NO146573C - 3a,4-dihydro-imidazo(1,5-a)(1,4)-diazepiner som anvendes som mellomprodukter for fremstilling av terapeutisk virksomme imidazo(1,5-a)(1,4)diazepiner - Google Patents

3a,4-dihydro-imidazo(1,5-a)(1,4)-diazepiner som anvendes som mellomprodukter for fremstilling av terapeutisk virksomme imidazo(1,5-a)(1,4)diazepiner

Info

Publication number
NO146573C
NO146573C NO802718A NO802718A NO146573C NO 146573 C NO146573 C NO 146573C NO 802718 A NO802718 A NO 802718A NO 802718 A NO802718 A NO 802718A NO 146573 C NO146573 C NO 146573C
Authority
NO
Norway
Prior art keywords
diazepines
imidazo
dihydro
intermediates
preparation
Prior art date
Application number
NO802718A
Other languages
English (en)
Other versions
NO802718L (no
NO146573B (no
Inventor
Rodney Ian Fryer
Armin Walser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO802718L publication Critical patent/NO802718L/no
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO146573B publication Critical patent/NO146573B/no
Publication of NO146573C publication Critical patent/NO146573C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO802718A 1974-09-11 1980-09-12 3a,4-dihydro-imidazo(1,5-a)(1,4)-diazepiner som anvendes som mellomprodukter for fremstilling av terapeutisk virksomme imidazo(1,5-a)(1,4)diazepiner NO146573C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50492474A 1974-09-11 1974-09-11

Publications (3)

Publication Number Publication Date
NO802718L NO802718L (no) 1976-03-12
NO146573B NO146573B (no) 1982-07-19
NO146573C true NO146573C (no) 1982-10-27

Family

ID=24008278

Family Applications (4)

Application Number Title Priority Date Filing Date
NO753069A NO147109C (no) 1974-09-11 1975-09-08 Analogifremgangsmaate ved fremstilling av terapeutisk aktive diazepin-derivater
NO802718A NO146573C (no) 1974-09-11 1980-09-12 3a,4-dihydro-imidazo(1,5-a)(1,4)-diazepiner som anvendes som mellomprodukter for fremstilling av terapeutisk virksomme imidazo(1,5-a)(1,4)diazepiner
NO802719A NO147914C (no) 1974-09-11 1980-09-12 Mellomprodukt ved fremstilling av farmakologisk aktive imidazol (1,5-a)(1,4)diazepinforbindelser
NO802720A NO148188C (no) 1974-09-11 1980-09-12 Benzofenon-derivater som mellomprodukter ved fremstilling av imidazo (1,5-alfa)(1,4)-benzodiazepiner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO753069A NO147109C (no) 1974-09-11 1975-09-08 Analogifremgangsmaate ved fremstilling av terapeutisk aktive diazepin-derivater

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO802719A NO147914C (no) 1974-09-11 1980-09-12 Mellomprodukt ved fremstilling av farmakologisk aktive imidazol (1,5-a)(1,4)diazepinforbindelser
NO802720A NO148188C (no) 1974-09-11 1980-09-12 Benzofenon-derivater som mellomprodukter ved fremstilling av imidazo (1,5-alfa)(1,4)-benzodiazepiner

Country Status (32)

