NO132482B - - Google Patents

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Info

Publication number: NO132482B
Authority: NO; Norway
Prior art keywords: coating; solution; mandrel; cellulose ether; aqueous
Prior art date: 1969-06-16

Application number

NO2293/70A

Other languages

English (en)

Norwegian (no)

Other versions

NO132482C (fr

Inventor

C A J Langman

Original Assignee

Dow Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-06-16

Filing date

1970-06-12

Publication date

1975-08-11

1970-06-12 Application filed by Dow Chemical Co filed Critical Dow Chemical Co

1975-08-11 Publication of NO132482B publication Critical patent/NO132482B/no

1975-11-19 Publication of NO132482C publication Critical patent/NO132482C/no

Links

238000000576 coating method Methods 0.000 claims description 29
239000011248 coating agent Substances 0.000 claims description 28
229920003086 cellulose ether Polymers 0.000 claims description 27
239000000243 solution Substances 0.000 claims description 20
230000006698 induction Effects 0.000 claims description 17
239000002775 capsule Substances 0.000 claims description 16
238000003618 dip coating Methods 0.000 claims description 15
238000010438 heat treatment Methods 0.000 claims description 13
238000000034 method Methods 0.000 claims description 11
239000007864 aqueous solution Substances 0.000 claims description 10
238000006467 substitution reaction Methods 0.000 claims description 9
229920013820 alkyl cellulose Polymers 0.000 claims description 5
125000002768 hydroxyalkyl group Chemical group 0.000 claims description 5
150000002170 ethers Chemical class 0.000 claims description 4
239000007787 solid Substances 0.000 claims description 4
125000000217 alkyl group Chemical group 0.000 claims description 2
238000007598 dipping method Methods 0.000 claims description 2
238000001816 cooling Methods 0.000 claims 1
239000000499 gel Substances 0.000 description 22
230000015572 biosynthetic process Effects 0.000 description 5
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 5
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 5
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 5
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
238000001035 drying Methods 0.000 description 4
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000010949 copper Substances 0.000 description 3
229910052802 copper Inorganic materials 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
239000011734 sodium Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
108010010803 Gelatin Proteins 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
238000001879 gelation Methods 0.000 description 2
-1 hydroxypropyl Chemical group 0.000 description 2
239000007788 liquid Substances 0.000 description 2
150000002739 metals Chemical class 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
238000001248 thermal gelation Methods 0.000 description 2
RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 description 1
229910001369 Brass Inorganic materials 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
239000010951 brass Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000002385 cottonseed oil Substances 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
239000000975 dye Substances 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
230000005672 electromagnetic field Effects 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
239000004519 grease Substances 0.000 description 1
RLMXGBGAZRVYIX-UHFFFAOYSA-N hexane-1,2,3,6-tetrol Chemical compound OCCCC(O)C(O)CO RLMXGBGAZRVYIX-UHFFFAOYSA-N 0.000 description 1
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
229920013819 hydroxyethyl ethylcellulose Polymers 0.000 description 1
230000003100 immobilizing effect Effects 0.000 description 1
230000001050 lubricating effect Effects 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000010959 steel Substances 0.000 description 1
239000010936 titanium Substances 0.000 description 1
229910052719 titanium Inorganic materials 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S264/00—Plastic and nonmetallic article shaping or treating: processes
- Y10S264/37—Processes and molds for making capsules
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S264/00—Plastic and nonmetallic article shaping or treating: processes
- Y10S264/46—Molding using an electrical heat

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Mechanical Engineering (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Manufacturing Of Micro-Capsules (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

NO2293/70A 1969-06-16 1970-06-12 NO132482C (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US83371569A	1969-06-16	1969-06-16

Publications (2)

Publication Number	Publication Date
NO132482B true NO132482B (fr)	1975-08-11
NO132482C NO132482C (fr)	1975-11-19

Family

ID=25265092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO2293/70A NO132482C (fr)	1969-06-16	1970-06-12

Country Status (6)

