NL8520012A - Aceetaminofeen gelatinecapsule, die snelle aanvang van therapeutische activiteit na orale toediening oplevert. - Google Patents

Aceetaminofeen gelatinecapsule, die snelle aanvang van therapeutische activiteit na orale toediening oplevert. Download PDF

Info

Publication number: NL8520012A
Authority: NL; Netherlands
Prior art keywords: capsule; molecular weight; polyethylene glycol; filler material; weight polyethylene
Prior art date: 1984-02-08

Application number

NL8520012A

Other languages

English (en)

Dutch (nl)

Original Assignee

Scherer Corp R P

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-08

Filing date

1985-01-07

Publication date

1986-01-02

1985-01-07 Application filed by Scherer Corp R P filed Critical Scherer Corp R P

1986-01-02 Publication of NL8520012A publication Critical patent/NL8520012A/nl

Links

RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title claims description 88
239000007903 gelatin capsule Substances 0.000 title claims description 29
230000001225 therapeutic effect Effects 0.000 title description 15
229920001223 polyethylene glycol Polymers 0.000 claims description 64
239000000463 material Substances 0.000 claims description 57
239000000945 filler Substances 0.000 claims description 56
239000002202 Polyethylene glycol Substances 0.000 claims description 46
239000002775 capsule Substances 0.000 claims description 45
108010010803 Gelatin Proteins 0.000 claims description 31
239000008273 gelatin Substances 0.000 claims description 31
229920000159 gelatin Polymers 0.000 claims description 31
235000019322 gelatine Nutrition 0.000 claims description 31
235000011852 gelatine desserts Nutrition 0.000 claims description 31
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 28
229960005489 paracetamol Drugs 0.000 claims description 28
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
239000000203 mixture Substances 0.000 claims description 19
239000004094 surface-active agent Substances 0.000 claims description 17
239000004034 viscosity adjusting agent Substances 0.000 claims description 17
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 16
238000000034 method Methods 0.000 claims description 11
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
230000000916 dilatatory effect Effects 0.000 claims description 7
241000124008 Mammalia Species 0.000 claims description 5
229910021485 fumed silica Inorganic materials 0.000 claims description 5
239000000499 gel Substances 0.000 claims description 5
239000002245 particle Substances 0.000 claims description 5
239000000377 silicon dioxide Substances 0.000 claims description 5
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 4
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
229920000053 polysorbate 80 Polymers 0.000 claims description 4
229940068968 polysorbate 80 Drugs 0.000 claims description 4
239000004925 Acrylic resin Substances 0.000 claims description 3
230000036470 plasma concentration Effects 0.000 claims description 3
230000009747 swallowing Effects 0.000 claims description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
235000012239 silicon dioxide Nutrition 0.000 claims description 2
210000005095 gastrointestinal system Anatomy 0.000 claims 3
239000007905 soft elastic gelatin capsule Substances 0.000 description 21
238000009472 formulation Methods 0.000 description 14
238000004519 manufacturing process Methods 0.000 description 13
239000000843 powder Substances 0.000 description 12
239000000047 product Substances 0.000 description 9
239000003814 drug Substances 0.000 description 7
239000012530 fluid Substances 0.000 description 7
230000002496 gastric effect Effects 0.000 description 7
229940079593 drug Drugs 0.000 description 6
239000007887 hard shell capsule Substances 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
238000010521 absorption reaction Methods 0.000 description 5
238000004090 dissolution Methods 0.000 description 5
239000004014 plasticizer Substances 0.000 description 5
230000000202 analgesic effect Effects 0.000 description 3
239000003921 oil Substances 0.000 description 3
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
229930195708 Penicillin V Natural products 0.000 description 2
206010037660 Pyrexia Diseases 0.000 description 2
229960001138 acetylsalicylic acid Drugs 0.000 description 2
230000002411 adverse Effects 0.000 description 2
230000001754 anti-pyretic effect Effects 0.000 description 2
238000000576 coating method Methods 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
229940072647 panadol Drugs 0.000 description 2
229940056367 penicillin v Drugs 0.000 description 2
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 2
229940072651 tylenol Drugs 0.000 description 2
239000011782 vitamin Substances 0.000 description 2
229940088594 vitamin Drugs 0.000 description 2
229930003231 vitamin Natural products 0.000 description 2
235000013343 vitamin Nutrition 0.000 description 2
239000000080 wetting agent Substances 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000002221 antipyretic Substances 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000036765 blood level Effects 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000001934 delay Effects 0.000 description 1
235000015872 dietary supplement Nutrition 0.000 description 1
230000010339 dilation Effects 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000009969 flowable effect Effects 0.000 description 1
230000037406 food intake Effects 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
239000003349 gelling agent Substances 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
238000002483 medication Methods 0.000 description 1
239000000155 melt Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
229960000564 nitrofurantoin Drugs 0.000 description 1
-1 polyethylene Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229940050929 polyethylene glycol 3350 Drugs 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NL8520012A 1984-02-08 1985-01-07 Aceetaminofeen gelatinecapsule, die snelle aanvang van therapeutische activiteit na orale toediening oplevert. NL8520012A (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US57807084A	1984-02-08	1984-02-08
US57807084		1984-02-08
US8500019		1985-01-07
PCT/US1985/000019 WO1985003439A1 (en)	1984-02-08	1985-01-07	Acetaminophen gelatin capsule providing rapid onset of therapeutic activity upon oral administration

