287B (en)	1986-03-05
FR2544198B1 (fr)	1987-11-20
AU2514884A (en)	1984-10-25
DE3414377A1 (de)	1984-11-15

Legal Events

Date	Code	Title	Description
1985-01-01	A85	Still pending on 85-01-01
1990-11-01	BV	The patent application has lapsed

Publication	Publication Date	Title
EP0782855B1 (fr)	2001-09-12	Nimesulide a usage externe
US20210353594A1 (en)	2021-11-18	Apremilast pharmaceutical compositions and methods
US20240252426A1 (en)	2024-08-01	Improved and stable apremilast pharmaceutical compositions
NL8400933A (nl)	1984-11-16	Meclofenaminezuur bevattende topicale farmaceutische preparaten.
US4602040A (en)	1986-07-22	Meclofenamic acid topical pharmaceutical composition
EP0352826B1 (fr)	1994-10-26	Utilisation de l'acide 5-aminosalicylique pour le traitement des maladies de la peau
JPH039089B2 (fr)	1991-02-07
CZ868686A3 (en)	1993-12-15	Primicin-containing colloidal elementary gel, and process for preparing thereof
EP0751928B1 (fr)	1999-11-17	Esters d'alcoyle de dl- di- ou tri-hydroxyphenylglycine destines au traitement d'etats inflammatoires et allergiques
US5244880A (en)	1993-09-14	Stable aqueous solutions of prymicin and pharmaceutical and cosmetic compositions containing these solutions
JP3193028B2 (ja)	2001-07-30	ニトロイミダゾール系化合物を含むアトピー性皮膚炎治療用の外用剤
HU224686B1 (hu)	2005-12-28	Külsőleg alkalmazható, nimeszulidot tartalmazó gyógyszerkészítmény és eljárás előállítására
JPS5839616A (ja)	1983-03-08	消炎鎮痛軟膏剤
JPH0323525B2 (fr)	1991-03-29
EP0367586B1 (fr)	1992-06-17	Solutions de primycine
KR890003842B1 (ko)	1989-10-05	항생제 프리마이신을 포함하는 신규 약제의 제조방법
CA3285859A1 (fr)	2026-01-19	Formulation pharmaceutique topique contenant un inhibiteur de kinase
EP0685230A1 (fr)	1995-12-06	Preparation dermatologique stable contenant de l'acide mycophenolique
JPH04275215A (ja)	1992-09-30	消炎鎮痛外用剤
JPH06145055A (ja)	1994-05-24	局所投与用医薬
JPWO1996011002A1 (ja)	1997-08-26	外用抗炎症剤
HK1001374B (en)	2002-03-28	Nimesulide for external use
JPS63238018A (ja)	1988-10-04	薬学的組成物