Country	Link
US (1)	US3617588A (fr)
CH (1)	CH542887A (fr)
DK (1)	DK128053B (fr)
GB (1)	GB1310697A (fr)
NO (1)	NO132482C (fr)
SE (1)	SE366322B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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US4001211A (en) *	1974-12-02	1977-01-04	The Dow Chemical Company	Pharmaceutical capsules from improved thermogelling methyl cellulose ethers
US4026986A (en) *	1975-05-22	1977-05-31	The Dow Chemical Company	Capsule shell
EP0198582B1 (fr)	1985-02-28	1990-09-19	The Dow Chemical Company	Hydroxypropylméthylcellulose utile comme agent de suspension pour la polymérisation en suspension de chlorure de vinyle
US4747992A (en) *	1986-03-24	1988-05-31	Sypula Donald S	Process for fabricating a belt
US4705658A (en) *	1986-04-07	1987-11-10	Capsule Technology International, Ltd.	Method for drying gelatin in the manufacture of hard shell gelatin capsules
KR900000254B1 (ko) *	1986-05-12	1990-01-24	신에쯔까 가가꾸 고우교우 가부시끼가이샤	의약용 경질 캅셀의 제조방법과 그 제조장치
GB8710833D0 (en) *	1987-05-07	1987-06-10	Porous Plastics Ltd	Microwave heating
JPH02113912A (ja) *	1988-10-24	1990-04-26	Dobashi Kikai:Kk	複合発泡成形体の製造方法
JPH0634807B2 (ja) *	1989-06-08	1994-05-11	信越化学工業株式会社	医薬用硬質カプセルの製造方法
US5576306A (en) *	1991-03-01	1996-11-19	Dow Chemical Company	Pharmaceutical compositions and uses of water-soluble, high-viscosity grade cellulose ethers
US5698155A (en) *	1991-05-31	1997-12-16	Gs Technologies, Inc.	Method for the manufacture of pharmaceutical cellulose capsules
ES2170288T3 (es)	1991-05-31	2002-08-01	Scherer Technologies Inc R P	Metodo y aparato para fabricar capsulas farmaceuticas de celulosa, con secado de la capsula.
US5756123A (en) *	1994-12-01	1998-05-26	Japan Elanco Co., Ltd.	Capsule shell
US5993185A (en) *	1996-03-21	1999-11-30	Farmacapsulas S.A.	Deck plate assemblies for forming capsules
US6000928A (en) *	1997-04-03	1999-12-14	Technophar Equipment & Service Limited	Capsule making machine having improved pin bars and air flow characteristics
US5945136A (en) *	1997-04-03	1999-08-31	Technophar Equipment & Service Limited	Heating elevator for capsule making machine
US6217815B1 (en) *	1998-06-10	2001-04-17	Carter-Wallace, Inc.	Method and apparatus for manufacturing prophylactic devices
US6752953B2 (en) *	2001-12-03	2004-06-22	Yung Shin Pharmaceutical Co., Ltd.	Method for manufacturing hard non-gelatin pharmaceutical capsules
GB0314832D0 (en) *	2003-06-25	2003-07-30	Phoqus Pharmaceuticals Ltd	Production of capsule shells and capsules
US7485609B2 (en) *	2005-09-29	2009-02-03	Kimberly-Clark Worldwide, Inc.	Encapsulated liquid cleanser
CN101595133B (zh)	2006-10-27	2012-11-14	比利时胶囊公司	羟丙基甲基纤维素硬胶囊及制备方法
US20090321087A1 (en) *	2008-06-27	2009-12-31	Electrical/Electronic Mechanical Industrial Equipment Ltd.	Expandable plug
EP3354335A1 (fr)	2010-10-26	2018-08-01	Capsugel Belgium NV	Enveloppes de gélules entériques en vrac
EP3446713A3 (fr)	2012-05-02	2019-05-15	Capsugel Belgium NV	Dispersions aqueuses de polymères à libération contrôlée et coques et capsules de celles-ci
EP2874613A1 (fr)	2012-07-23	2015-05-27	Dow Global Technologies, Inc.	Composition de film pour des enveloppes de capsule dure
US20160015647A1 (en)	2013-03-07	2016-01-21	Capsugel Belgium Nv	Bismuth liquid filled hard capsules
US20160256399A1 (en)	2013-11-04	2016-09-08	Capsugel Belgium Nv	Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
US10259921B2 (en)	2014-01-16	2019-04-16	Dow Global Technologies Llc	Support materials for 3D printing
US10471152B2 (en)	2014-08-29	2019-11-12	Capsugel Belgium Nv	Colloidal dispersion comprising HPMCAS
JP6412853B2 (ja) *	2015-12-16	2018-10-24	信越化学工業株式会社	フィルム成型用組成物
WO2018008660A1 (fr)	2016-07-06	2018-01-11	クオリカプス株式会社	Capsule dure à dureté améliorée et son procédé de fabrication
KR102406542B1 (ko)	2016-12-07	2022-06-13	쿠오리카프스 가부시키가이샤	겔화 보조제의 석출이 개선된 경질 캡슐 및 그 조제 방법
WO2021119271A1 (fr)	2019-12-10	2021-06-17	Capsugel Belgium Nv	Particules contenant un noyau de matrice lipidique et un ingrédient actif
WO2021154774A1 (fr)	2020-01-29	2021-08-05	Lonza Consumer Health Inc.	Composition pour la santé articulaire et son utilisation chez des mammifères sains
KR102448007B1 (ko) *	2021-11-25	2022-09-28	한국원자력환경공단	콘크리트 처분고의 방사성폐기물 처분용기 부식 지연을 위한 시공 공법
EP4472608A1 (fr)	2022-03-07	2024-12-11	Lonza Greenwood LLC	Méthode et composition pour améliorer la santé de la peau
US20260027188A1 (en)	2022-07-29	2026-01-29	Lonza Greenwood Llc	Method and Composition for Treating Conditions Associated with a Leaky Gut Barrier
CN116922647A (zh) *	2023-07-10	2023-10-24	安徽黄山胶囊股份有限公司	一种用于生产羟丙甲基纤维素热凝胶胶囊的模具加热装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1010389A (en) *	1963-05-16	1965-11-17	Veedip Ltd	Improvements in the manufacture of hollow articles by dip moulding
US3315016A (en) *	1964-06-25	1967-04-18	Davidson Rubber Company Inc	Induction heated-slush molding process
GB1144225A (en) *	1965-09-07	1969-03-05	Dow Chemical Co	Preparation of medicinal capsule shells from hydroxyalkyl-alkyl cellulose ethers

1969
- 1969-06-16 US US833715A patent/US3617588A/en not_active Expired - Lifetime
1970
- 1970-06-11 SE SE08121/70A patent/SE366322B/xx unknown
- 1970-06-12 NO NO2293/70A patent/NO132482C/no unknown
- 1970-06-15 DK DK307570AA patent/DK128053B/da unknown
- 1970-06-15 CH CH902170A patent/CH542887A/de not_active IP Right Cessation
- 1970-06-16 GB GB2911970A patent/GB1310697A/en not_active Expired

Also Published As

Publication number	Publication date
DK128053B (da)	1974-02-25
US3617588A (en)	1971-11-02
NO132482C (fr)	1975-11-19
CH542887A (de)	1973-10-15
SE366322B (fr)	1974-04-22
DE2029402A1 (de)	1970-12-17
GB1310697A (en)	1973-03-21

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