Publications (1)

Publication Number	Publication Date
NL8520012A true NL8520012A (nl)	1986-01-02

Family

ID=24311318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8520012A NL8520012A (nl)	1984-02-08	1985-01-07	Aceetaminofeen gelatinecapsule, die snelle aanvang van therapeutische activiteit na orale toediening oplevert.

Country Status (9)

Country	Link
EP (1)	EP0152292A3 (de)
JP (1)	JPH0713012B2 (de)
KR (1)	KR850700213A (de)
AU (1)	AU3880185A (de)
DK (1)	DK456485D0 (de)
FI (1)	FI853861A0 (de)
NL (1)	NL8520012A (de)
WO (1)	WO1985003439A1 (de)
ZA (1)	ZA85211B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8522453D0 (en) *	1985-09-11	1985-10-16	Lilly Industries Ltd	Chewable capsules
US5071643A (en) *	1986-10-17	1991-12-10	R. P. Scherer Corporation	Solvent system enhancing the solubility of pharmaceuticals for encapsulation
US4771077A (en) *	1986-10-21	1988-09-13	American Home Products Corporation (Del.)	Spray dried acetaminophen
US4760094A (en) *	1986-10-21	1988-07-26	American Home Products Corporation (Del.)	Spray dried acetaminophen
US5288479A (en) *	1989-01-17	1994-02-22	Sterling Drug, Inc.	Extrudable elastic oral pharmaceutical gel compositions and metered dose dispensers containing them and method of making and method of use thereof
EP0421825A1 (de) *	1989-08-11	1991-04-10	Kadem Farmaseutiese Produktie B.K.	Paracetamol enthaltende Lösungen
GB8926612D0 (en) *	1989-11-24	1990-01-17	Erba Farmitalia	Pharmaceutical compositions
US5141961A (en) *	1991-06-27	1992-08-25	Richrdson-Vicks Inc.	Process for solubilizing difficulty soluble pharmaceutical actives
US5431916A (en) *	1993-04-29	1995-07-11	The Procter & Gamble Company	Pharmaceutical compositions and process of manufacture thereof
ITRM980488A1 (it) *	1998-07-23	2000-01-23	Nyl Service S R L	Capsule autosigillanti e procedimento per la loro produzione
KR100614032B1 (ko) *	2005-02-21	2006-08-22	주식회사 서흥캅셀	피막 강도를 개선시킨 젤라틴 경질캅셀
GB0506982D0 (en) *	2005-04-06	2005-05-11	Mw Encap Ltd	Abuse resistant capsules
AU2007271088A1 (en) *	2006-07-06	2008-01-10	Ares Trading S.A.	An oral pharmaceutical composition of an anilinopyrimidine, its preparation and use thereof
EP2512520B1 (de) *	2009-12-18	2013-09-11	Koninklijke Philips Electronics N.V.	POLYETHYLENGLYKOL ENTHALTENDE & xA;ZUSAMMENSETZUNG FÜR EIN RASIERHILFSMITTEL
AU2014306759B2 (en)	2013-08-12	2018-04-26	Pharmaceutical Manufacturing Research Services, Inc.	Extruded immediate release abuse deterrent pill
US9492444B2 (en)	2013-12-17	2016-11-15	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
US10172797B2 (en)	2013-12-17	2019-01-08	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
EP3169315B1 (de)	2014-07-17	2020-06-24	Pharmaceutical Manufacturing Research Services, Inc.	Missbrauchssichere flüssigkeitsfülldosierform mit unmittelbarer freisetzung
US20160106737A1 (en)	2014-10-20	2016-04-21	Pharmaceutical Manufacturing Research Services, Inc.	Extended Release Abuse Deterrent Liquid Fill Dosage Form
CA3100314A1 (en) *	2018-05-16	2019-11-21	Bayer Healthcare Llc	High concentration suspension formulation for cold and flu soft gel capsule medications
KR102050069B1 (ko) *	2019-03-29	2019-11-28	(주)알피바이오	안정성이 향상된 연질캡슐 제제용 충진조성물 및 이를 포함하는 연질캡슐 제제