Country Link
JP (1) JPS51125099A (no)
AT (1) AT360023B (no)
AU (1) AU505998B2 (no)
BE (1) BE833248A (no)
BR (1) BR7505864A (no)
CA (1) CA1067491A (no)
CH (2) CH619953A5 (no)
CU (1) CU34346A (no)
DD (1) DD121640A5 (no)
DE (1) DE2540522A1 (no)
DK (1) DK157615C (no)
ES (1) ES440850A1 (no)
FI (3) FI801764A7 (no)
FR (2) FR2285890A1 (no)
GB (1) GB1527131A (no)
HK (1) HK63381A (no)
HU (1) HU174752B (no)
IE (1) IE41844B1 (no)
IL (1) IL48069A (no)
KE (1) KE3173A (no)
LU (1) LU73356A1 (no)
MX (1) MX160600A (no)
MY (1) MY8200214A (no)
NL (1) NL171060C (no)
NO (4) NO147109C (no)
NZ (1) NZ178635A (no)
PH (2) PH16152A (no)
PL (1) PL106563B1 (no)
SE (4) SE425785B (no)
SU (1) SU814278A3 (no)
YU (1) YU40267B (no)
ZA (1) ZA755418B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125726A (en) * 1977-03-11 1978-11-14 Hoffmann-La Roche Inc. Imidazo[1,5-a][1,4]benzodiazepines
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
US4226768A (en) * 1979-05-29 1980-10-07 Hoffmann-La Roche Inc. Process for the preparation of imidazobenzodiazepines
US4226771A (en) * 1979-07-25 1980-10-07 Hoffmann-La Roche Inc. 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives
US4256637A (en) * 1979-12-20 1981-03-17 Hoffmann-La Roche Inc. Intermediates for the production of imidazobenzodiazepines
FR2479818A1 (en) * 1980-04-03 1981-10-09 Roussel Uclaf 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione
US4335042A (en) * 1980-04-21 1982-06-15 Hoffmann-La Roche Inc. Process to produce imidazobenzodiazepine intermediates
DE3329515C2 (de) * 1983-08-16 1985-11-14 Krohne Meßtechnik GmbH & Co KG, 4100 Duisburg Elektrische Schaltanordnung für einen magnetisch-induktiven Meßwertgeber
ZA845757B (en) * 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
FI880814A7 (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
CA2150805C (en) * 1992-12-04 2006-08-15 Frans Eduard Janssens Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives
US5843941A (en) * 1993-05-14 1998-12-01 Genentech, Inc. Ras farnesyl transferase inhibitors
CA2143246C (en) * 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
IN184976B (no) * 1996-06-13 2000-10-14 Ranbaxy Lab Ltd
IT1399764B1 (it) 2010-05-04 2013-05-03 F S I Fabbrica Italiana Sint Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam.
CN103086986B (zh) * 2011-11-01 2015-11-04 上海医药工业研究院 1,4-苯二氮卓-n-亚硝胺类中间体的制备方法及其应用
CN103804384B (zh) * 2014-01-27 2016-01-20 李宏 苯并二氮杂卓类化合物的制备方法
EP4129297A1 (en) 2016-03-18 2023-02-08 UWM Research Foundation, Inc. Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with alpha5-containing gabaa receptor agonists
AU2017313753B2 (en) 2016-08-16 2022-01-27 The Trustees Of Columbia University In The City Of New York GABA(A) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma
CN111410658B (zh) * 2020-03-30 2021-03-26 江苏恩华药业股份有限公司 咪达唑仑或其药物组合物的杂质a和杂质b及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA721060B (en) * 1970-10-30 1972-11-29 Takeda Chemical Industries Ltd Benzodiazepine derivatives
DE2056265A1 (en) * 1970-11-16 1972-05-31 Sumitomo Chemical Co. Ltd., Osaka (Japan) Benzodiazepine derivs - from glycylamidobenzophenone derivs in dmso
JPS4932874B1 (no) * 1970-12-11 1974-09-03
BE787251A (fr) * 1971-08-04 1973-02-05 Upjohn Co Nouvelles benzodiazepines et leur preparation
BE790839A (fr) * 1971-11-02 1973-04-30 Upjohn Co Nouvelles benzodiazepines, leur procede de preparation et medicament les contenant
BE792972A (fr) * 1971-12-20 1973-06-19 Hoffmann La Roche Derives de benzodiazepine
FR2183716A1 (en) * 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants
CA1005443A (en) * 1972-06-22 1977-02-15 Michio Nakanishi Thienodiazepine compounds

