NL8503213A - Prostaglandine-analogen, werkwijzen ter bereiding ervan alsmede farmaceutische preparaten, die de prostaglandine-analogen bevatten. - Google Patents

Prostaglandine-analogen, werkwijzen ter bereiding ervan alsmede farmaceutische preparaten, die de prostaglandine-analogen bevatten. Download PDF

Info

Publication number: NL8503213A
Authority: NL; Netherlands
Prior art keywords: group; formula; prostaglandin analog; carbon atoms; hydrogen atom
Prior art date: 1984-11-22

Application number

NL8503213A

Other languages

English (en)

Dutch (nl)

Original Assignee

May & Baker Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1985-11-21

Publication date

1986-06-16

1985-11-21 Application filed by May & Baker Ltd filed Critical May & Baker Ltd

1986-06-16 Publication of NL8503213A publication Critical patent/NL8503213A/nl

Links

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KOARADCEQDEFIO-UHFFFAOYSA-N hexan-1-olate;titanium(4+) Chemical compound CCCCCCO[Ti](OCCCCCC)(OCCCCCC)OCCCCCC KOARADCEQDEFIO-UHFFFAOYSA-N 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
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229910000041 hydrogen chloride Inorganic materials 0.000 description 1
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239000000314 lubricant Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
230000013011 mating Effects 0.000 description 1
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RPNNPZHFJPXFQS-UHFFFAOYSA-N methane;rhodium Chemical compound C.[Rh] RPNNPZHFJPXFQS-UHFFFAOYSA-N 0.000 description 1
QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
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IVYMDQDVHDERHD-UHFFFAOYSA-N methyl 5-(6a-silyloxy-3a,4,5,6-tetrahydro-1H-pentalen-2-yl)-5-oxopentanoate Chemical compound [SiH3]OC12CCCC2C=C(C1)C(CCCC(=O)OC)=O IVYMDQDVHDERHD-UHFFFAOYSA-N 0.000 description 1
YBTZROCKNUIONO-UHFFFAOYSA-N methyl 5-oxopentanoate Chemical compound COC(=O)CCCC=O YBTZROCKNUIONO-UHFFFAOYSA-N 0.000 description 1
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WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
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BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
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150000003174 prostaglandin I2 derivatives Chemical class 0.000 description 1
LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
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239000000377 silicon dioxide Substances 0.000 description 1
125000004469 siloxy group Chemical group [SiH3]O* 0.000 description 1
125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
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239000007858 starting material Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
239000003206 sterilizing agent Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000004434 sulfur atom Chemical group 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
DRDCQJADRSJFFD-UHFFFAOYSA-N tris-hydroxymethyl-methyl-ammonium Chemical compound OC[N+](C)(CO)CO DRDCQJADRSJFFD-UHFFFAOYSA-N 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
239000012808 vapor phase Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NL8503213A 1984-11-22 1985-11-21 Prostaglandine-analogen, werkwijzen ter bereiding ervan alsmede farmaceutische preparaten, die de prostaglandine-analogen bevatten. NL8503213A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8429545		1984-11-22
GB848429545A GB8429545D0 (en)	1984-11-22	1984-11-22	Compositions of matter

Publications (1)

Publication Number	Publication Date
NL8503213A true NL8503213A (nl)	1986-06-16

Family

ID=10570117

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8503213A NL8503213A (nl)	1984-11-22	1985-11-21	Prostaglandine-analogen, werkwijzen ter bereiding ervan alsmede farmaceutische preparaten, die de prostaglandine-analogen bevatten.

Country Status (8)

Country	Link
US (1)	US4698363A (fr)
JP (1)	JPS61129146A (fr)
BE (1)	BE903687A (fr)
DE (1)	DE3541384A1 (fr)
FR (1)	FR2573422B1 (fr)
GB (2)	GB8429545D0 (fr)
IT (1)	IT1207509B (fr)
NL (1)	NL8503213A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0680027B2 (ja) *	1985-09-18	1994-10-12	財団法人相模中央化学研究所	プロスタサイクリン類及びこれらを含有する薬剤
ATE306256T1 (de)	1999-08-05	2005-10-15	Teijin Ltd	Mittel zur besserung der neuropathie, die als wirkstoff stickstoffhaltige verbindungen enthalten
US6906046B2 (en)	2000-12-22	2005-06-14	Celltech R & D Inc.	Pharmaceutical uses and synthesis of benzobicyclooctanes