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2870062A (en) *	1956-04-27	1959-01-20	Scherer Corp R P	Gelatin composition for capsules
US2889252A (en) *	1956-05-14	1959-06-02	American Cyanamid Co	Gelatin capsule containing hexylresorcinol and a lower polyalkylene glycol
US2973301A (en) *	1959-03-12	1961-02-28	Lloyd Brothers Inc	Soft gelatin capsule
US2990334A (en) *	1959-06-29	1961-06-27	Upjohn Co	Gelatin capsules enclosing a watermiscible vehicle
US2990333A (en) *	1959-06-29	1961-06-27	Upjohn Co	Gelatin capsule with nu-alkyl amide, for aqueous vehicles
FR1599474A (de) *	1968-12-27	1970-07-15
US3779942A (en) *	1970-12-04	1973-12-18	Minnesota Mining & Mfg	Capsules and process for forming capsules
ZA728764B (en) *	1971-12-29	1973-08-29	Squibb & Sons Inc	One piece gelatin capsules containing chloral hydrate
US3859431A (en) *	1973-01-04	1975-01-07	Lilly Industries Ltd	Drug formulations
US4198391A (en) *	1973-07-20	1980-04-15	R. P. Scherer Ltd.	Pharmaceutical compositions
DE2614864C3 (de) *	1976-04-06	1979-11-29	Schwabe, Willmar, Dr., 7500 Karlsruhe	Verfahren zur Herstellung Digoxin enthaltender Arzneipräparate in Weichgelatinekapseln zur oralen Verabfolgung
GB1572226A (en) *	1977-11-03	1980-07-30	Hoechst Uk Ltd	Pharmaceutical preparations in solid unit dosage form
GB2075837B (en) *	1980-05-14	1984-03-14	Hisamitsu Pharmaceutical Co	Topical pharmaceutical gel containing anti-inflammatory analgesic agents
US4310543A (en) *	1980-10-09	1982-01-12	Hoffmann-La Roche Inc.	Prostaglandin compositions
US4428927A (en) *	1981-05-11	1984-01-31	R. P. Scherer Corporation	Masticatory soft elastic gelatin capsules and method for the manufacture thereof
US4507276A (en) *	1982-08-20	1985-03-26	Bristol-Myers Company	Analgesic capsule
US4486412A (en) *	1983-03-15	1984-12-04	Pharmacaps, Inc.	Encapsulated antacid dispersions

