NL8500351A - Kweken van cellen met behulp van inborrelen van gas. - Google Patents

Kweken van cellen met behulp van inborrelen van gas. Download PDF

Info

Publication number: NL8500351A
Authority: NL; Netherlands
Prior art keywords: cells; medium; gas; oxygen; culture
Prior art date: 1984-02-13

Application number

NL8500351A

Other languages

English (en)

Dutch (nl)

Original Assignee

Damon Biotech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-13

Filing date

1985-02-07

Publication date

1985-09-02

1985-02-07 Application filed by Damon Biotech Inc filed Critical Damon Biotech Inc

1985-09-02 Publication of NL8500351A publication Critical patent/NL8500351A/nl

Links

238000012258 culturing Methods 0.000 title claims description 10
210000004027 cell Anatomy 0.000 claims description 133
239000002609 medium Substances 0.000 claims description 72
239000007789 gas Substances 0.000 claims description 63
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 46
229910052760 oxygen Inorganic materials 0.000 claims description 46
239000001301 oxygen Substances 0.000 claims description 46
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 42
239000002775 capsule Substances 0.000 claims description 41
238000000034 method Methods 0.000 claims description 32
229910002092 carbon dioxide Inorganic materials 0.000 claims description 21
239000001569 carbon dioxide Substances 0.000 claims description 18
210000004102 animal cell Anatomy 0.000 claims description 15
239000012528 membrane Substances 0.000 claims description 13
210000002421 cell wall Anatomy 0.000 claims description 7
230000011278 mitosis Effects 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 6
230000003833 cell viability Effects 0.000 claims description 4
206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
239000001963 growth medium Substances 0.000 claims description 3
201000000050 myeloid neoplasm Diseases 0.000 claims description 3
210000004216 mammary stem cell Anatomy 0.000 claims description 2
230000004060 metabolic process Effects 0.000 claims description 2
230000005587 bubbling Effects 0.000 description 16
238000004113 cell culture Methods 0.000 description 13
210000004379 membrane Anatomy 0.000 description 12
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
230000012010 growth Effects 0.000 description 8
235000018102 proteins Nutrition 0.000 description 7
108090000623 proteins and genes Proteins 0.000 description 7
102000004169 proteins and genes Human genes 0.000 description 7
238000005538 encapsulation Methods 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
230000010261 cell growth Effects 0.000 description 5
210000004408 hybridoma Anatomy 0.000 description 5
210000004962 mammalian cell Anatomy 0.000 description 5
239000000243 solution Substances 0.000 description 5
210000000481 breast Anatomy 0.000 description 4
238000012832 cell culture technique Methods 0.000 description 4
239000006260 foam Substances 0.000 description 4
238000011218 seed culture Methods 0.000 description 4
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000003094 microcapsule Substances 0.000 description 3
231100000419 toxicity Toxicity 0.000 description 3
230000001988 toxicity Effects 0.000 description 3
241000894006 Bacteria Species 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
MKWKNSIESPFAQN-UHFFFAOYSA-N N-cyclohexyl-2-aminoethanesulfonic acid Chemical compound OS(=O)(=O)CCNC1CCCCC1 MKWKNSIESPFAQN-UHFFFAOYSA-N 0.000 description 2
230000008901 benefit Effects 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
230000018044 dehydration Effects 0.000 description 2
238000006297 dehydration reaction Methods 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
239000012091 fetal bovine serum Substances 0.000 description 2
238000005187 foaming Methods 0.000 description 2
238000003306 harvesting Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
238000012544 monitoring process Methods 0.000 description 2
230000035699 permeability Effects 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
239000000725 suspension Substances 0.000 description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
239000008000 CHES buffer Substances 0.000 description 1
101100465890 Caenorhabditis elegans sel-12 gene Proteins 0.000 description 1
VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
210000000712 G cell Anatomy 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
238000005273 aeration Methods 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
238000013459 approach Methods 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000012620 biological material Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000000648 calcium alginate Substances 0.000 description 1
235000010410 calcium alginate Nutrition 0.000 description 1
229960002681 calcium alginate Drugs 0.000 description 1
OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000007599 discharging Methods 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
235000020774 essential nutrients Nutrition 0.000 description 1
229910001447 ferric ion Inorganic materials 0.000 description 1
239000012737 fresh medium Substances 0.000 description 1
238000007654 immersion Methods 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000011534 incubation Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
230000003211 malignant effect Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
229910052573 porcelain Inorganic materials 0.000 description 1
239000011148 porous material Substances 0.000 description 1
210000001236 prokaryotic cell Anatomy 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
238000013341 scale-up Methods 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000004114 suspension culture Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000014616 translation Effects 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/16—Particles; Beads; Granular material; Encapsulation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers