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4192891A (en) *	1979-04-25	1980-03-11	E. R. Squibb & Sons, Inc.	Prostacyclin analogs and their use in inhibition of arachidonic acid-induced platelet aggregation and bronchoconstriction
US4254041A (en) *	1979-07-05	1981-03-03	The Upjohn Company	19-Hydroxy-5-hydroxy-PGI compounds
JPS56150039A (en) *	1980-04-22	1981-11-20	Sankyo Co Ltd	Clathrate compound of prostacycline derivative
US4517202A (en) *	1982-05-28	1985-05-14	May & Baker Limited	Prostaglandin analogues
JPS59137445A (ja) *	1983-01-27	1984-08-07	Teijin Ltd	プロスタサイクリン類及びその製法
JPS59210044A (ja) *	1983-05-13	1984-11-28	Teijin Ltd	プロスタサイクリン類の製法
EP0136779B1 (fr) *	1983-07-26	1988-09-14	Sankyo Company Limited	Dérivés de carbacycline, procédés pour leur préparation et compositions les contenant
JPS6028943A (ja) *	1983-07-26	1985-02-14	Sankyo Co Ltd	カルバサイクリン類縁体
EP0134153B1 (fr) *	1983-08-19	1989-04-19	Sagami Chemical Research Center	Dérivés du bicyclo[3.3.0]octane et leur préparation
JPS60202840A (ja) *	1984-03-28	1985-10-14	Sagami Chem Res Center	（３’−アルコキシ−１’−アルケニル）−シス−ビシクロ〔３．３．０〕オクテン誘導体
JPS6130549A (ja) *	1984-07-23	1986-02-12	Sankyo Co Ltd	ビシクロオクタン化合物
EP0171992B1 (fr) *	1984-08-09	1990-06-06	Mitsubishi Kasei Corporation	Médicaments contenant la prostaglandine I2
JPS6185346A (ja) *	1984-10-03	1986-04-30	Sagami Chem Res Center	ビシクロ〔３．３．０〕オクタン誘導体
JPS6185348A (ja) *	1984-10-03	1986-04-30	Sagami Chem Res Center	ビシクロ〔３．３．０〕オクタノン誘導体
JPS61122292A (ja) *	1984-11-16	1986-06-10	Teijin Ltd	新規カルバサイクリン中間体の製法
JPH11539A (ja) *	1997-06-12	1999-01-06	Asahi Chem Ind Co Ltd	ポリアクリロニトリル系膜およびその製造方法

1984
- 1984-11-22 GB GB848429545A patent/GB8429545D0/en active Pending
1985
- 1985-11-19 FR FR8517058A patent/FR2573422B1/fr not_active Expired
- 1985-11-20 US US06/799,796 patent/US4698363A/en not_active Expired - Fee Related
- 1985-11-20 GB GB8528522A patent/GB2167415B/en not_active Expired
- 1985-11-21 NL NL8503213A patent/NL8503213A/nl not_active Application Discontinuation
- 1985-11-21 BE BE0/215899A patent/BE903687A/fr not_active IP Right Cessation
- 1985-11-22 IT IT8522959A patent/IT1207509B/it active
- 1985-11-22 DE DE19853541384 patent/DE3541384A1/de not_active Withdrawn
- 1985-11-22 JP JP60261613A patent/JPS61129146A/ja active Pending

Also Published As

Publication number	Publication date
GB2167415B (en)	1989-06-07
JPS61129146A (ja)	1986-06-17
FR2573422A1 (fr)	1986-05-23
GB2167415A (en)	1986-05-29
DE3541384A1 (de)	1986-05-22
US4698363A (en)	1987-10-06
GB8429545D0 (en)	1985-01-03
IT8522959A0 (it)	1985-11-22
GB8528522D0 (en)	1985-12-24
IT1207509B (it)	1989-05-25
FR2573422B1 (fr)	1988-08-26
BE903687A (fr)	1986-05-21

Legal Events

Date	Code	Title	Description
1989-07-03	BV	The patent application has lapsed

Publication	Publication Date	Title
DE3153474C2 (fr)	1990-05-31
GB2099814A (en)	1982-12-15	15-deoxy-16-hydroxy prostaglandins
NL8503213A (nl)	1986-06-16	Prostaglandine-analogen, werkwijzen ter bereiding ervan alsmede farmaceutische preparaten, die de prostaglandine-analogen bevatten.
US3950363A (en)	1976-04-13	Prostaglandin cyclic ethers
GB2048254A (en)	1980-12-10	19,20-didehydro, 19-hydroxy and 19-oxo-prostaglandin derivatives
US4517202A (en)	1985-05-14	Prostaglandin analogues
IE52623B1 (en)	1988-01-06	Prostaglandin analogues and process for making same
US3904679A (en)	1975-09-09	15-Methyl and 15-ethyl prostaglandin F{HD 2{331 {0 {B analogs
JP3502952B2 (ja)	2004-03-02	プロスタグランジン誘導体
JPS6034931A (ja)	1985-02-22	プロスタグランジン類
US4681951A (en)	1987-07-21	Bicyclo(3.3.0)octene derivatives
US4634782A (en)	1987-01-06	7-fluoro-dihydro PGI compounds
US3822303A (en)	1974-07-02	Trimethyl silyl esters of prostaglandin e acids and esters and process therefor
GB2140418A (en)	1984-11-28	Carbacyclin analogues
FR2547818A1 (fr)	1984-12-28	Nouveaux analogues de prostaglandines, leur preparation, les compositions pharmaceutiques qui les contiennent et les intermediaires-cles pour les preparer
GB2121410A (en)	1983-12-21	9 alpha -oxo and hydroxy carbacyclins
US4021467A (en)	1977-05-03	9-Deoxy-9α-hydroxymethyl-PGF2 analogs
US4680415A (en)	1987-07-14	Intermediates for 7-fluoro dihydro PGI compounds
JPS58126835A (ja)	1983-07-28	インタア−ｍ−フエニレン−プロスタサイクリン類縁体及びその製法
CA1112240A (fr)	1981-11-10	Derives bicycloalkyles de prostaglandines
US4069386A (en)	1978-01-17	15-Alkyl prostaglandins E1
US4681962A (en)	1987-07-21	Novel 7-fluoro-dihydro PGI compounds
IE44248B1 (en)	1981-09-23	4-hydroxy-5-oxo-1-cyclopentene alkanoic acid derivatives,methods for their preparation and their use
KR840001569B1 (ko)	1984-10-06	△ 2-pgf_₂및 △2-pge_₂계열의 프로스타글란딘 유도체의 제조방법
JP3363489B2 (ja)	2003-01-08	プロスタグランジン誘導体