1985
- 1985-01-07 JP JP60500517A patent/JPH0713012B2/ja not_active Expired - Lifetime
- 1985-01-07 NL NL8520012A patent/NL8520012A/nl unknown
- 1985-01-07 WO PCT/US1985/000019 patent/WO1985003439A1/en not_active Ceased
- 1985-01-07 AU AU38801/85A patent/AU3880185A/en not_active Abandoned
- 1985-01-07 KR KR1019850700246A patent/KR850700213A/ko not_active Withdrawn
- 1985-01-09 ZA ZA85211A patent/ZA85211B/xx unknown
- 1985-02-08 EP EP85300870A patent/EP0152292A3/de not_active Withdrawn
- 1985-10-04 FI FI853861A patent/FI853861A0/fi not_active Application Discontinuation
- 1985-10-07 DK DK456485A patent/DK456485D0/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1985003439A1 (en)	1985-08-15
EP0152292A3 (de)	1987-03-04
DK456485A (da)	1985-10-07
DK456485D0 (da)	1985-10-07
JPH0713012B2 (ja)	1995-02-15
FI853861A7 (fi)	1985-10-04
KR850700213A (ko)	1985-12-26
EP0152292A2 (de)	1985-08-21
FI853861A0 (fi)	1985-10-04
ZA85211B (en)	1985-08-28
AU3880185A (en)	1985-08-27
JPS61501202A (ja)	1986-06-19

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JP3678745B2 (ja)	2005-08-03	高濃度アセトアミノフェン溶液含有ゼラチンカプセル
EP0152292A2 (de)	1985-08-21	Acetaminophen-Gelatinekapseln
US10357467B2 (en)	2019-07-23	All-natural enteric soft capsules
ES2603225T3 (es)	2017-02-24	Sistema de cápsulas blandas sin gelatina
RU2121344C1 (ru)	1998-11-10	Лекарственная форма двухфазного действия с высвобождением для липофильных лекарственных препаратов и способ ее получения
US5431916A (en)	1995-07-11	Pharmaceutical compositions and process of manufacture thereof
JPS61158921A (ja)	1986-07-18	イブプロフエン含有ゼラチン軟カプセルおよびその製造方法
JPS6322032A (ja)	1988-01-29	ゼラチン封入徐放性組成物及びその製造方法
JPS62116508A (ja)	1987-05-28	咀嚼用カプセル剤
JP2856817B2 (ja)	1999-02-10	医薬組成物
WO2002067852A2 (en)	2002-09-06	A controlled release pharmaceutical composition
KR880002673B1 (ko)	1988-12-20	진통 캡슐제와 그 제조방법
JPH08253412A (ja)	1996-10-01	ポリエチレングリコールのためのゲル化剤
US7691411B2 (en)	2010-04-06	Pharmaceutical formulae for thyroid hormones and procedures for obtaining them
KR920007832B1 (ko)	1992-09-18	고온 용융성 테르페니딘 조성물의 제조방법
JPH0729916B2 (ja)	1995-04-05	鎮痛性を有する医薬組成物
JPH069381A (ja)	1994-01-18	イブプロフェン含有軟カプセル剤
JPS5988420A (ja)	1984-05-22	シ−ムレスカプセル化ニフエジピン製剤
AU2002356936A1 (en)	2003-06-10	Acetaminophen compositions
JPH05238954A (ja)	1993-09-17	咀嚼服用に適した担体
EP0695544A1 (de)	1996-02-07	Hartgelatine-Kapseln beständig gegen Denaturierung und Verfahren zu ihrer Herstellung
US5626872A (en)	1997-05-06	Pharmaceutical soft capsules containing lysine clonixinate and a process for their preparation
WO2022072099A1 (en)	2022-04-07	Immediate release dosage forms, methods of making and using
KR100558070B1 (ko)	2006-03-07	가용성 덱시부프로펜의 연질캅셀제 조성물 및 그의 제조방법
JPH0665078A (ja)	1994-03-08	リシンクロニキシネート含有医薬用軟カプセル