Landscapes

Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Sustainable Development (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NL8500351A 1984-02-13 1985-02-07 Kweken van cellen met behulp van inborrelen van gas. NL8500351A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57949384A	1984-02-13	1984-02-13
US57949384		1984-02-13

Publications (1)

Publication Number	Publication Date
NL8500351A true NL8500351A (nl)	1985-09-02

Family

ID=24317121

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8500351A NL8500351A (nl)	1984-02-13	1985-02-07	Kweken van cellen met behulp van inborrelen van gas.

Country Status (11)

Country	Link
JP (1)	JPS60199380A (fr)
AU (1)	AU572608B2 (fr)
BE (1)	BE901702A (fr)
DE (1)	DE3504748A1 (fr)
DK (1)	DK65085A (fr)
FR (1)	FR2559500A1 (fr)
GB (1)	GB2154246B (fr)
IT (1)	IT1184884B (fr)
NL (1)	NL8500351A (fr)
NO (1)	NO850534L (fr)
SE (1)	SE8500622L (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4724206A (en) *	1984-02-13	1988-02-09	Damon Biotech, Inc.	Protein production using hypertonic media
US4829002A (en) *	1986-05-12	1989-05-09	Baxter International Inc.	System for metering nutrient media to cell culture containers and method
EP0318487B1 (fr) *	1986-08-04	1993-10-13	The University Of New South Wales	Milieu de culture de tissus sans serum contenant un agent protecteur de cellules polymere
JPS6423888A (en) *	1987-07-16	1989-01-26	Etsuko Kakizaki	Culture vessel with micro-cellular wall
JP2509630B2 (ja) *	1987-07-29	1996-06-26	三井石油化学工業株式会社	培養方法及び培養装置
DE3739650C1 (de) *	1987-11-23	1989-05-24	Immuno Ag	Fermenter zum Zuechten von Zellkulturen
JP4740138B2 (ja)	2003-10-10	2011-08-03	ノボノルディスクヘルスケアアクチェンゲゼルシャフト	真核生物細胞におけるポリペプチドの大規模生産方法及びそれに適した培養容器

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4409331A (en) *	1979-03-28	1983-10-11	Damon Corporation	Preparation of substances with encapsulated cells
US4352883A (en) *	1979-03-28	1982-10-05	Damon Corporation	Encapsulation of biological material
US4724206A (en) *	1984-02-13	1988-02-09	Damon Biotech, Inc.	Protein production using hypertonic media

1985
- 1985-02-07 NL NL8500351A patent/NL8500351A/nl not_active Application Discontinuation
- 1985-02-08 GB GB08503248A patent/GB2154246B/en not_active Expired
- 1985-02-08 AU AU38571/85A patent/AU572608B2/en not_active Expired - Fee Related
- 1985-02-11 BE BE0/214491A patent/BE901702A/fr not_active IP Right Cessation
- 1985-02-12 SE SE8500622A patent/SE8500622L/xx not_active Application Discontinuation
- 1985-02-12 IT IT67141/85A patent/IT1184884B/it active
- 1985-02-12 DE DE19853504748 patent/DE3504748A1/de active Granted
- 1985-02-12 DK DK65085A patent/DK65085A/da not_active Application Discontinuation
- 1985-02-12 FR FR8501963A patent/FR2559500A1/fr active Pending
- 1985-02-12 NO NO850534A patent/NO850534L/no unknown
- 1985-02-13 JP JP60026134A patent/JPS60199380A/ja active Granted