Also Published As

Publication number Publication date
HU174752B (hu) 1980-03-28
DE2540522A1 (de) 1976-04-08
CA1067491A (en) 1979-12-04
FI63234B (fi) 1983-01-31
SE433080B (sv) 1984-05-07
SE7902666L (sv) 1979-03-23
NO147109C (no) 1983-02-02
NO147914B (no) 1983-03-28
FI801764A7 (fi) 1981-01-01
FR2285890B1 (no) 1981-12-31
NO802720L (no) 1976-03-12
MY8200214A (en) 1982-12-31
NO148188B (no) 1983-05-16
FI752517A7 (no) 1976-03-12
NO148188C (no) 1983-08-24
JPS562073B2 (no) 1981-01-17
DE2540522C2 (no) 1988-10-20
YU228575A (en) 1983-01-21
NL7510620A (nl) 1976-03-15
NO802718L (no) 1976-03-12
SE7902667L (sv) 1979-03-23
CU20892L (es) 1982-08-24
IL48069A0 (en) 1975-11-25
FR2303016A1 (fr) 1976-10-01
IE41844B1 (en) 1980-04-09
PL106563B1 (pl) 1979-12-31
PH16152A (en) 1983-07-12
ZA755418B (en) 1977-06-29
NO802719L (no) 1976-03-12
SE425785B (sv) 1982-11-08
NL171060C (nl) 1983-02-01
JPS51125099A (en) 1976-11-01
FI63234C (fi) 1983-05-10
CH619953A5 (en) 1980-10-31
AU505998B2 (en) 1979-12-13
ES440850A1 (es) 1977-07-01
NO146573B (no) 1982-07-19
SU814278A3 (ru) 1981-03-15
SE449098B (sv) 1987-04-06
SE440504B (sv) 1985-08-05
SE7902668L (sv) 1979-03-23
AU8470475A (en) 1977-03-17
BR7505864A (pt) 1976-08-03
BE833248A (fr) 1976-03-10
NO753069L (no) 1976-03-12
HK63381A (en) 1981-12-24
PH15091A (en) 1982-08-03
FI801763A7 (fi) 1981-01-01
YU40267B (en) 1985-12-31
MX160600A (es) 1993-09-01
FR2303016B1 (no) 1982-07-09
CU34346A (es) 1982-08-24
NO147914C (no) 1983-07-06
AT360023B (de) 1980-12-10
DD121640A5 (no) 1976-08-12
DK157615B (da) 1990-01-29
GB1527131A (en) 1978-10-04
CH628053A5 (en) 1982-02-15
NO147109B (no) 1982-10-25
FR2285890A1 (fr) 1976-04-23
NZ178635A (en) 1982-12-21
IE41844L (en) 1976-03-11
DK157615C (da) 1990-06-25
ATA697775A (de) 1980-05-15
LU73356A1 (no) 1977-05-11
KE3173A (en) 1982-01-08
SE7509991L (sv) 1976-03-12
DK404175A (da) 1976-03-12
IL48069A (en) 1980-09-16

Similar Documents

Publication Publication Date Title
NO140301C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo(5,1-f)-as-triaziner
NL7611576A (nl) Werkwijze voor de bereiding van nieuweimidazo- lidinen.
NO146909C (no) Fremgangsmaate til fremstilling av terapeutisk virksomme pyrrolidinderivater.
SE422799B (sv) Analogiforfarande for framstellning av 1,3-dihydroimidazo (4,5-b)pyridin-2-oner
NL7510620A (nl) Werkwijze voor de bereiding van farmacologisch actieve imidazo (1,5-a) (1,4) diazepineverbin- dingen.
SE422580B (sv) Analogiforfarande for framstellning av imidazo (1,5-a)(1,4)diazepin-foreningar
SE410604B (sv) Analogiforfarande for framstellning av pyrazolo(3,4-e)(1,4)diazepinforeningar
SE402012B (sv) Analogiforfarande for framstellning av s-triazolo(1,5-a)(1,4)diazepinderivat
NL7501449A (nl) Werkwijze voor de bereiding van imidazo(2,1-b)- olen.
SE399895B (sv) Forfarande for framstellning av s-triazolo(3,4-b)benstiazoler
NO793447L (no) Fenyl-lavere-alkanoylaminer for bruk til fremstilling av terapeutisk virksomme forbindelser
SE443142B (sv) Forfarande for framstellning av rifamycinforeningar
SE7607786L (sv) Forfarande for framstellning av sulfamylbensylforeningar
NO146141C (no) Fremgangsmaate til fremstilling av aminocyklitolantibiotika
SE7600910L (sv) Forfarande for framstellning av polyuretaner
SE380804B (sv) Anologiforfarande for framstellning av s-triazolo (1,5-a) (1,4)
SE431450B (sv) Mellanprodukt till anvendning for framstellning av prostaglandinderivat
AR215887A1 (es) Procedimiento para la preparacion de compuestos imidazo(1,5-a)(1,4)diacepinicos
SE397093B (sv) Forfarande for framstellning av oktahydro-oxazolo(3,2-a)pyrrolo(2,1-c)pyrazinderivat
RO72884A (ro) Procedeu pentru prepararea de compusi indolici
SE7606761L (sv) Forfarnde for framstellning av l-oxo-lh-6-substiturerade pyrimido(1,2-a)-kinolin-2-karbonsyror
SE429044B (sv) Analogiforfarande for framstellning av imidazo-pyridiniumsalter
FI55664C (fi) Foerfarande foer framstaellning av blodtryckssaenkande 5-oxo-2,3-dihydro-imidazo-(1,2-a)-s-triaziner
SE394282B (sv) Forfarande for framstellning av imidazo(1,5-c)-tiazolidin-3-spiro-piperidinforeningar
SE424076B (sv) Analogiforfarande for framstellning av pyrrolo(2,1-b) (3)bensoazepinforeningar