Also Published As

Publication number	Publication date
AU572608B2 (en)	1988-05-12
SE8500622D0 (sv)	1985-02-12
DK65085D0 (da)	1985-02-12
DE3504748A1 (de)	1985-09-05
JPS60199380A (ja)	1985-10-08
DK65085A (da)	1985-08-14
DE3504748C2 (fr)	1987-07-23
NO850534L (no)	1985-08-14
BE901702A (fr)	1985-05-29
AU3857185A (en)	1985-08-22
IT1184884B (it)	1987-10-28
SE8500622L (sv)	1985-08-14
JPS6110115B2 (fr)	1986-03-28
IT8567141A1 (it)	1986-08-12
FR2559500A1 (fr)	1985-08-16
GB8503248D0 (en)	1985-03-13
IT8567141A0 (it)	1985-02-12
GB2154246B (en)	1987-09-09
GB2154246A (en)	1985-09-04

Legal Events

Date	Code	Title
1985-09-02	A1A	A request for search or an international-type search has been filed
1988-04-05	BB	A search report has been drawn up
1989-10-02	BV	The patent application has lapsed

Publication	Publication Date	Title
CA1275272C (fr)	1990-10-16	Aerateur et appareil ainsi que methode pour la culture des cellules
US4778749A (en)	1988-10-18	Tissue culture and production in permeable gels
US4724206A (en)	1988-02-09	Protein production using hypertonic media
JP7053827B2 (ja)	2022-04-12	細胞培養方法、生産物の製造方法、及び細胞培養装置
US20220204905A1 (en)	2022-06-30	Bioreactor and methods of use thereof
US5260211A (en)	1993-11-09	Process for cultivating adhesive cells in a packed bed of solid cell matrix
US20100203591A1 (en)	2010-08-12	Bioreactor, in particular for NMR spectroscopy
GB2154246A (en)	1985-09-04	Improved method of culturing cells
EP1500944A1 (fr)	2005-01-26	Bioreacteur, in particulier pour la spectroscopie par resonance magnetique
JPH0416153B2 (fr)	1992-03-23
Reuveny et al.	1986	Apparatus and methodology for microcarrier cell culture
JPS60102187A (ja)	1985-06-06	細胞生産物の連続大量培養法
CA2095197A1 (fr)	1993-11-02	Methode de regulation des vitesses de perfusion dans des cultures continues de cellules animales dans un bioreacteur
JPS61108371A (ja)	1986-05-27	微小担体上またはカプセル内で細胞を培養するための容器
JPH0428352B2 (fr)	1992-05-14
JPH10108673A (ja)	1998-04-28	中空糸型培養器を用いた動物細胞の培養方法
EP0198821B1 (fr)	1988-10-05	Procede de developpement en masse de cellules et appareil de mise en o euvre de ce procede
JPH0229310B2 (fr)	1990-06-28
JPH06105680A (ja)	1994-04-19	動物細胞の培養方法および培養装置
WO1987000197A1 (fr)	1987-01-15	Emprisonnement de cellules dependant de l'ancrage
US5223429A (en)	1993-06-29	Method for the mass growth of cells in a thin film of nutrient medium foam
EP0289616A1 (fr)	1988-11-09	Procede de multiplication de cellules animales
JPS60156378A (ja)	1985-08-16	細胞培養器
JPS6265681A (ja)	1987-03-24	付着性細胞の連続大量培養法
JPH0360477B2 (fr)	1991-09-13